Publications (selected)

2023

• Pokoyski C, Baars W, Windheim M, Reubold TF, Zischke J, Brinkmann A, Kay-Fedorov PC, Schwinzer R. Expression of viral CD45 ligand E3/49K on porcine cells reduces human anti-pig immune responses. Sci Rep. 2023 Oct 11;13(1):17218. doi: 10.1038/s41598-023-44316-y
  
  
• Schmalkuche K, Schwinzer R, Wenzel N, Valdivia E, Petersen B, Blasczyk R, Figueiredo C. Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells. Int J Mol Sci. Aug 12;24(16):12711. doi: 10.3390/ijms241612711.

2021

• Fischer*, Rieblinger* (Co-first author), Hein R, Sfriso R, Zuber J, Schäffler A, Klinger B, Wei L, Flisikowski K, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Rieben R, Schwinzer R, Kind A, Schnieke A. Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2. Xenotransplantation,  27(1):e12560.
  
  
• Reichart B, Längin M, Denner J, Schwinzer R, Cowan PJ, Wolf E. Pathways to Clinical Cardiac Xenotransplantation. Transplantation. Sep 1;105(9):1930-1943. doi: 10.1097/TP.0000000000003588.

2020

• Carvalho-Oliveira M, Valdivia E, Verboom M, Sake H, Pogozhykh O, Niemann H, Schwinzer R, Petersen B, Seissler J, Blasczyk R, Figueiredo C. Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation. J Cell Mol Med. Mar 25. doi: 10.1111/jcmm.15136. Online ahead of print.

2019

• Hein R, Sake HJ, Pokoyski C, Hundrieser J, Brinkmann A, Baars W, Nowak-Imialek M, Lucas-Hahn A, Figueiredo C, Schuberth HJ, Niemann H, Petersen B, Schwinzer R. Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class-I^low phenotype - effects on immune status and susceptibility to human immune responses. Am J Transplant. Nov 15. doi: 10.1111/ajt.15710. [Epub ahead of print]
  
  
• Hundrieser J, Hein R, Pokoyski C, Brinkmann A, Düvel H, Dinkel A, Trautewig B, Siegert JF, Römermann D, Petersen B, Schwinzer R. Role of human and porcine MHC DRB1 alleles in determining the intensity of individual human anti-pig T-cell responses. Xenotransplantation. May 9:e12523. doi: 10.1111/xen.12523. [Epub ahead of print]
  
  
• Mederacke YS, Vondran FW, Kollrich S, Schulde E, Schmitt R, Manns MP, Klempnauer J, Schwinzer R, Noyan F, Jaeckel E. Transient increase of activated regulatory T cells early after kidney transplantation. Sci Rep. Jan 31;9(1):1021. doi: 10.1038/s41598-018-37218-x.
  
  
• Sake HJ, Frenzel A, Lucas-Hahn A, Nowak-Imialek M, Hassel P, Hadeler KG, Hermann D, Becker R, Eylers H, Hein R, Baars W, Brinkmann A, Schwinzer R, Niemann H, Petersen B. Possible detrimental effects of beta-2-microglobulin knockout in pigs. Xenotransplantation. May 22:e12525. doi: 10.1111/xen.12525. [Epub ahead of print]

2018

• Buermann A, Petkov S, Petersen B, Hein R, Lucas-Hahn A, Baars W, Brinkmann A, Niemann H, Schwinzer R. Pigs expressing the human inhibitory ligand PD-L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties. Xenotransplantation. Feb 15. doi: 10.1111/xen.12387.
  
  
• Rieblinger B, Fischer K, Kind A, Saller BS, Baars W, Schuster M, Wolf-van Buerck L, Schäffler A, Flisikowska T, Kurome M, Zakhartchenko V, Kessler B, Flisikowski K, Wolf E, Seissler J, Schwinzer R, Schnieke A. Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus. Xenotransplantation Jan 23. doi: 10.1111/xen.12382.
  
  
• Thude H, Rother S, Sterneck M, Klempnauer J, Nashan B, Schwinzer R, Koch M. The killer cell lectin-like receptor B1 (KLRB1) 503T>C polymorphism (rs1135816) and acute rejection after liver transplantation. HLA. Jan;91(1):52-55. doi: 10.1111/tan.13172.

