2012

• Abicht JM, Beiras-Fernandez A, Bengel D, Vicol C. Deep Pericardial Traction Suture versus Vacuum-Assisted Apical Suction to Expose the Posterior Wall of the Heart in Off-Pump Coronary Artery Bypass: A Prospective, Randomized Study. Heart Surgery Forum 15, 224-231.
  
  
• Ale, A., Ermolayev, V., Herzog, E., Cohrs, C., de Angelis, M.H., and Ntziachristos, V. FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography. Nat. Methods 9, 615–620.
  
  
• Bamberg F*, Hinkel R*, Schwarz F, Sandner TA, Baloch E, Marcus R, Becker A, Kupatt C, Wintersperger BJ, Johnson TR, Theisen D, Klotz E, Reiser MF, and Nikolaou K. Accuracy of dynamic computed tomography adenosine stress myocardial perfusion imaging in estimating myocardial blood flow at various degrees of coronary artery stenosis using a porcine animal model. Invest Radiol. 47, 71-77. (*contributed equally)
  
  
• Barthels M (Hrsg.) und Mitarbeiter: Das Gerinnungskompendium, 2. Auflage, Stuttgart. Thieme-Verlag. (Autor der Kapitel "Hämophilie A und B", "Erworbene Faktorenmängel", "Vitamin-K-Mangel", "Leberfunktionsstörungen", "Disseminierte intravasale Gerinnung", "Grundlagen der Gerinnungsdiagnostik", "Faktorenkonzentrate")
  
  
• Behrendt R, Fiebig U, Schmolke M, Kurth R, Denner J; Induction of antibodies specific for gp41 of HIV-1 by gene gun DNA vaccination. J Vaccines Vaccin. 3, 145.
  
  
• Bittmann I, Mihica D, Plesker R, Denner J; Expression of porcine endogenous retroviruses (PERV) in different organs of a pig. Virology 433, 329-336.
  
  
• Bohne, F., Martínez-Llordella, M., Lozano, J.J., Miquel, R., Benítez, C., Londoño, M.C., Manzia, T.M., Angelico, R., Swinkels, D.W., Tjalsma, H., López, M., Abraldes, J.G., Bonaccorsi-Riani, E., Jaeckel, E., Taubert, R., Pirenne, J., Rimola, A., Tisone, G., Sánchez-Fueyo, A. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest 123: 368-382.
  
  
• Bulek, A.M., Cole, D.K., Skowera, A., Dolton, G., Gras, S., Madura, F., Fuller, A., Miles, J.J., Gostick, E., Price, D.A., et al., Peakman, M.*, Rizkallah, P.J.*, Sewell, A.K.*;*Joint last authors. Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nature Immunology 13, 283-289.
  
  
• DeAngelis R A*, Markiewski M M*, Kourtzelis I* , Rafail S*, Syriga M, Maurya M R, Gupta S, Subramaniam S, Lambris J D. A complement-interleukin-4 regulatory circuit controls liver regeneration. J Immunol, 188(2):641-8. [* Equal contribution].
  
  
• Denner J, Tönjes RR. Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses. Clinical Microbiology Reviews; 25(2): 318-343
  
  
• Denner J, Tönjes RR: Berlin Symposium on Xenotransplantation. July 13, Robert Koch Institute, Berlin, in association with the 24th International Congress of the Transplantation Society (TTS), July 15-19, 2012 at the ICC in Berlin. Xenotransplantation 20: 39-64.
  
  
• Denner J, Mihica D, Kaulitz D, Schmidt CM; Increased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs). Virol. J. 9, 260.
  
  
• Deshmukh RS, Østrup O, Strejcek F, Vejlsted M, Lucas-Hahn A, Petersen B, Li J, Callesen H, Niemann H, Hyttel P. Early aberrations in chromatin dynamics in embryos produced under in vitro conditions. Cell Reprogram;14(3):225-34. doi: 10.1089/cell.2011.0069. Epub 2012 Apr 2.
  
  
• Eskan M.A., Jotwani R., Abe T., Chmelar J., Lim J.H., Liang S., Ciero P., Krauss J., Li F., Rauner M., Hofbauer L.C., Choi E.Y., Chung K.J., Hashim A., Curtis M., Chavakis T.*, Hajishengallis G.* (2012).The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nature Immunology 13, 465-473. * These authors contributed equally as senior authors to the work.Santoso
  
  
• Flisikowska T, Merkl C, Landmann T, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D and Schnieke A. A porcine model of familial adenomatous polyposis. Gastroenterology 143, 1173-1175.
  
