Startseite » Members » Principal Investigator » A3 » Chavakis, Triantafyllos Prof. Dr. med. » Publikations (selected)

Publikations (selected)

2020

Troullinaki M, Chen LS, Witt A, Pyrina I, Phieler J, Kourtzelis I, Chmelar J, Sprott D, Gercken B, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes. FASEB J. Jan 9. doi: 10.1096/fj.201900125RR. [Epub ahead of print]

Hajishengallis G, Chavakis T. DEL-1-Regulated Immune Plasticity and Inflammatory Disorders. Trends Mol Med. May;25(5):444-459. doi: 10.1016/j.molmed.2019.02.010. Epub 2019 Mar 15. Review.

Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. Jan;20(1):40-49. doi: 10.1038/s41590-018-0249-1. Epub 2018 Nov 19.

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034.
Singh RP, Grinenko T, Ramasz B, Franke K, Lesche M, Dahl A, Gassmann M, Chavakis T, Henry I, Wielockx B. Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice. Stem Cell Reports. Jun 5;10(6):1908-1919. doi: 10.1016/j.stemcr.2018.04.012. Epub 2018 May 10.

Abicht JM, Kourtzelis I, Reichart B, Koutsogiannaki S, Primikyri A, Lambris JD, Chavakis T, Holdt L, Kind A, Guethoff S, Mayr T. Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood. Xenotransplantation. Jan;24(1). doi: 10.1111/xen.12262. Epub 2016 Sep 27.
Kourtzelis I, Mitroulis I, von Renesse J, Hajishengallis G, Chavakis T. From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins. J Leukoc Biol. Sep;102(3):677-683. doi: 10.1189/jlb.3MR0117-024R.

Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb Haemost. Apr;115(4):781-8. doi: 10.1160/TH15-05-0429.

Subramanian P, Mitroulis I, Hajishengallis G, Chavakis T. Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors. Curr Opin Hematol. Jan;23(1):36-43. doi: 10.1097/MOH.0000000000000198. Review.

Kourtzelis I, Ferreira A, Mitroulis I, Ricklin D, Bornstein SR, Waskow C, Lambris JD, Chavakis T. Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium. Horm Metab Res. Jan;47(1):36-42. doi: 10.1055/s-0034-1390452. Epub 2014 Oct 28.

Maekawa T., Hosur K., Abe T., Kantarci A., Ziogas A., Wang B., Van Dyke T.E., Chavakis T.*, Hajishengallis G.* (2015) Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β–C/EBPβ pathway. Nature Communications 6, 8272. * These authors contributed equally as senior authors to the work.

Rahmig S, Bornstein SR, Chavakis T, Jaeckel E, and Waskow C. Humanized mouse models for type 1 diabetes including pancreatic islet transplantation. Hormone and metabolic research 47, 43-47.

Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res; 47(1):31-5.

Shin J., Maekawa T., Abe T., Hajishengallis E., Hosur K., Pyaram K., Mitroulis I., Chavakis T.*, Hajishengallis* G. (2015) Del-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates. Science Translational Medicine in press. *These authors contributed equally as senior authors to the work.
Norata G.D., Caligiuri G., Chavakis T., Matarese G., Netea M.G., Nicoletti A., O'Neill L.A., Marelli-Berg F.M. (2015). The Cellular and Molecular Basis of Translational Immunometabolism. Immunity. 43, 421-434.

Weber G.F., Chousterman B.G., He S., Fenn A.M., Nairz M., Anzai A., Brenner T., Uhle F., Iwamoto Y., Robbins C.S., Noiret L., Maier S.L., Zönnchen T., Rahbari N.N., Schölch S., Klotzsche-Von Ameln A., Chavakis T., Weitz J., Hofer S., Weigand M.A, Nahrendorf M., Weissleder R., Swirski F.K. (2015). Interleukin-3 amplifies acute inflammation and is apotential therapeutic target in sepsis. Science 347, 1260-1265.

Eskan M.A., Jotwani R., Abe T., Chmelar J., Lim J.H., Liang S., Ciero P., Krauss J., Li F., Rauner M., Hofbauer L.C., Choi E.Y., Chung K.J., Hashim A., Curtis M., Chavakis T.*, Hajishengallis G.* (2012).The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nature Immunology 13, 465-473. * These authors contributed equally as senior authors to the work.Santoso

Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A. Mar 27;109(13):5022-7.

Economopoulou M., Langer H.F., Celeste A., Orlova V.V., Choi E.Y., Ma M., Vassilopoulos A., Callen E., Deng C., Bassing C.H., Boehm M., Nussenzweig A., Chavakis, T. (2009). Histone H2AX is integral to hypoxia-driven neovascularisation. Nature Medicine 15, 553-558.

Choi E.Y., Chavakis E., Czabanka M.A., Langer H., Fraemohs L., Economopoulou M., Kundu R.K., Orlandi A, Zheng Y.Y., Prieto D.A., Ballantyne C.M., Constant S.L., Aird W., Papayannopoulou T., Gahmberg C.G., Udey M.C., Vajkoczy P., Quertermous T., Dimmeler S., Weber C., and Chavakis T. (2008) Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science 322, 1101-1104.

Chavakis, T., Bierhaus A., Al-Fakhri N., Schneider D., Witte S., Linn T., Nagashima M., Morser J., Arnold B., Preissner K.T., Nawroth PP. (2003). The Pattern Recognition Receptor (RAGE) is a Counter-receptor for Leukocyte Integrins: A novel pathway for inflammatory cell recruitment. The Journal of Experimental Medicine 198, 1507-1515.

S., Sachs U.J., Kroll H., Linder M., Ruf A., Preissner K.T., Chavakis, T. (2002). The Junctional Adhesion Molecule-3 on human platelets is a counter-receptor for the leukocyte integrin Mac-1. The Journal of Experimental Medicine 196, 679-691.