Publications (selected)
2020
- Moretti, A., Fonteyne L., Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Abdel Rahman F, Haufe T, Sun S, Jurisch V, Kessler BV, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C. Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Nature Medicine Feb;26(2):207-214. doi: 10.1038/s41591-019-0738-2. Epub 2020 Jan 27
- Reichart B, Längin M, Radan J, Mokelke M, Buttgereit I, Ying J, Fresch AK, Mayr T, Issl L, Buchholz S, Michel S, Ellgass R, Mihalj M, Egerer S, Baehr A, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Steen S, Sjöberg T, Paskevicius A, Krüger L, Fiebig U, Denner J, Godehardt AW, Tönjes RR, Milusev A, Rieben R, Sfriso R, Walz C, Kirchner T, Ayares D, Lampe K, Schönmann U, Hagl C, Wolf E, Klymiuk N, Abicht JM, Brenner P. Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation? J Heart Lung Transplant. Aug;39(8):751-757.
2019
- Kola I, Egerer S, Bähr A, Godehardt AW, Tönjes RR, Ayares D, Wolf E, Klymiuk N. Removal of PERV- C proviruses from xenotransplanation donor pigs by marker-assisted breeding or gene editing. Xenotransplantation 2019;xen12553 [Abstract]
- Kurome M, Baehr A, Simmet K, Jemiller EM, Egerer S, Dahlhoff M, Zakhartchenko V, Nagashima H, Klymiuk N, Kessler B, Wolf E. Targeting αGal epitopes for multi-species embryo immunosurgery. Reprod Fertil Dev.;31(4):820-826
2018
- Abicht JM, Sfriso R, Reichart B, Längin M, Gahle K, Puga Yung GL, Seebach JD, Rieben R, Ayares D, Wolf E, Klymiuk N, Baehr A, Kind A, Mayr T, Bauer A. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. Xenotransplantation. Sep;25(5):e12390. doi: 10.1111/xen.12390. Epub 2018 Mar 14.
- Buerck LW, Schuster M, Oduncu FS, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Klymiuk N, Wolf E, Seissler J. LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy. Sci Rep. Jun 15;7(1):3572. doi: 10.1038/s41598-017-03913-4.
- Egerer S, Fiebig U, Kessler B, Zakhartchenko V, Kurome M, Reichart B, Kupatt C, Klymiuk N, Wolf E, Denner J, Bähr A. Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation. Xenotransplantation Jul. 25(4):e12449
- Fiebig U, Fischer K, Bähr A, Runge C, Schnieke A, Wolf E, Denner J. Porcine endogenous retroviruses: Quantification of the copy number in cell lines, pig breeds, and organs. Xenotransplantation Jul. 25(4):e12445.
- Fiebig U, Abicht JM, Mayr T, Längin M, Bähr A, Guethoff S, Falkenau A, Wolf E, Reichart B, Shibahara T, Denner J; Distribution of Porcine Cytomegalovirus in Infected Donor Pigs and in Baboon Recipients of Pig Heart Transplantation. Viruses, 10(2) Feb 6, E66; doi:10.3390/v10020066
- Gromann LB, De Marco F, Willer K, Noël PB, Scherer K, Renger B, Gleich B, Achterhold K, Fingerle AA, Muenzel D, Auweter S, Hellbach K, Reiser M, Baehr A, Dmochewitz M, Schroeter TJ, Koch FJ, Meyer P, Kunka D, Mohr J, Yaroshenko A, Maack HI, Pralow T, van der Heijden H, Proksa R, Koehler T, Wieberneit N, Rindt K, Rummeny EJ, Pfeiffer F, Herzen J. In-vivo X-ray Dark-Field Chest Radiography of a Pig. Sci Rep. Jul 6;7(1):4807. doi: 10.1038/s41598-017-05101-w.
- Hauke C, Bartl P, Leghissa M, Ritschl L, Sutter SM, Weber T, Zeidler J, Freudenberger J, Mertelmeier T, Radicke M, Michel T, Anton G, Meinel FG, Baehr A, Auweter S, Bondesson D, Gaass T, Dinkel J, Reiser M, Hellbach K. A preclinical Talbot-Lau prototype for x-ray dark-field imaging of human-sized objects. Med Phys. Jun;45(6):2565-2571. doi: 10.1002/mp.12889. Epub 2018 Apr 27.
