2016

Abicht J, Mayr T, Plotzki E, Falkenau A, Reichart B, Denner J, Guethoff S; Hepatic failure after pig heart transplantation into a baboon: No involvement of porcine hepatitis E virus. Ann Transplant. 21: 12-16.
Abicht J, Mayr TA, Jauch J, Guethoff S, Buchholz S, Reichart B, Bauer A. Large-Animal Biventricular Working Heart Perfusion System with Low Priming Volume-Comparison between in vivo and ex vivo Cardiac Function. Thorac Cardiovasc Surg. Apr 4.
Anastasiou, V., Ninou, E., Alexopoulou, D., Stertmann, J., Müller, A., Dahl, A., Solimena, M., Speier, S., Serafimidis, I. and Gavalas, A. Aldehyde dehydrogenase activity is necessary for β cell development and functionality. Diabetologia, 59, 139-50
Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H. Identification of proliferative and mature β-cells in the islets of Langerhans. Nature. Jul 21;535(7612):430-4. Epub 2016 Jul 11.
Bähr A, Käser T, Kemter E, Gerner W, Kurome M, Baars W, Herbach N, Witter K, Wünsch A, Talker SC, Kessler B, Nagashima H, Saalmüller A, Schwinzer R, Wolf E, Klymiuk N. Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs. PLoS One. 2016 May 13;11(5):e0155676. doi: 10.1371/journal.pone.0155676.
Bartlett ST, Markmann JF, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell P, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Kovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T. Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation. Feb;100 Suppl 2:S1-44.
Baumann AK, Schlue J, Noyan F, Hardtke-Wolenski M, Lehner F, Barg-Hock H, Klempnauer J, Manns MP, Taubert R, Jaeckel E. Preferential accumulation of T helper cells but not cytotoxic T cells characterizes benign subclinical rejection of human liver allografts. Liver Transpl. Jul;22(7):943-55. doi: 10.1002/lt.24427.
Buermann A, Römermann D, Baars W, Hundrieser J, Klempnauer J, Schwinzer R. Inhibition of B-cell activation and antibody production by triggering inhibitory signals via the PD-1/PD-ligand pathway. Xenotransplantation 23, 347-56.
Chen, C., Chmelova, H., Cohrs, C.M., Chouinard, J.A., Jahn, S.R., Stertmann, J., Uphues, I. and Speier, S. Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Diabetes 65, 840–846.
Cooper DK, Matsumoto S, Abalovich A, Itoh T, Mourad NI, Gianello PR, Wolf E, Cozzi E. Progress in Clinical Encapsulated Islet Xenotransplantation.Transplantation Nov;100(11):2301-2308. Review.
Cozzi E, Tönjes RR, Gianello P, Bühler LH, Rayat GR, Matsumoto S, Park CG, Kwon I, Wang W, O'Connell P, Jessamine S, Elliott RB, Kobayashi T, Hering BJ: First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 1: update on national regulatory frameworks pertinent to clinical islet xenotransplantation. Xenotransplantation 23: 14-24.
Denner J, Tönjes RR, Takeuchi Y, Fishman J, Scobie L: First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Chapter 5: recipient monitoring and response plan for preventing disease transmission. Xenotransplantation 23: 53-59.
Denner J; Immunosuppressive properties or retroviruses. Eur J Immunol. 46(1): 253-255.
Denner J. Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV) and the Koala Retrovirus (KoRV). Viruses. Dec 20;8(12). pii: E336. doi: 10.3390/v8120336. Review.
Denner J. Recent Progress in Xenotransplantation, with Emphasis on Virological Safety. Ann Transplant. Nov 22;21:717-727. Review.

Denner J. Expression and function of endogenous retroviruses in the placenta. APMIS. Jan-Feb;124(1-2):31-43. doi: 10.1111/apm.12474. Review.

