Klinische Massenspektrometrie / Clinical Mass Spectrometry

Habler K, Vogeser M, Teupser D. An UHPLC-MS/MS method for quantification of the CDK4/6 inhibitor abemaciclib in human serum. J Mass Spectrom Adv Clin Lab. 2022 Feb 7;24:15-21.

Vogeser M, Brüggemann M, Lennerz J, Stenzinger A, Gassner UM. Laboratory-Developed Tests in the New European Union 2017/746 Regulation: Opportunities and Risks. Clin Chem. 2021 Dec 30;68(1):40-42.

Mörlein S, Schuster C, Paal M, Vogeser M. Collision energy-breakdown curves - An additional tool to characterize MS/MS methods. Clin Mass Spectrom. 2020 Oct 20;18:48-53.

Habler K, Koeppl B, Bracher F, Vogeser M. Targeted profiling of 24 sulfated and non-sulfated bile acids in urine using two-dimensional isotope dilution UHPLC-MS/MS. Clin Chem Lab Med. 2021 Nov 22;60(2):220-228.

Habler K, Kalla AS, Rychlik M, Bruegel M, Teupser D, Nährig S, Vogeser M, Paal M. Isotope dilution LC-MS/MS quantification of the cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor, lumacaftor, tezacaftor, elexacaftor, and their major metabolites in human serum. Clin Chem Lab Med. 2021 Oct 20;60(1):82-91.

Paal M, Scharf C, Denninger AK, Ilia L, Kloft C, Kneidinger N, Liebchen U, Michel S, Schneider C, Schröpf S, Schuster C, Vogeser M, Weinelt F, Zander J, Zoller M, Schroeder I. Target Site Pharmacokinetics of Meropenem: Measurement in Human Explanted Lung Tissue by Bronchoalveolar Lavage, Microdialysis, and Homogenized Lung Tissue. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0156421.

Rakete S, Schuster C, Paal M, Vogeser M. An isotope-dilution LC-MS/MS method for the simultaneous quantification of meropenem and its open-ring metabolite in serum. J Pharm Biomed Anal. 2021 Apr 15;197:113944.

Vogeser M, Stone JA.

A suggested standard for validation of LC-MS/MS based analytical series in diagnostic laboratories. Clinical Mass Spectrometry 2020;16:25–32.

Schuster C, Habler K, Vogeser M.

Averaging of results derived from different, simultaneously acquired mass transitions in ID-LC-MS/MS – potential impact on measurement imprecision. Clinical Mass Spectrometry, 2020;17:1-3.

Scharf C, Liebchen U, Paal M, Taubert M, Vogeser M, Irlbeck M, Zoller M, Schroeder I.

The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome.

J Intensive Care. 2020 Nov 23;8(1):86. doi: 10.1186/s40560-020-00504-w.

Paal M, Habler K, Vogeser M.

Mass spectrometric sample identification with indicator compounds introduced via labeled sample tubes.

Clin Chem Lab Med. 2020 Jul 27:/j/cclm.ahead-of-print/cclm-2020-0667/cclm-2020-0667.xml. doi: 10.1515/cclm-2020-0667.

Vogeser M.

From therapeutic drug monitoring to total drug monitoring and drug-omics.

Clin Chem Lab Med. 2020 May 5:/j/cclm.ahead-of-print/cclm-2020-0339/cclm-2020-0339.xml. doi: 10.1515/cclm-2020-0339.

Paal M, Habler K, Northoff B, Vogeser M.

Comparative Routine Therapeutic Drug Monitoring of Mycophenolic Acid in human Plasma with HPLC-UV and Isotope Dilution LC-MS/MS.

Clin Lab. 2020 Apr 1;66(4). doi: 10.7754/Clin.Lab.2019.190820.

Scharf C, Paal M, Schroeder I, Vogeser M, Draenert R, Irlbeck M, Zoller M, Liebchen U.

Therapeutic Drug Monitoring of Meropenem and Piperacillin in Critical Illness-Experience and Recommendations from One Year in Routine Clinical Practice.

Antibiotics (Basel). 2020 Mar 21;9(3):131. doi: 10.3390/antibiotics9030131.

Habler K, Paal M, Vogeser M.

Isotope dilution-LC-MS/MS method for quantification of the urinary cotinine-to-creatinine ratio.

Clin Chem Lab Med. 2020 Mar 25;58(9):1469-1476. doi: 10.1515/cclm-2020-0177. Print 2020 Aug 27.

