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Seminars

i-Target Seminars

 

Location for results colloquium, journal club, educational colloquium and research seminars

Seminar room A0.11 (Lindwurmstraße 2a, MKG-Chirurgie (Ground floor, right side))

 

Time

Results colloquium or educational colloquium: Monday, 17:00 to 18:00

Journal club: Monday, 18:00 to 18:30

 

Winter semester 2022/2023 

 

No. Date Speaker Topic
326 March 27th, 2023
Guest speaker Dr. Johannes vom Berg Local Immunotherapy of Brain Cancer with Compartment Locked Biologics - Science & Translation
325 March 20th, 2023
Results colloquium Amar Hadzic, AG Theurich Metabolic engineering of T cells through ectopic expression of CD98
Journal club Mila Gislon, AG Kobold Su et al. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome, Nature 2022
324 March 13th, 2023
Results colloquium David Andreu Sanz, AG Kobold Cytokine stimulation to improve adoptive cell therapy
Journal club Maximilian Zwermann, AG Feuchtinger Lanna et al. An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory, Nature Cell Biology 2022
323 March 6th, 2023
Results colloquium Jan Gärtig, AG Anz Block the riposte: Influence of CCL22 on GM-CSF-based cancer immunotherapy
Journal club Martin Kirmaier, AG Theurich Ye et al. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means
to enhance CAR-T therapy, Cell Metabolism2022
322 February 20th, 2023
Educational colloquium Dr. Marcel Trefny, AG Kobold Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
Journal club Lisa Rohrbacher, AG Subklewe Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma, Science Advances 2023
321 February 13th, 2023
Results colloquium Monika Sponheimer, AG Subklewe The two sides of the coin: pro-inflammatory stimuli lead to upregulation of CD70 in AML, but also reduce NK-cell based immunotherapy efficacy
Journal club Pia Winter, AG Kobold CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models, Science translational medicine 2022
320 February 6th, 2023
Results colloquium Anja Wittner, AG Hopfner Achieving T cell co-stiumlation via OX40L fusion antibodies
Journal club Alina Schwedas, AG Feuchtinger Se-Chang et al. NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse, Nature Immunology 2023
319 January 30th. 2023
Results colloquium Eva Grüner, AG Grüner High burden of HPV infection in people living with HIV – Baseline description

Journal club 

cancelled 
318

January 23th, 2023

Results colloquium

Lena Jablonowski, AG Feuchtinger CRISPR-screen based identification of target genes controlling bi-specific T-cell engager therapy (BiTE) in acute lymphoblastic B-lineage leukemia

Journal club

Sabine Oganesian, AG Theurich Borcherding N, et al. Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood, Cell Metabolism 2022
317

January 9th, 2023

Results colloquium

Lisa Gregor, AG Kobold Development of new CAR T cells for hepatocellular carcinoma (HCC)

Journal club

Julia Teppert, AG König/Schnurr Brägelmann et al. MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I, Nature Communications 2021
316

December 19th, 2022

Results colloquium

Janina Dörr, AG Kobold Generation of Prostaglandin E2-resistant CAR T cells

Journal club

Luisa Fertig, AG Kobold  Anthony-Gonda et al. In vivo killing of primary HIV-infected cells by peripheral-injected early memory-enriched anti-HIV duoCAR T cells JCI insight, 2022
315

December 12th, 2022 

Results colloquium

Magdalena Zaucha, AG Rothenfußer  Genetic factors and immune characteristics influencing the immune response to the yellow fever vaccination

Journal club

Anja Wittner, AG Hopfner Nishiga et al. Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect, Nature Cancer 2022
314

December 5th, 2022

Results colloquium

Magdalena Zaucha, AG Rothenfußer  cGAS/STING

Journal club

Judith Rial Saborido, AG Mougiakakos Hong et al. OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment, Science Immunology 2022
313

November 28th, 2022

Research colloquium

Prof. Dr. Frederick Klauschen  Al in Cancer Research and Diagnostics 
312

November 21st, 2022

Results colloquium

Jingke Tu, AG Theurich The differentiation of obesity-associated NK cells from hematopoietic stem/progenitor cells

Journal club

Ramya Nair, AG Baldauf Zhang et al. A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepi topes targetable by immunotherapy Cancer Cell, 2022
311

November 14th, 2022

Results colloquium

Duc Huynh, AG Kobold NK memory formation 

Journal club

Antonio Santos, AG Rothefußer  Woodruff et al: Dysregulated naive B cells and de novo autoreactivity in severe COVID-19, Nature2022
310

November 7th, 2022

Results colloquium

Jonathan Trautwein, AG Mougiakakos/Mackensen Characterization of ferroptosis-an iron dependent form of regulated cell death in T cells

Journal club

Christina Tsiverioti, AG Kobold Zhu et al. Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression, Immunity 2017
309

October 24th, 2022

Educational colloquiium

Dr. Maryam Kazerani Characterization of ferroptosis-an iron dependent form of regulated cell death in T cells

Journal club

Magdalena Zaucha, AG Rothefußer  Zhu et al. Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression, Immunity 2017
308

October 17th, 2022

Results colloquium

Antonio Santos, AG Rothenfußer Cross-reactive antibodies increase the immunogenicity of the yellow fever 17D vaccine

Journal club

Nicolas Röhrle, AG König-Schnurr Mirji, G. et al. The microbiome-derived metabolite TMAO drives immune activation and boots responses to immune checkpoint blockade in pancreatic cancer. Science Immunoloy 2022

Summer semester 2022 

 

No. Date Speaker Topic
316 December 19th, 2022
Results colloquium Janina Dörr, AG Kobold Generation of Prostaglandin E2-resistant CAR T cells
Journal club Luisa Fertig, AG Kobold 

Anthony-Gonda et al. In vivo killing of primary HIV-infected cells by peripheral-injected early memory-enriched anti-HIV duoCAR T cells JCI insight, 2022

315 December 12th, 2022 
Results colloquium Magdalena Zaucha, AG Rothenfußer  Genetic factors and immune characteristics influencing the immune response to the yellow fever vaccination
Journal club Anja Wittner, AG Hopfner  Nishiga et al. Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect, Nature Cancer 2022
314 December 5th, 2022
Educational colloquium Prof. Dr. Karl-Peter Hopfner cGAS/STING
Journal club Judith Rial Saborido, AG Mougiakakos Hong et al. OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment, Science Immunology 2022
313 November 28th, 2022
Research colloquium Prof. Dr. Frederick Kluaschen  Al in Cancer Research and Diagnostics 
312 November 21st, 2022
Results colloquium Jingke Tu, AG Theurich The differentiation of obesity-associated NK cells from hematopoietic stem/progenitor cells
Journal club Ramya Nair, AG Baldauf Zhang et al. A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepi topes targetable by immunotherapy Cancer Cell, 2022
311 November 14th, 2022
Results colloquium Duc Huynh, AG Kobold NK memory formation 
Journal club Antonio Santos, AG Rothefußer  Woodruff et al: Dysregulated naive B cells and de novo autoreactivity in severe COVID-19, Nature2022
310 November 7th, 2022
Results colloquium Jonathan Trautwein, AG Mougiakakos/Mackensen Characterization of ferroptosis-an iron dependent form of regulated cell death in T cells
Journal club Christina Tsiverioti, AG Kobold Zhu et al. Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression, Immunity 2017
309 October 24th, 2022
Educational colloquiium Dr. Maryam Kazerani T cell evolution
Journal club Magdalena Zaucha, AG Rothefußer  Laurent et al. Sensingof SARS-CoV-2 by pDCs andthier subsequent production of IFN-I conttribute to macrophage-induced cytokine storm during COVID-19, Science Immunology 20022
308 October 17th, 2022
Results colloquium Antonio Santos, AG Rothenfußer Cross-reactive antibodies increase the immunogenicity of the yellow fever 17D vaccine
Journal club Nicolas Röhrle, AG König-Schnurr Mirji, G. et al. The microbiome-derived metabolite TMAO drives immune activation and boots responses to immune checkpoint blockade in pancreatic cancer. Science Immunoloy 2022
307 September 26th, 2022 
Results colloquium Monika Sponheimer, AG Subklewe The two sides of the coin: pro-inflammatory stimuli lead to upregulation of CD70 in AML, but also reduce NK-cell-based immunotherapy efficacy
Journal club  Lina Majed, AG Kobold Albrengues et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice, Sciences 2018
306 September 19th, 2022
Educational colloquium Dr. rer. nat. Donjete Simnica, AG Kobold Next-generation Sequencing of Adaptive Immune Receptor Repertoires (AIRR-Seq)
Journal club Magdalena Zaucha, AG Rothenfußer  cancelled
305 July 25th, 2022
Results colloquium Florian Märkl, AG Kobold Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma
Journal club Adriano Carboniero, AG Theurich Caputa et al., Intracellular infection and immune system cues rewire adipocytes to acquire immune function, Cell Metabolism 2022 
304 July 18th, 2022
Results colloquium  Anja Wittner, AG Hopfner Tumor-targeted fusion antibodies provide T-cell co-stimulation via OX40 signaling
Journal club Kevin Bahner, AG Anz Tahtinen et al. IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines, Nature Immunology 2022
303 July 11th, 2022
Educational colloquium