2016

• Bähr A, Käser T, Kemter E, Gerner W, Kurome M, Baars W, Herbach N, Witter K, Wünsch A, Talker SC, Kessler B, Nagashima H, Saalmüller A, Schwinzer R, Wolf E, Klymiuk N. Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs. PLoS One. 2016 May 13;11(5):e0155676. doi: 10.1371/journal.pone.0155676.
  
  
• Buermann A, Römermann D, Baars W, Hundrieser J, Klempnauer J, Schwinzer R. Inhibition of B-cell activation and antibody production by triggering inhibitory signals via the PD-1/PD-ligand pathway. Xenotransplantation 23, 347-56.
  
  
• Fischer K, Kraner-Scheiber S, Petersen B, Rieblinger B et al. Efficient production of multi-modified pigs for xenotransplantation by cobineering, gene stacking and gene editing. Nature Scientific Reports 2016; doi: 10.1038/srep29081

2015

• Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res; 47(1):31-5.
  
  
• Rother S, Hundrieser J, Pokoyski C, Kollrich S, Borns K, Blasczyk R, Poehnert D, Klempnauer J, and Schwinzer R. The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules. PloS one 10, e0135682.
  
  
• Pokoyski C, Lienen T, Rother S, Schock E, Plege-Fleck A, Geffers R, and Schwinzer R. Overexpression of CD45RA isoforms in carriers of the C77G mutation leads to hyporeactivity of CD4CD25Foxp3 regulatory T cells. Genes and immunity 10. doi: 10.1038/gene.2015.39. (in press)

2014

• Plege-Fleck A, Lieke T, Romermann D, Duvel H, Hundrieser J, Buermann A, Kraus L, Klempnauer J, and Schwinzer R. Pig to rat cell transplantation: reduced cellular and antibody responses to xenografts overexpressing PD-L1. Xenotransplantation 21, 533-542.

2012

• Vondran FW, Timrott K, Kollrich S, Klempnauer J, and Becker T*/Schwinzer R*. Decreased frequency of peripheral CD4(+) CD161(+) Th(17) -precursor cells in kidney transplant recipients on long-term therapy with Belatacept. Transpl Int 25, 455-463. *equal senior authorship.

2011

• Hauschild J, Petersen B, Santiago Y, Queisser AL, Carnwath JW, Lucas-Hahn A, Zhang L, Meng X, Gregory PD, Schwinzer R, Cost GJ, and Niemann H. Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci U S A 108, 12013-12017.
  
  
• Petersen B, Ramackers W, Lucas-Hahn A, Lemme E, Hassel P, Queißer A-L, et al. Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys. Xenotransplantation; 18: 355–368.

2010

• Plege A. Borns K, Baars W, Klempnauer J, Schwinzer R. Downregulation of cytolytic activity of human effector cells by transgenic expression of human PD-Ligand-1 on porcine target cells. Transplant Int 23:1293-300
  
  
• Vondran, FWR, Timrott K, Tross J, Kollrich S, Schwarz A, Lehner F, Klempnauer J, Becker T, Schwinzer R. Impact of Basiliximab on regulatory T-cells early after kidney transplantation: down-regulation of CD25 by receptor modulation. Transplant Int, 23:514-23

2009

• Plege A., Borns K, Baars W, Schwinzer R. Suppression of human T cell activation and expansion of regulatory T cells by pig cells overexpressing PD-Ligands. Transplantation 87:975-982

2006

• Do HT, Baars W, Borns K, Windhagen A, Schwinzer R. The 77C→G mutation in the human CD45 (PTPRC) gene leads to increased intensity of TCR signaling in T cell lines from healthy individuals and patients with multiple sclerosis. J Immunol 176:931-938
  
  

2000

• Jacobsen, M., Schweer, D., Ziegler, A., Gaber, R., Schock, S., Schwinzer, R., Wonigeit, K., Lindert, R.B., Kantarei, O., Schaefer-Klein, J., Schipper, H.I., Oertel, W.H., Heidenreich, F., Weinshenker, B.G., Sommer, N., and Hemmer, B. A point mutation in PTPRC (CD45) is associated with the development of multiple sclerosis. Nature Gen 26, 495-499.
  
  

1990

• Schwinzer R and Wonigeit K. Genetically determined lack of CD45R- T cells in healthy individuals: Evidence for a regulatory polymorphism of CD45R antigen expression. J Exp Med 171:1803-18088