2017

Abalovich A, Matsumoto S, Wechsler CJ, Carulla ME, Siciliano ME, Sznaider D, Denner J, Elliott RB. Level of acceptance of islet cell and kidney xenotransplants by personnel of hospitals with and without experience in clinical xenotransplantation. Xenotransplantation. Jul;24(4). doi: 10.1111/xen.12315. Epub 2017 Jun 17.
Abicht JM, Kourtzelis I, Reichart B, Koutsogiannaki S, Primikyri A, Lambris JD, Chavakis T, Holdt L, Kind A, Guethoff S, Mayr T. Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood. Xenotransplantation. Jan;24(1). doi: 10.1111/xen.12262. Epub 2016 Sep 27.
Balyura M, Gelfgat E, Ullmann E, Ludwig B, Barnea ER, Bornstein SR. PreImplantation Factor (PIF*) Regulates Stress-Induced Adrenal Steroidogenesis and Anti-Inflammatory Cytokines: Potential Application for Bioartificial Adrenal Transplant. Horm Metab Res. Oct 24.
Böttcher, A., Lickert, H., and Tschöp, M. Engineering Skin with Skinny Genes. Cell Stem Cell 21, 153-155.
Chen C, Cohrs CM, Stertmann J, Bozsak R, Speier S. Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis. Mol Metab. Jul 8;6(9):943-957
Cohrs, C.M., Chen, C., Jahn, S.R., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., et al. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology 158(5), 1373-1385.
Cooper DKC, Pierson RN III, Hering BJ, Mohiuddin MM, Fishman JA, Denner J, Ahn C, Azimzadeh AM, Buhler LH, Cowan PJ, Hawthorne WJ, Kobayashi T, Sachs DH; Regulation of Clinical Xenotransplantation - Time for a Reappraisal. Transplantation Post Acceptance: February 9
Cooper DKC, Cowan P, Fishman JA, Hering BJ, Mohiuddin MM, Pierson RN 3rd, Sachs DH, Schuurman HJ, Dennis JU, Tönjes RR; Miscellaneous. Xenotransplantation Nov;24(6). Tönjes RR. Assays: Methods for detection of PERV. Xenotransplantation Nov;24(6). doi: 10.1111/xen.12365. Epub Nov 28.
Cooper DKC, Cowan P, Fishman JA, Hering BJ, Mohiuddin MM, Pierson RN 3rd, Sachs DH, Schuurman HJ, Dennis JU, Tönjes RR. Joint FDA‐IXA Symposium, September 20, 2017. Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12365. Epub Nov 28. No abstract available. Erratum in: Xenotransplantation. 2018 Nov;25(6):e12477.

Denner J. Advances in organ transplant from pigs. Science. Sep 22;357(6357):1238-1239. doi: 10.1126/science.aao6334. No abstract available.
Denner J; Xenotransplantation - A special case of One Health. One Health 3, 17-22
Denner J, Mankertz A; Porcine Circoviruses and Xenotransplantation. Viruses 9, 83
Denner J; Sensitive methods and improved screening strategies are needed for the detection of pig viruses. Xenotransplantation Apr 21 [Epub ahead of print]
Denner J; Paving the Path toward Porcine Organs for Transplantation. N Engl J Med. Nov 9;377(19):1891-1893. doi: 10.1056/NEJMcibr1710853. No abstract available.

Denner J. The porcine virome and xenotransplantation. Virol J. Sep 6;14(1):171. doi: 10.1186/s12985-017-0836-z.

Denner J. Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation? Viruses. Aug 8;9(8). pii: E213. doi: 10.3390/v9080213. Review.
Denner J. Function of a retroviral envelope protein in the placenta of a viviparous lizard. Proc Natl Acad Sci U S A. Dec 19;114(51):13315-13317. doi: 10.1073/pnas.1719189114. Epub 2017 Dec 7. No abstract available.
Denner J. Xenotransplantation: Today and Tomorrow. Ann Transplant Res 2017;1:1002
Diestelhorst J, Junge N, Schlue J, Falk CS, Manns MP, Baumann U, Jaeckel E, Taubert R. Pediatric autoimmune hepatitis shows a disproportionate decline of regulatory T cells in the liver and of IL-2 in the blood of patients undergoing therapy. PLoS One. Jul 11;12(7):e0181107. doi: 10.1371/journal.pone.0181107. eCollection 2017.
Dudeck J, Medyukhina A, Fröbel J, Svensson CM, Kotrba J, Gerlach M, Gradtke AC, Schröder B, Speier S, Figge MT, Dudeck A. Mast cells acquire MHCII from dendritic cells during skin inflammation. J Exp Med. Dec 4;214(12):3791-3811. doi: 10.1084/jem.20160783. Epub 2017 Oct 30.
Fiebig U, Holzer A, Ivanusic D, Plotzki E, Hengel H, Neipel F, Denner J. Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6). Viruses. Oct 28;9(11). pii: E317. doi: 10.3390/v9110317.

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget. May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.