Dr. Selina Keppler, AG Ruland

B cells and (auto-)antibodies as novel players in intestinal inflammation

Journal club

Abhinav Joshi, AG Ruland

Yshii et. Al Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation, Nature Immunology 2022

302 July 4th, 2022
Results colloquium 

Sabine Oganesian, AG Theurich 

Spatio-functional characterization of tumor-infiltrating B cells in cutaneous T cell lymphoma

Journal club

Heike Anders, AG Lauber 

Patin et al. Harnessing radiotherapy-induced NKcell activity by combining DNA damage–response inhibition and immune checkpoint blockade, Journal for ImmunoTherapy of Cancer 2022

301  June 27th, 2022
Results colloquium  Heike Anders, AG Lauber 

Inhibition of the DNA Damage Response in Sarcoma

Results colloquium 

Daniel Bergér, AG Kobold

Dual Targeting of leukemic stem cells​ in AML

300 June 20th, 2022
Guest Speaker 

Prof. Wischusen, Würzburg

Moving a new target into the clinics: From early discoveries on GDF-15 to the GDFATHER trial

Jounal club

Lisa Gregor, AG Kobold

T. Stüber,…J. Wischhusen et al. Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-­specific CAR T-­cells against triple-negative breast cancer, Journal of ImmunoTherapy of Cancer 2020

299 June 13th, 2022
  Results colloquiium 

Daniel Bergér, AG Klein

cancelled

journal club 

Jonathan Trautwein, AG Mougiakakos/Mackensen

Han et al. PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity, Biomedical and Biophysical Research Communications 2021

298 May 30th, 2022

Guest Speaker PD Dr. med. Arndt Schottelius, Chief Scientific Officer Affimed, Heidelberg.

Innate Cell Engagers - Harnessing Innate Immunity to Fight Cancer

297 May 23th, 2022
Guest Speaker Prof. Dr. Maya Saleh, University of Bordeaux Exploiting innate immunity for cancer immunotherapy
296 May 16th, 2022
Results colloquium Alexandra Leutbecher, AG Subklewe Characterization of Ovarian Cancer and Evaluation of a TCB targeting Wilm’s Tumor 1 to Treat Ovarian Cancer
cancelled Journal club Anne Marie Senz, AG König-Schnurr Jin et al. CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in sold cancers, Nature Biomedical Engineering 2022
295 May 9th, 2022
cancelled Results colloquium Miriam Back, AG Feuchtinger Characterisation of high ranked transcription factors in transcriptomes from T cells of patients with acute lymphatic leukemia
Results colloquium Veronika Igl, AG Kobold CD180 CAR T cells and their possibilities in haematological malignancies
294 May 2nd, 2022
Educational colloquium Dr. med. Daniel Böhmer, AG König-Schnurr Endogenous dsRNAs and their recognition by the innate immune system
Journal club Jingle Tu, AG Theurich Poznanski et al. Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment, Cell Metabolism 2021
293 April 4th, 2022
Guest Speaker Dr. Daniela Thommen, NKI Amsterdam Dissecting and modulating reactive anti-tumor immunity in human cancers
Journal club Thaddäus Strzalkowski, AG Kobold Agarwalla et al. Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells, Nature Biotechnology 2022
293 April 25th, 2022
Results colloquium Abhinav Joshi, AG Ruland PD-1 represses mTOR activity in pre-malignant cells
Journal club Alejandra Hernandez Caceres, AG Hopfner Belmontes et al. Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors, Science Translational Medicine 2021
291 April 4th, 2022
Guest Speaker Lauriane Cabon, PhD, F. Hoffmann-La Roche AG, Basel Reimagining preclinical safety assessment of cancer immunotherapeutics
Journal club Elena Nikolova, AG Rothenfußer Glaros et al. Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response, Immunity 2021

 

 

 

 

Winter semester 2021/2022

 

No. Date Speaker Topic
290 March 28th, 2022
Results colloquium Anne Marie Senz, AG König/Schnurr Combining RIG-I-targeted therapy with CAR T cells to treat pancreatic cancer
Journal club Frederike Warlitz, AG Feuchtinger Melenhorst et al. Decade-long leukaemia remissions with persistence of CD4+ CAR T cells, Nature 2021
289 March 21th, 2022
Results colloquium Judit Rial Saborido, AG Mougiakakos/Machensen Metabolic adaptation of T cells in Chronic lymphocytic leukemia
Journal club Sebastian Spajic, AG Kobold Gahessmi et al. Rapid manufacturing of non-activated potent CAR T cells, Nature Biomedical Engineering 2022
288 March 14th, 2022
Guest Speaker Frau Prof. Helfrich, LMU Hospital Munich Plasticity & Resistance in Melanoma – The chicken or egg hypothesis
Journal club Sabine Oganesian, AG Theurich Liu et al. Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma, Nature Communication 2022
287 March 7th, 2022
Results colloquium Jan Gaertig, AG Anz Block the riposte: Influence of CCL22 on GM-CSF-based cancer immunotherapy
Journal club David Andreu Sanz, AG Kobold Prinzing et al. Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity, Science Translation Medicine 2021
286 February 28th, 2022
Results colloquium Anna-Kristina Kluever, AG Kobold Th9 CD4+ T cells as effector cells for CAR T cell therapy
Journal club Monika Sponheimer, AG Subklewe Mansilla-Soto et al., HLA-independent T cell receptors for targeting tumors with low antigen density, Nature medicine 2022
285 February 21th, 2022
Educational colloquium Dr. Martin Böttcher, AG Mougiakakos/Mackensen CSI in the Lab: Metabolicc profiling of cells
Journal club Theresa Seifert, AG Rothenfusser Jarosch et al. Multiplexed imaging and automated signal quantification in formalin-fixed paraffin-embedded tissues by ChipCytometry, Cell Reports Methods 2021
284 February 14th, 2022
Results colloquium Lisa Rohrbacher, AG Subklewe CARs and Bi(TE)cycles on the way to cure AML
Journal club Antonia Beimert, AG Anz Davar et al. Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients, Science 2021
283 February 7th, 2022
Results colloquium Alejandra Hernandez Caceres, AG Hopfner First steps in the development and characterization of a T cell regulating monoclonal antibody
Journal club Amar Hadzic, AG Theurich Sun et al. Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion, Nature 2021
282 January 31th, 2022
i-Target Quiz Emanuele Carlini, AG Kobold Heitzeneder et al. GPC2-CAR T cells turned for low antigen density mediate potent activity against neuroblastoma without toxicity, Cancer Cell 2022
281 January 24th, 2022
Educational colloquium Dr. med. Sophia Stock, AG Kobold The Process of CAR-T Cell Therapy
Journal Club Titus Butzlaff, AG Feuchtinger Gardner et al. Engineering CAR-T cells to activate small-molecule drugs in situ, Nature Chemical Biology 2021
280 January 17th, 2022
Results colloquium Amar Hadzic, AG Theurich Metabolic engineering of murine T cells via ectopic expression of the large neutral amino acid transporter 1 (LAT1, CD98)
Journal Club Daniel Bergér, AG Klein Luo et al. Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration, Cell death and Disease 2020
279 January 10th, 2022
Results colloquium Stephanos Michaelides, AG Kobold Generating a human chemokine receptor library as a screening platform for T cell infiltration in Adpotive Cellular Therapy
Journal Club Larsen Vornholz, AG Ruland Wu et al. Interferon-independent activities of Mammalian STING mediate antiviral response and tumor immune evasion, Immunity 2020
278 Dezember 13th, 2021
Educational colloquium Dr. Maike Buchner, AG Ruland B cell development, antibody production, and malignant transformation
Journal club Lisa Rohrbacher, AG Subklewe Good et al. An NK-like CAR T cell transition in CAR T cell dysfunction, Cell 2021
277 Dezember 6th, 2021
Results colloquium Janina Dörr, AG Kobold Prostaglandin E2-resistant CAR T cells
Journal club Veronika Igl, AG Kobold Haftmann et al. Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of Treg development, Science Immunology 2021
276 November 29th, 2021
Results colloquium  Magdalena Zaucha, Ag Rothenfußer Host and genetic factors influencing the immune response to Yellow Fever vaccination
Journal club Anja Wittner, AG Hopfner Moghimi et al. Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma, Nature Communications 2021
275 November 22nd, 2021
Results colloquium Jonathan Trautwein, AG Mougiakakos/Mackensen Ferroptosis-an iron dependent form of regulated cell death in immune cells
Journal club Ramya Nair, AG Baldauf Xu et al. An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma, Nature Communications 2021
Canceld, postponed to 2022 November 15th, 2021
Guest speaker Prof. Dr. med. Frederick Klauschen, Direktor Pathalogisches Institut, LMU
274 November 8th, 2021
Results colloquium Anne Marie Senz, AG König/Schnurr Combining RIG-I-targeted therapy with CAR T cells to treat pancreatic cancer
Journal club Sabine Oganesian, AG Theurich Phillips et al. Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
273 October 25th, 2021
Results colloquium Alexandra Leutbecher, AG Subklewe Characterization of ovarian cancer and evaluation of a bifunctional antibody in ovarian cancer
Journal club Anne Marie Senz, AG König/Schnurr Johnson et al. The immunostimulatory RNARN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function, Cell 2021
272 October 11th, 2021
Results colloquium Larsen Vorholz, AG Ruland Role of CBM signaling in autoinflammatory disease
Journal club Judit Rial Saborido, AG Mougiakakos/Mackensen Luu et al. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer, Nature Communications 2021
271 October 4th, 2021
Results colloquium Antonio Santos del Peral, AG Rothenfußer Impact of pre-existing immunity on the response to Yellow Fever Virus
Journal club Jan Gärtig, AG Anz Abdel-Hakeem et al. Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation, Nature Immunology 2021