  
• Flisikowski K, Venhoranta H, Bauersachs S, Hänninen R, Fürst RW, Saalfrank A, Ulbrich, SE, Taponen J, Lohi H, Wolf E, Kind A, Andersson M and Schnieke A. Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle. Biol Reprod. 87, 140 doi: 10.1095/biolreprod.112.104240.
  
  
• Fuchs, H., Gailus-Durner, V., Neschen, S., Adler, T., Afonso, L.C., Aguilar-Pimentel, J.A., Becker, L., Bohla, A., Calzada-Wack, J., Cohrs, C., et al. Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm. Genome 23, 611–622.
  
  
• Garrels W, Ivics Z, Kues WA. Precision genetic engineering in large mammals. Trends Biotechnol. 30, 386-393.
  
  
• Hagen K, Schnieke A and Thiele F. (Editors) Large Animals as Biomedical Models: Ethical, Societal, Legal and Biological Aspects. Pub. European Academy, Bad Neuenahr.
  
  
• Hergert P, Tönjes RR: Rechtliche Grundlagen. Kap. 1.5. Genehmigung von Gewebezubereitungen nach § 21a AMG / Kap. 1.6. Pflichten nach Erhalt einer Genehmigung nach § 21a AMG. In: Jerosch J, Katthagen BD, Pruß A (Hrsg.), Knochentransplantation - Knochenbank und klinische Anwendung von Bankknochen. Köln: Deutscher Ärzte-Verlag, S. 9-12 ISBN 978-3-7691-0623-7
  
  
• Hoyningen-Huene, P., and Lohse, S. Die Kuhn´sche Wende. In: Handbuch Wissenschaftssoziologie, ed. Maasen, S. et al. Wiesbaden: Springer VS, 73-84.
  
  
• Huang, L.R., Gabel, Y.A., Graf, S., Arzberger, S., Kurts, C., Heikenwalder, M., Knolle, P.A., and Protzer, U. Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology 142, 1447-1450 e1443.
  
  
• Ignea C, Trikka F A, Kourtzelis I, Argiriou A, Kanellis A K, Kampranis S C, Makris A M. Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae. Microb Cell Fact: 162.
  
  
• Jaimes, Y., Gras, C., Goudeva, L., Buchholz, S., Eiz-Vesper, B., Seltsam, A., Immenschuh, S., Blasczyk, R., and Figueiredo, C. Semaphorin 7A inhibits platelet production from CD34+ progenitor cells. Journal of thrombosis and haemostasis : JTH 10, 1100-1108.
  
  
• Kambas K, Mitroulis I, Apostolidou E, Girod A, Chrysanthopoulou A, Pneumatikos I, Skendros P, Kourtzelis I, Koffa M, Kotsianidis I, Ritis K.  Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis. PLoS One;7(9):e45427.
  
  
• Kautz, S., van Bürck, L., Schuster, M., Wolf, E., Wanke, R., Herbach, N.  Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2C95S). Diabetologia, 55: 382-391
  
• Kaye, J., Meslin, E.M., Knoppers, B.M., Juengst, E.T., Deschênes, M., Cambon-Thomsen, A., Chalmers, D., De Vries, J., Edwards, K., Hoppe N.C., et al. ELSI 2.0: A New International Collaboratory for Genomics and Society Research. Science 336, 673-674.
  
  
• Kemter E, Lieke T, Kessler B, Kurome M, Wuensch A, Summerfield A, Ayares D, Nagashima H, Baars W, Schwinzer R, Wolf E. Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses.  Xenotransplantation. Jan; 19(1):40-51.
  
  
• Khaladj N, Guethoff S, Pichlmaier M, Hagl C. Kanülierung der Aorta ascendens bei akuter Aortendissektion Stanford A Z Herz- Thorax- Gefäßchir, 26: 25-26.
  
  
• Klymiuk N, Bocker W, Schonitzer V, Bahr A, Radic T, Frohlich T, Wunsch A, Kessler B, Kurome M, Schilling E, et al. First inducible transgene expression in porcine large animal models. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 26, 1086-1099.
  
  
• Klymiuk N, Mundhenk L, Kraehe K, Wuensch A, Plog S, Emrich D, Langenmayer MC, Stehr M, Holzinger A, Kröner C, Richter A, Kessler B, Kurome M, Eddicks M, Nagashima H, Heinritzi K, Gruber AD, Wolf E. Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis. J Mol Med (Berl;90 (5):597-608.
  
