Publications (selected)

2019

• Mederacke YS, Vondran FW, Kollrich S, Schulde E, Schmitt R, Manns MP, Klempnauer J, Schwinzer R, Noyan F, Jaeckel E. Transient increase of activated regulatory T cells early after kidney transplantation. Sci Rep. Jan 31;9(1):1021. doi: 10.1038/s41598-018-37218-x.

2018

• Dywicki J, Noyan F, Misslitz AC, Hapke M, Galla M, Schlue J, Liblau RS, Taubert R, Manns MP, Jaeckel E, Hardtke-Wolenski M. Hepatic T Cell Tolerance Induction in An Inflammatory Environment. Dig Dis. 36(2):156-166. doi: 10.1159/000481341. Epub 2017 Oct 12.

2017

• Hardtke-Wolenski M, Dywicki J, Fischer K, Hapke M, Sievers M, Schlue J, Anderson MS, Taubert R, Noyan F, Manns MP, Jaeckel E. The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development. J Autoimmun. Mar;78:39-45. doi: 10.1016/j.jaut.2016.12.001. Epub 2016 Dec 11.
  
  
• Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, Hust M, Huehn J, Galla M, Morgan M, Jokuszies A, Manns MP, Jaeckel E. Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor. Am J Transplant. Apr;17(4):917-930. doi: 10.1111/ajt.14175. Epub 2017 Feb 6.

• Taubert R, Hardtke-Wolenski M, Noyan F, Lalanne C, Jonigk D, Schlue J, Krech T, Lichtinghagen R, Falk CS, Schlaphoff V, Bantel H, Muratori L, Manns MP, Jaeckel E. Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis. PLoS One. Jun 8;12(6):e0179074. doi: 10.1371/journal.pone.0179074. eCollection 2017.

2016

• Baumann AK, Schlue J, Noyan F, Hardtke-Wolenski M, Lehner F, Barg-Hock H, Klempnauer J, Manns MP, Taubert R, Jaeckel E. Preferential accumulation of T helper cells but not cytotoxic T cells characterizes benign subclinical rejection of human liver allografts. Liver Transpl.  Jul;22(7):943-55. doi: 10.1002/lt.24427.

• Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. J Am Heart Assoc. Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429.

2015

• Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, et al. Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens. Hepatology.

2014

• Noyan F, Lieke T, Taubert R, Sievers M, Dywicki J, Hapke M, et al. Naive tumour-specific CD4+ T cells were efficiently primed in acute lymphoblastic leukaemia. Scandinavian journal of immunology, 80(3): 161-168.
  
  
• Noyan F, Lee YS, Zimmermann K, Hardtke-Wolenski M, Taubert R, Warnecke G, et al. Isolation of human antigen-specific regulatory T cells with high suppressive function. Eur J Immunol, 44(9): 2592-2602.
  
  
• Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, et al. Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens. Hepatology.
  
  
• Taubert R, Hardtke-Wolenski M, Noyan F, Wilms A, Baumann AK, Schlue J, et al. Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies. Journal of hepatology, 61(5): 1106-1114.

2013

• Noyan F, Lee YS, Hardtke-Wolenski M, Knoefel AK, Taubert R, Baron U, et al. Donor-specific regulatory T cells generated on donor B cells are superior to CD4+CD25high cells in controlling alloimmune responses in humanized mice. Transplant Proc, 45(5): 1832-1837.
  
  
• Hardtke-Wolenski M, Kraus L, Schmetz C, Trautewig B, Noyan F, Vondran FW, et al. Exchange of cytosolic content between T cells and tumor cells activates CD4 T cells and impedes cancer growth. PLoS One, 8(10): e78558.

• Hardtke-Wolenski, M, Fischer, K, Noyan, F, Schlue, J, Falk, C.S, Stahlhut, M, Woller, N, Kuehnel, F, Taubert, R, Manns, M.P, Jaeckel, E Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells. Hepatology 58(2):718-28.

 2012

• Noyan F, Diez IA, Hapke M, Klein C, Dewey RA. Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy. Cancer gene therapy, 19(5): 352 357.
  
  
• Taubert R, Pischke S, Schlue J, Wedemeyer H, Noyan F, Heim A, et al. Enrichment of regulatory T cells in acutely rejected human liver allografts. Am J Transplant, 12(12): 3425-3436.

 2009

• Boztug K, Appaswamy G, Ashikov A, Schaffer AA, Salzer U, Diestelhorst J, et al. A syndrome with congenital neutropenia and mutations in G6PC3. The New England journal of medicine, 360(1): 32-43.
  
  
• Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, et al. MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells. The EMBO journal, 28(10): 1392-1406.
  
  
• Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schaffer AA, Noyan F, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. The New England journal of medicine, 361(21): 2033-2045

2006

• Dewey RA, Avedillo Diez I, Ballmaier M, Filipovich A, Greil J, Gungor T, et al. Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitro. Experimental hematology, 34(9): 1161-1169.