Publications (selected)

2020

• Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S. Dysfunction of Persisting β-Cells is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Rep. Apr 7;31(1):107469. doi: 10.1016/j.celrep.2020.03.033.

2018

• Balyura M, Gelfgat E, Steenblock C, Androutsellis-Theotokis A, Ruiz-Babot G, Guasti L, Werdermann M, Ludwig B, Bornstein T, Schally AV, Brennand A, Bornstein SR. Expression of progenitor markers is associated with the functionality of a bioartificial adrenal cortex. PLoS One. Mar 29;13(3):e0194643. doi: 10.1371/journal.pone.0194643. eCollection 2018.
  
  
• Evron Y, Colton CK, Ludwig B, Weir GC, Zimermann B, Maimon S, Neufeld T, Shalev N, Goldman T, Leon A, Yavriyants K, Shabtay N, Rozenshtein T, Azarov D, DiIenno AR, Steffen A, de Vos P, Bornstein SR, Barkai U, Rotem A. Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply. Sci Rep. Apr 25;8(1):6508. doi: 10.1038/s41598-018-23862-w.
  
  
• Simeonovic CJ, Popp SK, Starrs LM, Brown DJ, Ziolkowski AF, Ludwig B, Bornstein SR, Wilson JD, Pugliese A, Kay TWH, Thomas HE, Loudovaris T, Choong FJ, Freeman C, Parish CR. Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans. PLoS One. Feb 7;13(2):e0191360. doi: 10.1371/journal.pone.0191360. eCollection 2018.

2017

• Cohrs, C.M., Chen, C., Jahn, S.R., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., et al. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology 158(5), 1373-1385.
  
  
• Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, Lehmann S, Schubert U, Schmid J, Bleyer M, Schönmann U, Colton CK, Bonifacio E, Solimena M, Reichel A, Schally AV, Rotem A, Barkai U, Grinberg-Rashi H, Kaup FJ, Avni Y, Jones P, Bornstein SR. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A. Oct 31;114(44):11745-11750.
  
  
• Steffen A, Kiss T, Schmid J, Schubert U, Heinke S, Lehmann S, Bornstein S, Ludwig B, Ludwig S. Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation. Jan;24(1).

2016

• Heinke S*, Ludwig B*, Schubert U, Schmid J, Kiss T, Steffen A, Bornstein S, Ludwig S. Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: a feasible approach for advanced diabetes research. Xenotransplantation. Sep;23(5):405-13 * shared first authorship

• Morozov VA, Ludwig S, Ludwig B, Rotem A, Barkai U, Bornstein SR, Denner J. Islet cell transplantation from Göttingen minipigs to cynomolgus monkeys: analysis of virus safety. Xenotransplantation. Jul;23(4):320-7.

2015

• Balyura, M, Gelfgat E, Ehrhart-Bornstein M, Ludwig B, Gendler Z, Barkai U, Zimerman B, Rotem A, Block NL, Schally AV and Bornstein SR. Transplantation of bovine adrenocortical cells encapsulated in alginate. Proceedings of the National Academy of Sciences of the United States of America 112, 2527-2532.
  
  
• Kourtzelis I, Ferreira A, Mitroulis I, Ricklin D, Bornstein SR, Waskow C, Lambris JD, Chavakis T. Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium. Horm Metab Res. Jan;47(1):36-42. doi: 10.1055/s-0034-1390452. Epub 2014 Oct 28.

• Ludwig B, Reichel A, Kruppa A, Ludwig S, Steffen A, Weitz J, and Bornstein SR. Islet transplantation at the Dresden diabetes center: five years' experience. Hormone and Metabolic Research 47(1), 4-8.
  
  
• Morozov VA, Morozov AV, Rotem A, Barkai U, Bornstein S, Denner J; Extended microbiological characterization of Göttingen Minipigs in the context of xenotransplantation: Detection and vertical transmission of Hepatitis E virus. PLOS ONE. 10(10): e0139893.

• Rahmig S, Bornstein SR, Chavakis T, Jaeckel E, and Waskow C. Humanized mouse models for type 1 diabetes including pancreatic islet transplantation. Hormone and metabolic research 47, 43-47.

• Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res; 47(1):31-5.

• Shungin, D, Winkler TW, Croteau-Chonka DC, Bornstein SR, Morris AP, Lindgren CM, Mohlke KL et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518, 187-196.

2014

• Chatzigeorgiou A et al. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci U S A. Feb 3.

2013

• Barkai U, Weir GC, Colton CK, Ludwig B, Bornstein SR, Brendel MD, Neufeld T, Bremer C, Leon A, Evron Y, Yavriyants K, Azarov D, Zimermann B, Maimon S, Shabtay N, Balyura M, Rozenshtein T, Vardi P, Bloch K, de Vos P, Rotem A. Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 22(8):1463-76. doi: 10.3727/096368912X657341. Epub 2012 Oct 3.

