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A user-friendly online tool was developed by Dr. Tracy Williams, Prof. Dr. Martin Reincke and Italian researchers to guide the clinical management of patients with Primary Aldosteronism. The PASO [Primary Aldosteronism Surgical Outcome] predictor was developed to individually advise patients on their likely improvement in hypertension status after adrenalectomy and to facilitate the decision for an operation.

The results were published in peer reviewed journals (Burrello et al. 2019) and non-peer reviewed magazines(https://www.n-tv.de/21028667, http://www.gesundheitsstadt-berlin.de/bluthochdruck-manchmal-heilbar-durch-operation-13320/).

Online tool PASO

Latest Publications

Yang Y, Reincke M, Williams TA 2019: Treatment of Unilateral PA by Adrenalectomy: Potential Reasons for Incomplete Biochemical Cure. Exp Clin Endocrinol Diabetes. 127, 100-108

Perez-Rivas LG, Williams TA, Reincke M 2019: Inherited Forms of Primary Hyperaldosteronism: New Genes, New Phenotypes and Proposition of A New Classification. Exp Clin Endocrinol Diabetes. 12, 93-99

Reincke M, Beuschlein F, Bornstein F, Eisenhofer G, Fassnacht M, Reisch N, Williams TA 2019: The Adrenal Gland: Central Relay in Health and Disease. Exp Clin Endocrinol Diabetes. 127, 81-83

Burrello J, Burrello A, Stowasser M, Nishikawa T, Quinkler M, Prejbisz A, Lenders JWM, Satoh F, Mulatero P, Reincke M, Williams TA 2019: The Primary Aldosteronism Surgical Outcome Score for the Prediction of Clinical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism. Ann Surg. Jan 2019  [Epub ahead of print]

Yang Y, Burrello J, Burrello A, Eisenhofer G, Peitzsch M, Tetti M, Knösel T, Beuschlein F, Lenders JWM, Mulatero P, Reincke M, Williams TA 2019: Classification of microadenomas in patients with primary aldosteronism by steroid profiling. Steroid Biochem Mol Biol. 189, 274-282

Williams TA, Burrello J, Sechi LA, Fardella CE, Matrozova J, Adolf C, Baudrand R, Bernardi S, Beuschlein F, Catena C, Doumas M, Fallo F, Giacchetti G, Heinrich DA, Saint-Hilary G, Jansen PM, Januszewicz A, Kocjan T, Nishikawa T, Quinkler M, Satoh F, Umakoshi H, Widimský J, Hahner S, Douma S, Stowasser M, Mulatero P, Reincke M 2018: Computed Tomography and Adrenal Venous Sampling in the Diagnosis of Unilateral Primary Aldosteronism. Hypertension. 72, 641–649

Meyer LS, Wang X, Sušnik E, Burrello J, Burrello A, Castellano I, Eisenhofer G, Fallo F, Kline GA, Knösel T, Kocjan T, Lenders JWM, Mulatero P, Naruse M, Nishikawa T, Peitzsch M, Rump LC, Beuschlein F, Hahner S, Gomez-Sanchez CE, Reincke M, Williams TA 2018: Immunohistopathology and Steroid Profiles Associated With Biochemical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism. Hypertension. 72, 650–657

Williams TA, Reincke M 2018: MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and Management of Primary Aldosteronism: the Endocrine Society guideline 2016 revisited. Eur J Endocrinol. 179, R19-R29

Reincke M 2018: Anxiety, Depression, and Impaired Quality of Life in Primary Aldosteronism: Why We Shouldn't Ignore It! J Clin Endocrinol Metab. 103, 1-4

Reincke M 2018: Primary Aldosteronism and Cardiovascular Events: It Is Time to Take Guideline Recommendations Seriously. Hypertension. 71, 413-414

Heinze B, Fuss CT, Mulatero P, Beuschlein F, Reincke M, Mustafa M, Schirbel A, Deutschbein T, Williams TA, Rhayem Y, Quinkler M, Rayes N, Monticone S, Wild V, Gomez-Sanchez CE, Reis A-C, Petersenn S, Wester H-J, Kropf S, Fassnacht M, Lang K, Herrmann K, Buck AK, Bluemel C, Hahner S 2018: Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma. Hypertension. 71, 317-325

Aristizabal Prada ET, Castellano I, Sušnik E, Yang Y, Meyer LS, Tetti M, Beuschlein F, Reincke M, Williams TA 2018: Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism. Int. J. Mol. Sci. 19, 1124

Lenders J, Williams TA, Reincke M, Gomez-Sanchez CE, 2018: DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18-Hydroxycortisol. Is there clinical utility of these steroids? Eur J Endocrinol., 178, R1-R9

Reincke M, Williams, TA, Beuschlein F, 2017: Diagnosis and Treatment of Primary Aldosteronism in 2017: Did We Achieve Our Goals? Horm Metab Res. 49, 905-907

Lenders J, Eisenhofer G, Reincke M, 2017: Subtyping of Patients with Primary Aldosteronism: An Update. Horm Metab Res. 49, 922-928

Gomez-Sanchez CE, Kuppusamy M, Reincke M, Williams TA, 2017: Disordered CYP11B2 Expression in Primary Aldosteronism. Horm Metab Res. 49, 957-962

Aristizabal Prada ET, Burrello J, Reincke M, Williams TA, 2017: Old and New Concepts in the Molecular Pathogenesis of Primary Aldosteronism. Hypertension. 70, 875-881

Aragao-Santiago L, Gomez-Sanchez CE, Mulatero P, Spyroglou A, Reincke M, Williams TA, 2017: Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology. Endocrinology. 158, 4129-4138

Williams TA, Lenders J, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L, Quinkler M, Deinum J, Beuschlein F, Kitamoto KK, Pham U, Morimoto R, Umakoshi H, Prejbisz A, Kocjan T, Naruse M, Stowasser M, Nishikawa T, Young WF, Gomez-Sanchez CE, Funder JW, Reincke M, Primary Aldosteronism Surgery Outcome (PASO) investigators, 2017: Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol. 5, 689-699

Arlt W, Lang K, Sitch AJ, Dietz AS, Rhayem Y, Bancos I, Feuchtinger A, Chortis V, Gilligan LC, Ludwig P, Riester A, Asbach E, Hughes BA, O'Neil DM, Bidlingmaier M, Tomlinson JW, Hassan-Smith ZK, Rees DA, Adolf C, Hahner S, Quinkler M, Dekkers T, Deinum J, Biehl M, Keevil BG, Shackleton CHL, Deeks JJ, Walch AK, Beuschlein F, Reincke M, 2017: Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. JCI Insight. 2, e93136