Taibon J, van Rooij M, Schmid R, Singh N, Albrecht E, Anne Wright J, Geletneky C, Schuster C, Mörlein S, Vogeser M, Seger C, Pongratz S, Kobold U.

An isotope dilution LC-MS/MS based candidate reference method for the quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human whole blood.

Clin Biochem. 2020 Aug;82:73-84. doi: 10.1016/j.clinbiochem.2019.11.006.

Klenk C, Brunner H, Nickel T, Sagmeister F, Yilmaz A, Infanger D, Billich C, Scharhag J, Vogeser M, Beer M, Schütz U, Schmidt-Trucksäss A.

Cardiac structure and function in response to a multi-stage marathon over 4486 km.

Eur J Prev Cardiol. 2019 Oct 26:2047487319885035. doi: 10.1177/2047487319885035.

Paal M, Heilmann M, Koch S, Bertsch T, Steinmann J, Höhl R, Liebchen U, Schuster C, Kleine FM, Vogeser M.

Comparative LC-MS/MS and HPLC-UV Analyses of Meropenem and Piperacillin in Critically Ill Patients.

Clin Lab. 2019 Sep 1;65(9). doi: 10.7754/Clin.Lab.2019.190210.

Lang R, Rolny V, Leinenbach A, Karl J, Swiatek-de Lange M, Kobold U, Schrader M, Krause H, Mueller M, Vogeser M.

Investigation on core-fucosylated prostate-specific antigen as a refined biomarker for differentiation of benign prostate hyperplasia and prostate cancer of different aggressiveness.

Tumour Biol. 2019 Mar;41(3):1010428319827223. doi: 10.1177/1010428319827223.

Schuster C, Paal M, Lindner J, Zoller M, Liebchen U, Scharf C, Vogeser M.

Isotope dilution LC-orbitrap-HRMS with automated sample preparation for the simultaneous quantification of 11 antimycotics in human serum.

J Pharm Biomed Anal. 2019 Mar 20;166:398-405. doi: 10.1016/j.jpba.2019.01.038.

Homann C, Hennig G, Maier F, Stepp H, Holdt LM, Vogeser M, Sroka R, Koletzko B.

Non-invasive measurement of erythrocyte zinc protoporphyrin in children.

Pediatr Res. 2019 Feb;85(3):349-354. doi: 10.1038/s41390-018-0247-x.

Li X, Zoller M, Fuhr U, Huseyn-Zada M, Maier B, Vogeser M, Zander J, Taubert M.

Ciprofloxacin in critically ill subjects: considering hepatic function, age and sex to choose the optimal dose.

J Antimicrob Chemother. 2019 Mar 1;74(3):682-690. doi: 10.1093/jac/dky485.

Vogeser M, Schuster C, Rockwood AL.

A proposal to standardize the description of LC–MS-based measurement methods in laboratory medicine.

Clinical Mass Spectrometry 2019; 13:36-38.

Zander J, Paal M, Vogeser M.

The role of mass spectrometry in antibiotic stewardship.

Clinical Mass Spectrometry 2019;14:31-33.

Vogeser M, Zhang, YV.

Understanding the strategic landscape surrounding the implementation of mass spectrometry in the clinical laboratory: A SWOT analysis.

Clin Mass Spec 2018 (9):1-6

Lindner JM, Vogeser M, Sorg K, Grimm SH.

A semi-automated, isotope-dilution high-resolution mass spectrometry assay for therapeutic drug monitoring of antidepressants.

Clinical Mass Spectrometry 2019;14:89-98

Homann C, Hennig G, Maier F, Stepp H, Holdt LM, Vogeser M, Sroka R, Koletzko B.

Non-invasive measurement of erythrocyte zinc protoporphyrin in children.

Pediatr Res. 2019 Feb;85(3):349-354. doi: 10.1038/s41390-018-0247-x. Epub 2018 Dec 9.

Paal M, Lindner JM, Schmoeckel P, Suhr AC, Schafferer S, Koal T, Briegel J, Vogeser M.

Assessment of Plasma Amino Acid Dynamics in Response to ACTH Stimulation by Liquid Chromatography Tandem-Mass Spectrometry.

Clin Lab. 2018 Oct 1;64(10):1695-1700. doi: 10.7754/Clin.Lab.2018.180513.