• Willer CJ et al. Discovery and refinement of loci associated with lipid levels. Nat Genet. Nov; 45(11):1274-83.

• Ludwig B. et al. Transplantation of human islets without immunosuppression Proc Natl Acad Sci U S A. Nov 19;110(47):19054-8.

• Lin Z. et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice Cell Metab. May 7;17(5):779-89.

• Neufeld T*, Ludwig B*, Barkai U, Weir GC, Colton CK, Evron Y, Balyura M, Yavriyants K, Zimermann B, Azarov D, Maimon S, Shabtay N, Rozenshtein T, Lorber D, Steffen A, Willenz U, Bloch K, Vardi P, Taube R, de Vos P, Lewis EC, Bornstein SR, Rotem A. The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS One. Aug 1;8(8):e70150.

2012

• Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A. Mar 27;109(13):5022-7.

• Santana MM et al. Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla. Stem Cells Transl Med. Nov;1(11):783-91.

2011

• Schmid J et al. Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase.Proc Natl Acad Sci U S A. Aug 16;108(33):13722-7.

• Ehret GB et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. Sep 11.

• Bornstein SR, et al. Improving the efficacy of translational medicine by optimally integrating health care, academia and industry. Nat Med. Dec 6; 17(12):1567-9.

2010

• Dupuis J et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. Feb;42(2):105-16.
  
  
• Ludwig B, Zimerman B, Steffen A, Yavriants K, Azarov D, Reichel A, Vardi P, German T, Shabtay N, Rotem A, Evron Y, Neufeld T, Mimon S, Ludwig S, Brendel MD, Bornstein SR, Barkai U. A Novel Device for Islet Transplantation Providing Immune Protection and Oxygen Supply. Horm Metab Res. Dec;42(13):918-22.

• Saxena R. et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet. Feb;42(2):142-8.

2009

• Bornstein SR. Predisposing factors for adrenal insufficiency.N Engl. J. Med. May 28; 360(22):2328-39.

2008

• Sicard F et al. Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate. Proc. Natl. Acad. Sci. USA Feb 6;104(6):2007-12.

2005

• Merke D, Bornstein SR. Congenital adrenal hyperplasia. Lancet, 365:2125-36.

2004

• Schott M et al. Acquired and inherited lipodystrophies.N Engl. J. Med, 351:103-4.

• Steidl U et al. Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators. Blood. Jul 1;104(1):81-8.

2003

• Bornstein SR et al. Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2) FASEB J;17,:1928-30.

• Ehrhart-Bornstein et al. Human adipocytes secrete mineralocorticoid-releasing factors. Proc. Natl. Acad. Sci. USA; 100:14211-6.

2002

• Galon J et al. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J 16:61-71.

• Merke D et al. NIH conference. Future directions in the study and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Annals of Int Med; 136:320-34.

• Alesci S et al. Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy. Proc Natl Acad Sci USA; 99:7484-9.

2000 

• Bornstein SR et al. Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture. Diabetes; 49:532-538.

• Bornstein SR et al. Plasma dehydroepiandrosterone levels during experimental endotoxemia and anti-inflammatory therapy in humans.Crit Care Med; 28:2103-2106.

• Franchimont D et al. Adrenal cortical activation in murine colitis. Gastroenterology; 119:1560-1568.

• Merke DP et al. Adrenomedullary dysplasia and hypofunction in patients with classic 21-hydroxylase deficiency. N Engl. J. Med; 343:1362.

• Bornstein SR et al. Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo. Proc. Natl. Acad. Sci. USA; 97:14742-7.

1999

• Bornstein SR et al. Ann Intern Med; 130: 757-765.

• Tajima T et al. Restoration of adrenal steroidogenesis by adenovirus-mediated transfer of human cytochromeP450 21-hydroxylase into the adrenal gland of21-hydroxylase-deficient mice. Gene Therapy; 6:1898-1903.

• Bornstein SR, et al. FASEB J 1999; 13:1185-1194; Hilbers U et al. Hypertension; 33:1025-1030.

1998

• Bornstein SR et al. Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation. Endocrinology;139:1546-1555.

• Bornstein SR et al. Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans. J Infect Dis;178:887-890.

• Willenberg HS et al. Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. N Engl J Med; 339:27-31.

• Ehrhart-Bornstein M et al. Endocr Rev;30:416-420

1997

• Bornstein SR et al. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Nature Med;3:937. Bornstein SR et al. Diabetes 1997;46:1235-1238.

1994

• Bornstein SR et al. Intimate contact of chromaffin and cortical cells within the human adrenal gland forms the cellular basis for important intraadrenal interactions. J Clin Endocrinol Metab;78:225-232.

1990

• Bornstein SR et al. Effects of splanchnic nerve stimulation on the adrenal cortex may be mediated by chromaffin cells in a paracrine manner. Endocrinology;127:900-906.