 

 

 

 

Summer semester 2021

 

No. Date Speaker Topic
270 September 27th, 2021
Guest speaker

Dr. James Yarmolinsky,
University of Bristol

Using human genetics to evaluate the causal role of circulating inflammatory markers in risk of adult cancer
269 September 20th, 2021
Results colloquium Laura Velezmoro, AG Lauber Inhibition of DNA damage response in sarcoma: Radiosensitization and more
Journal club Anna-Kristina Klüver,
AG Kobold
Weber et al. Transient “rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling, Science 2021 
268 September 13th, 2021
Results colloquium Martin Kirmaier, AG Theurich Adapting immune cells to the nutrient deprivation in the tumor microenvironment by Solute Carrier (Slc) Overexpression
Journal club Lisa Brandmeir, AG Ruland Kohlhaas er al. Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1, Blood 2021 
267 September 6th, 2021
Educational colloquium Dr. Florian Gothe Multisystemic autoimmunity as a consequence of variants in the beta-chain of the IL-2 receptor impairing Treg survival and NK/CD8-T cell maturation
Journal club Paul Trinkner, AG Theurich Cortellini et al. Another side of the association between body mass index (BMI) and clinical outcomes of cancer patients receiving programmed cell death protein-1 (PD-1)/ Programmed cell death-ligand 1 (PD-L1) checkpoint inhibitors, European Journal of Cancer 2021
Summer break until September 6th 2021
266 July 19th, 2021
Results colloquium Ann-Sophie Schücke,
AG Kobold
Investigation of thermosensitive fluorchromes
Journal club Daryna Kechur, AG Kobold Griffin et al. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity, Nature 2021 
265 July 12th, 2021
Results colloquium Duc Huynh, AG Kobold NK Memory Formation
Introduction round
264 July 5th, 2021
Educational colloquium Dr. rer. nat. Lars König Targeting innate immune receptors for immunotherapy of tumors
Journal club Florian Märkl, AG Kobold Forsberg et al. HER2 CAR-T cells eradicate uveal melanoma and T-cell therapy–resistant human melanoma in IL2 transgenic NOD/SCID IL2 receptor knockout mice, Cancer Research 2019
263 June 28th, 2021
Results colloquium Lisa Rohrbacher, AG Subklewe On the road to cure AML: Bi(TE)cycles versus CARs
Journal club Stefanos Michaelides,
AG Kobold
Guo et al. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity, Nature Immunology 2021
262 June 21th, 2021
Results colloquium

Isabel Brand/Leonard Gilberg, Infectiology/AG Kobold

Broad T cell targeting of structural proteins after SARS-CoV-2 infection
Journal club Duc Huynh, AG Kobold Rousso-Noori et al. P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas, Nature Communications 2021
261 June 14th, 2021
Educational colloquium PD Dr. Hanna-Mari Baldauf SAMHD1 as a biomarker for cytarabine drug resistance in AML cells
Journal club Larsen Vornholz, AG Ruland Lu et al. DNA Sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity, Cancer Cell 2020
260 June 7th, 2021
Results colloquium Öykü Umut, AG Kobold Improvement of adoptive T cell therapy of solid tumors with combined expression of chemokine receptors CCR4 and CXCR6 in CD8+ T cells
Journal club Monika Sponheimer,
AG Subklewe
Sauer et al. CD70 specific CAR T-cells have potent activity against acute myeloid leukemia without HSC toxicity, Blood 2021.
259 May 31th, 2021
Results colloquium Daniel Bergér, AG Klein Dual targeting of AML cancer stem cells
Journal club Leonrad Gilberg, Infectiology/AG Kobold Ogbe at al. T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses, Nature Commun. 2021
258 May 17th, 2021
Educational colloquium Dr. Hadi Karimzadeh,
AG Rothenfußer
Viral escape mutations and persistent infections: a matter of concern for Covid-19 pandemic?
Journal club

Jonathan Trautwein,
AG Mougiakakos

Beatty et al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1, Nature Com. 2021
257 May 10th, 2021
Results colloquium Abhinav Joshi, AG Ruland Targeting mTOR signalling in Pd-1 null T cell NHL
Journal Club Theodora Ispyridou,
AG Feuchtinger
Awwad et al. Selective elimination of immunosuppressive T cells in patients with multiple myeloma, Leukemia 2021
256 May 3rd, 2021
Results colloquium Hannah Obeck, AG Kobold Inducible Apoptosis as a safetymechanism in adoptive T cell therapy
Journal Club Laura Sellmer, AG Tufman Lu et al. Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer, Nature Medicine 2020
255 April 26th, 2021
Educational colloquium Dr. Sonja Lacher,
AG Subklewe
Checkpoint Expression and Function in GvHD
Journal Club Laura Velezmoro, AG Lauber Zheng et al. Irradiation induces cancer lung metastasis through
activation of the cGAS–STING–CCL5 pathway in
mesenchymal stromal cells, Cell Death and Disease 2020
254 April 19th, 2021
Results colloquium Monika Sponheimer,
AG Subklewe
Evaluation of CD70 as an immunotherapeutic target for the treatment of acute myeloid leukemia
Journal club Ann-Sophie Schücke,
AG Theurich
Boulch et al. A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity, Science Immunology 2021
253 April 12th, 2021
Educational colloquium Dr. Björn Hiller, AG Hopfner Prevent collateral damage – know the off-target effects
Journal club Alexandra Leutbecher, 
AG Subklewe
Deuse et al. The SIRPα–CD47 immune checkpoint in NK cells, JEM 2021

 

Winter semester 2020/2021

 

