Publications (selected)

2023

• Fischer N, Gulich B, Keßler B, Längin M, Fishman JA, Wolf E, Boller K, Tönjes RR, Godehardt AW. PCR and peptide based PCMV detection in pig - development and application of a combined testing procedure differentiating newly from latent infected pigs. Xenotransplantation. 30:e12803. doi: 10.1111/xen.12803. Online ahead of print.
  
  
• Flecks M, Fischer N, Krijnse Locker J, Tönjes RR, Godehardt AW. Analysis of PERV-C superinfection resistance using HA-tagged viruses. Retrovirology Aug 21;20(1):14. doi: 10.1186/s12977-023-00630-x Online ahead of print.
  
  
• Rodrigues Costa M, Fischer N, Gronewold A, Gulich B, Godehardt AW, Tönjes RR. Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLA^D/D Inbred Miniature Swine. Journal of Virology: DOI: 10.11.28/jvi.00062-23

2020

• Reichart B, Längin M, Radan J, Mokelke M, Buttgereit I, Ying J, Fresch AK, Mayr T, Issl L, Buchholz S, Michel S, Ellgass R, Mihalj M, Egerer S, Baehr A, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Steen S, Sjöberg T, Paskevicius A, Krüger L, Fiebig U, Denner J, Godehardt AW, Tönjes RR, Milusev A, Rieben R, Sfriso R, Walz C, Kirchner T, Ayares D, Lampe K, Schönmann U, Hagl C, Wolf E, Klymiuk N, Abicht JM, Brenner P. Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation? J Heart Lung Transplant. Aug;39(8):751-757.

2019

• Godehardt AW, Ramm R, Gulich B, Tönjes RR, Hilfiker A. Decellularized pig pulmonary heart valves-Depletion of nucleic acids measured by proviral PERV pol. Xenotransplantation. Nov 6:e12565. doi: 10.1111/xen.12565. [Epub ahead of print]
  
  
• Godehardt AW, Fischer N, Rauch P, Gulich B, Boller K, Church GM, Tönjes RR. Characterization of porcine endogenous retrovirus particles released by the CRISPR/Cas9 inactivated cell line PK15 clone 15. Xenotransplantation. Oct 31:e12563. doi: 10.1111/xen.12563. [Epub ahead of print]
  
  
• Kola I, Egerer S, Bähr A, Godehardt AW, Tönjes RR, Ayares D, Wolf E, Klymiuk N. Removal of PERV- C proviruses from xenotransplanation donor pigs by marker-assisted breeding or gene editing. Xenotransplantation 2019;xen12553 [Abstract]

2018

• Denner J, Godehardt AW, Tönjes RR. Infektionsrisiken und mikrobiologische Sicherheit. In: Jochen Sautermeister (Hrsg.), Tierische Organe in menschlichen Körpern. Biomedizinische, kulturwissenschaftliche, theologische und ethische Zugänge zur Xenotransplantation. Paderborn: mentis, 2018. S 45-63, ISBN 978-3-95743-011-3. Tönjes RR. Non-viral pathogens: Identification, relevance and prevention for xenotransplantation. Xenotransplantation. 25:e12413
  
  
• Godehardt AW, Petkov S, Gulich B, Fischer N, Niemann H, Tönjes RR. Comparative gene expression profiling of pig-derived iPSC-like cells: Effects of induced pluripotency on expression of porcine endogenous retroviruses (PERV). Xenotransplantation. 25 Mai. 25:e12429.

2015

• Godehardt AW, Schilling-Leiß D, Sanzenbacher R, Tönjes RR. Xenogeneic cell therapeutics. Treatment of type 1 diabetes using porciner pancreatic inslets and inslet cells. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58: 1281-1288.
  
  
• Godehardt AW, Rodrigues Costa M, Tönjes RR: Review on porcine endogenous retrovirus detection assays-impact on quality and safety of xenotransplants. Xenotransplantation 22: 95-10

2014

• Godehardt AW, Rodrigues Costa M, Tönjes RR. Update on PERV detection assays – impact on quality and safety of xenotransplants. Xenotransplantation [accepted]
  
  
• Godehardt AW, Tönjes RR. Gene expression profiling of porcine cells and tissues by microarray analysis. Xenotransplantation 21, 187.

 2013

• Godehardt AW, Tönjes RR. Update on assays for detection of PERVs. Xenotransplantation 20, 363.

 2008

• Schilling-Leiß D, Godehardt AW, Scherer J, Cichutek K, Tönjes RR. Genehmigungsverfahren für klassische Gewebezubereitungen gemäß § 21a Arzneimittelgesetz (AMG). Transfus Med Hemother 35, 453-462.

 2007

• Dinkla K, Sastalla I, Godehardt AW, Janze N, Chhatwal G, Rohde M, Medina E. Upregulation of capsule enables Streptococcus pyogenes to evade immune recognition by antigen-specific antibodies directed to the G-related alpha2-macroglobulin-binding protein GRAB located on the bacterial surface. Microbes Infect 9, 922-31.

 2005

• Schulze K, Goldmann O, Toppel A, Medina E, Guzmán CA. The FAI protein of group C streptococci targets B-cells and exhibits adjuvant activity. Vaccine 23:1408-13.

 2004

• Toppel AW, Hammerschmidt S, Frank R, Chhatwal GS. Binding of alpha2-macroglobulin to GRAB (Protein G-related alpha2-macroglobulin-binding protein), an important virulence factor of group A streptococci, is mediated via two charged motifs in the DeltaA region. Biochem J 381, 877-85.

 2003

• Toppel AW, Rasmussen M, Rohde M, Medina E, Chhatwal GS. Contribution of protein G-related alpha2-macroglobulin-binding protein to bacterial virulence in a mouse skin model of group A streptococcal infection. J Infect Dis 187, 1694-703.
  
  
• Medina E, Goldmann O, Toppel AW, Chhatwal GS. Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion. J Infect Dis 187, 597-603.