Publications (selected)
- Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S. Dysfunction of Persisting β-Cells is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Rep. Apr 7;31(1):107469. doi: 10.1016/j.celrep.2020.03.033.
- Cohrs CM, Chen C, Speier S. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging. Methods Mol Biol. 2020;2128:149-157. doi: 10.1007/978-1-0716-0385-7_11.
- Panzer JK, Hiller H, Cohrs CM, Almaca J, Enos SJ, Beery M, Cechin S, Drotar DM, Weitz JR, Santini J, Huber MK, Qadir MMF, Pastori RL, Domínguez-Bendala J, Phelps EA, Atkinson MA, Pugliese A, Caicedo A, Kusmartseva I, Speier S. Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis. JCI Insight Apr 23;5(8):e134525. doi: 10.1172/jci.insight.134525
- Panzer JK, Cohrs CM, Speier S. Using Pancreas Tissue Slices for the Study of Islet Physiology. Methods Mol Biol. 2020;2128:301-312. doi: 10.1007/978-1-0716-0385-7_20.
- Tang X, Kusmartseva I, Kulkarni S, Posgai A, Speier S, Schatz DA, Haller MJ, Campbell-Thompson M, Wasserfall CH, Roep BO, Kaddis JS, Atkinson MA. Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas. Am J Pathol. 2020 Dec 8:S0002-9440(20)30551-4. doi: 10.1016/j.ajpath.2020.11.010. Online ahead of print. PMID: 33307036
2018
- Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov SA, Schraven B, Dudeck A. Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency. J Allergy Clin Immunol. Oct 17. pii: S0091-6749(18)31443-X. doi: 10.1016/j.jaci.2018.08.052. [Epub ahead of print]
- Weitz JR, Makhmutova M, Almaça J, Stertmann J, Aamodt K, Brissova M, Speier S, Rodriguez-Diaz R, Caicedo A. Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity. Diabetologia. Jan;61(1):182-192. doi: 10.1007/s00125-017-4416-y. Epub 2017 Sep 7.
2017
- Chen C, Cohrs CM, Stertmann J, Bozsak R, Speier S. Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis. Mol Metab. Jul 8;6(9):943-957
- Cohrs, C.M., Chen, C., Jahn, S.R., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., et al. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology 158(5), 1373-1385.
- Dudeck J, Medyukhina A, Fröbel J, Svensson CM, Kotrba J, Gerlach M, Gradtke AC, Schröder B, Speier S, Figge MT, Dudeck A. Mast cells acquire MHCII from dendritic cells during skin inflammation. J Exp Med. Dec 4;214(12):3791-3811. doi: 10.1084/jem.20160783. Epub 2017 Oct 30.
- Kemter E, Cohrs CM, Schäfer M, Schuster M, Steinmeyer K, Wolf-van Buerck L, Wolf A, Wuensch A, Kurome M, Kessler B, Zakhartchenko V, Loehn M, Ivashchenko Y, Seissler J, Schulte AM, Speier S, Wolf E. INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters. Diabetologia 60, 1152-1156.
2016
- Anastasiou, V., Ninou, E., Alexopoulou, D., Stertmann, J., Müller, A., Dahl, A., Solimena, M., Speier, S., Serafimidis, I. and Gavalas, A. Aldehyde dehydrogenase activity is necessary for β cell development and functionality. Diabetologia, 59, 139-50
- Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H. Identification of proliferative and mature β-cells in the islets of Langerhans. Nature. Jul 21;535(7612):430-4. Epub 2016 Jul 11.
- Chen, C., Chmelova, H., Cohrs, C.M., Chouinard, J.A., Jahn, S.R., Stertmann, J., Uphues, I. and Speier, S. Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Diabetes 65, 840–846.
- Kragl M, Schubert R, Karsjens H, Otter S, Bartosinska B, Jeruschke K, Weiss J, Chen C, Alsteens D, Kuss O, Speier S, Eberhard D, Müller DJ, Lammert E. The biomechanical properties of an epithelial tissue determine the location of its vasculature. Nat Commun. Dec 20;7:13560. doi: 10.1038/ncomms13560.
2015
- Chmelova H, Cohrs CM, Chouinard JA, Petzold C, Kuhn M, Chen C, Roeder I, Kretschmer K, and Speier S. Distinct Roles of β-Cell Mass and Function During Type 1 Diabetes Onset and Remission. Diabetes 64, 2148–2160.
- Schubert, N., Dudeck, J., Liu, P., Karutz, A., Speier, S., Maurer, M., Tuckermann, J., and Dudeck, A. Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed. Arthritis Rheumatol. (Hoboken, N.J.) 67, 903–913.
2014
- Marciniak, A., Cohrs, C.M., Tsata, V., Chouinard, J.A., Selck, C., Stertmann, J., Reichelt, S., Rose, T., Ehehalt, F., Weitz, J., et al. Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology. Nat. Protoc. 9, 2809–2822.
2013
- Marciniak A, Selck C, Friedrich B, and Speier S. Mouse pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ. PloS one 8, e78706.
- Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Muller A, Liu Y, Andree C, Mulligan B., Munster C, Kurth T, Bickle M, Speier S. Anastassiadis K und Solimena M. Age-dependent labeling and imaging of insulin secretory granules. Diabetes 2, 3687 - 3696.
- Ilegems E, Dicker A, Speier S, Sharma A, Bahow A, Edlund PK, Leibiger IB and Berggren PO. Reporter islets in the eye reveal the plasticity of the endocrine pancreas. Proceedings of the National Academy of Sciences of the United States of America.
2012
- Rodriguez-Diaz R, Speier S, Molano RD, Formoso A, Gans I, Abdulreda MH, Cabrera O, Molina J, Fachado, A, Ricordi, C, Leibiger, I, Pileggi, A, Berggren, PO and Caicedo, A. Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function. Proceedings of the National Academy of Sciences of the United States of America 109, 21456-21461.
2011
- Speier S. Experimental approaches for high-resolution in vivo imaging of islet of Langerhans biology. Current diabetes reports 11, 420-425.
- Nyqvist D, Speier S, Rodriguez-Diaz R, Molano RD, Lipovsek S, Rupnik M, Dicker A, Ilegems E, Zahr-Akrawi E, Molina J, Lopez-Cabeza M, Villate S, Abdulreda MH, Ricordi C, Caicedo A, Pileggi A and Berggren PO. Donor islet endothelial cells in pancreatic islet revascularization. Diabetes 60, 2571-2577.
2010
2008
- Speier S, Nyqvist D, Cabrera O, YuJ, Molano RD, Pileggi A, Moede T, Kohler M, Wilbertz J, Leibiger B, Ricordi C, Leibiger IB, Caicedo A and Berggren PO. Noninvasive in vivo imaging of pancreatic islet cell biology. Nature Medicine 14, 574-578.
- Speier S, Nyqvist D, Kohler M, Caicedo A, Leibiger IB and Berggren PO. Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye. Nature Protocols 3, 1278-1286.
- Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Kohler M, Fachado A, Vieira E, Zierath, JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A and Berggren PO. Glutamate is a positive autocrine signal for glucagon release. Cell Metabolism 7, 545-554.
2007
2005
2003
