Publications (selected)
2023
- Hansen S, Fischer K, Krabben L, Rinke Carrapeiro A, Klinger B, Schnieke A, Kaufer B, Denner J. Detection of porcine cytomegalovirus, a roseolovirus, in pig ovaries and follicular fluid: Implications for somatic cells nuclear transfer, cloning and xenotransplantation. Virol J. Jan 27;20(1):15. doi.org/10.1186/s12985-023-01975-7
2021
- Fischer*, Rieblinger* (Co-first author), Hein R, Sfriso R, Zuber J, Schäffler A, Klinger B, Wei L, Flisikowski K, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Rieben R, Schwinzer R, Kind A, Schnieke A. Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2. Xenotransplantation, 27(1):e12560.
2018
- Fiebig U, Fischer K, Bähr A, Runge C, Schnieke A, Wolf E, Denner J. Porcine endogenous retroviruses: Quantification of the copy number in cell lines, pig breeds, and organs. Xenotransplantation Jul. 25(4):e12445.
- Fischer K, Kind A, Schnieke A. Assembling multiple xenoprotective transgenes in pigs. Xenotransplantation. Nov;25(6):e12431. doi: 10.1111/xen.12431. Epub 2018 Jul 28. Review.
- Rieblinger B, Fischer K, Kind A, Saller BS, Baars W, Schuster M, Wolf-van Buerck L, Schäffler A, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Wolf E, Seissler J, Schwinzer R, Schnieke A. Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus. Xenotransplantation Jan 23. doi: 10.1111/xen.12382.
2016
2015
- Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res; 47(1):31-5.
2014
- Pausch H, Schwarzenbacher H, Burgstaller J, Flisikowski K, Wurmser C, Jansen S, Jung S, Schnieke A, Wittek T and Fries R. Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle. (submitted to PLoS Genetics).
- Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes R, Wolf E and Bornstein R. Xenotransplantation of porcine islet cells as a potential option for the treatment of type-1-diabetes in the future. (Submitted to Hormone and Metabolic Research).
- Venhoranta H, Pausch P, Flisikowski K, Wurmser C, Taponen J, Rautala H, Kind A, Schnieke A, Fries R, Lohi H and Andersson M. In frame exon skipping in UBE3B causes developmental disorders and increased mortality in cattle. BMC genomics 15, 890.
- Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy A M, Banerjee R, Yang FT, Lee C-L, Moding EJ, Kirsch DG, Scheideler A, Alessi DR, Varella I, Bradley A, Kind A, Schnieke A E, Rodewald H-R, Rad R, Schmid RM, Schneider G and Saur D. A next generation dual-recombination system resource for sequential time and host specific genetic manipulation of pancreatic cancer. Nature Medicine; Oct 19. Epub ahead of print.
- Weigel S, Flisikowska T, Schnieke A and Luksch H. Hybrid voltage sensor imaging of eGFP-F expressing neurons in chicken midbrain slices. J. Neuroscience Methods ; 4 June. Epub ahead of print.
- Li S, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Saur D, Kind A, Wolf E, Flisikowski K and Schnieke A. Dual fluorescent reporter pig for Cre recombination; transgene placement at the ROSA26 locus. PLoS ONE Jul 15;9(7):e102455. doi: 10.1371/journal.pone.0102455.
- Eser S, Rad R, Schnieke A, Schneider G and Saur D. Oncogenic KRAS signalling in pancreatic cancer. Br J Cancer 111, 817-822.
- Flisikowska T, Kind A and Schnieke A. Production of genetically modified rabbits. In: Transgenic Animal Technology: A Laboratory Handbook. 3rd Edition (Ed. Pinkert, C.A). Pub. Elsevier Science, USA. pp 277-306.
- Stachowiak M, Szydlowski M, Flisikowski K, Flisikowska T, Bartz M, Schnieke A, Switonski, M. Polymorphism in 3’UTR of the pig PPARA gene influences on its transcript level and is associated with adipose tissue accumulation. J. Anim. Sci. 92, 2363-2371.
- Venhoranta H, Li L, Salamon S, Flisikowska T, Andersson M, Switonski M, Kind A and Schnieke A. Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses. Biochem. Bioph. Res. Commun. 444, 391-394.
2013
- Flisikowska T, Kind A and Schnieke A. Genetically modified pigs to model human diseases. J. Appl. Genet. 55, 53-64.
