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Publications (selected)

2021

Carvalho-Oliveira M, Valdivia E, Blasczyk R, Figueiredo C. Immunogenetics of xenotransplantation. Int J Immunogenet. 2021 Apr;48(2):120-134. doi: 10.1111/iji.12526. Epub Jan 7

Carvalho-Oliveira M, Valdivia E, Verboom M, Sake H, Pogozhykh O, Niemann H, Schwinzer R, Petersen B, Seissler J, Blasczyk R, Figueiredo C. Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation. J Cell Mol Med. Mar 25. doi: 10.1111/jcmm.15136. Online ahead of print.
Yuzefovych Y, Valdivia E, Rong S, Hack F, Rother T, Schmitz J, Bräsen JH, Wedekind D, Moers C, Wenzel N, Gueler F, Blasczyk R, Figueiredo C. Genetic engineering of the kidney to permanently silence MHC transcripts during ex vivo organ perfusion. Front. Immunol. Feb 19;11:265. doi: 10.3389/fimmu.2020.00265.

Figueiredo C, Carvalho Oliveira M, Chen-Wacker C, Jansson K, Höffler K, Yuzefovych Y, Pogozhykh O, Jin Z, Kühnel M, Jonigk D, Wiegmann B, Sommer W, Haverich A, Warnecke G, Blasczyk R. Immunoengineering of the Vascular Endothelium to Silence MHC Expression During Normothermic Ex Vivo Lung Perfusion. Hum Gene Ther. Apr;30(4):485-496. doi: 10.1089/hum.2018.117. Epub 2018 Nov 20
Hein R, Sake HJ, Pokoyski C, Hundrieser J, Brinkmann A, Baars W, Nowak-Imialek M, Lucas-Hahn A, Figueiredo C, Schuberth HJ, Niemann H, Petersen B, Schwinzer R. Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class-I^low phenotype - effects on immune status and susceptibility to human immune responses. Am J Transplant. Nov 15. doi: 10.1111/ajt.15710. [Epub ahead of print]

Wiegmann, B.*, Figueiredo, C.*, Gras, C., Pflaum, M., Schmeckebier, S., Korossis, S., Haverich, A., and Blasczyk, R. Prevention of rejection of allogeneic endothelial cells in a biohybrid lung by silencing HLA-class I expression. Biomaterials 35, 8123-8133. *These authors contributed equally for the work.
Gras, C., Eiz-Vesper, B., Jaimes, Y., Immenschuh, S., Jacobs, R., Witte, T., Blasczyk, R., and Figueiredo, C. Secreted semaphorin 5A activates immune effector cells and is a biomarker for rheumatoid arthritis. Arthritis & rheumatology 66, 1461-1471.
Schlahsa, L., Zhang, H., Battermann, A., Verboom, M., Immenschuh, S., Eiz-Vesper, B., Stripecke, R., Engelmann, K., Blasczyk, R., and Figueiredo, C. Semaphorin 3A alters endothelial cell immunogenicity by regulating Class II transactivator activity circuits. Transfusion 54, 1961-1970.

Gras, C., Schulze, K., Goudeva, L., Guzman, C.A., Blasczyk, R., and Figueiredo, C. HLA-universal platelet transfusions prevent platelet refractoriness in a mouse model. Human gene therapy 24, 1018-1028.
Figueiredo, C., Wedekind, D., Muller, T., Vahlsing, S., Horn, P.A., Seltsam, A., and Blasczyk, R. MHC universal cells survive in an allogeneic environment after incompatible transplantation. BioMed research international 2013, 796046.

Jaimes, Y., Gras, C., Goudeva, L., Buchholz, S., Eiz-Vesper, B., Seltsam, A., Immenschuh, S., Blasczyk, R., and Figueiredo, C. Semaphorin 7A inhibits platelet production from CD34+ progenitor cells. Journal of thrombosis and haemostasis : JTH 10, 1100-1108.

Jaimes, Y., Seltsam, A., Eiz-Vesper, B., Blasczyk, R., and Figueiredo, C. Regulation of HLA class II expression prevents allogeneic T-cell responses. Tissue antigens 77, 36-44.

Figueiredo, C., Goudeva, L., Horn, P.A., Eiz-Vesper, B., Blasczyk, R., and Seltsam, A. Generation of HLA-deficient platelets from hematopoietic progenitor cells. Transfusion 50, 1690-1701.

Figueiredo, C., Horn, P.A., Blasczyk, R., and Seltsam, A. Regulating MHC expression for cellular therapeutics. Transfusion 47, 18-27.

Figueiredo, C., Seltsam, A., and Blasczyk, R. Class-, gene-, and group-specific HLA silencing by lentiviral shRNA delivery. Journal of molecular medicine 84, 425-437.