Gromann LB, De Marco F, Willer K, Noël PB, Scherer K, Renger B, Gleich B, Achterhold K, Fingerle AA, Muenzel D, Auweter S, Hellbach K, Reiser M, Baehr A, Dmochewitz M, Schroeter TJ, Koch FJ, Meyer P, Kunka D, Mohr J, Yaroshenko A, Maack HI, Pralow T, van der Heijden H, Proksa R, Koehler T, Wieberneit N, Rindt K, Rummeny EJ, Pfeiffer F, Herzen J. In-vivo X-ray Dark-Field Chest Radiography of a Pig. Sci Rep. Jul 6;7(1):4807. doi: 10.1038/s41598-017-05101-w.

Hardtke-Wolenski M, Dywicki J, Fischer K, Hapke M, Sievers M, Schlue J, Anderson MS, Taubert R, Noyan F, Manns MP, Jaeckel E. The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development. J Autoimmun. Mar;78:39-45. doi: 10.1016/j.jaut.2016.12.001. Epub 2016 Dec 11.

Harrison PT, Hoppe N, Martin U; Gene Editing and Stem Cells. Journal of Cystic Fibrosis. doi: 10.1016/j.jcf.2017.11.018. Epub Dec 9.

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C. Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium. J Am Coll Cardiol. Jan 69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.

Hinkel R, Kupatt C. Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease. Methods Mol Biol. 1521:249-260.
John K, Hardtke-Wolenski M, Jaeckel E, Manns MP, Schulze-Osthoff K, Bantel H. Increased apoptosis of regulatory T cells in patients with active autoimmune hepatitis. Cell Death Dis. Dec 14;8(12):3219. doi: 10.1038/s41419-017-0010-y. No abstract available.
Kemter E, Cohrs CM, Schäfer M, Schuster M, Steinmeyer K, Wolf-van Buerck L, Wolf A, Wuensch A, Kurome M, Kessler B, Zakhartchenko V, Loehn M, Ivashchenko Y, Seissler J, Schulte AM, Speier S, Wolf E. INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters. Diabetologia 60, 1152-1156.

Kourtzelis I, Mitroulis I, von Renesse J, Hajishengallis G, Chavakis T. From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins.J Leukoc Biol. Sep;102(3):677-683. doi: 10.1189/jlb.3MR0117-024R.

Laird CT, Burdorf L, French BM, Kubicki N, Cheng X, Braileanu G, Sun W, O'Neill NA, Cimeno A, Parsell D, So E, Bähr A, Klymiuk N, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN. Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury. Xenotransplantation. Mar;24(2). doi: 10.1111/xen.12294. Epub Mar 3.

Lohse S. Die Multiparadigmatik der Soziologie als Erklärungsgegenstand einer integrierten Wissenschaftsforschung. Zeitschrift für theoretische Soziologie 6(2): 237-246

Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, Lehmann S, Schubert U, Schmid J, Bleyer M, Schönmann U, Colton CK, Bonifacio E, Solimena M, Reichel A, Schally AV, Rotem A, Barkai U, Grinberg-Rashi H, Kaup FJ, Avni Y, Jones P, Bornstein SR. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A. Oct 31;114(44):11745-11750.
Mayr T, Bauer A, Reichart B, Guethoff S, Schoenmann U, Längin M, Panelli A, Kind A, Brenner P, Abicht JM. Hemodynamic and perioperative management in two different preclinical pig-to-baboon cardiac xenotransplantation models. Xenotransplantation. May;24(3). doi: 10.1111/xen.12295. Epub 2017 Mar 5.
Morozov VA, Heinrichs G, Denner J; Effective Detection of Porcine Cytomegalovirus Using Non-Invasively Taken Samples from Piglets . Viruses 9(1),9
Morozov VA, Wynyard S, Matsumoto S, Abalovich A, Denner J, Elliott R. No PERV transmission during a clinical trial of pig islet cell transplantation. Virus Res. Jan 2;227:34-40. doi: 10.1016/j.virusres.2016.08.012. Epub 2016 Sep 24.

