Jahrestagung 2011
9. MD-NET-Meeting in Bonn: Cross-striated Muscle in Health and Disease
| Termin: | 18.05.2011, 00:00 – 20.05.2011, 00:00 |
|---|---|
| Veranstaltungsort: | Uniclub, Konviktstraße 9, 53113 Bonn |
Joint Meeting of DFG Research Groups (FOR 1228, FOR1352, KFO192), COST WG4 Meeting (BM 1002) NANONET* and the MD-NET (BMBF)
*) A European Cooperation in Science and Technology (COST) Biomedicine and Molecular Biosciences (BMBS) Action BM 1002: NANONET - Nanomechanics of Intermediate Filament Networks (www.cost.esf.org)
MD-NET Coordinators
Maggie Walter (Munich)
Janbernd Kirschner (Freiburg)
Matthias Vorgerd (Bochum)
MD-NET Project Management
Christine Scholz (Munich)
Scientific Programm
Rolf Schröder (Erlangen), Speaker of DFG Research Group FOR 1228: Molecular Pathogenesis of Myofibrillar Myopathies)
Dieter Fürst (Bonn), Speaker of DFG Research Group FOR1352: Structure, Function and Regulation of the Myofibrillar Z-disc Interactome
Simone Spuler (Berlin), Speaker of DFG Clinical Research Group KFO 192: Skeletal Muscle Growth Regulation and Dysregulation
General Information
Venue: Uniclub, Konviktstraße 9, 53113 Bonn
Language: Scientific presentations: English (MD-NET-Sessions: German)
Organization: MD-NET, Dr. Christine Scholz, info.bitte.entfernen@md-net.org
Accommodation and Travel: www.hrs.de and venue
Conference Fee: 140 Euro
Participants: Members of MD-NET and DFG Research Groups Space is limited and registration is required!
Mittwoch/Wednesday 18.5.2011
12:00 – 12:45 Anreise / Mittagessen (Arrival/Lunch)
12:45 – 13:00 Begrüßung (Welcome Address) (D. Fürst / M. Vorgerd)
13:00 – 15:00 Scientific Session 1: Structure and Composition of Myofibrillar Z-discs (Chair: D. Fürst)
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13:00 |
Fürst |
Structure and function of the Z-disc |
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13:15 |
Warscheid |
Z-disc proteomics |
FOR1352 (P4) |
|
13:30 |
Wilmanns |
Structure of myofibrillar protein complexes |
FOR1352 (P5) |
|
13:45 |
Frangakis |
Structural investigation of the Z-disc |
FOR1352 (P7) |
|
14:00 |
Stehle & Pfitzer |
Z-disc mechanotransduction |
FOR1352 (P9) |
|
14:15 |
Gotthardt & Radke |
Titin in Z-disc assembly and mechanotransduction |
FOR1352 (P3)/ KFO192 (P1) |
|
14:30 |
Frey |
Characterization of CEFIP |
FOR1352 (P2) |
15:00 – 15:30 Coffee Break
15:30 – 16:30 External Speaker: Thomas Voit, Paris
16:45 – 18:45 9. MD-NET Meeting
MD-NET: Verstetigung nationaler und europäischer Strukturen (Moderation M. Walter, J. Kirschner, M. Vorgerd)
(Sustainability of National and European Service Structures for Neuromuscular Diseases)
Bericht über die Verstetigungsaktivitäten nationaler Strukturen (Maggie Walter)
(Sustainability Reports from MD-NET Service Structures)
Bericht über die Verstetigung europäischer Strukturen (Janbernd Kirschner)
(Sustainability Reports from EU-Projects on Neuromuscular Diseases)
Diskussion und Abstimmung über weitere Aktivitäten
19:00 Dinner
20:00 – 22:00 Oversight-Committee-Meeting
(closed session)
Donnerstag/Thursday 19.5.2011
9:00 – 10:45 Scientific Session 2: Desmin-, Plectin- and Lamin-related Diseases (Chair: R. Schröder)
|
9:00 |
Schröder |
Introduction: clinics and myopathology |
|
|
9:15 |
Herrmann |
Desmin filament assembly |
FOR1228 (P5) |
|
9:30 |
Clemen |
Characterization of the skeletal muscle pathology in a R350P desmin knock-in mouse: a model for human desminopathies |
MD-NET (P7) |
|
9:45 |
Schessl & Schoser |
Desminopathy proteomics |
FOR1228 (P6) |
|
10:00 |
Thirion & Walter |
SIFT analysis of desmin |
FOR1228 (P4) |
|
10:15 |
Wiche |
Plectin mouse models |
FOR1228 (P7) |
|
10:30 |
Jordan & Boschmann |
Skeletal muscle metabolism in patients with lamin A/C-dependent familial partial lipodystophy |
KFO192 (P9) |
10:45 – 11:00 Coffee Break