No. Date Speaker Topic
252 March 29th, 2021
Results colloquium Judit Rial, AG Mougiakakos CLL cells impair T cells via lipotoxicity
Journal club Luisa Delius, AG König-Schnurr Xiao et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation, Cancer Cell 2021
251 March 22nd, 2021
Results Colloquium Vera Bauer, AG Mocikat Targeting regulatory T cells in an endogenous lymphoma mouse model
  Journal Club Janina Dörr, AG Kobold Yingzhong et al. Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity, Nature Cancer 2021
250 March 15th, 2021
Results colloquium Ruth Grünmeier, AG Kobold Dual T cell-based CSF1R targeting approach for the treatment of Hodgkin Lymphoma
Journal club

Moritz Schrenk, AG Rothenfußer

Wu et al. SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO, Cell Press 2021
249 March 8th, 2021
Educational Colloquium Prof. Dr. Sebastian Theurich The impact of energy metabolism on cancer and immune cells
Journal Club Isabel Brand, Infectiology/AG Kobold Sekine et al. Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID 19, Cell Press 2020
248 March 1st, 2021
Guest speaker Prof. Dr. Almut Schulze, DKFZ Heidelberg Targeting Lipid Metabolism in Cancer
247 February 22th, 2021
Results colloquium Nora Zieger, AG Subklewe Recovering from Burnout: Resting Mitigates CD19xCD3 BiTE®-Mediated T-Cell Exhaustion
Journal club Sophie Günther, AG Theurich Cortellini et al. Weighing the role of skeletal muscle mass and muscle density in cancer patients receiving PD-1/ PD-L1 checkpoint inhibitors: a multicenter real-life study, Nature 2020
246 February 15th, 2021
Results colloquium Anja Wittner, AG Hopfner Development and functional in vitro characterization of OX40L-fusion antibodies
Journal club Melanie Schwerdtfeger, AG Kobold Srivastava et al. Immunogenic chemotherapy enhances recruitment of CAR-T cells to lung tumors and improves antitumor efficacy when combined with checkpoint blockade, Cancer Cell 2020
245 February 8th, 2021
Results colloquium Sabine Oganesian, AG Theurich Characterization of the immunometabolic microenvironment in cutaneous T-cell lymphoma focusing on tumor infiltrating B cells
Journal club Juliane Grün, AG Anz Xu et al. Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4+ Treg cells in ovarian cancer cells microenvironment, Cell Death and Disease 2021
244 February 1st, 2021
Results colloquium Laura Sellmer, AG Tufman Theruvath et al. Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors, Nature Medicine 2020
Journal club Julian Kolorz, AG Kappler Morphological and molecular characteristics in NSCLC tumors and matched tumor bearing and non-tumor bearing lymph nodes
243 January 24th, 2021
Educational colloquium Dr. Katrin Manske, AG Kobold T cell immunity against viral infection of the liver
Journal club Lena Jablonowski, AG Feuchtinger Liu et al. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor, Nature Immunology 2021
242 January 18th, 2021
Results colloquium Lisa Pfeuffer, AG Ruland The role of Wasp-Interacting protein in B-cell acute lymphoblastic leukemia
Journal club Daniel Bergér, AG Klein Forte et al. Bone marrow mesenchymal stem cells support acute myeloid leukemia bioenergetics and enhance antioxidant defense and escape from chemotherapy, Cell Metabolism 2020
241 January 11th, 2021
Results colloquium Florian Märkl, AG Kobold Bispecific antibody-driven synthetic agonistic receptor-transduced T cell mediate specific and conditional therapy in melanoma cancer models
Journal club Malte Ohlemeyer, AG Subklewe HS Han et al. TOX-expressing terminally exhausted tumor-infiltrating CD8+ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer, Cancer Letters 2021
240 December 14th, 2020
Results colloquium Magdalena Zaucha, AG Rothenfußer Genetic factors influencing the immune response to Yellow Fever vaccination.
i-Target Quiz
239 December 7th, 2020
Educational colloquium Dr. Christof Winter, AG Ruland Liquid profiling of head and neck cancer patients in blood and saliva
Journal club Ruth Grünmeier, AG Kobold Amor et al. Senolytic CAR T cells reverse senescence-associated pathologies, Nature 2020
238 November 30th, 2020
Results colloquium Janina Dörr, AG Kobold Influence of interleukin-37 on cancer
Journal club Anja Wittner, AG Hopfner Semionatto et al. Extracellular vesicles produced by immunomodulatory cells harboring OX40 ligand and 4‐1BB ligand enhance antitumor immunity, Scientific Reports 2020
237 November 23th, 2020
Guest speaker

Dr. Carsten Marr

Institute of Computational Biology, Helmholtz Zentrum München

Artificial intelligence in computational hematopathology 
236 November 9th, 2020
Results colloquium Jonathan Trautwein, AG Mougiakakos/Mackensen Ferroptosis-an iron dependent form of regulated cell death in immune cells.
Journal club Veronika Ecker, AG Ruland Chan et al. Signalling input from divergent pathways subverts B cell transformation, Nature 2020
235 November 2nd, 2020
Results colloquium Anne Marie Senz, AG König/Schnurr IDO1-deleted CAR T cells show improved  therapeutic efficacy in murine pancreatic cancer models
Journal club Hannah Obeck ,AG Kobold Liu et al. TGF-β suppresses type 2 immunity to cancer, Nature 2020
234 October 26th, 2020
Educational colloquium Dr. Heiko Bruns, AG Mougiakakos/Mackensen Effector mechanisms of therapeutic antibodies
Journal club Sabine Oganesian, AG Theurich Kumagai et al. The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies, Nature immunology 2020
233 October 19th, 2020
Results colloquium Larsen Vornholz, AG Ruland CBM signaling in innate immunity
Journal club Daryna Kechur, AG König/Schnurr Li et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection, Nature Communications 2020
232 October 12th, 2020
  Results colloquium

Malte Ohlmeyer,

AG Subklewe

Understanding the modulation of T cell function by costimulatory and coinhibitory molecules during continous application of CD19/CD3 T cell recruiting antibody constructs for treatment of B cell malignancies
Journal club

Sebastian Goresch,

AG Rothenfußer

Folegatti et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial, Lancet 2020
231 October 5th, 2020

Results colloquium

Antonio Santos,

AG Rothenfußer

Generation of protective anti-viral immunity by the effective immunopriming of yellow fever vaccine virus
Journal club

Jakob Jobst,

AG Kobold

La Sala et al. Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains. Nat. Commun. 2020

   

Summer semester 2020

 

No. Date Speaker Topic
230 29th of September
Results colloquium Wyona Claire Mate AG Feuchtinger The influence of the CD200 – CD200 receptor axis on the functionality of CAR T cells against acute lymphoblastic leukemia
Journal club Judit Rial Saborido AG Mougiakakos/Mackensen Manzo et al. Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells, JEM 2020
229 21th of September
Results colloquium Martin Kirmaier AG Theurich Adapting immune cells to the nutrient deprivation in the tumor microenvironment by solute carrier (Slc) overexpression.
Journal club Öykü Umut AG Kobold Nelson et al. Identification of human CD4+ T cell populations with distinct antitumor activity, Science Advances 2020
228 14th of September
Educational colloquium Dr. rer. nat. Lars König Databases, Resources and Online Tools for your PhD
Journal club Anne Marie Senz AG König-Schnurr Li et al. cGAS-STING–mediated DNA sensing maintains CD8+  T cell stemness and promotes antitumor T cell therapy, Sci. Transl. Med. 2020
227 7th of September
Results colloquium Melanie Schwerdtfeger AG Kobold Engineering synthetic agonistic receptor-transduced T-cells with chemokine receptors for improved homing in solid tumor models
Journal club Monika Sponheimer Riether et al. Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents, Nature medicine 2020
Summer break 27th of July until 7th of September
226 20th of July
(per Video) Results colloquium Nora Zieger AG Subklewe Recovering from Burnout: Resting Mitigates BiTE®-Mediated T-Cell Exhaustion
Journal club Duc Huynh AG Kobold Klichinsky et al. Human chimeric antigen receptor macrophages for cancer immunotherapy, Nature Biotechnology 2020
225 13th of July
(per Video) Educational colloquium Prof. Dr. Sebastian Kobold How to write an abstract and prepare a poster
Journal club Lisa Brandmeier AG Ruland Abdelrasoul et al. Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in philadelphia chromosome-positive acute lymphoblastic leukemia, Nat Communication 2020
224 6th of July 2020 Guest speaker
per Video Dr. Oliver Kepp, INSERM Paris Surface-exposed and soluble calreticulin: conflicting  biomarkers for cancer prognosis
223 29th of June 2020
per Video Results colloquium Dario Dhoqina AG Kobold Using an anti-CSF1R-CAR T cell therapy against solid tumors
Journal club Magdalena Zaucha AG Rothenfußer Tonnerre et al. Evolution of the innate and adaptive immune response in women with acute Zika virus infection, Nat. Mircobiol 2020
222 22th of June 2020
per Video Educational colloquium Dr. Selina Keppler AG Ruland Inflammation and (Auto-)Immunity in the gut
Journal club Jan Wulf AG Subklewe Teijeira et al. CXCR1 and CXCR2 Chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity, Immunity 2020
221 15th of June 2020 Guest speaker
(per Video)

