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Presence of Luminal NETs in Atherosclerosis

München, 01.03.2012


A group of IPEK scientists have reported presence of Neutrophil Extracellular Traps (NETs) in both murine and human atherosclerotic lesions. The data has been published in the March issue of Thrombosis and Haemostasis. The presence of  Neutrophil Extracellular Traps (NETs) in atherosclerosis was demonstrated by utilizing in vivo two-photon laser scanning microscopic imaging and immunohistochemistry. The published observations for the first time link the formation of NETs with atherosclerosis in both mice in vivo and in human samples and positively stimulate further research on the contribution of NETs to atherogenesis. Exploring the functionality of NETs in atherosclerosis may lead to novel insights in the interaction between neutrophils and antigen-presenting cells in atherosclerosis.



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Megens RTA, Vijayan S, Lievens D, Döring Y, van Zandvoort MA, Grommes J, Weber C, Soehnlein O. Presence of luminal neutrophil extracellular traps in atherosclerosis. Thromb Haemost. 2012;107(3):597-8. Pubmed.



Oliver Soehnlein or Remco Megens