- Hellbach K, Baehr A, De Marco F, Willer K, Gromann LB, Herzen J, Dmochewitz M, Auweter S, Fingerle AA, Noël PB, Rummeny EJ, Yaroshenko A, Maack HI, Pralow T, van der Heijden H, Wieberneit N, Proksa R, Koehler T, Rindt K, Schroeter TJ, Mohr J, Bamberg F, Ertl-Wagner B, Pfeiffer F, Reiser MF. Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography. Sci Rep. Feb 8;8(1):2602. doi: 10.1038/s41598-018-20985-y.
- Hinkel R, Klett K, Bähr A, Kupatt C. Thymosin β4-mediated protective effects in the heart. Expert Opin Biol Ther. Jul;18:121-129. doi: 10.1080/14712598.2018.1490409. Review.
- Kurome M, Baehr A, Simmet K, Jemiller EM, Egerer S, Dahlhoff M, Zakhartchenko V, Nagashima H, Klymiuk N, Kessler B, Wolf E. Targeting αGal epitopes for multi-species embryo immunosurgery. Reprod Fertil Dev. 2018 Nov 2. doi: 10.1071/RD18120.
- Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht J. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 5. Dez.;564, pages430–433
- Puga Yung G, Bongoni AK, Pradier A, Madelon N, Papaserafeim M, Sfriso R, Ayares DL, Wolf E, Klymiuk N, Bähr A, Constantinescu MA, Voegelin E, Kiermeir D, Jenni H, Rieben R, Seebach JD. Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood. Xenotransplantation. Jan;25(1). doi: 10.1111/xen.12357. Epub 2017 Oct 22.
- Ziegler T, Bähr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R. Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs. Mol Ther. Jul 5;26(7):1706-1714. doi: 10.1016/j.ymthe.2018.06.004. Epub 2018 Jun 19.
2017
- Cohrs, C.M., Chen, C., Jahn, S.R., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., et al. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology 158(5), 1373-1385.
- Laird CT, Burdorf L, French BM, Kubicki N, Cheng X, Braileanu G, Sun W, O'Neill NA, Cimeno A, Parsell D, So E, Bähr A, Klymiuk N, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN. Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury. Xenotransplantation. Mar;24(2). doi: 10.1111/xen.12294. Epub 2017 Mar 3.
- Wolf-van Buerck, Schuster M, Oduncu FS, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Klymiuk N, Wolf E, Seissler J. LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy. Sci Rep 7(1), 3572.
2016
- Bähr A, Käser T, Kemter E, Gerner W, Kurome M, Baars W, Herbach N, Witter K, Wünsch A, Talker SC, Kessler B, Nagashima H, Saalmüller A, Schwinzer R, Wolf E, Klymiuk N. Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs. PLoS One. 2016 May 13;11(5):e0155676. doi: 10.1371/journal.pone.0155676.
- Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht J. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 5. Dez.;564, pages430–433
- Rataj D, Werwitzke S, Haarmeijer B, Winkler M, Ramackers W, Petersen B, Niemann H, Wünsch A, Bähr A, Klymiuk N, Wolf E, Abicht JM, Ayares D, Tiede A. Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation. Xenotransplantation Mar;23(2):117-27. doi: 10.1111/xen.12218. Epub 2016 Jan 16. PubMed PMID: 26773447.
2015
- Wolf-van Buerck L, Schuster M, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Nam-Apostolopoulos Y, Klymiuk N, Wolf E, et al. Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters. Xenotransplantation Oct 21., doi: 10.1111/xen.12201.
2014
- Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N. Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs. Transplantation. 97(2):138-47.
2013
- Kurome M, Geistlinger L, Kessler B, Zakhartchenko V, Klymiuk N, Wuensch A, Richter A, Baehr A, Kraehe K, Burkhardt K, Flisikowski K, Flisikowska T, Merkl C, Landmann M, Durkovic M, Tschukes A, Kraner S, Schindelhauer D, Petri T, Kind A, Nagashima H, Schnieke A, Zimmer R, Wolf E. Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set. BMC Biotechnol;13:43.
- Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wünsch A, Kessler B, Kurome M, Bähr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E. Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes;62(5):1505-11.
2012
- Klymiuk N, van Buerck L, Bähr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, Herbach N, Wanke R, Seissler J, Wolf E. Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes;61(6):1527-32.