Dr. med. Sarah Kim-Hellmuth

Dr. von Haunerschen Children’s Hospital, University Hospital LMU
Understanding the diversity of genetic
effects on gene expression in health and disease
220 25th of May 2020
(per Video) Results colloquium Lisa Pfeuffer AG Ruland The role of Wasp-interacting protein in pre B-ALL
Journal club Jonathan Trautwein AG Mougiakakos/Mackensen Kaparlov et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death, Nature Chemical Biology 2020
219 18th of May 2020
(per Video) Educational colloquium Dr. Anne Trefzer, AG Subklewe Antigen-exhausted CD4+ T cells deviate towards multiple states of anergy
Journal club Florian Märkl, AG Kobold Schober et al. Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection, Nature Immunology 2020
218 11th of May 2020
(per Video) Results colloquium Theo Lorenzini, AG Kobold Migration-optimized CAR T cell therapy for individual solid tumor patients

Journal club Laura Sellmer, AG Tufman

Yu et al. Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma. Journal of Toracic Oncology 2018

217 4th of May 2020 Guest speaker

Johannes vom Berg, PhD

Institute of Laboratory Animal Science,
University of Zurich

Local immunotherapy of brain cancer with
compartment locked biologics
216 27th of April 2020
(per Video) Results colloquium

Judit Rial Saborido

AG Mougiakakos

Metabolic alterations in T cells in the context of CLL
Journal club

Martin Kirmaier

AG Theurich

Roth et al. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies, Cell 2020
215  20th of April 2020
(per Video) Results colloquium

Vera Maria Bauer

AG Mocikat

Targeting regulatory T cells in an endogenous lymphoma mouse model
Journal club

Janina Dörr

AG Kobold

Millar et al. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy, Nature Biotechnology 2020

   

Winter semester 2019/2020

 

No. Date Speaker Topic
211-214  Pause due to the COVID pandemic
210 9th of March 2020
Journal club

Larsen Vornholz

AG Ruland

Luksch et al. STING-associated lung disease in mice relies on T cells but not type I interferon, J Allergy Clin Immunol 2019
209 2nd of March 2020
Educational colloquium

Prof. Lauber

AG Lauber

Radiotherapy in small animal models: Chances and challenges
Journal club

Melanie Schwerdtfeger

AG Kobold

Singh et al. Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction, Cancer Discovery 2020
208 24th of February 2020
Results colloquium

Julian Benkel

AG Subklewe

Intrinsic Resistance mechanisms to T-cell recruiting antibody constructs for therapy of AML.
Journal club

Daniel Lüthy

AG Berger

Li et al. Persistent polyfunctional chimeric antigen receptor T cells that target glypican 3 eliminate orthotopic hepatocellular carcinomas in mice, Gastroenterology 2020
207 17th of February 2020
Educational colloquium

Dr. Bastian Höchst

AG Knolle

Regulatory myeloid cells paralyze T cell immunity through cell-cell transfer of methylglyoxal
Journal club

Konstantin Schnell

AG Anz

Hatzioannou et al. An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion, Immunity 2019
206 10th of February 2020
Results colloquium

Saskia Schmitt

AG Hopfner

Multifunctional antibody derivative to target and activate dendritic cells in vivo
Journal club

Antonio Santos

AG Rothenfußer

Chng et al. Large-Scale HLA tetramer tracking of T cells during dengue infection reveals broad acute activation and differentiation into two memory cell fates, Immunity 2019
205 3rd of February 2020
Results colloquium

Lisa Brandmeier

AG Ruland

The Role of Diet and Exercise in CLL
Journal club

Dario Dhoqina

AG Kobold

Reinhard et al. An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors, Science 2020
204 27th of January 2020
Educational colloquium

Dr. Carolin Perleberg

AG Anz

Next generation sequencing – Applications and Hurdles
Journal club

Lisa Rohrbacher

AG Subklewe

Crowther MD et al. Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1, Nature Immunology 2020
203 20th of January 2020
Results colloquium

Daniel Berger

AG Klein

Dual targeting antibodies against AML steam cells.
Journal club

Theo Lorenzini

AG Kobold

Lynn et al. c-Jun overexpression in CAR T cells induces exhaustion resistance, Nature 2019
202 13th of January 2020
Results colloquium

Duc Huynh

AG Kobold

NK Memory Formation.
Journal club

Lisa Pfeuffer

AG Ruland

Guièze et al. Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies, Cancer Cell 2019
201 16th of December 2019
Results colloquium

Magdalena Zaucha

AG Rotherfußer

Analysis of expression quantitative trait loci after yellow fever vaccination.
Journal club

Matthias Seifert

AG Kobold

Scott et al. TOX is a critical regulator of tumour-specific T cell differentiation, Nature 2019
200 9th of December 2019
Educational colloquium

Dr. Lars König

AG König-Schnurr

Databases, Resources and Online Tools for your PhD.
199 25th of November 2019

Results colloquium

Larsen Vornholz

AG Ruland

CBM signaling in innate immunity

Journal Club

Wyona Claire Mate

AG Feuchtinger

Thaker et al. GTPase-activating protein RasalI associates with ZAP-70 of TCR and negatively regulates T cell tumor immunity, Nature Communications, 2019
198 18th of November 2019

Jan Böttcher

AG Böttcher (TUM)

Beyond pretty pictures – applying microscopic imaging techniques to resolve immune cell dynamics in tissues

Vera Maria Bauer

AG Mocikat (Helmholtz Zentrum)

Akkaya et al. Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells, Nature immunology 2019
197 11th of November 2019    
  Results Colloquium

Judit Rial Saborido

AG Mougiakakos

Implications of CD98 in Chronic lymphocytic leukemia
  Journal Club

Manouk Feinendegen

AG Kobold

Yang et al. Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity, Nature medicine, 2019
196 4th of November 2019

 

 
  Results Colloquium

Janina Dörr

AG Kobold

The influence of Interleukin-37 on cancer.
  Journal Club

Saskia Schmitt

AG Hopfner

Lee et al. Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters, Nature Communications 2019

195 28th of October 2019    
  Educational Colloquium

Dr.Martin Böttcher

AG Mougiakakos

Metabolism as a Determinant of Function
  Journal Club

Judit Rial Saborido

AG Mougiakakos

Mastelic-Gavillet et al. Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells,Journal for ImmunoTherapy of Cancer 2019
194 21th of October 2019

 

 
  Results Colloquium

Martin Kirmaier

AG Theurich

Adapting immune cells to the nutrient deprivation in the tumor microenvironment by solute carrier (SLC) overexpression.
  Journal Club

Laura Sellmer

AG Tufman

Mariathasan et al. TGFbeta attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells, Nature 2018
193 14th of October 2019    
  Results Colloquium

Anne Marie Senz

AG König-Schnurr

Indoleamine 2,3-dioxygenase 1 in T cells.
  Journal Club

Lisa Brandmeier

AG Ruland

Guièze et al. Mitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies, Cancer Cell 2019
192 7th of October 2019    
  Educational Colloquium

Bruno Cadilha

AG Kobold-Endres

Synergy of CCR8-guidance and TGF-β-resistance enables CAR T cells to reject pancreatic tumors.
  Journal Club

Arman Öner

AG Kobold-Endres

Langan et al. De novo design of bioactive protein switches, Nature 2019

   

 

Summer semester 2019

 

No. Date Speaker Topic
191 30th of September 2019
Results Colloquium

Florian Maerkl

AG Kobold-Endres

T cell engineering for improving T cell therapy in chronic lymphocytic leukemia.
Journal Club

