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Publications (selected)

2019

Jacome-Galarza CE, Percin GI, Muller JT, Mass E, Lazarov T, Eitler J, Rauner M, Yadav VK, Crozet L, Bohm M, Loyher PL, Karsenty G, Waskow C, Geissmann F. Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature 568(7753):541-545. doi: 10.1038/s41586-019-1105-7. Epub 2019 Apr 10.

Percin GI, Eitler J, Kranz A, Fu J, Pollard JW, Naumann R, Waskow C. CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages. Nat Commun. Dec 11;9(1):5279. doi: 10.1038/s41467-018-07685-x.

Kourtzelis I, Ferreira A, Mitroulis I, Ricklin D, Bornstein SR, Waskow C, Lambris JD, Chavakis T. Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium. Horm Metab Res. Jan;47(1):36-42. doi: 10.1055/s-0034-1390452. Epub 2014 Oct 28.

Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Hofer T, Calegari F, and Waskow C. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. Journal of Experimental Medicine 212, 1171-1183.
Rahmig S, Bornstein SR, Chavakis T, Jaeckel E, and Waskow C. Humanized mouse models for type 1 diabetes including pancreatic islet transplantation. Hormone and metabolic research 47, 43-47.

Cosgun* KN, Rahmig* S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C. Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier. Cell Stem Cell, 15:227-238. *Co-first authors.
Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 211:209-215.

Prewitz M, Seib PF, von Bonin M, Niehae C, Friedrichs J, Stißel A, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C. Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nature Methods. 10:788-794.
Singh RP, Franke K, Kalucka J, Mamlouk S, Mutschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B. HIF-prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steadystate and stress. Blood, 121:5158-5166.
Von Bonin M, Wermke M, Cosgun KN, Thiede C, Bornhauser M, Wagemaker G, Waskow C. In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemis in NSG mice . PLoS One. 8:e60680. Doi: 10.1371.
Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells. Proc Natl Acad Sci U S A. 110:5582-5587.

Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L, Grinenko T, Behrens K, Hubner N, Mann M, Waskow C, Stocking C, and Buchholz F. Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood 119: 4152-4161.

Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Kohler A, Peschke K, Vohringer D, Waskow C, Krieg T, Muller W, Waisman A, Hartmann K, Gunzer M, and Roers A. Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens. Immunity. 34:973-84.
Gerbaulet A, Wickenhauser C, Scholten J, Peschke K, Drube S, Horny HP, Kamradt T, Naumann R, Muller W, Krieg T, Waskow C, Hartmann K, and Roers A. Mast cell hyperplasia, B cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood.117:2012-2021.

Waskow C, Madan V, Bartels S, Costa C, Blasig R, and Rodewald HR. Hematopoietic stem cell transplantation without irradiation. Nat Methods. 6:267-9.

Waskow C, Liu K, Darrasse-Jeze G, Guermonprez P, Ginhoux F, Merad M, Shengelia T, Yao K, and Nussenzweig M. The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol. 9:676-83.

Liu K, Waskow C, Liu X, Yao K, Hoh J, and Nussenzweig M. Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol. 8:578-83.
Waskow C, Bartels S, Schlenner SM, Costa C, and Rodewald HR. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood. 109:5363-70.

Stumpf M, Waskow C, Krotschel M, van Essen D, Rodriguez P, Zhang X, Guyot B, Roeder RG, and Borggrefe T. The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A. 103:18504-9.

Terszowski G, Waskow C, Conradt P, Lenze D, Koenigsmann J, Carstanjen D, Horak I, and Rodewald HR. Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit (CFU-E). Blood.105:1937-45.
Kroll J, Shi X, Caprioli A, Liu HH, Waskow C, Lin KM, Miyazaki T, Rodewald HR, and Sato TN. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol Cell Biol. 25:8531-40.

Agosti V, Corbacioglu S, Ehlers I, Waskow C, Sommer G, Berrozpe G, Kissel H, Tucker CM, Manova K, Moore MA, Rodewald HR, and Besmer P. Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development. J Exp Med. 199:867-878.
Waskow C, Terszowski G, Costa C, Gassmann M, and Rodewald HR. Rescue of lethal c-KitW/W mice by erythropoietin. Blood.104:1688-95.

Waskow C, Paul S, Haller C, Gassmann M, and Rodewald HR. Viable c-kit(W/W) mutants reveal pivotal role for c-kit in the aintenance of lymphopoiesis. Immunity. 17:277-88.