11:00 – 11:45 9. MD-NET-Meeting: Gemeinsame Sitzung der Arbeitskreise (Discussion in Study Groups)
(Moderation: Arbeitskreissprecher/Study Group Speakers)
Zusammenfassende Berichte / Reports from Study Groups
aus den Arbeitskreisen Grundlagen, Diagnostik und Klinische Studien
(Heinrich Brinkmeier, Benedikt Schoser, Ulrike Schara)
Diskussion
11:45 – 12:30 MD-NET Mitgliederversammlung / Md_NET Assembly Meeting
12:45 – 13:45 Lunch
13:45 – 14:45 External Speaker: Wolfgang Linke, Bochum: "Myofilament protein maintenance via protein methylation in skeletal muscle"
14:45 – 15:00 Coffee Break
15:00 – 17:00 Scientific Session 3: Filamin C in Normal and Diseased Muscle (Chair: D. Fürst)
|
15:00 |
Fürst |
Introduction |
|
|
15:15 |
Hahn |
Filamin-associated signalling |
FOR1352 (P1) |
|
15:30 |
Höhfeld |
Filamin C homeostasis |
FOR1352 (P10) |
|
15:45 |
Kley |
Clinics and myopathology of filaminopathies |
MD-NET (P6) |
|
16:00 |
Fürst (Lab) |
Molecular analysis of FLNC mutations |
MD-Net (P6), FOR1228 (P1) |
|
16:15 |
Vorgerd & Marcus |
Filaminopathy proteomics |
MD-NET (P6) |
|
16:30 |
Djinovic-Carugo |
Filamin interactions/structures |
FOR1352 (P6) |
|
16:45 |
Rief |
Filamin biomechanics |
FOR1352 (P8) |
17:00 Social Evening: Museumsführung durch die Ausstellung „Liebermann und die Moderne“ bzw. „Heinz Mack – Licht, Raum, Farbe“ in der Kunst- und Ausstellungshalle Bonn mit anschließendem Essen im Restaurant Diners (ebenda).
Freitag/Friday 20.5.2011
9:00 – 11:15 Scientific Session 4: Membrane-associated Myopathies (Chair: S. Spuler)
|
9:00 |
Spuler |
Introduction |
|
|
9:15 |
Eichinger & Clemen |
Analysis of in vivo consequences of disease-relevant point mutations in p97 (VCP) in Dictyostelium discoideum, a simple and powerful model system for functional genomics |
FOR1228 (P3) |
|
9:30 |
Clemen & Schröder |
Identification of novel and disease related VCP binding partners and characterization of the skeletal muscle and cardiac pathology in an R155C-VCP knock-in mouse: a key to the understanding of human protein aggregate myopathies and cardiomyopathies |
FOR1228 (P1) |
|
9:45 |
Rottbauer & Just |
Functional analysis of VCP-binding proteins in the zebrafish |
FOR1228 (P8) |
|
10:00 |
Schülke-Gerstenfeld & Spuler |
Caveolar dynamics |
KFO192 (P4) |
|
10:15 |
Weis & Krüttgen |
Diagnostics of Caveolinopathies |
MD-NET (P4) |
|
10:30 |
Boschmann & Kintscher |
Skeletal muscle metabolism in patients with caveolopathies |
KFO192 (P6) |
|
10:45 |
Knoblauch & Co |
Caveolae in statin-induced myopathy |
KFO192 (P7) |
|
11:00 |
Morano & Haase |
The functional role of ahnak in skeletal muscle fibers in an ahnak knock-out mouse model |
KFO192 (P8) |
11:15 – 12:30 Lunch
12:30 – 14:45 Scientific Session 5: Regulation of Muscle Growth & Novel Treatment Approaches in NMD (Chair: C. Birchmeier)
|
12:30 |
Birchmeier |
Introduction |
|
|
12:45 |
Birchmeier |
The Met tyrosine kinase receptor in muscle growth |
KFO192 (P8) |
|
13:00 |
Spuler |
Myostatin in normal and diseased muscle |
KFO192 (P3) |
|
13:15 |
Spranger & Mai |
Regulation of muscle mass and function during periods of negative energy balance |
KFO192 (P9) |
|
13:30 |
Fielitz |
Regulation of muscular wasting disorders by protein kinase D1 |
KFO192 (P10) |
|
13:45 |
Weber-Carstens & Assmann |
Skeletal muscle metabolism and critical illness myopathy |
KFO192 (P2) |
|
14:00 |
Straub |
In situ and in vivo tissue distribution of antisense oligonucleotides in the mdx mouse |
MD-NET (P1) |
|
14:15 |
Thirion |
Dysregulated microRNAs – potential therapeutic approaches for the treatment of muscular dystrophies |
MD-NET (P2) |
|
14:30 |
Dittrich & Kirschner |
Preventive treatment of DMD |
MD-NET (P3) |
14:45 End of the Meeting
Kontakt:
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MD-NET |
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| E-Mail: | info@md-net.org |
