Publications (selected)

2019

• Mederacke YS, Vondran FW, Kollrich S, Schulde E, Schmitt R, Manns MP, Klempnauer J, Schwinzer R, Noyan F, Jaeckel E. Transient increase of activated regulatory T cells early after kidney transplantation. Sci Rep. Jan 31;9(1):1021. doi: 10.1038/s41598-018-37218-x.
  
  
• Pape S, Gevers TJG, Belias M, Mustafajev IF, Vrolijk JM, van Hoek B, Bouma G, van Nieuwkerk CMJ, Hartl J, Schramm C, Lohse AW, Taubert R, Jaeckel E, Manns MP, Papp M, Stickel F, Heneghan MA, Drenth JPH. Predniso(lo)ne Dosage and Chance of Remission in Patients With Autoimmune Hepatitis. Clin Gastroenterol Hepatol. Jan 6. pii: S1542-3565(19)30008-4. doi: 10.1016/j.cgh.2018.12.035. [Epub ahead of print]

2018

• Diestelhorst J, Junge N, Jonigk D, Schlue J, Falk CS, Manns MP, Baumann U, Jaeckel E, Taubert R. Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis. Sci Rep. Jan 11;8(1):419. doi: 10.1038/s41598-017-18818-5.
  
  
• Dywicki J, Noyan F, Misslitz AC, Hapke M, Galla M, Schlue J, Liblau RS, Taubert R, Manns MP, Jaeckel E, Hardtke-Wolenski M. Hepatic T Cell Tolerance Induction in An Inflammatory Environment. Dig Dis. 36(2):156-166. doi: 10.1159/000481341. Epub 2017 Oct 12.
  
  
• Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.
  
  
• Lingvay I, Harris S, Jaeckel E, Chandarana K, Ranthe M.F, Jódar E. Insulin degludec/liraglutide (IDegLira) was effective across a range of dysglycaemia and body mass index categories in the DUAL V randomized trial. Diabetes Obes Metab. 2018; 20: 200– 205. https://doi.org/10.1111/dom.13043
  
  
• Solbach P, Höner Zu Siederdissen C, Wellhöner F, Richter N, Heidrich B, Lenzen H, Kerstin P, Hueper K, Manns MP, Wedemeyer H, Jaeckel E. Automated low-flow ascites pump in a real-world setting: complications and outcomes. Eur J Gastroenterol Hepatol. Sep;30(9):1082-1089. doi: 10.1097/MEG.0000000000001149.
  
  
• Taubert R, Diestelhorst J, Junge N, Kirstein MM, Pischke S, Vogel A, Bantel H, Baumann U, Manns MP, Wedemeyer H, Jaeckel E. Increased seroprevalence of HAV and parvovirus B19 in children and of HEV in adults at diagnosis of autoimmune hepatitis. Sci Rep. Nov 28;8(1):17452. doi: 10.1038/s41598-018-35882-7.

2017

• Diestelhorst J, Junge N, Schlue J, Falk CS, Manns MP, Baumann U, Jaeckel E, Taubert R. Pediatric autoimmune hepatitis shows a disproportionate decline of regulatory T cells in the liver and of IL-2 in the blood of patients undergoing therapy. PLoS One. Jul 11;12(7):e0181107. doi: 10.1371/journal.pone.0181107. eCollection 2017.
  
  
• Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget. May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.
  
  
• Hardtke-Wolenski M, Dywicki J, Fischer K, Hapke M, Sievers M, Schlue J, Anderson MS, Taubert R, Noyan F, Manns MP, Jaeckel E. The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development. J Autoimmun. Mar;78:39-45. doi: 10.1016/j.jaut.2016.12.001. Epub 2016 Dec 11.
  
  
• John K, Hardtke-Wolenski M, Jaeckel E, Manns MP, Schulze-Osthoff K, Bantel H. Increased apoptosis of regulatory T cells in patients with active autoimmune hepatitis. Cell Death Dis. Dec 14;8(12):3219. doi: 10.1038/s41419-017-0010-y. No abstract available.
  
  
• Nikolouli E, Hardtke-Wolenski M, Hapke M, Beckstette M, Geffers R, Floess S, Jaeckel E, Huehn J. Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance. Front Immunol. Jun 28;8:748. doi: 10.3389/fimmu.2017.00748. eCollection 2017.
  
  
• Norwood P, Chen R, Jaeckel E, Lingvay I, Jarlov H, Lehmann L, Heller S. Rates of hypoglycaemia are lower in patients treated with insulin degludec/liraglutide (IDegLira) than with IDeg or insulin glargine, regardless of the hypoglycaemia definition used. Diabetes Obes Metab.  Nov;19(11):1562-1569. doi: 10.1111/dom.12972. Epub 2017 Jul 10.
  
  
• Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, Hust M, Huehn J, Galla M, Morgan M, Jokuszies A, Manns MP, Jaeckel E. Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor. Am J Transplant. Apr;17(4):917-930. doi: 10.1111/ajt.14175. Epub 2017 Feb 6.

• Solbach P, Höner Zu Siederdissen C, Taubert R, Ziegert S, Port K, Schneider A, Hueper K, Manns MP, Wedemeyer H, Jaeckel E. Home-based drainage of refractory ascites by a permanent-tunneled peritoneal catheter can safely replace large-volume paracentesis. Eur J Gastroenterol Hepatol. May;29(5):539-546. doi: 10.1097/MEG.0000000000000837.
  