Siegrist M, Hanssen H, Lammel C, Haller B, Koch AM, Stemp P, Dandl E, Liestak R, Parhofer KG, Vogeser M, Halle M.

Effects of a cluster-randomized school-based prevention program on physical activity and microvascular function (JuvenTUM 3).

Atherosclerosis. 2018 Nov;278:73-81. doi: 10.1016/j.atherosclerosis.2018.09.003.

Schuster C, Sterz S, Teupser D, Brügel M, Vogeser M, Paal M.

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses.

J Vis Exp. 2018 Aug 30;(138):58148. doi: 10.3791/58148.

Lang A, Heckl C, Vogeser M, Stauch T, Homann C, Hennig G, Sroka R, Stepp H.

Rapid spectrophotometric quantification of urinary porphyrins and porphobilinogen as screening tool for attacks of acute porphyria.

J Biomed Opt. 2018 May;23(5):1-12. doi: 10.1117/1.JBO.23.5.055006.

Paal M, Lang A, Hennig G, Buchholtz ML, Sroka R, Vogeser M.

A second-derivate fitting algorithm for the quantification of free hemoglobin in human plasma.

Clin Biochem. 2018 Jun;56:62-69. doi: 10.1016/j.clinbiochem.2018.04.007. Epub 2018 Apr 12.

Paal M, Zoller M, Schuster C, Vogeser M, Schütze G.

Simultaneous quantification of cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid and piperacillin in human serum using an isotope-dilution HPLC-MS/MS method.

J Pharm Biomed Anal. 2018 Apr 15;152:102-110. doi: 10.1016/j.jpba.2018.01.031.

Lang R, Leinenbach A, Karl J, Swiatek-de Lange M, Kobold U, Vogeser M.

An endoglycosidase-assisted LC-MS/MS-based strategy for the analysis of site-specific core-fucosylation of low-concentrated glycoproteins in human serum using prostate-specific antigen (PSA) as example.

Clin Chim Acta. 2018 May;480:1-8. doi: 10.1016/j.cca.2018.01.040. Epub 2018 Feb 20.

Lindner JM, Suhr AC, Grimm SH, Möhnle P, Vogeser M, Briegel J.

The dynamics of a serum steroid profile after stimulation with intravenous ACTH.

J Pharm Biomed Anal. 2018 Mar 20;151:159-163. doi: 10.1016/j.jpba.2017.12.045.

Verstraete AG, Rigo-Bonnin R, Wallemacq P, Vogeser M, Schuetzenmeister A, Schmiedel C, Shipkova M.

Multicenter Evaluation of a New Electrochemiluminescence Immunoassay for Everolimus Concentrations in Whole Blood.

Ther Drug Monit. 2018 Feb;40(1):59-68. doi: 10.1097/FTD.0000000000000474.

Stove V, Ramos PA, Wallemacq P, Vogeser M, Schuetzenmeister A, Schmiedel C, Shipkova M.

Measurement of sirolimus concentrations in human blood using an automated electrochemiluminescence immunoassay (ECLIA): a multicenter evaluation.

Clin Chem Lab Med. 2018 Apr 25;56(5):764-775. doi: 10.1515/cclm-2017-0583.

Stelzer D, Weber A, Ihle F, Matthes S, Ceelen F, Zimmermann G, Kneidinger N, Schramm R, Winter H, Zoller M, Vogeser M, Behr J, Neurohr C.

Posaconazole liquid vs tablet formulation in lung transplant recipients.

Mycoses. 2018 Mar;61(3):186-194. doi: 10.1111/myc.12724.

Vogeser M, Seger C.

Irregular analytical errors in diagnostic testing - a novel concept.

Clin Chem Lab Med. 2018 Feb 23;56(3):386-396. doi: 10.1515/cclm-2017-0454.

Vogeser M, Bidlingmaier M, Wallaschowski H, Lindner J, Kratzsch J; Division Endocrinological Diagnostics of the German Association of Clinical Chemistry and Laboratory Medicine (DGKL).

Quantification of 1,25-dihydroxyvitamin D - value of manufacturers' product information.

Clin Chem Lab Med. 2018 Jan 26;56(2):e46-e49. doi: 10.1515/cclm-2017-0385.

Lindner JM, Suhr AC, Grimm SH, Möhnle P, Vogeser M, Briegel J.

The dynamics of a serum steroid profile after stimulation with intravenous ACTH.

