Publications (selected)

2019

• Duin S, Schütz K, Ahlfeld T, Lehmann S, Lode A, Ludwig B, Gelinsky M. 3D Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose Hydrogel Blend. Adv Healthc Mater. Apr;8(7):e1801631. doi: 10.1002/adhm.201801631. Epub 2019 Mar 5.

2018

• Balyura M, Gelfgat E, Steenblock C, Androutsellis-Theotokis A, Ruiz-Babot G, Guasti L, Werdermann M, Ludwig B, Bornstein T, Schally AV, Brennand A, Bornstein SR. Expression of progenitor markers is associated with the functionality of a bioartificial adrenal cortex. PLoS One. Mar 29;13(3):e0194643. doi: 10.1371/journal.pone.0194643. eCollection 2018.
  
  
• Balyura M, Gelfgat E, Ullmann E, Ludwig B, Barnea ER, Bornstein SR. PreImplantation Factor (PIF*) Regulates Stress-Induced Adrenal Steroidogenesis and Anti-Inflammatory Cytokines: Potential Application for Bioartificial Adrenal Transplant. Horm Metab Res. Oct 24.
  
  
• Cohrs CM, Chen C, Jahn SR, Stertmann J, Chmelova H, Weitz J, Bähr A, Klymiuk N, Steffen A, Ludwig B, Kamvissi V, Wolf E, Bornstein SR, Solimena M, Speier S. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology.  May 1;158(5):1373-1385.
  
  
• Evron Y, Colton CK, Ludwig B, Weir GC, Zimermann B, Maimon S, Neufeld T, Shalev N, Goldman T, Leon A, Yavriyants K, Shabtay N, Rozenshtein T, Azarov D, DiIenno AR, Steffen A, de Vos P, Bornstein SR, Barkai U, Rotem A. Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply. Sci Rep. Apr 25;8(1):6508. doi: 10.1038/s41598-018-23862-w.
  
  
• Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, Lehmann S, Schubert U, Schmid J, Bleyer M, Schönmann U, Colton CK, Bonifacio E, Solimena M, Reichel A, Schally AV, Rotem A, Barkai U, Grinberg-Rashi H, Kaup FJ, Avni Y, Jones P, Bornstein SR. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A. Oct 31;114(44):11745-11750.
  
  
• Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. Review.
  
  
• Rickels MR, Stock PG, de Koning EJP, Piemonti L, Pratschke J, Alejandro R, Bellin MD, Berney T, Choudhary P, Johnson PR, Kandaswamy R, Kay TWH, Keymeulen B, Kudva YC, Latres E, Langer RM, Lehmann R, Ludwig B, Markmann JF, Marinac M, Odorico JS, Pattou F, Senior PA, Shaw JAM, Vantyghem MC, White S. Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop. Transplantation.  Sep;102(9):1479-1486. doi: 10.1097/TP.0000000000002158. Review.
  
  
• Simeonovic CJ, Popp SK, Starrs LM, Brown DJ, Ziolkowski AF, Ludwig B, Bornstein SR, Wilson JD, Pugliese A, Kay TWH, Thomas HE, Loudovaris T, Choong FJ, Freeman C, Parish CR. Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans. PLoS One. Feb 7;13(2):e0191360. doi: 10.1371/journal.pone.0191360. eCollection 2018.

2017

• Cohrs CM, Chen C, Jahn SR, Stertmann J, Chmelova H, Weitz J, Bähr A, Klymiuk N, Steffen A, Ludwig B, Kamvissi V, Wolf E, Bornstein SR, Solimena M, Speier S. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology.  May 1;158(5):1373-1385.
  
  
• Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, Lehmann S, Schubert U, Schmid J, Bleyer M, Schönmann U, Colton CK, Bonifacio E, Solimena M, Reichel A, Schally AV, Rotem A, Barkai U, Grinberg-Rashi H, Kaup FJ, Avni Y, Jones P, Bornstein SR. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A. Oct 31;114(44):11745-11750.

• Steffen A, Kiss T, Schmid J, Schubert U, Heinke S, Lehmann S, Bornstein S, Ludwig B, Ludwig S. Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation.  Jan;24(1).

2016

• Bartlett ST, Markmann JF, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell P, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Kovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T. Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation. Feb;100 Suppl 2:S1-44.

• Heinke S*, Ludwig B*, Schubert U, Schmid J, Kiss T, Steffen A, Bornstein S, Ludwig S. Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: a feasible approach for advanced diabetes research. Xenotransplantation. Sep;23(5):405-13 * shared first authorship
  
  

• Grützmann R*, Ludwig B*, Weitz J, Ludwig S. Total Pancreatectomy and Islet Autotransplantation in a Child with Recurrent Pancreatitis. Zentralbl Chir. Feb;141(1):17-20. * shared first authorship
  
  

• Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb Haemost. Apr;115(4):781-8. doi: 10.1160/TH15-05-0429.