  
• Klymiuk N, van Buerck L, Bahr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, et al. Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes 61, 1527-1532.
  
  
• Koscielny J, Beyer-Westendorf J, von Heymann C, Braun J, Klamroth R, Lindhoff-Last E, Tiede A, Spannagl M. Blutungsrisiko und Blutungsnotfälle unter Rivaroxaban. Hämostaseologie; 32: 287-293.
  
  
• Kronenberg, D., Knight, R.R., Estorninho, M., Ellis, R.J., Kester, M.G., de Ru, A., Eichmann, M., Huang, G.C., Powrie, J., Dayan, C.M., Skowera, A., van Veelen, P.A., and Peakman, M. Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill beta-cells. Diabetes 61,1752-1759.
  
  
• Labisso WL, Wirth M, Stojanovic N, Stauber R, Schnieke A, Schmid R, Kraemer O, Saur D and Schneider G. MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells towards HDAC inhibitors. Cell Cycle 11, 1593-1602.
  
  
• Lange, A., Gegg, M., Burtscher, I., Bengel, D., Kremmer, E., and Lickert, H. Fltp(T2AiCre): a new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues. Differentiation 83, S105-113.
  
  
• Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E and Schnieke A. Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PLoS ONE 7, e43323.
  
  
• Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E, Schnieke A. Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig. PLoS One;7(10):e43323.
  
  
• Lieke, T., Ramackers, W., Bergmann, S., Klempnauer, J., Winkler, M., and Klose, J. Impact of Salinomycin on human cholangiocarcinoma: induction of apoptosis and impairment of tumor cell proliferation in vitro. BioMed Central cancer 12, 466.
  
  
• Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A. Mar 27;109(13):5022-7.
  
  
• Mair H, Sachweh J, Sodian R, Brenner P, Schmoeckel M, Schmitz C, Reichart B, Daebritz S. Long-term self-management of anticoagulation therapy after mechanical heart valve replacement in outside trial conditions. Interac Cardiovasc Thorac Surg:14(3):253-257.
  
  
• Mohr H, Mohr CA, Schneider M R, Scrivano L, Adler B, Kraner-Scheiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski U and Ruzsics Z. Cytomegalovirus replicon based regulation of gene expression in vitro and in vivo. PLoS Pathogens 8, e1002728.
  
  
• Morozov V, Morozov A, Semaan M, Denner J; Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV -1. Retrovirology.9-67.
  
  
• Mühle M, Löchelt M, Denner J; Optimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen. Protein Expression and Purification 81, 96–105.
  
  
• Nees S, Juchem G, Eberhorn N, Thallmair M, Forch S, Knott M, Senftl A, Fischlein T, Reichart B, Weiss DR. Wall structures of myocardial precapillary arterioles and postcapillary venules reexamined and reconstructed in vitro for studies on barrier functions. American journal of physiology Heart and circulatory physiology; 302(1): H51-68.
  
  
• Niemann H, Kind A and Schnieke A. The production of biopharmaceuticals in transgenic animals. In: Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications (Eds. Kayser, O., Warzecha, H.) Pub. Wiley-VCH, Weinheim.
  
  
• Niemann, H., Lucas-Hahn, A. Somatic cell nuclear transfer cloning: practical applications and current legislation. Reproduction in Domestic Animals 47, 2-10.
  
  
• Nowak-Imialek M, Niemann H. Pluripotent cells in farm animals: state of the art and future perspectives. Reprod Fertil Dev. 25(1):103-28. doi: 10.1071/RD12265. Review.

• Ramackers, W., Klose, J., and Winkler, M. Xeno-kidney transplantation: from idea to reality. Transplantation proceedings 44, 1773-1775.
  
  
• Renner, S., Romisch-Margl, W., Prehn, C., Krebs, S., Adamski, J., Goke, B., Blum, H., Suhre, K., Roscher, A.A., and Wolf, E. Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass. Diabetes 61, 2166-2175.
  
  
• Richter A, Kurome M, Kessler B, Zakhartchenko V, Klymiuk N, Nagashima H, Wolf E, Wuensch A. Potential of primary kidney cells for somatic cell nuclear transfer mediated transgenesis in pig. BMC Biotechnol. Nov 9;12(1):84.
  