- Schnieke A and Kupatt C. Transplantation, Stammzellen und Tissue Engineering. In: Zukunft der biomedizinische Wissenschaften. (Eds. Albrecht, C., Kersten, J., Kummer, C., Raabe, G., Rauck, H., Schleissing, S.) Pub. Nomos, Baden-Baden, pp. 37-45.
- Kraner-Scheiber S and Schnieke A. Perspektiven der Roten Gentechnik. Rolle der Wissenschaft im Globalen Wandel, Nova Acta Leopoldina, 118, No. 400.
- Flisikowska T, Kind A and Schnieke A. The new pig on the block: modelling cancer in pigs. Transgenic Res. 22, 673-680.
- Venhoranta H, Bauersachs S, Taponen J, Lohi H, Taira T, Andersson M, Kind A, Schnieke A and Flisikowski K. Fetal growth restriction caused by MIMT1 deletion alters brain transcriptome in cattle. Int. J. Dev. Neurosci. 31, 463-467.
- Kurome M, Geistlinger L, Kessler B, Zakhartchenko V, Klymiuk N, Wuensch A, Richter A, Baehr A, Kraehe K, Burkhardt K, Flisikowski K, Flisikowska T, Merkl C, Landmann M, Durkovic M, Tschukes A, Kraner S, Schindelhauer D, Petri T, Kind A, Nagashima H, Schnieke A, Zimmer R and Wolf E. Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set. BMC Biotechnology May 20;13(1):43. doi: 10.1186/1472-6750-13-43.
- Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber H, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind A J, Rad L, Schnieke AE, Baccarini M, Alessi D R, Rad R, Schmid RM, Schneider G and Saur D. Selective requirement of PI3K/PDK1 signalling for KRAS oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell 23, 406-420.
- Merkl C, Saalfrank A, Riesen N, Kühn R, Pertek A, Eser S, Hardt M, Kind A, Saur D, Wurst W, Iglesias A and Schnieke A. Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector. PLoS ONE 8, e55170.
- Kind A and Schnieke A. Nuclear transfer to produce transgenic mammals. In: Encyclopedia of Sustainability Science and Technology. Sustainable Food Production. (Ed. Meyers, R.A). Pub. Springer-Verlag, New York, pp. 1240-1251.
- Cieslak J, Flisikowska T, Schnieke A, Kind A, Szydlowski M, Switonski M and FlisikowskiK. Polymorphisms in the promoter region of adiponectin (ADIPOQ) gene are associated with transcription level and carcass traits. Animal Genetics 44, 340-343.
2012
- Flisikowski K, Venhoranta H, Bauersachs S, Hänninen R, Fürst RW, Saalfrank A, Ulbrich, SE, Taponen J, Lohi H, Wolf E, Kind A, Andersson M and Schnieke A. Truncation of MIMT1 gene in the PEG3 domain leads to major changes in placental gene expression and stillbirth in cattle. Biol Reprod. 87, 140 doi: 10.1095/biolreprod.112.104240.
- Flisikowska T, Merkl C, Landmann T, Eser S, Rezaei N, Cui X, Kurome M, Zakhartchenko V, Kessler B, Wieland H, Rottmann O, Schmid RM, Schneider G, Kind A, Wolf E, Saur D and Schnieke A. A porcine model of familial adenomatous polyposis. Gastroenterology 143, 1173-1175.
- Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M, Rezaei N, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Kind A, Wolf E and Schnieke A. Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PLoS ONE 7, e43323.
- Mohr H, Mohr CA, Schneider M R, Scrivano L, Adler B, Kraner-Scheiber S, Schnieke A, Dahlhoff M, Wolf E, Koszinowski U and Ruzsics Z. Cytomegalovirus replicon based regulation of gene expression in vitro and in vivo. PLoS Pathogens 8, e1002728.
- Labisso WL, Wirth M, Stojanovic N, Stauber R, Schnieke A, Schmid R, Kraemer O, Saur D and Schneider G. MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells towards HDAC inhibitors. Cell Cycle 11, 1593-1602.
- Hagen K, Schnieke A and Thiele F. (Editors) Large Animals as Biomedical Models: Ethical, Societal, Legal and Biological Aspects. Pub. European Academy, Bad Neuenahr.
- Niemann H, Kind A and Schnieke A. The production of biopharmaceuticals in transgenic animals. In: Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications (Eds. Kayser, O., Warzecha, H.) Pub. Wiley-VCH, Weinheim.
