Publications (selected)

2023

• Jhelum H, Bender M, Reichart B, Mokelke M, Radan J, Neumann E, Krabben L, Abicht J, Kaufer B, Längin M, Denner J. Evidence for Microchimerism in Baboon Recipients of Pig Hearts. Viruses Jul 24;15(7):1618. doi: 10.3390/v15071618

2020

• Denner J, Längin M, Reichart B, Krüger L, Fiebig U, Mokelke M, Radan J, Mayr T, Milusev A, Luther F, Sorvillo N, Rieben R, Brenner P, Walz C, Wolf E, Roshani B, Stahl‑Hennig C, Abicht JM. Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival. Sci Rep Oct 16;10(1):17531. doi: 10.1038/s41598-020-73150-9.

• Reichart B, Längin M, Radan J, Mokelke M, Buttgereit I, Ying J, Fresch AK, Mayr T, Issl L, Buchholz S, Michel S, Ellgass R, Mihalj M, Egerer S, Baehr A, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Steen S, Sjöberg T, Paskevicius A, Krüger L, Fiebig U, Denner J, Godehardt AW, Tönjes RR, Milusev A, Rieben R, Sfriso R, Walz C, Kirchner T, Ayares D, Lampe K, Schönmann U, Hagl C, Wolf E, Klymiuk N, Abicht JM, Brenner P. Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation? J Heart Lung Transplant. Aug;39(8):751-757.

2019

• Krüger L, Längin M, Reichart B, Fiebig U, Kristiansen Y, Prinz C, Kessler B, Egerer S, Wolf E, Abicht JM, Denner J. Transmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboons. Viruses. Jul 16;11(7). pii: E650. doi: 10.3390/v11070650.

2018

• Abicht JM, Sfriso R, Reichart B, Längin M, Gahle K, Puga Yung GL, Seebach JD, Rieben R, Ayares D, Wolf E, Klymiuk N, Baehr A, Kind A, Mayr T, Bauer A. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. Xenotransplantation. Sep;25(5):e12390. doi: 10.1111/xen.12390. Epub 2018 Mar 14.
  
  
• Abicht JM, Mayr TAJ, Jauch J, Guethoff S, Buchholz S, Reichart B, Bauer A. Large-Animal Biventricular Working Heart Perfusion System with Low Priming Volume-Comparison between in vivo and ex vivo Cardiac Function. Thorac Cardiovasc Surg. Jan;66(1):71-82. doi: 10.1055/s-0036-1580604. Epub 2016 Apr 4.
  
  
• Fiebig U, Abicht JM, Mayr T, Längin M, Bähr A, Guethoff S, Falkenau A, Wolf E, Reichart B, Shibahara T, Denner J; Distribution of Porcine Cytomegalovirus in Infected Donor Pigs and in Baboon Recipients of Pig Heart Transplantation. Viruses, 10(2) Feb 6, E66; doi:10.3390/v10020066
  
  
• Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, Dashkevich A, Baehr A, Egerer S, Bauer A, Mihalj M, Panelli A, Issl L, Ying J, Fresch AK, Buttgereit I, Mokelke M, Radan J, Werner F, Lutzmann I, Steen S, Sjöberg T, Paskevicius A, Qiuming L, Sfriso R, Rieben R, Dahlhoff M, Kessler B, Kemter E, Klett K, Hinkel R, Kupatt C, Falkenau A, Reu S, Ellgass R, Herzog R, Binder U, Wich G, Skerra A, Ayares D, Kind A, Schönmann U, Kaup FJ, Hagl C, Wolf E, Klymiuk N, Brenner P, Abicht J. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 5. Dez.;564, pages430–433
  
  
• Längin M, Panelli A, Reichart B, Kind A, Brenner P, Mayr T, Abicht JM. Perioperative Telemetric Monitoring in Pig-to-Baboon Heterotopic Thoracic Cardiac Xenotransplantation. Ann Transplant. Jul 20;23:491-499. doi: 10.12659/AOT.909522.
  
  
• Li M, Eckl J, Abicht JM, Mayr T, Reichart B, Schendel DJ, Pohla H. Induction of porcine-specific regulatory T cells with high specificity and expression of IL-10 and TGF-β1 using baboon-derived tolerogenic dendritic cells. Xenotransplantation. Jan;25(1). doi: 10.1111/xen.12355. Epub 2017 Oct 22.

2017

• Abicht JM, Kourtzelis I, Reichart B, Koutsogiannaki S, Primikyri A, Lambris JD, Chavakis T, Holdt L, Kind A, Guethoff S, Mayr T. Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood. Xenotransplantation. Jan;24(1). doi: 10.1111/xen.12262. Epub 2016 Sep 27.
  
  
• Buerck LW, Schuster M, Oduncu FS, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Klymiuk N, Wolf E, Seissler J. LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy. Sci Rep. Jun 15;7(1):3572. doi: 10.1038/s41598-017-03913-4.
  
  
• Mayr T, Bauer A, Reichart B, Guethoff S, Schoenmann U, Längin M, Panelli A, Kind A, Brenner P, Abicht JM. Hemodynamic and perioperative management in two different preclinical pig-to-baboon cardiac xenotransplantation models. Xenotransplantation. May;24(3). doi: 10.1111/xen.12295. Epub 2017 Mar 5.