• Morozov VA, Ludwig S, Ludwig B, Rotem A, Barkai U, Bornstein SR, Denner J. Islet cell transplantation from Göttingen minipigs to cynomolgus monkeys: analysis of virus safety. Xenotransplantation. Jul;23(4):320-7.
  
  

• Markmann JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell PJ, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Khovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T. Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement. Transplantation. Jul;100(7):e25-31.
  
  

• Bartlett ST, Markmann JF, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, OʼConnell P, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Kovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T. Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation. Feb;100 Suppl 2:S1-44.
  
  

• Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb Haemost. Apr;115(4):781-8.

2015

• Balyura M, Gelfgat E, Ehrhart-Bornstein M, Ludwig B, Gendler Z, Barkai U, Zimerman B, Rotem A, Block NL, Schally AV, and Bornstein SR. Transplantation of bovine adrenocortical cells encapsulated in alginate. Proceedings of the National Academy of Sciences of the United States of America 112(8), 2527-2532.

• Ludwig B, and Ludwig S. Transplantable bioartificial pancreas devices: current status and future prospects. Langenbecks Archive of Surgery, Langenbeck´s Archives of Surgery 400(5), 531-540.
  
  
• Ludwig B, Reichel A, Kruppa A, Ludwig S, Steffen A, Weitz J, and Bornstein SR. Islet transplantation at the Dresden diabetes center: five years' experience. Hormone and Metabolic Research 47(1), 4-8.

• Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res; 47(1):31-5.

2014

• Ludwig B, Barthel A, Reichel A, Block NL, Ludwig S, Schally AV, and Bornstein SR. Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus. Vitamins & Hormones 95,195-222.

2013

• Barkai U, Weir GC, Colton CK, Ludwig B, Bornstein SR, Brendel MD, Neufeld T, Bremer C, Leon A, Evron Y, Yavriyants K, Azarov D, Zimermann B, Maimon S, Shabtay N, Balyura M, Rozenshtein T, Vardi P, Bloch K, de Vos P, Rotem A. Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 22(8):1463-76. doi: 10.3727/096368912X657341. Epub 2012 Oct 3.

• Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, Bornstein SR. Transplantation of human islets without immunosuppression. Proc Natl Acad Sci U S A. Nov 19;110(47):19054-8.
  
  
• Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, and Bornstein SR. Transplantation of human islets without immunosuppression.#mce_temp_url# Proceedings of the National Academy of Sciences of the United States of America 110(47),19054-19058.
  
  
• Neufeld T*, Ludwig B*, Barkai U, Weir GC, Colton CK, Evron Y, Balyura M, Yavriyants K, Zimermann B, Azarov D, Maimon S, Shabtay N, Rozenshtein T, Lorber D, Steffen A, Willenz U, Bloch K, Vardi P, Taube R, de Vos P, Lewis EC, Bornstein SR, Rotem A. The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS One. Aug 1;8(8):e70150.

* gemeinsame Erst-/Seniorautorenschaft

2012

• Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A. Mar 27;109(13):5022-7.

2010

• Ludwig B, Zimerman B, Steffen A, Yavriants K, Azarov D, Reichel A, Vardi P, German T, Shabtay N, Rotem A, Evron Y, Neufeld T, Mimon S, Ludwig S, Brendel MD, Bornstein SR, Barkai U. A Novel Device for Islet Transplantation Providing Immune Protection and Oxygen Supply. Horm Metab Res. Dec;42(13):918-22.

2007

• Armann B, Hanson MS, Hatch E, Steffen A, Fernandez LA. Quantification of Basal and Stimulated ROS Levels as Predictors of Islet Potency and Function. Am J Transplant. July (1):38-47.

Reviews

2014

• Ludwig B, Barthel A, Reichel A, Block NL, Ludwig S, Schally AV, Bornstein SR. Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus. Vitam Horm. 95:195-222.

2010

• Ludwig B, Ludwig S, Steffen A, Saeger HD, Bornstein SR. 2010. Islet versus Pancreas Transplantation in Type 1 Diabetes. Competitive of Complementary? Curr Diab Rep. Dec;10(6):506-11.

Co-author / original publication 

• Barkai U, Weir G, Colton C, Ludwig B, Bornstein S, Brendel M, Neufeld T, Leon A, Evron Y, Yavriyants K, Azarov D, Zimerman B, Maimon S, Shabtay Noa, Balyura M, Rozenshtein T, Vardi P, Bloch K, de Vos P, Rotem A. Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas. Cell Transplant. 2013;22(8):1463-76.
  