Denner J. How Active Are Porcine Endogenous Retroviruses (PERVs)? Viruses. Aug 3;8(8). pii: E215. doi: 10.3390/v8080215. Review.
Fischer K, Kraner-Scheiber S, Petersen B, Rieblinger B et al. Efficient production of multi-modified pigs for xenotransplantation by cobineering, gene stacking and gene editing. Nature Scientific Reports 2016; doi: 10.1038/srep29081
Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun. Aug 31;7:12597. doi: 10.1038/ncomms12597.
Grützmann R*, Ludwig B*, Weitz J, Ludwig S. Total Pancreatectomy and Islet Autotransplantation in a Child with Recurrent Pancreatitis. Zentralbl Chir. Feb;141(1):17-20. * shared first authorship
Heinke S*, Ludwig B*, Schubert U, Schmid J, Kiss T, Steffen A, Bornstein S, Ludwig S. Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: a feasible approach for advanced diabetes research. Xenotransplantation. Sep;23(5):405-13 * shared first authorship
Heinze J, Plotzki E, Denner J. Virus Safety of Xenotransplantation: Prevalence of Porcine Cicrovirus 2 (PCV2) in Pigs. Ann Virol Res 2016;2:1023
Hering BJ, Cozzi E, Spizzo T, Cowan PJ, Rayat GR, Cooper DK, Denner J. First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Executive summary. Xenotransplantation. Jan-Feb;23(1):3-13. doi: 10.1111/xen.12231. Epub 2016 Mar 4.
Hermann MR, Jakobson M, Colo GP, Rognoni E, Jakobson M, Kupatt C, Posern G, Fässler R. Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion. J Cell Sci. Apr 1;129(7):1391-403. doi: 10.1242/jcs.177592. Epub 2016 Feb 12.
Hoppe N; Privacy Laws and Biobanking in Germany. The Journal of Law, Medicine & Ethics 44(1): 35-44.
Hoyningen-Huene, P., and Lohse, S. Kuhn, Thomas S. (1922-96). In: International Encyclopedia of the Social & Behavioral Sciences. 2^nd edition, Vol. 13, ed. Wright, James D. (editor-in-chief). Oxford: Elsevier, 133-138.
Kaye J, Briceño Moraia L, Curren L, Bell J, Mitchell C, Soini S, Hoppe N, Øien M, Rial-Sebbag, E; Consent for Biobanking: The Legal Frameworks of Countries in the BioSHaRE-EU Project. Biopreservation and Biobanking 14(3): 195-200.
Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. J Am Heart Assoc. Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429.
Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb Haemost. Apr;115(4):781-8.
Kragl M, Schubert R, Karsjens H, Otter S, Bartosinska B, Jeruschke K, Weiss J, Chen C, Alsteens D, Kuss O, Speier S, Eberhard D, Müller DJ, Lammert E. The biomechanical properties of an epithelial tissue determine the location of its vasculature. Nat Commun. Dec 20;7:13560. doi: 10.1038/ncomms13560.
Lohse, S., and Reydon, T. Grundriss Wissenschaftsphilosophie: Die Philosophien der Einzelwissenschaften. Hamburg: Meiner (forthcoming).
Lohse, S., and Greve, J. Philosophie der Soziologie. In: Grundriss Wissenschaftsphilosophie: Die Philosophien der Einzelwissenschaften, ed. Lohse, S. & Reydon, T. Hamburg: Meiner (forthcoming).
Lohse, S. Pragmatism, Ontology, and Philosophy of the Social Sciences in Practice. Philosophy of the Social Sciences 46, online first; abstract
Markmann JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell PJ, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Khovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T. Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement. Transplantation. Jul;100(7):e25-31.
Mathieu R. Jewish ethics and xenotransplantation. Xenotransplantation. Jul;23(4):258-68. doi: 10.1111/xen.12247. Epub 2016 Jul 7.
Morozov VA, Morozov AV, Denner J; New PCR diagnostic systems for the detection and quantification of the porcine cytomegalovirus (PCMV), Arch Virol Arch Virol. 161(5): 1159-1168.
Morozov VA, Plotzki E, Rotem A, Barkai U, Denner J. Extended microbiological characterization of Göttingen minipigs: porcine cytomegalovirus and other viruses. Xenotransplantation. Nov;23(6):490-496. doi: 10.1111/xen.12265. Epub 2016 Sep 11.

