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Journal of Clinical Investigation - ApoE in atherosclerosis


Atherosclerosis is a chronic inflammatory disease of the arterial walls that often leads to myocardial infarction and/or stroke. Hypercholesterolemia and an imbalance of peripheral leukocyte counts, leading to arterial leukocyte infiltration, are considered independent risk factors for atherosclerosis. However, in this issue of the Journal of Clinical Investigation (JCI), Murphy and colleagues identify a mechanistic link between hypercholesterolemia, leukocytosis, and the subsequent development of atherosclerotic lesions in mice. These findings could pave the way for the development of novel treatment strategies to control leukocyte homeostasis and atherosclerosis.



ApoE controls the interface linking lipids and inflammation in atherosclerosis.

Weber C. et al.

Journal of Clinical Investigation, 03. October 2011



Professor Christian Weber

Leitung des Instituts für Prophylaxe und Epidemiologie der Kreislaufkrankheiten am Klinikum der Universität München

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For more information read the following paper.