  
• Richter A, Kurome M, Kessler B, Zakhartchenko V, Klymiuk N, Nagashima H, Wolf E, Wuensch A. Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. BMC Biotechnol;12:84.
  
  
• Rodriguez-Diaz R, Speier S, Molano RD, Formoso A, Gans I, Abdulreda MH, Cabrera O, Molina J, Fachado, A, Ricordi, C, Leibiger, I, Pileggi, A, Berggren, PO and Caicedo, A. Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function. Proceedings of the National Academy of Sciences of the United States of America 109, 21456-21461.
  
  
• Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L, Grinenko T, Behrens K, Hubner N, Mann M, Waskow C, Stocking C, and Buchholz F. Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood 119: 4152-4161.
  
  
• Santagostino E, Negrier C, Klamroth R, Tiede A, Pabinger-Fasching I, Voigt C, Jacobs I, Morfini M. Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients. Blood, 120: 2405-2411.
  
  
• Santana MM et al. Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla. Stem Cells Transl Med. Nov;1(11):783-91.
  
  
• Sax G, Kessler B, Wolf E, Winter G. In-vivo biodegradation of extruded lipid implants in rabbits. J Control Release; 163(2):195-202.
  
  
• Semaan M, Kaulitz D, Petersen B, Niemann H, Denner J; Long-term effects of PERV-specific RNA interference in transgenic pigs. Xenotransplantation. 19(2), 112-121
  
  
• Sørensen B, Dargaud Y, Kenet G, Lusher J, Mumford A, Pipe S, Tiede A. On-demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII. Haemophilia; 18: 255-262.
  
  
• Steinman, L., Merrill, J.T., McInnes, I.B., and Peakman, M. Optimization of current and future therapy for autoimmune diseases. Nature Medicine 18, 59-65.
  
  
• Taubert, R., Pischke, S., Schlue, J., Wedemeyer, H., Noyan, F., Heim, A., Lehner, F., Barg-Hock, H., Klempnauer, J., Olek, S., Manns, M.P., Hardtke-Wolenski, M., Jaeckel, E. Enrichment of regulatory T cells in acutely rejected human liver allografts. Am J Transplant 12(12): 3425-36.
  
  
• Thiele, F., Cohrs, C.M., Flor, A., Lisse, T.S., Przemeck, G.K.H., Horsch, M., Schrewe, A., Gailus-Durner, V., Ivandic, B., Katus, H.A., et al. Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Hum. Mol. Genet. 21, 3535–3545.
  
  
• Tiede A. Diagnosis and treatment of acquired von Willebrand syndrome. Thromb Res. 130 (Suppl 2): 2-6.
  
  
• van Bürck, L., Schuster, M., Rathkolb, B., Wagner, S., Hrabé de Angelis, M., Wolf, E., Aigner, B., Wanke, R., Herbach, N. Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich GckD217V mutants. Mol Cell Endocrinol 362: 139-148
  
  
• Vondran FW, Timrott K, Kollrich S, Klempnauer J, and Becker T*/Schwinzer R*. Decreased frequency of peripheral CD4(+) CD161(+) Th(17) -precursor cells in kidney transplant recipients on long-term therapy with Belatacept. Transpl Int 25, 455-463. *equal senior authorship.
  
  
• Waechter A, Eschricht M, Denner J; Neutralisation of the porcine endogenous retrovirus (PERV) by antibodies against the membrane proximal external region (MPER) of the transmembrane envelope protein. J. Gen. Virol. 2013, 643-651
  
  
• Warnecke G, Moradiellos J, Tudorache I, Kuhn C, Avsar M, Wiegmann B, Sommer W, Ius F, Kunze C, Gottlieb J, et al. Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients. Lancet 380, 1851-1858.
  
  
• Watanabe M, Kurome M, Matsunari H, Nakano K, Umeyema K, Shiota A, Nakauchi H, Nagashima H. The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer. Transgenic Res;21(3):605-18.
  
  
• Wilhelmi M H, Tiede A, Teebken OE, Bisdas T, Haverich A, Mischke R. Ovine blood: establishment of a list of reference values relevant for blood coagulation in sheep. ASAIO J ; 58: 79-82.
  
  
• Wohlleber, D., Kashkar, H., Gartner, K., Frings, MK., Odenthal, M., Hegenbarth, S., Borner, C., Arnold, B., Hammerling, G., Nieswandt, B., et al. TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell reports 2, 478-487.