Publications (selected)
2019
2018
- Abicht JM, Sfriso R, Reichart B, Längin M, Gahle K, Puga Yung GL, Seebach JD, Rieben R, Ayares D, Wolf E, Klymiuk N, Baehr A, Kind A, Mayr T, Bauer A. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. Xenotransplantation. Sep;25(5):e12390. doi: 10.1111/xen.12390. Epub 2018 Mar 14.
- Egerer S, Fiebig U, Kessler B, Zakhartchenko V, Kurome M, Reichart B, Kupatt C, Klymiuk N, Wolf E, Denner J, Bähr A. Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation. Xenotransplantation Jul. 25(4):e12449
- Kurome M, Baehr A, Simmet K, Jemiller EM, Egerer S, Dahlhoff M, Zakhartchenko V, Nagashima H, Klymiuk N, Kessler B, Wolf E. Targeting αGal epitopes for multi-species embryo immunosurgery. Reprod Fertil Dev. 2018 Nov 2. doi: 10.1071/RD18120.
- Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht J. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 5. Dez.;564, pages430–433
- Puga Yung G, Bongoni AK, Pradier A, Madelon N, Papaserafeim M, Sfriso R, Ayares DL, Wolf E, Klymiuk N, Bähr A, Constantinescu MA, Voegelin E, Kiermeir D, Jenni H, Rieben R, Seebach JD. Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood. Xenotransplantation. Jan;25(1). doi: 10.1111/xen.12357. Epub 2017 Oct 22.
2017
- Buerck LW, Schuster M, Oduncu FS, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Klymiuk N, Wolf E, Seissler J. LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy. Sci Rep. Jun 15;7(1):3572. doi: 10.1038/s41598-017-03913-4.
- Cohrs, C.M., Chen, C., Jahn, S.R., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., et al. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology 158(5), 1373-1385.
- Laird CT, Burdorf L, French BM, Kubicki N, Cheng X, Braileanu G, Sun W, O'Neill NA, Cimeno A, Parsell D, So E, Bähr A, Klymiuk N, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN. Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury. Xenotransplantation. Mar;24(2). doi: 10.1111/xen.12294. Epub 2017 Mar 3.
2016
- Bähr A, Käser T, Kemter E, Gerner W, Kurome M, Baars W, Herbach N, Witter K, Wünsch A, Talker SC, Kessler B, Nagashima H, Saalmüller A, Schwinzer R, Wolf E, Klymiuk N. Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs. PLoS One. 2016 May 13;11(5):e0155676. doi: 10.1371/journal.pone.0155676.
- Rataj D, Werwitzke S, Haarmeijer B, Winkler M, Ramackers W, Petersen B, Niemann H, Wünsch A, Bähr A, Klymiuk N, Wolf E, Abicht JM, Ayares D, Tiede A. Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation. Xenotransplantation Mar;23(2):117-27. doi: 10.1111/xen.12218. Epub 2016 Jan 16. PubMed PMID: 26773447.
2015
- Bongoni AK, Kiermeir D, Schnider J, Jenni H, Garimella P, Bahr A, Klymiuk N, Wolf E, Ayares D, Voegelin E, et al. Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions. Transplantation 99, 2061-2069.
- Plotzki E, Wolf-van Buerck L, Knauf Y, Becker T, Maetz-Rensing K, Schuster M, Baehr A, Klymiuk N, Wolf E, Seissler J, et al. Virus safety of islet cell transplantation from transgenic pigs to marmosets. Virus research 204, 95-102.
- Iwase H, Ekser B, Satyananda V, Bhama J, Hara H, Ezzelarab M, Klein E, Wagner R, Long C, Thacker J, et al. Pig-to-baboon heterotopic heart transplantation-exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens. Xenotransplantation 22, 211-220.
- Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res; 47(1):31-5.
- Wolf-van Buerck L, Schuster M, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Nam-Apostolopoulos Y, Klymiuk N, Wolf E, et al. Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters. Xenotransplantation Oct 21., doi: 10.1111/xen.12201.
2014
- Klymiuk N, Fezert P, Wunsch A, Kurome M, Kessler B, and Wolf E. Homologous recombination contributes to the repair of zinc-finger-nuclease induced double strand breaks in pig primary cells and facilitates recombination with exogenous DNA. Journal of biotechnology 177, 74-81.
- Mohiuddin MM, Singh AK, Corcoran PC, Hoyt RF, Thomas ML 3rd, Lewis BG, Eckhaus M, Reimann, KA, Klymiuk N, Wolf E, et al. One-year heterotopic cardiac xenograft survival in a pig to baboon model. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, 488-489.
- Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke, A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, et al. Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs. Transplantation 97, 138-147.
2013
- Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, et al. Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle. Human molecular genetics 22, 4368-4382.
- Bongoni AK, Kiermeir D, Jenni H, Wunsch A, Bahr A., Ayares D, Seebach JD, Wolf E, Klymiuk N, Constantinescu MA, et al. Activation of the lectin pathway of complement in pig-to-human xenotransplantation models. Transplantation 96, 791-799.
2012
- Klymiuk N, Bocker W, Schonitzer V, Bahr A, Radic T, Frohlich T, Wunsch A, Kessler B, Kurome M, Schilling E, et al. First inducible transgene expression in porcine large animal models. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 26, 1086-1099.
- Klymiuk N, van Buerck L, Bahr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, et al. Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice. Diabetes 61, 1527-1532.
2010
- Plog S, Mundhenk L, Bothe M K, Klymiuk N, Gruber A D. Tissue and Cellular Expression Patterns of Porcine CFTR: Similarities and Differences to Human CFTR. J Histochem Cytochem. May 24.
- Aigner B, Renner S, Kessler B, Klymiuk N, Kurome M, Wünsch A, Wolf E. Transgenic pigs as models for translational biomedical research. J Mol Med. Jul;88(7):653-64.
2006
2005
2003