2011
- Conradt L, Godl K, Schaab C, Tebbe A, Eser S, Diersch S, Michalski CW, Kleeff J, Schnieke A, Schmid RM, Saur D and Schneider G. Disclosure of Erlotinib targets in pancreatic ductal adenocarcinoma. Neoplasia 13, 1026-1034.
- Eser S, Messer M, Eser P, von Werder A, Seidler B, Bajbouj M, Vogelmann R, Meining A, von Burstin J, Alguel H, Pagel P, Schnieke A, Schmid R, Schneider G and Saur D. In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging. Proc. Natl. Acad. Sci. USA 108, 9945-9950.
- Flisikowska T, Thorey I S, Offner S, Ros F, Lifke V, Zeitler B, Rottmann O, Vincent A, Zhang, L, Jenkins S, Niersbach H, Kind AJ, Gregory PD, Schnieke AE and Platzer J. Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases. PLoS ONE 6, e21045.
- Merkl C, Leuchs S, Saalfrank A, Kind A and Schnieke A. RNA interference in pigs: comparison of RNAi test systems and expression vectors. Mol. Biotechnol. 48, 38-48.
- Zakhartchenko V, Flisikowska T, Li S, Richter T, Wieland H, Durkovic M, Rottmann O, Kessler B, Gungor T, Brem G, Kind A, Wolf E and Schnieke A. Cell-mediated transgenesis in rabbits: chimeric and nuclear transfer animals. Biol. Reprod. 84, 229-237.
2009
- Pardo P, Engelhard M, Hagen K, Jørgensen RB, Rehbinder E, Schnieke A, Szmulewicz M and Thiele F. The role of means and goals in technology acceptance. A differentiated landscape of public perceptions of pharming. EMBO reports 10, 1069-1075.
- Fritsche P, Seidler B, Schüler S, Schnieke A, Göttlicher M, Schmid RM, Saur D and Schneider G. HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA. Gut 58, 1399 - 1409.
- Von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke AE, Schmid RM, Schneider G, and Saur D. E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC2 repressor complex. Gastroenterology 137, 361-71.
2008
- Schnieke A. Large animal models for biomedicine. Acta Biochimica Polonica S4, L5.1
- Schnieke A. Gene technology in raising livestock. Tagungsband 7. BOKU Symposium Tierernährung. pp 26-33.
- Kind A and Schnieke A. Cloning mammals: more than just another sheep. In: Frontiers of Knowledge. Pub. BBVA, Madrid. pp. 185-201.
- Von Burstin J, Eser S, Seidler B, Meining A, Bajbouj M, Mages J, Lang R, Kind AJ, Schnieke AE, Schmid RM, Schneider G and Saur D. Highly sensitive detection of early-stage pancreatic cancer by multimodal near-infrared molecular imaging in living mice. Int. J. Cancer. 123, 2138-2147.
- Schnieke A. Animal pharming: past experience and future prospects. In: Genetic engineering in livestock. (Eds. Engelhard M., Hagen K., Boysen M.) Pub. Springer Berlin, Heidelberg. pp. 49-67.
- Kind A and Schnieke A. Animal pharming, two decades on. Transgenic Res. 17, 1025-1033.
- Rehbinder E, Engelhard M, Hagen K, Jørgensen R B, Pardo-Avellaneda R, Schnieke A and Thiele F. Pharming. Promises and risks of biopharmaceuticals derived from genetically modified animals. Pub. Springer Berlin, Heidelberg.
2007
2006
2005
- Barrow J, Bernardo AS, Hay CW, Blaylock M, Duncan L, MacKenzie A, McCreath K, Kind AJ, Schnieke AE, Colman A, Hart AW and Docherty K. Purification and characterisation of a population of EGFP-expressing cells from the developing pancreas of a neurogenin3/EGFP transgenic mouse. Organogenesis 2, 22-27.
2003
- Young LE, Schnieke AE, McCreath KJ, Wieckowski S, Konfortova G, Fernandes K, Ptak G, Kind AJ, Wilmut I, Loi P and Feil R. Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer. Mech. Dev. 120, 1433-1442.
2002
- Chen SH, Vaught TD, Monahan JA, Boone J, Emslie E, Jobst PM, Lamborn AE, Schnieke A, Robertson L, Colman A, Dai Y, Polejaeva IA and Ayares DL. Efficient production of transgenic cloned calves using preimplantation screening. Biol. Reprod. 67, 1488-1492.