Anja Wessely

AG Berking

Koopmans et al. Bispecific Antibody Approach for Improved Melanoma-Selective PD-L1 Immune Checkpoint Blockade,  Journal of Investigative Dermatology 2019
190 23rd of September 2019
Results Colloquium

Eva Ortner

AG Feuchtinger

Induction of T-cell attack against ALL through a TIM-3/CD28 fusion receptor.
Journal Club

Lisa Lehmann

AG Rothenfußer

Kao et al. Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection, Immunologists 2019
189 9th of September 2019
Results Colloquium

Duc Huynh

AG Kobold

TBA
Journal Club

Vasil Toskov

AG Feuchtinger

S. Gautam et al. The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity, Nature Immun 2019
188 22nd of July 2019
Guest Speaker

Prof. Dr. Angela Krackhardt

IIIrd Medical Department, Hematology and Oncology, Klinikum rechts der Isar, TU Munich

Development of personalised treatment and novel monitoring approaches for T-cell based immunotherapies in cancer
187 15th of July 2019
Educational Colloquium

Dr. Justyna Ogonek

AG Kobold

Chemokine receptor-overexpressing CAR T cells for enhanced adoptive therapy of solid cancer
Journal Club

Martin Kirmaier

AG Theurich

Hamieh et al. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape, Nature 2019
186 8th of July 2019
Results Colloquium

Anja Wessely

AG Berking

The transcription factor SOX10 and its functional role in uveal melanoma
Journal Club

Daniel Berger

AG Klein

F. Basheer et al. Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML, JEM 2019
185 1st of July 2019
Guest Speaker

Prof. Dr. Jörg Renkawitz

Biomedical Center Munich (BMC)

Principles of leukocyte navigation in 3D microenvironments.
 
184 24th of June 2019
Results colloquium Philipp Metzger

AG König-Schnurr

TBA.
Journal Club Mohamed-Reda Benmebarek

AG Kobold-Endres

Claus et al. Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy, Sci. Transl. Med 2019.
 
183 17th of June 2019
Results colloquium Lisa Rohrbacher

AG Subklewe

Effects of Idelalisib on immune cells.
Journal Club Siret Tahk

AG Hopfner

Su et al. Immune checkpoint inhibition overcomes ADCP-induced immunosuppression by macrophages, Cell 2018.
 
182 3rd of June 2019
Results colloquium Sascha Göttert

AG Haas/Poeck

The role of type I interferon-inducing metabolites in Prophylaxis of Graft-versus-Host disease.
Journal Club Carlotta Rambuscheck

AG König-Schnurr

XM. Evrard et al. Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector function, Cell Press 2018.
 
181 27th of Mai 2019
Results colloquium Dr. Maike Buchner

AG Ruland

Pathologically enforced RANK signaling in B Cells triggers autoimmune lymphoproliferation and chronic lymphoytic leukemia development.
Journal Club Konstantinos Panagiotidis

AG Mougiakaos

Xu et al. Translation control of the immune checkpoint in cancer and its therapeutic trageting, Nature medicine 2019.
 
180 20th of Mai 2019
Results colloquium Steffen Dickopf, Roche

AG Kobold-Endres

Next generation T cell bispecific antibodies.
Statistical lecture Larsen Vornholz

AG Ruland

Statistic lecture 101.
 
179 6th of April 2019
Results colloquium Jasmin Mahdawi

AG Feuchtinger

Generation and Characterization of CD19 CAR T cells with CTLA-4/CD28 fusion receptor.
Journal Club Janina Dörr

AG Kobold

Rosato et al. Virus-specific memory T cells populate tumors and can be repurposes for tumor immunotherapy, Nature communications 2019.
 
178 29th of April 2019
Results colloquium Prof. Dr. Marion Subklewe

AG Subklewe

The Evolution of Immunotherapy in AML.
Journal Club Lisa Rohrbacher

AG Subklewe

Poggio et al. Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory, Cell 2019.
 
177 15th of April 2019
Results colloquium Sehmus Tohumeken

AG Mackensen

AML exosomes promote TLR2-mediated induction of glycolytic MDSC.
Research Seminar Simone Formisano

AG König/Schnurr

Staedtke et al. Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome, Nature 2018.
 
176 8th of April 2019
Results colloquium Veronika Ecker

AG Ruland

Negative feedback inhibition as novel therapeutic approach in chronic lymphocytic leukemia
Research Seminar Kim Pawelka

AG Knolle

Smith et al. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors, JCI 2017.
 
175 1st of April 2019
Results colloquium Prof. Dr. Dimitrios Mougiakakos

AG Mougiakakos Erlangen

Stroma cells: an immune metabolic hub.
Journal Club Sascha Göttert

AG Poeck/Haas

Gopalakrishnan et al. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018.
 

 

Winter semester 2018/2019

 

  

No. Date Speaker Topic
174 25th of March 2019
Journal Club Larsen Vornholz

AG Ruland

Cox et al. Choline acetyltransferase-expressing T cells are required to control chronic viral infection, Science 2019.
 
173 18th of March 2019
Guest Speaker

Professor Charles Dinarello

University of Colorado, Denver

Role of NLRP3 regulation of IL-1beta in cancer.
 
172 11th of March 2019
Guest Speaker

Vincenzo Desiderio, Ph.D.

Inhibition of pentose phosphate pathway suppresses tumor growth and metastasis by inducing endoplasmic reticulum stress and autophagy.
 
171 4th of March 2019
Results colloquium Dr. Daria Briukhovetska

AG Kobold

The roles of C5a receptor 1 and chemokine receptor 5 in Toxoplasma gondii infection.
Journal Club Konstantinos Panagiotidis

AG Mougiakakos

Jones et al. Inhibition of amino acid metabolism selectively targets human leukemia stem cells, Cancer Cell 2018.
 
170 25th of February 2019
Results colloquium Javier Suarez Gosalvez

AG Kobold

The impact of interleukin-22 on metastasis formation.
Journal Club Natascha Röhrle

AG Anz

Spranger et al. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy, Cancer Cell 2017.
 
 
169 18th of February 2019
i-Target seminar awards 2018 the presentation of the i-Target seminar awards 2018 for the best talk, the best discussing person and the best journal club quiz performance.
Results colloquium

Daniel Bergér

AG Klein

Multi-specific Antibodies to target Cancer stem cells in AML via CD200.
Journal Club

Dana Stenger

AG Feuchtinger

Yamamoto et al. T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy, JCI 2019.
168 11th of February 2019
Results colloquium Dr. Laia Pascual Ponce

AG Hopfner

CD47-SIRPalpha: the myeloid-specific immune checkpoint.
Journal Club Clara Karches

AG Kobold

Feucht et al. Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency, Nature Medicine 2018.
 
167 4th February 2019
Results colloquium Alina Lohner

AG Subklewe

Expansion & Characterization of AML-specific T Cells to test novel in vivo DC targeting AB Constructs.
Journal Club Anne Marie Senz

AG Schnurr

André et al. Anti-NKG2A mAb is a checkpoint Inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells, Cell 2018.
 
166 21th January 2019
Educational colloquium Dr. Meino Rohlfs

AG Klein

Next generation sequencing.
Journal Club Magdalena Zaucha

AG Rothenfußer

Boettcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell 2018.
 
165 14th January 2019
Results colloquium Kim Pawelka

AG Knolle

iMATE-forming monocytes - a population with unique functional properties.
Journal Club Duc Huynh

AG Kobold

Wight et al. Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses, PNAS 2018.
 
164 7th January 2019
Results colloquium Svenja Rausch

AG Kobold

Effect of PD-1-CD28 fusion receptor transduced T cells in adoptive T cell therapy.
Journal Club Alina Lohner

AG Subklewe

Sahin et al: Personalized vaccines for cancer immunotherapy, Sciences 2018.
 
163 17th December 2018
Research Seminar Prof.Dr. Sebastian Theurich

Professorship for Cancer & Immuno-Metabolism, Attending Physician, Dpt. of Medicine III, University Hospital Munich

NK cells in Metaflammation
 
162 10th December 2018
Journal Club Daniel Bergér

AG Klein

Shivange et al. A single-agent dual-specificity targeting of FOLR1 and DR5 as an effective strategy for ovarian cancer, Cancer Cell 2018
 
161 3rd December 2018
Educational colloquium Dr. Nicholas Tokarew

AG Kobold

The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and its Relationship with the Sonic Hedgehog Pathway.
Journal Club Saskia Schmitt

AG Hopfner

Akahori et al. Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination, Blood 2018.
 