J Pharm Biomed Anal. 2018 Mar 20;151:159-163. doi: 10.1016/j.jpba.2017.12.045. Epub 2017 Dec 26.

Stelzer D, Weber A, Ihle F, Matthes S, Ceelen F, Zimmermann G, Kneidinger N, Schramm R, Winter H, Zoller M, Vogeser M, Behr J, Neurohr C.

Posaconazole liquid vs tablet formulation in lung transplant recipients.

Mycoses. 2018 Mar;61(3):186-194. doi: 10.1111/myc.12724.

Ehmann L, Zoller M, Minichmayr IK, Scharf C, Maier B, Schmitt MV, Hartung N, Huisinga W, Vogeser M, Frey L, Zander J, Kloft C.

Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study.

Crit Care. 2017 Oct 21;21(1):263. doi: 10.1186/s13054-017-1829-4.

Taubert M, Zander J, Frechen S, Scharf C, Frey L, Vogeser M, Fuhr U, Zoller M.

Optimization of linezolid therapy in the critically ill: the effect of adjusted infusion regimens.

J Antimicrob Chemother. 2017 Aug 1;72(8):2304-2310. doi: 10.1093/jac/dkx149.

Lindner JM, Vogeser M, Grimm SH.

Biphenyl based stationary phases for improved selectivity in complex steroid assays.

J Pharm Biomed Anal. 2017 Aug 5;142:66-73. doi: 10.1016/j.jpba.2017.04.020.

Briegel J, Möhnle P, Vogeser M, Thiemermann C, Radermacher P.

Relative Adrenal Insufficiency in Cardiogenic Shock: Is There a Need for Action?

Shock. 2017 Oct;48(4):498-499. doi: 10.1097/SHK.0000000000000870.

Stelzer D, Weber A, Ihle F, Matthes S, Ceelen F, Zimmermann G, Kneidinger N, Schramm R, Winter H, Zoller M, Vogeser M, Behr J, Neurohr C.

Comparing Azole Plasma Trough Levels in Lung Transplant Recipients: Percentage of Therapeutic Levels and Intrapatient Variability.

Ther Drug Monit. 2017 Apr;39(2):93-101. doi: 10.1097/FTD.0000000000000371.

Clauss S, Scherr J, Hanley A, Schneider J, Klier I, Lackermair K, Hoster E, Vogeser M, Nieman DC, Halle M, Nickel T.

Impact of polyphenols on physiological stress and cardiac burden in marathon runners - results from a substudy of the BeMaGIC study.

Appl Physiol Nutr Metab. 2017 May;42(5):523-528. doi: 10.1139/apnm-2016-0457.

Vogeser M, Kratzsch J, Ju Bae Y, Bruegel M, Ceglarek U, Fiers T, Gaudl A, Kurka H, Milczynski C, Prat Knoll C, Suhr AC, Teupser D, Zahn I, Ostlund RE.

Multicenter performance evaluation of a second generation cortisol assay.

Clin Chem Lab Med. 2017 May 1;55(6):826-835. doi: 10.1515/cclm-2016-0400.

Lucha S, Taibon J, Pongratz S, Geletneky C, Huber E, Wintterle-Roehm C, Lang R, Grimm SH, Duelffer T, Tarasov K, Zander J, Vogeser M, Kobold U.

An LC-MS/MS based candidate reference method for the quantification of total gentamicin in human serum and plasma using NMR characterized calibrator material.

Clin Chim Acta. 2017 Jan;464:211-217. doi: 10.1016/j.cca.2016.11.029. Epub 2016 Nov 19.

Vogeser M, Kratzsch J, Ju Bae Y, Bruegel M, Ceglarek U, Fiers T, Gaudl A, Kurka H, Milczynski C, Prat Knoll C, Suhr AC, Teupser D, Zahn I, Ostlund RE

Multicenter performance evaluation of a second generation cortisol assay.

Clin Chem Lab Med. 2017 May 1;55(6):826-835. doi: 10.1515/cclm-2016-0400.

Lucha S, Taibon J, Pongratz S, Geletneky C, Huber E, Wintterle-Roehm C, Lang R, Grimm SH, Duelffer T, Tarasov K, Zander J, Vogeser M, Kobold U.

An LC-MS/MS based candidate reference method for the quantification of total gentamicin in human serum and plasma using NMR characterized calibrator material.

Clin Chim Acta. 2017 Jan;464:211-217. doi: 10.1016/j.cca.2016.11.029