2020

Buitinga M, Cohrs CM, Eter WA, Claessens-Joosten L, Frielink C, Bos D, Sandker G, Brom M, Speier S, Gotthardt M. Noninvasive Monitoring of Glycemia-Induced Regulation of GLP-1R Expression in Murine and Human Islets of Langerhans. Diabetes. 2020 Nov;69(11):2246-2252. doi: 10.2337/db20-0616. Epub 2020 Aug 25. PMID: 32843570
Carvalho-Oliveira M, Valdivia E, Verboom M, Sake H, Pogozhykh O, Niemann H, Schwinzer R, Petersen B, Seissler J, Blasczyk R, Figueiredo C. Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation. J Cell Mol Med. Mar 25. doi: 10.1111/jcmm.15136.
Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S. Dysfunction of Persisting β-Cells is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Rep. Apr 7;31(1):107469. doi: 10.1016/j.celrep.2020.03.033.
Cohrs CM, Chen C, Speier S. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging. Methods Mol Biol. 2020;2128:149-157. doi: 10.1007/978-1-0716-0385-7_11.
Denner J, LETTER TO THE EDITOR By definition…Xenotransplantation. 00:e12599.
Denner J, Längin M, Reichart B, Krüger L, Fiebig U, Mokelke M, Radan J, Mayr T, Milusev A, Luther F, Sorvillo N, Rieben R, Brenner P, Walz C, Wolf E, Roshani B, Stahl‑Hennig C, Abicht JM. Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival. Sci Rep Oct 16;10(1):17531. doi: 10.1038/s41598-020-73150-9.
Denner J. Sensitive detection systems for infectious agents in xenotransplantation*. Xenotransplantation. Apr 18;e12594. doi: 10.1111/xen.12594.
Denner J, Tanzi R, Jacobson S. Animal Models of Alzheimer's Disease Should Be Controlled for Roseolovirus. J Alzheimers Dis.;77(2):543-545.
Erikainen S, Friesen P, Rand L, Jongsma K, Dunn M, Sorbie A, McCoy M, Bell J, Burgess M, Chen H, Chico V, Cunningham-Burley S, Darbyshire J, Dawson R, Evans A, Fahy N, Finlay T, Frith L, Goldenberg A, Hinton L, Hoppe N, Hughes N, Koenig B, Lignou S, McGowan M, Parker M, Prainsack B, Shabani M, Staunton C, Thompson R, Varnai K, Vayena E, Wiliams O, Williamson M, Chan S, Sheehan M. Public involvement in the governance of population-level biomedical research: unresolved questions and future directions. J Med Ethics. 2020 Oct 6:medethics-2020-106530. doi: 10.1136/medethics-2020-106530. Epub ahead of print. PMID: 33023977.
Fischer*, Rieblinger* (Co-first author), Hein R, Sfriso R, Zuber J, Schäffler A, Klinger B, Wei L, Flisikowski K, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Rieben R, Schwinzer R, Kind A, Schnieke A. Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2. Xenotransplantation, 27(1):e12560.
Kögel J, Marckmann G. Xenotransplantation challenges us as a society. EMBO Rep. Aug 11:e50274. doi: 10.15252/embr.202050274.
Krüger L, Stillfried M, Prinz C, Schröder V, Neubert LK, Denner J. Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars. Viruses. Apr 8;12(4):419
Lanzerath D, Illig T, Bernemann I, Hoppe N, Robienski J. Humanbiobanken. Verlag Karl Alber, 2020, ISBN: 978-3-495-49037-2.
Moretti, A., Fonteyne L., Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Abdel Rahman F, Haufe T, Sun S, Jurisch V, Kessler BV, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C. Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Nature Medicine Feb;26(2):207-214. doi: 10.1038/s41591-019-0738-2. Epub 2020 Jan 27
Panzer JK, Hiller H, Cohrs CM, Almaca J, Enos SJ, Beery M, Cechin S, Drotar DM, Weitz JR, Santini J, Huber MK, Qadir MMF, Pastori RL, Domínguez-Bendala J, Phelps EA, Atkinson MA, Pugliese A, Caicedo A, Kusmartseva I, Speier S. Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis. JCI Insight Apr 23;5(8):e134525. doi: 10.1172/jci.insight.134525
Panzer JK, Cohrs CM, Speier S. Using Pancreas Tissue Slices for the Study of Islet Physiology. Methods Mol Biol. 2020;2128:301-312. doi: 10.1007/978-1-0716-0385-7_20.
Reichart B, Längin M, Denner J, Schwinzer R, Cowan PJ, Wolf E. Pathways to Clinical Cardiac Xenotransplantation. Transplantation. Dec 21;Publish Ahead of Print. doi: 10.1097/TP.0000000000003588.
Reichart B, Längin M, Radan J, Mokelke M, Buttgereit I, Ying J, Fresch AK, Mayr T, Issl L, Buchholz S, Michel S, Ellgass R, Mihalj M, Egerer S, Baehr A, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Steen S, Sjöberg T, Paskevicius A, Krüger L, Fiebig U, Denner J, Godehardt AW, Tönjes RR, Milusev A, Rieben R, Sfriso R, Walz C, Kirchner T, Ayares D, Lampe K, Schönmann U, Hagl C, Wolf E, Klymiuk N, Abicht JM, Brenner P. Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation? J Heart Lung Transplant. Aug;39(8):751-757.
Reydon TAC. What attitude should scientists have? Good academic practice as a precondition for the production of knowledge in: McCain, K.R. & Kampourakis, K. (Hrsg.): What is Scientific Knowledge? An Introduction to Contemporary Epistemology of Science, Abingdon: Routledge.
Tang X, Kusmartseva I, Kulkarni S, Posgai A, Speier S, Schatz DA, Haller MJ, Campbell-Thompson M, Wasserfall CH, Roep BO, Kaddis JS, Atkinson MA. Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas. Am J Pathol. 2020 Dec 8:S0002-9440(20)30551-4. doi: 10.1016/j.ajpath.2020.11.010.
Troullinaki M, Chen LS, Witt A, Pyrina I, Phieler J, Kourtzelis I, Chmelar J, Sprott D, Gercken B, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes. FASEB J. Jan 9. doi: 10.1096/fj.201900125RR. Epub Jan. 9
Yuzefovych Y, Valdivia E, Rong S, Hack F, Rother T, Schmitz J, Bräsen JH, Wedekind D, Moers C, Wenzel N, Gueler F, Blasczyk R, Figueiredo C. Genetic engineering of the kidney to permanently silence MHC transcripts during ex vivo organ perfusion. Front. Immunol. Feb 19;11:265. doi: 10.3389/fimmu.2020.00265.