  
• Barkai U, Weir GC, Colton CK, Ludwig B, Bornstein SR, Brendel MD, Neufeld T, Bremer C, Leon A, Evron Y, Yavriyants K, Azarov D, Zimermann B, Maimon S, Shabtay N, Balyura M, Rozenshtein T, Vardi P, Bloch K, de Vos P, Rotem A. Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 2013;22(8):1463-76.

2011

• Steffen A, Ludwig B, Krautz C, Bornstein S, Solimena M. Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry. Islets. 2011 Sep-Oct;3(5):267-70.

2009

• Yesil P, Michel M, Chwalek K, Pedack S, Jany C, Ludwig B, Bornstein SR, Lammert E. A new collagenase blend increases the number of islets isolated from mouse pancreas. Islets. 1(3):1-6.

2008

• Hanson MS, Steffen A, Danobeitia JS, Ludwig B, Fernandez LA. Flow cytometric quantification of glucose-stimulated beta-cell metabolic flux can reveal impaired islet functional potency. Cell Transplant.17(12):1337-47.

2007

• Hanson MS, Armann B, Steffen A, Sperger LM, Hullett DA, Odorico JS, D´Alessandro AM, Sollinger HW, Fernandez LA. Evaluation of islet quality from donation after cardiac death using a novel extended quality control assessment program. Xenotransplantation. 14(5):419-419.
  
  
• Hirsch DM, Odorico JS, Radke NA, Hanson MS, Armann B, Munoz A, Sollinger HW, Fernandez LA. Metabolic assays may predict return to exogenous insulin. Xenotransplantation. 14(5):469-469.
  
  
• Hirsch DM, Odorico JS, Radke NA, Hanson MS, Armann B, Sollinger HW, Fernandez LA. Insulin secretory reserve is impaired in islet recipients despite return to normoglycemia. Xenotransplantation. 14(5):473-474.

2005

• Fernandez LA, Hatch EW, Armann B, Odorico JS, Hullett DA, Sollinger HW, Hanson MS. Validation of large particle flow cytometry for the analysis and sorting of intact pancreatic islets. Transplantation. 27;80(6):729-37.
  
  
• Fernandez LA, Hanson MS, Armann B, Hatch EW, Hullett DA, Odorico JS, Sollinger HW. Kinetic flow cytometry-based glucose response assay for the assessment of human islet cell potency. Am J Transpl. 5:356-357.
  
  
• Hanson MS, Armann B, Hatch EW, Hullett DA, Odorico JS, Sollinger HW, Fernandez LA. Rapid and sensitive assessment of human islet viability by multiparameter flow cytometry on intact and dissociated islets. Am J Transpl. 5:512-512.

Review

2009

• Reimann M, Bonifacio E, Solimena M, Schwarz PE, Ludwig B, Hanefeld M, Bornstein SR. An update on preventive and regenerative therapies in diabetes mellitus. Pharmacol Ther. 121(3):317-31.

Book contribution

2014

• Ludwig B. Inseltransplantation als Therapieoption bei Diabetes mellitus Typ 1: Für wen, mit welchem Ziel, mit welchem Erfolg? J Gastroenterol Hepatol Erk;12:1-5.

2013

• Ludwig B. Transplantation von allogenen Pankreasinseln ohne Immunsuppression. Erste klinische Ergebnisse. Current Congress, 22. Jahrestagung der Deutschen Transplantationsgesellschaft;12.

2011

• Ludwig B. Transplantation von Langerhans-Inseln als Therapie des Typ-1-Diabetes Adipositas; 5:171 - 172.
  
  
• Ludwig B. Diabetes mellitus. Inseltransplantation als Therapieoption. MedReport; 31:13
  
  
• Farkas SA, Ludwig B. Die kombinierte Nieren-Pankreastransplantation. Diatra;1:51-56.

2010

• Ludwig B. Insel- und Pankreastransplantation bei Typ-1-Diabetes – Update 2010. Diabetes Congress-Report, Dec; 6:29-33.
  
  
• Ludwig B, Ludwig S, Reichel A, Saeger HD, Solimena M, Bornstein SR. Pankreaserkrankungen und Diabetes mellitus. Der Diabetologe. 6(1):9-15.

2009

• Ludwig B, Reichel A, Bornstein SR, Saeger HD, Witzigmann H, Brendel MD. Neue Therapieoptionen bei Typ-1-Diabetes. Pankreas- und Inseltransplantation. Kompendium Diabetes. 4:67-70.
  
  
• Ludwig B. Inseltransplantation als Therapieoption bei Diabetes mellitus Typ 1. Aktueller Stand und Perspektive. Diabetes aktuell. 2009. 1:26-31.