  
• Taubert R, Hardtke-Wolenski M, Noyan F, Lalanne C, Jonigk D, Schlue J, Krech T, Lichtinghagen R, Falk CS, Schlaphoff V, Bantel H, Muratori L, Manns MP, Jaeckel E. Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis. PLoS One. Jun 8;12(6):e0179074. doi: 10.1371/journal.pone.0179074. eCollection 2017.

2016

• Baumann AK, Schlue J, Noyan F, Hardtke-Wolenski M, Lehner F, Barg-Hock H, Klempnauer J, Manns MP, Taubert R, Jaeckel E. Preferential accumulation of T helper cells but not cytotoxic T cells characterizes benign subclinical rejection of human liver allografts. Liver Transpl.  Jul;22(7):943-55. doi: 10.1002/lt.24427.
  
  

• Taubert R, Danger R, Londoño MC, Christakoudi S, Martinez-Picola M, Rimola A, Manns MP, Sánchez-Fueyo A, Jaeckel E. Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated. Am J Transplant. Apr;16(4):1285-93. doi: 10.1111/ajt.13617. Epub 2016 Feb 18.

• Vondran FW, Schumacher C, Johanning K, Hartleben B, Knitsch W, Wiesner O, Jaeckel E, Manns MP, Klempnauer J, Bektas H, Lehner F. Application of the Liver Maximum Function Capacity Test in Acute Liver Failure: A Helpful Tool for Decision-Making in Liver Transplantation? Case Rep Transplant. 2016:7074636. doi: 10.1155/2016/7074636. Epub 2016 May 4.

2015

• Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, et al. Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens. Hepatology.

• Rahmig S, Bornstein SR, Chavakis T, Jaeckel E, and Waskow C. Humanized mouse models for type 1 diabetes including pancreatic islet transplantation. Hormone and metabolic research 47, 43-47.

• Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res; 47(1):31-5.

2014

• Bohne, F., Londoûo, M.C., Benitez C., Miquel, R., Martænez-Llordella, M., Russo, C., Ortiz, C., Bonaccorsi-Riani, E., Brander, C., Bauer, T., Protzer, U., Jaeckel, E., Taubert, R., Forns, X., Navasa, M., Berenguer, M., Rimola, A., Lozano, J.J., Sanchez-Fueyo, A. Role of HCV-induced immune responses on the establishment of operational tolerance following liver transplantation in humans. Sci Transl Med 2014; 6:242.
  
  
• Noyan, F., Lee, Y.S., Hardtke-Wolenski, M., Taubert, R., Warnecke, G., Knoefel, A.K., Schulde, E., Olek, S., Manns, M.P., Jaeckel, E. Isolation of human antigen-specific regulatory T cells with high suppressive function. Eur J Immunol 44.2592.
  
  
• Taubert, R., Hardtke-Wolenski, M., Noyan, F., Wilms, A., Baumann, A.K., Schlue, J., Olek, S., Falk, C.S., Manns, M.P., Jaeckel, E. Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies. J Hepatol 61: 1106.

2013

• Hardtke-WolenskiM., Kraus, I., Schmetz, C., Trautewig, B., Noyan, F., Vondran, F.W., Bektas, H., Klempnauer, J., Lieke, T., Jaeckel, E. (equal senior authors). Exchange of cytosolic content between T Cells and tumor cells activates CD4 T Cells and impedes cancer growth. PLoS One 8 (10):e78558.
  
  
• Hardtke-Wolenski, M., Fischer, K., Noyan, F., Schlue, J., Falk, C.S., Stahlhut, M., Woller, N., Kuehnel, F., Taubert, R., Manns, M.P., Jaeckel, E. Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells. Hepatology 58(2):718-28.

2012

• Taubert, R., Pischke, S., Schlue, J., Wedemeyer, H., Noyan, F., Heim, A., Lehner, F., Barg-Hock, H., Klempnauer, J., Olek, S., Manns, M.P., Hardtke-Wolenski, M., Jaeckel, E. Enrichment of regulatory T cells in acutely rejected human liver allografts. Am J Transplant 12(12): 3425-36.
  
  
• Bohne, F., Martínez-Llordella, M., Lozano, J.J., Miquel, R., Benítez, C., Londoño, M.C., Manzia, T.M., Angelico, R., Swinkels, D.W., Tjalsma, H., López, M., Abraldes, J.G., Bonaccorsi-Riani, E., Jaeckel, E., Taubert, R., Pirenne, J., Rimola, A., Tisone, G., Sánchez-Fueyo, A. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest 123: 368-382.

2004

• Jaeckel, E., Lipes, M.A., von Boehmer, H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol 5:1028-35.

2003

• Jaeckel, E., Klein, L., Martin-Orozco, N., von Boehmer, H. Normal incidence of diabetes in nod mice tolerant to glutamic acid decarboxylase. J Exp Med 197: 1635-1644.

2001

• Jaeckel, E., Cornberg, M., Wedemeyer, H., Santantonio, T., Mayer, J., Zankel, M., Pastore, G., Dietrich, M., Trautwein, C., Manns, M.P. Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med 345:1452-7