Morticelli L, Granados M, , Andriopoulou S, Kalozoumis P, Pflaum M, Iablonskii P, Glasmacher B, Harder M, Hegermann J, Wredel C, Tudorache I, Cebotari S, Hilfiker R, Haverich A, Korossis S. Development and characterization of a porcine mitral valve scaffold for tissue engineering. J Cardiovasc Transl Res. Aug;10(4):374-390.
Nikolouli E, Hardtke-Wolenski M, Hapke M, Beckstette M, Geffers R, Floess S, Jaeckel E, Huehn J. Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance. Front Immunol. Jun 28;8:748. doi: 10.3389/fimmu.2017.00748. eCollection 2017.
Norwood P, Chen R, Jaeckel E, Lingvay I, Jarlov H, Lehmann L, Heller S. Rates of hypoglycaemia are lower in patients treated with insulin degludec/liraglutide (IDegLira) than with IDeg or insulin glargine, regardless of the hypoglycaemia definition used. Diabetes Obes Metab. Nov;19(11):1562-1569. doi: 10.1111/dom.12972. Epub 2017 Jul 10.
Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, Hust M, Huehn J, Galla M, Morgan M, Jokuszies A, Manns MP, Jaeckel E. Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor. Am J Transplant. Apr;17(4):917-930. doi: 10.1111/ajt.14175. Epub 2017 Feb 6.
Ostheimer J. Begleitung bei der Identitätsarbeit. Überlegungen zur kulturellen Dimension der Seelsorge, in: MThZ 68 366–374
Rahmig S, Kronstein-Wiedemann R, Fohgrub J, Kronstein N, Nevmerzhitskaya A, Bornhäuser M, Gassmann M, Platz A, Ordemann R, Tonn T, Waskow C; Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice. Stem Cell Reports 7(4):591-601
Reydon TAC. Philosophie der Biologie in: Lohse, S. & Reydon, T.A.C. (Hrsg.): Grundriss Wissenschaftsphilosophie: Die Philosophien der Einzelwissenschaften, Hamburg: Felix Meiner Verlag, S. 253-286.
Rickels MR, Stock PG, de Koning EJP, Piemonti L, Pratschke J, Alejandro R, Bellin MD, Berney T, Choudhary P, Johnson PR, Kandaswamy R, Kay TWH, Keymeulen G, Kudva YC, Latres E, Langer RM, Lehmann R, Ludwig B, Markmann JF, Marinac M, Odorico JS, Pattou F, Senior PA, Shaw JAM, Vantyghem, M-C, and White S. Defining Outcomes for β-Cell Replacement Therapy in the Treatment of Diabetes: a Consensus Report on the Igls Criteria from the IPITA/EPITA Opinion Leaders Workshop. Transplantation 2018 (in press).
Scobie L, Denner J, Schuurman HJ. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9, editorial commentary. Xenotransplantation. Nov;24(6). doi: 10.1111/xen.12363. Epub 2017 Nov 12. No abstract available.
Solbach P, Höner Zu Siederdissen C, Taubert R, Ziegert S, Port K, Schneider A, Hueper K, Manns MP, Wedemeyer H, Jaeckel E. Home-based drainage of refractory ascites by a permanent-tunneled peritoneal catheter can safely replace large-volume paracentesis. Eur J Gastroenterol Hepatol. May;29(5):539-546. doi: 10.1097/MEG.0000000000000837.
Steffen A, Kiss T, Schmid J, Schubert U, Heinke S, Lehmann S, Bornstein S, Ludwig B, Ludwig S. Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation. Jan;24(1).
Taubert R, Hardtke-Wolenski M, Noyan F, Lalanne C, Jonigk D, Schlue J, Krech T, Lichtinghagen R, Falk CS, Schlaphoff V, Bantel H, Muratori L, Manns MP, Jaeckel E. Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis. PLoS One. Jun 8;12(6):e0179074. doi: 10.1371/journal.pone.0179074. eCollection 2017.
Theodoridis K, Tudorache I, Cebotari S, Calistru A, Meyer T, Sarikouch S, Bara C, Haverich A, Hilfiker A. Six-Year-Old Sheep as a Clinically Relevant Large Animal Model for Aortic Valve Replacement Using Tissue-Engineered Grafts Based on Decellularized Allogenic Matrix. Tissue Eng Part C Methods. Dec;23(12):953-963. doi: 10.1089/ten.tec.2017.0163. Epub 2017 Nov 3.
Tönjes RR. Assays: Methods for detection of PERV. Xenotransplantation Nov 28 [Epub ahead of print].
Tritschler, S., Theis, F.J., Lickert, H., and Böttcher, A. Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas. Mol Metab 6, 974-990.

Steffen A, Kiss T, Schmid J, Schubert U, Heinke S, Lehmann S, Bornstein S, Ludwig B, Ludwig S; Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation, vol. 24, no. 1, Jan

Wolf-van Buerck, Schuster M, Oduncu FS, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Klymiuk N, Wolf E, Seissler J. LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy. Sci Rep 7(1), 3572.
Xu H, Pausch H, Venhoranta H, Rutkowska K, Wurmser C, Rieblinger B, Flisikowska T, Frishman D, Zwierzchowski L, Fries R, Andersson M, Kind A, Schnieke A, Flisikowski K. Maternal placenta modulates a deleterious fetal mutation. Biol Reprod. 97(2):249-257.
Ziegler T, Hinkel R, Stöhr A, Eschenhagen T, Laugwitz KL, le Noble F, David R, Hansen A, Kupatt C. Thymosin β4 Improves Differentiation and Vascularization of EHTs. Stem Cells Int. 2017:6848271. doi: 10.1155/2017/6848271. Epub Jan 16.

Ziegler T, Kraus M, Husada W, Gesenhues F, Jiang Q, Pinkenburg O, Trenkwalder T, Laugwitz KL, le Noble F, Weber C, Kupatt C, Hinkel R. Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization. Hum Gene Ther. Oct 3. doi: 10.1089/hum.2017.013. [Epub ahead of print]