160 26th November 2018
Journal Club Eva Ortner

AG Feuchtinger

Han et al. Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Nature communications 2018.
 
159 19th November 2018
Results colloquium Corinna Meyer-Gehlen

AG Rothenfußer

Characterization of new potential MAVS interaction partners.
Journal Club Maryam Schübele

AG Kobold

Zhang et al. Blockade of the checkpoint receptor TIGIT prevent NK cell exhaustion and elicits potent anti-tumor immunity, Nature Immunology 2018.
 
158 12th November 2018
Results colloquium Dr. Heiko Bruns

AG Mackensen

Tumour associated macrophages and therapeutic antibodies.
Journal Club Tanja Stief

AG Feuchtinger

Osborn et al. CRISPR-based cellular engineering for targeted gene overexpression, Int. J. Mol. Sci. 2018.
 
157 5th November 2018
Results colloquium Paula Rothämel and Jonas Wilhelm

AG Feuchtinger

Blast-T cell interaction in pediatric leukaemia.
Journal Club Bruno Cadilha

AG Kobold

Deng et al. LILRB4 signaling in leukaemia cells mediates T cell suppression and tumour infiltration, Nature letters 2018.
 
156 29th October 2018
Results colloquium Mohamed-Reda Benmebarek

AG Kobold

Mesothelin-targeted bispecific antibodies drive synthetic agonistic receptor-transduced T cells to mediate specific and conditional therapy of human pancreatic cancer models.
Journal Club Judit Rial

AG Mougiakakos

Pilipow et al. Antioxidant metabolism regulates CD8+ T cell memory stem cell formation and antitumor immunity, JCI insight 2018.
 
155 22nd October 2018
Educational colloquium Prof. Dr. Percy Knolle

Local immune regulation in the liver: new insights into an organ with dual function in controlling immunity and metabolism.
Journal Club Jasmin Mahdawi

AG Feuchtinger

Lai et al. Toll-like receptor 2 costimulation potentiates antitumor efficacy of CAR T Cells, Leukemia 2018.
 
154 15th October 2018
Journal Club Johannes Lutz

AG Kobold

Adachi et al. Il-7 and CC19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor, Nature biotechnology 2018.
 

  

  

Summer semester 2018

(9th April 2018 till 14th July 2018)

153 8th October 2018
Results colloquium Lara Hartjes

AG Ruland

Identification of novel MALT1 substrate.
Journal Club Raphael Rubens

AG Kobold

Rafiq et al. Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo, Nature Biotechnology, 2018.
 
156 1st October 2018

Prof. Dr. Hans-Georg Rammensee

Head of the Department of Immunology, Institute for Cell Biology, University of Tübingen

On the development of personalized cancer vaccines
 
153 24th September 2018
Results colloquium Sehmus Tohumeken

AG Mackensen

AML exosomes promote induction of glycolytic MDSCs.
Journal Club Konstantinos Panagiotidis

AG Mougiakakos

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
 
153 10th September 2018
Educational colloquium Prof. Dr. Marion Subklewe

Women in science.
Results colloquium Bruno Cadilha

AG Kobold

C-C Chemokine receptor 8 and TGF-β-Receptor 2 genetic engineering combination make for successful Chimeric antigen receptor T cell therapy in solid tumors.
 
152 23th July 2018
Research colloquium Philipp Metzger

AG Schnurr

The role of IRF4 in MDSC in an orthotopic pancreatic cancer mode.
 
151 18th July 2018

PD Dr. Louisa von Baumgarten

Neurologische Klinik und Poliklinik, Klinikum Großhadern, München

In vivo imaging of brain tumors to monitor novel therapeutic strategies
150 9th July 2018
Educational colloquium Dr. Maike Buchner

AG Ruland

The impact of nutrition on cancer and immune cell signaling.
Journal club Philipp Metzger

AG Schnurr

Li et al. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy, Immunity 2018.
 
149 2nd July 2018
Journal club Sehmus Tohumeken

AG Mackensen

Wang et al. Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis, AACR Journal 2018
 
148 2nd July 2018

Professor Shaun McColl

Professor of Immunology, Head of Chemokine Biology, Faculty of Sciences, The University of Adelaide, Australia

Chemokines and their receptors in metastatic cancer.
 
147 25th June 2018
Results colloquium Dana Stenger

AG Feuchtinger

Generation of CD19 CAR T cells with a CRISPR/Cas9 mediated T cell receptor knock out.
Journal club Javier Suarez Gosalvez

AG Kobold

Brown et al. Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice, Science 2018.
 
146 18th June 2018
Educational colloquium Dr. Jin Zhang

AG Kobold

Understanding T cell receptor initial triggering.
Journal club Paula Rothämel

AG Feuchtinger

Morsut et al. Engineering customized cell sensing and response behaviors using synthetic notch receptors, Cell 2016.
 
145 11th June 2018
Educational colloquium Professor Lauber

AG Lauber

Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and precinical experiences.
Journal club Svenja Rausch

AG Kobold

Cho et al. Universal chimeric antigen receptors for multiplexed and logical control of T cell responses, Cell 2018 .
 
144 28th May 2018
Educational colloquium Justyna Ogonek

AG Kobold

CMV-specific T cells in immunotherapy for stem cell transplantation - associated complications.
Journal club Lara Hartjes

AG Ruland

Wong, B. Visual strategies for biological data, part I, Nat. Methods.
 
143 14th May 2018
Results colloquium Laura Frey

AG Klein

Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45).
Journal club Clarissa Zappe

AG Rothenfußer

Yu et al. Activation of the MDA5-IPS1 viral sensing pathway induces cancer cell death and type I interferon-dependent antitumor immunity, Cancer Res, 2016.
 
142 7th May 2018
Results colloquium Siret Tahk

AG Hopfner

Targeting the AML leukemic stem cell population using anti-CD123 antibodies that simultaneously disrupt the CD47–SIRPα interaction.
Journal club Simone Formisano

AG Schnurr

Xiaolin Yu, et al. Targeting EGFR/HER2/HER3 with a three-in-one aptamer-siRNA chimera confers superior activity against HER2+ breast cancer, Molecular Therapy, Nucleic Acids, 2017.
 
141 23th April 2018
Educational colloquium Daniel Böhmer

AG Schnurr

Molecular mechanisms of nucleic acid-mediated cytotoxicity.
Journal club Simon Dedic

AG Hopfner

Cheng et al. Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma, CellDeath and Disease, 2018.
 
140 16th April 2018
29th Research Seminar Dr. Georg Fertig

Head of Dept. Screening & Functional Assays, Large Molecule Research Roche, Penzberg

Transformative antibody therapeutics at Roche
 
139 9th April 2018
Results colloquium Bastian Meyer

AG Anz

Identification of functional receptors for CCL22 via APEX2 proximity labeling.
 

 

 

Winter semester 2017/2018

(16th Oktober 2017 till 10th February 2018)

No. Date Speaker Topic
138 26th March 2018
Results colloquium Saskia Schmitt

AG Hopfner

Multispecific antibody derivatives to target and activate dendritic cells in vivo.
Journal club Angelina Krächan

AG Kobold

Barrow et al. Natural killer cells control tumor growth by sensing a growth factor, Cell, 2018.
 
137 19th March 2018
Results colloquium Anna Maier

AG Subklewe

Influence of immunosuppressive cellular and humoral factors on T-cell function in Acute Myeloid Leukemia.
Journal club Kim Pawelka

AG Knolle

Wang et al. A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair, Cell, 2016.
 
136 12th March 2018
Results colloquium Raphael Kfuri Rubens

AG Schnurr

Indolamine 2,3-dioxygenase in T cells.
Journal club Svenja Rausch

AG Kobold

Böttcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell, 2018.
 
135 5th March 2018
Educational colloquium Dr. Martin Böttcher

AG Mougiakakos

2-HG-A a novel oncometabolite with immune modulation properties.
Journal club Veronika Ecker

AG Ruland

Kikushige et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia, Cancer Cell, 2011.
 