Morozov VA, Ludwig S, Ludwig B, Rotem A, Barkai U, Bornstein SR, Denner J. Islet cell transplantation from Göttingen minipigs to cynomolgus monkeys: analysis of virus safety. Xenotransplantation. Jul;23(4):320-7.
Morozov VA, Abicht JM, Reichart B, Mayr T, Guethoff S, Denner J. Active Replication of Porcine Cytomegalovirus (PCMV) Following Transplantation of a Pig Heart into a Baboon despite Undetected Virus in the Donor Pig. Ann Virol Res 2016;2:1018
Mühle M, Kroniger T, Hoffmann K, Denner J. The immunosuppressive domain of the transmembrane envelope protein gp41 of HIV-1 binds to human monocytes and B cells. Immunol Res. 64(3): 721-729.
Niemann H, Petersen B. The production of multi-transgenic pigs: update and perspectives for xenotransplantation. Transgenic Res Jun;25(3):361-74.
Petersen B, Frenzel A, Lucas-Hahn A, Herrmann D, Hassel P, Klein S, Ziegler M, Hadeler KG, Niemann H. Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes. Xenotransplantation. Sep;23(5):338-46. doi: 10.1111/xen.12258. Epub 2016 Sep 9.
Petkov S, Glage S, Nowak-Imialek M, Niemann H. Long-Term Culture of Porcine Induced Pluripotent Stem-Like Cells Under Feeder-Free Conditions in the Presence of Histone Deacetylase Inhibitors. Stem Cells Dev. Mar 1;25(5):386-94. doi: 10.1089/scd.2015.0317. Epub 2016 Jan 29.
Plotzki E, Heinrichs G, Kubícková B, Ulrich RG, Denner J; Microbiological characterization of a newly established pig breed, Aachen Minipigs. Xenotransplantation. 23(2): 159-167.
Plotzki E, Keller M, Ivanusic D, Denner J. A new Western blot assay for the detection of porcine cytomegalovirus (PCMV). J Immunol Methods. Oct;437:37-42. doi: 10.1016/j.jim.2016.08.001. Epub 2016 Aug 4.
Plotzki E, Keller M, Ehlers B, Denner J. Immunological methods for the detection of porcine lymphotropic herpesviruses (PLHV). J Virol Methods. Jul;233:72-7. doi: 10.1016/j.jviromet.2016.02.017. Epub 2016 Mar 29.
Ramm R, Niemann H, Petersen B, Haverich A, Hilfiker A Decellularized GGTA1-KO pig heart valves do not bind preformed human xenoantibodies. Basic Res Cardiol 111:1–13. doi: 10.1007/s00395-016-0560-7
Rataj D, Werwitzke S, Haarmeijer B, Winkler M, Ramackers W, Petersen B, Niemann H, Wünsch A, Bähr A, Klymiuk N, Wolf E, Abicht JM, Ayares D, Tiede A. Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation. Xenotransplantation Mar;23(2):117-27. doi: 10.1111/xen.12218. Epub 2016 Jan 16. PubMed PMID: 26773447.
Reydon, T.A.C.: ‘From a zooming-in model to a co-creation model: Towards a more dynamic account of classification and kinds’, in: Kendig, C.E. (Ed.): Natural Kinds and Classification in Scientific Practice, London & New York: Routledge, pp. 59-73.
Sautermeister J. Resilienz zwischen Selbstoptimierung und Identitätsbildung, in: Münchener Theologische Zeitschrift 67; 209-223
Sautermeister J. Wenn Krankheit zum Makel wird. Theologisch-ethische Reflexionen zur Stigmatisierung psychischer Erkrankungen, in: Stimmen der Zeit 234; 525-536
Spizzo T, Denner J, Gazda L, Martin M, Nathu D, Scobie L, Takeuchi Y; First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes—Chapter 2a: source pigs—preventing xenozoonoses. Xenotransplantation. 23(1): 25-31.

Subramanian P, Mitroulis I, Hajishengallis G, Chavakis T. Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors. Curr Opin Hematol. Jan;23(1):36-43. doi: 10.1097/MOH.0000000000000198. Review.
Taubert R, Danger R, Londoño MC, Christakoudi S, Martinez-Picola M, Rimola A, Manns MP, Sánchez-Fueyo A, Jaeckel E. Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated. Am J Transplant. Apr;16(4):1285-93. doi: 10.1111/ajt.13617. Epub 2016 Feb 18.

Theodoridis K, Müller J, Ramm R, Findeisen K, Andrée B, Korossis S, Haverich A, Hilfiker A. Acta Biomater. Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves. 2016 Oct 1;43:71-7. doi: 10.1016/j.actbio.2016.07.013. PMID: 27422199

Tudorache I, Horke A, Cebotari S, Sarikouch S, Boethig D, Breymann T, Beerbaum P, Bertram H, Westhoff-Bleck M, Theodoridis K, Bobylev D, Cheptanaru E, Ciubotaru A, Haverich A., Decellularized aortic homografts for aortic valve and aorta ascendens replacement. J Cardiothorac Surg. 2016 Jul;50(1):89-97. doi: 10.1093/ejcts/ezw013. PMID: 26896320

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Höffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S., Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. Eur J Cardiothorac Surg. 2016 Apr;49(4):1228-38. doi: 10.1093/ejcts/ezv362. PMID: 26503725

Vondran FW, Schumacher C, Johanning K, Hartleben B, Knitsch W, Wiesner O, Jaeckel E, Manns MP, Klempnauer J, Bektas H, Lehner F. Application of the Liver Maximum Function Capacity Test in Acute Liver Failure: A Helpful Tool for Decision-Making in Liver Transplantation? Case Rep Transplant. 2016:7074636. doi: 10.1155/2016/7074636. Epub 2016 May 4.
Ziegler T, Horstkotte M, Lange P, Ng J, Bongiovanni D, Hinkel R, Laugwitz KL, Sperandio M, Horstkotte J, Kupatt C. Endothelial RAGE exacerbates acute postischaemic cardiac inflammation. Thromb Haemost. Aug 1;116(2):300-8. doi: 10.1160/TH15-11-0898. Epub 2016 Jun 2.