2016

• Abicht J, Mayr T, Plotzki E, Falkenau A, Reichart B, Denner J, Guethoff S; Hepatic failure after pig heart transplantation into a baboon: No involvement of porcine hepatitis E virus. Ann Transplant. 21: 12-16.
  
  
• Abicht J, Mayr TA, Jauch J, Guethoff S, Buchholz S, Reichart B, Bauer A. Large-Animal Biventricular Working Heart Perfusion System with Low Priming Volume-Comparison between in vivo and ex vivo Cardiac Function. Thorac Cardiovasc Surg. Apr 4.
  
  
• Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation. J Am Heart Assoc. Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429.
  
  
• Morozov VA, Abicht JM, Reichart B, Mayr T, Guethoff S, Denner J. Active Replication of Porcine Cytomegalovirus (PCMV) Following Transplantation of a Pig Heart into a Baboon despite Undetected Virus in the Donor Pig. Ann Virol Res 2016;2:1018
  
  
• Rataj D, Werwitzke S, Haarmeijer B, Winkler M, Ramackers W, Petersen B, Niemann H, Wünsch A, Bähr A, Klymiuk N, Wolf E, Abicht JM, Ayares D, Tiede A. Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation. Xenotransplantation Mar;23(2):117-27. doi: 10.1111/xen.12218. Epub 2016 Jan 16. PubMed PMID: 26773447.

2015

• Abicht JM, Mayr T, Reichart B, Buchholz S, Werner F, Lutzmann I, Schmoeckel M, Bauer A, Thormann M, Langenmayer MC, et al. Preclinical heterotopic intrathoracic heart Xenotransplantation: a possibly useful clinical technique. Accepted for publication in Xenotransplantation 09/2015.
  
  
• Wolf-van Buerck L, Schuster M, Baehr A, Mayr T, Guethoff S, Abicht JM, Reichart B, Nam-Apostopoulos Y, Klymiuk N, Wolf E, et al. Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters. Accepted for publication in Xenotransplantation 09/2015.
  
  
• Geiger, D, Buchholz S, Michel S, Abicht J, Reichel CA, Reichart B, Hagl C, Brenner P and Schramm R. The Coronary Microcirculation in Hamster to Rat Cardiac Xenografts. European surgical research 55, 364-373.
  
  
• Reichart B, Guethoff S, Brenner P, Poettinger T, Wolf E, Ludwig B, Kind A, Mayr T, Abicht JM. Xenotransplantation of cells, tissues, organs and the German Research Foundation Transregio Collaborative Research Centre 127. In: Immune Responses to Biosurfaces. Advances in experimental medicine and biology 865, 143-155.
  
  
• Reichart B, Guethoff S, Mayr T, Thormann M, Buchholz S, Abicht JM, Kind A, Brenner P. Discordant Cellular and Organ Xenotransplantation – from Bench to Bedside. In: Organ Transplantation in Times of Donor Shortage: Challenges and Solutions, International Library of Ethics, Law, and the New Medicine 59, 209-220.

• Wolf-van Buerck L, Schuster M, Baehr A, Mayr T, Guethoff S, Abicht J, Reichart B, Nam-Apostolopoulos Y, Klymiuk N, Wolf E, et al. Engraftment and reversal of diabetes after intramuscular transplantation of neonatal porcine islet-like clusters. Xenotransplantation Oct 21., doi: 10.1111/xen.12201.

2014

• Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, et al. Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs. Transplantation 97, 138-147.
  
  
• Reichart B, Guethoff S, Mayr T, Thormann M, Buchholz S, Postrach J, Ayares D, Elliott RB, Tan P, Kind A, Hagl C, Brenner P, Abicht JM. Discordant cardiac xenotransplantation: broadening the horizons. European journal of cardio-thoracic surgery 45, 1-5.

2012

• Abicht JM, Beiras-Fernandez A, Bengel D, Vicol C. Deep Pericardial Traction Suture versus Vacuum-Assisted Apical Suction to Expose the Posterior Wall of the Heart in Off-Pump Coronary Artery Bypass: A Prospective, Randomized Study. Heart Surgery Forum 15, 224-231.

2011

• Abicht JM, Bauer A, Christ F, Vicol C. A haemodynamic study during OPCAB surgery using a new multi-suction cardiac positioner. Thorac Cardiovasc Surg. Jun;59(4):217-21. Epub 2011 Mar 15.
  
  
• Bauer A, Renz V, Baschnegger H, Abicht JM, Beiras-Fernandez A, Brenner P, Thein E, Schmoeckel M, Reichart B, Christ F. Microcirculatory alterations after orthotopic pig-to-baboon heart transplantation. Xenotransplantation.  Jul-Aug;18(4):232-8

2010

• Bauer A, Postrach J, Thormann M, Blanck S, Faber C, Wintersperger B, Michel S, Abicht JM, Christ F, Schmitz C, Schmoeckel M, Reichart B, Brenner P. First experience with heterotopic thoracic pig-to-baboon cardiac xenotransplantation. Xenotransplantation. May-Jun;17(3):243-9.

2005

• Bauer A, Baschnegger H, Abicht JM, Brandl U, Brenner P, Thein E, Hammer C, Reichart B, Peter K, Schmoeckel M, Christ F. hDAF porcine cardiac xenograft maintains cardiac output after orthotopic transplantation into baboon--a perioperative study. Xenotransplantation. Nov;12(6):444-9.