2001
2000
1999
- Wilmut I, Schnieke A, McWhir J, Kind AJ, Colman A, and Campbell KHS. Nuclear transfer in the production of transgenic farm animals. In: Transgenic Animals in Agriculture. (Eds. Murray, J.D., Anderson, G.B., Oberbauber, A.M., McGloughlin, M.M) Pub. CAB International, Oxon, pp. 67-78.
- Shiels PG, Kind AJ, Campbell KH, Wilmut I, Waddington D, Colman A and Schnieke AE. Analysis of telomere lengths in Dolly, a sheep derived by nuclear transfer. Cloning 1, 119-125.
- Evans MJ, Gurer C, Loike JD, Wilmut I, Schnieke AE and Schon EA. Mitochondrial genotypes in nuclear transfer derived cloned sheep. Nature Genetics 23, 90-93.
- Shiels PG, Kind AJ, Campbell KH, Waddington D, Wilmut I, Colman A and Schnieke AE Analysis of telomere lengths in cloned sheep. Nature 399, 316-317.
- Huett AS, Innes DA, Moore MJ, Schnieke AE and Shiels PG. Idendification of a novel HaeIII PCR-RFLP in the SLA DQB gene. Animal Genetics 30, 397.
- Ashworth D, Bishop M, Campbell K, Colman A, Kind A, Schnieke A, Blott S, Griffin H, Haley, C, McWhir J and Wilmut I (1998). DNA microsatellite analysis of Dolly. Nature 394, 329.
1997
- Schnieke AE, Kind AJ, Ritchie WA, Mycock K, Scott AR, Ritchie M, Wilmut I, Colman A and Campbell KHS. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278, 2130-2133.
- Wilmut I, Schnieke A, McWhir J, Kind AJ and Campbell KHS. Viable offspring derived from foetal and adult mammalian cells. Nature 385, 810-813.
- Finch LMB, Craig V, Kind AJ, Schnieke A, Scott A, Wells M and Wilde CJ. Genetic manipulation of mammary epithelial cells in primary culture. In: Animal Cell Technology: basic and applied aspects (Eds. Funatsu, K., Shirai, Y., Matsushita,T.) Vol 8, Pub. Kluwer Academic, pp. 347-350.
1996
- McWhir, J, Schnieke AE, Ansell R, Wallace H, Scott AR and Kind AJ. Selective ablation of differentiated cells permits isolation of ES lines from murine embryos with a non-permissive genetic background. Nature Genetics, 14, 223-226.
- Finch LMB, Craig V, Kind AJ, Schnieke A, Scott A, Wells M and Wilde CJ. Primary culture of ovine mammary epithelial cells. Biochemical Society Transactions 24, 369S.
1994
- Stacey AJ and Schnieke AE. The murine alpha-lactalbumin gene inactivation and replacement. In: Intercellular Signalling in the Mammary Gland. (Eds. Wilde, C.J., Knight, C.H., Peaker, M.) Pub. Plenum press, New York. pp.187-188.a. Murine
- Bowen RA, Reed ML, Schnieke A, Seidel GE, Stacey AJ, Thomas WK and Kajikawa O. Transgenic cattle resulting from biopsied embryos: expression of c-ski in a transgenic calf. Biol. Reprod. 50, 664-668.
1993
1992
1990
- Stacey AJ and Schnieke AE. SVpoly: A versatile mammalian expression vector. Nuc Acids Res. 18, 2829.
- Wu H, Bateman J F, Schnieke A, Sharpe A, Barker D, Mascara T, Eyre D, Bruns R, Krimpenfort P, Berns A and Jaenisch R. Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov-13 mutant mouse embryos. Mol. Cell. Biol. 10, 1452-1460.
1987
- Schnieke A et al. Introduction of the human pro alpha 1(l) collagen gene into pro alpha 1(l) collagen deficient Mov-13 mouse cells leads to formation of functional mouse:human hybrid type I collagen. Proc. Natl. Acad. Sci. USA 84, 764-768.a, Dziadek M, Bateman J F, Mascara T, Harbers K, Gelinas R and Jaenisch R. Introduction of the human pro
1985
1983
- Jaenisch R, Harbers K, Schnieke A, Chumakov I, Jähner D, Löhler J, Grotkopp D and Hoffmann E. Germline integration of Moloney leukemia at the Mov-13 locus leads to recessive lethal mutation and early embryonic death. Cell 32, 209-216.
- Schnieke A, Stuhlmann H, Harbers K, Chumakov I and Jaenisch R. Endogenous Moloney leukemia virus in nonviremic Mov substrains of mice carries defects in the proviral genome. J. Virol. 45, 505-513.
1982
1981
