Classification of pediatric lung diseases
This clinical-pathological-genetic classification of diseases in children was established by M. Griese. It is based on the histology-based classification systems by Deutsch et al 2007 (1) and Rice et al 2013 (2).
Below is a listing of the categories. A continuously updated and detailed listing of all subcategories and diagnoses can be found in the data capture system of the register. The system has been used in several previous publications (3-6).
A Childhood diffuse parenchymal lung diseases
A1 DPLD-Diffuse developmental disorders
A2 DPLD-Growth abnormalities reflecting deficient alveolarisation
A3 DPLD-Infant chronic tachypnoe and firm morphology
A4 DPLD-related to alveolar surfactant region
Ax DPLD-unclear RDS in the mature neonate
Ay DPLD-unclear RDS in the almost (30-36 wks) mature neonate
B Diffuse parenchymal lung diseases
B1 DPLD-related to systemic disease processes
B2 DPLD-in the presumed immune intact host, related to exposures (infectious/non-infectious)
B3 DPLD-in the immunocompromised host or transplanted
B4 DPLD-related to lung vessels structural processes
B5 DPLD-related to reactive lymphoid lesions
Bx DPLD-unclear RDS in the NON-neonate
C Localized parenchymal lung diseases
C1 congenital
C2 acquired
D Airway disorders
E Pleural disease
F Lung infections
Literature
1) Deutsch GH1, Young LR, Deterding RR, Fan LL, Dell SD, Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston C; Pathology Cooperative Group, Albright EA, Askin FB, Baker P, Chou PM, Cool CM, Coventry SC, Cutz E, Davis MM, Dishop MK, Galambos C, Patterson K, Travis WD, Wert SE, White FV; ChILD Research Co-operative. Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1120-8. Epub 2007 Sep 20.
2) Rice A, Tran-Dang MA, Bush A, Nicholson AG. Diffuse lung disease in infancy and childhood: expanding the chILD classification. Histopathology. 2013 Dec;63(6):743-55.
3) Griese M, Seidl E, Hengst M, Reu S, Rock H, Anthony G, Kiper N, Emiralioğlu N, Snijders D, Goldbeck L, Leidl R, Ley-Zaporozhan J, Krüger-Stollfuss I, Kammer B, Wesselak T, Eismann C, Schams A, Neuner D, MacLean M, Nicholson AG, Lauren M, Clement A, Epaud R, de Blic J, Ashworth M, Aurora P, Calder A, Wetzke M, Kappler M, Cunningham S, Schwerk N, Bush A; and the other chILD-EU collaborators. International management platform for children's interstitial lung disease (chILD-EU). Thorax. 2017 Oct 22. pii: thoraxjnl-2017-210519. doi: 10.1136/thoraxjnl-2017-210519.
4) Griese M, Irnstetter A, Hengst M, Burmester H, Nagel F, Ripper J, Feilcke M, Pawlita I, Gothe F, Kappler M, Schams A, Wesselak T, Rauch D, Wittmann T, Lohse P, Brasch F, Kröner C. Categorizing diffuse parenchymal lung disease in children. Orphanet J Rare Dis. 2015 Sep 25;10:122. doi: 10.1186/s13023-015-0339-1.
5) Griese M, Irnstetter A, Hengst M, Burmester H, Nagel F, Ripper J, Feilcke M, Pawlita I, Gothe F, Kappler M, Schams A, Wesselak T, Rauch D, Wittmann T, Lohse P, Brasch F, Kröner C. Categorizing diffuse parenchymal lung disease in children. Orphanet J Rare Dis. 2015 Sep 25;10:122. doi: 10.1186/s13023-015-0339-1.
6) Griese M, Kirmeier HG, Liebisch G, Rauch D, Stückler F, Schmitz G, Zarbock R; ILD-BAL working group of the Kids-Lung-Register. Surfactant lipidomics in healthy children and childhood interstitial lung disease. PLoS One. 2015 Feb 18;10(2):e0117985. doi: 10.1371/journal.pone.0117985.
7) Griese M, Haug M, Brasch F, Freihorst A, Lohse P, von Kries R, Zimmermann T, Hartl D. Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany. Orphanet J Rare Dis. 2009 Dec 12;4:26. doi: 10.1186/1750-1172-4-26.
