Our Lab

Neurobiology of Multiple Sclerosis

Welcome to the lab of Martin Kerschensteiner, MD



Group photo (with Bareyre Lab and Misgeld Lab, TUM)


Our Aim

In multiple sclerosis infiltrating immune cells damage resident cells of the nervous system such as neurons and oligodendrocytes. This structural damage is responsible for the irreversible functional deficits in patients with multiple sclerosis. The aim of our work is to better understand how immune cells cause nervous system damage and use this knowledge to develop novel treatment strategies that limit tissue damage in multiple sclerosis.

Our Approach

We use in vivo imaging techniques in combination with viral and transgenic labelling to follow in real-time the cellular and molecular interactions that underlie tissue damage in animal models of multiple sclerosis. Based on these insights into the in vivo pathogenesis we then use genetic and pharmacological manipulations to design and evaluate new therapeutic strategies that foster tissue protection and repair.

Our Support

Our Research Unit has been established with funds from Institute of Clinical Neuroimmunology, the Verein “Therapieforschung für MS-Kranke e.V.”, as well as generous private donations. Our current work is supported by multiple national and international funding agencies including the German National Science Foundation (DFG), the Hertie Foundation (Multiple Sklerosis Program), the German Federal Ministry for Research and Education (BMBF) as well as a Starting Grant of the European Research Council (ERC). We are part of several local and national research consortia including the Excellence Cluster „SyNergy – Munich Cluster for Systems Neurology“, the Collaborative Research Centres TRR 128 („Initiating/effector versus regulatory mechanisms in multiple sclerosis“) and 870 („Assembly and function of neuronal circuits in sensory processing“) as well as the Federal Competence Network on Multiple Sclerosis.



Prof. Dr.

Martin Kerschensteiner


Important links