134 26th February 2018
Results colloquium Tanja Stief

AG Feuchtinger

CRISPR/Cas-mediated T cell editing for the treatment of refractory viral infections.
Journal club Magdalena Scheck

AG Rothenfußer

Clift et al. A method for the acute and rapid degradation of endogenous proteins, Cell, 2018.
 
133 19th February 2018
Results colloquium Julius Keyl

AG Kobold

Fusion receptor- transduced T cells combined with bispecific antibodies to improve the therapy of malignant melanomas.
Journal club Jonas Wilhelm

AG Feuchtinger

Duell et al. Frequency of regulatory T cells determines the outcome of theT-cell-engaging antibody blinatumomab in patients with B-precursor ALL, Leukemia, 2017.
 
132 12th February 2018
Educational colloquium Dr. Selina Keppler

AG Ruland

Dectin-1: a C- type lectin receptor on dendritic cells in antifungal immunity.
Journal club Clara Karches

AG Kobold

Lan et al. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β, Science Translational Medicine, 2018.
 
131 5th February 2018
28th Research seminar Ph.D., Ph.D. Santiago González Intravital characterization of the inflammatory response that follows vaccination in the draining lymph node
 
130 29th January 2018
Results colloquium Stefanie Lesch

AG Kobold

Whole transcriptome analysis of adoptively transferred tumor infiltrating T-cells.
Journal club Antonia Apfelbeck

AG Feuchtinger

Xiaojun et al. A chimeric switch-receptor targeting PD1 augments the efficacy of second generation CAR T-Cells in advanced solid tumors, Cancer Res, 2017.
 
129 22nd January 2018
Educational colloquium Dr. Claudia Roskopf

AG Hopfner

Insights into cell-mediated cytotoxicity and phagocytosis: how tumor cells are killed.
Journal club Raphael Kfuri Rubens

AG Schnurr

Routy et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science 2017.
 
128 15th January 2018
Results colloquium Kim Pawelka

AG Knolle

Unique functional properties of iMATE forming myeloid cells.
Journal club Steffeni Mountford

AG Bufler

Hong et al. Correction of a pathogenic gene mutation in human embryos. Nature 2017
 
127 8th January 2018
Results colloquium Clara Karches

AG Kobold

Synthetic agonistic receptors as an approach for immunotherapy.
Journal club Maurine Rothe

AG Subclewe

Shapiro et al. Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia. Haematologica, 2017.
 
126 18th December 2017
Results colloquium Mohamed-Reda Benmebarek

AG Kobold

Combination of bispecific antibodies with genetically modified T-cells for cancer immunotherapy.
Journal club Mohamed-Reda Benmebarek

AG Kobold

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nature medicine, 2017
 
125 11th December 2017
Educational colloquium Dr. Jin Zhang

AG Kobold

Phospholipid Scramblase 1 regulates T-cell antitumor immunity by activating PI3K signaling.
Journal club Steffeni Moundford

AG Bufler

NLRP1 promotes tumor growth by enhancing inflammasone activation and suppresisng apoptosis in metastatic melanoma. Oncogene, 2017
 
124 4th December 2017
Results colloquium Laura Frey

AG Klein

Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45).
Journal club Steffen Dickopf

AG Kobold

Patel et al. Identification of essential genes for cancer immuntherapy. Nature, 2017
 
123 27th November 2017
27th Research seminar Dr. Arndt Schottelius

Kymab, Cambridge UK

KY1044, a novel anti-ICOS antibody, elicits long term in vivo anti-tumour efficacy as monotherapy and in combination with immune checkpoint inhibitors.
 
122 20th November 2017
Results colloquium Steffen Dickopf

AG Kobold

A robust tool for optimizing CRISPR/Cas9-mediated gene editing - the whole story.
Journal club Dana Stenger

AG Feuchtinger

Hu B. et al. Augmentation of antitumor immunity by human and mouse CAR T Cells secreting IL-18. Cell Reports, 2017
 
121 13th November 2017
Results colloquium Javier S. Golsavez

AG Kobold

Impact of interleukin-22 on metastasis formation
Journal club Anna Maier

AG Subklewe

Mangaonkar A. et al. A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression. Scientific Reports, 2017
 
120 6th November 2017
26th Research seminar Dr. Alexander Buchner

Urologische Klinik und Poliklinik, Klinikum der Universität München

Basics of statistics - important for doctoral thesis and publication
 
119 16th October 2017
25th Research seminar Dr. Sebastian P. Haen

Med. Universitätsklinik, Tübingen

T cell reactivity against self-antigens - Autoimmunity after allogeneic hematopoietic cell transplantation 
 
118 9th October 2017
Results colloquium Prof. Duska Dragun

AG Subklewe

TBA
Journal club

cancelled
 
117 2nd October 2017
Results colloquium Lara Hartjes

AG Ruland

Identification of novel MALT1 substrates
Journal club

 

 

Summer semester 2017

(24th April 2017 till 29th July 2017)

No. Date Speaker Topic
116 25th September 2017
24th Research seminar Prof. Dr. Jürgen Bernhagen

Munich

Immune-mediated mechanisms in cardiovascular disease and cancer: focus on MIF proteins
 
115 18th September 2017
Educational colloquium

AG Mougiakakos

Immune metabolic interplay in cancer
Journal club Semjon Willier

AG Feuchtinger

Mezzadra R. et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 2017
 
114 24th July 2017
Educational colloquium Dr. Benedikt Jacobs

AG Mackensen

NK cells - from biology to clinical trials.
Journal club Sehmus Tohumeken

AG Mackensen

Liu Y. et al. Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell, 2016
 
113 17th July 2017
23th Research seminar Dr. Matthias Klinger

AMGEN Research, Munich

Innovative drug development at AMGEN
 
112 10th July 2017
Result colloquium Romy Loschinski

AG Mougiakakos

IL-21 as an immunometabolic T-cell modulator.
Journal club Javier Suarez Gosalvez

AG Kobold

Whole-body imaging of lymphovascular niches identifies pre- metastatic roles of midkine. Nature Letters, 2017
 
111 3rd July 2017
Educational colloquium Dr. Lars König

AG Kobold

How-to guide to creating CRISPR-KOs
Journal club Clara Karches

AG Kobold

Rulla M et al. Overcoming the immunosuppressive tumor microenviroment of Hodgking lymphoma using chimeric antigen receptor T cells. American Association for Cancer, 2017
 
110 26th June 2017
Results colloquium Bruno Cadilha

AG Kobold

Redirecting T cells through CCR8-CCL1 axis and shielding from TGF-β for effective adoptive T cell therapy
Journal club Tanja Stief

AG Feuchtinger

Rupp LJ et al. CRISPR/Cas9-mediated PD-1disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Nature, 2017
 
109 19th June 2017
22th Research seminar Dr. Rajkumar Savai

Max Planck Institute, Bad Nauheim

The lung tumor microenvironment: targeting the soil to kill the tumor seed
 
108 29th May 2017
Results colloquium Sehmus Tohumeken

AG Mackensen

Characterization and targeting of myeloid-derived suppressor cells in acute myeloid leukemia
Journal club Heike Anders

AG Lauber

Rodriguez-Ruiz M E et al. Abscopal effects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming, Cancer Research 2016
 
107 22th May 2017
Results colloquium Dr. Selina Keppler

AG Ruland

Imaging B cells: linking receptors, the actin cytoskeleton and aberrant immune responses
 
106 15th May 2017
Progress report Veronika Ecker

AG Ruland

Drug delivery improvement for leukemia and lymphoma
 
105 8th Mai 2017
Educational colloquium Dr. Marcin Lyszkiewicz

AG Klein

T cell development by the numbers
Journal club Stefan Stoiber

AG Kobold

Long A H et al. 4-1BB costimulation ameliorates T cell exhaustion induces by tonic signaling of chimeric antigen receptors. Nature Medicine, 2015
 
104 24th April 2017
Results colloquium Steffeni Mountford

AG Bufler

Modulation of liver inflammation and fibrosis by the IL-1 homologue IL-37
 
103 3rd April 2017
Results colloquium Maurine Rothe

AG Subklewe

Blockade of LAG-3 enhances dentritic cell-induced T-cell responses more than blockade of PD-1
Journal club Mareike Lepenies

AG Feuchtinger

McGranahan N et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science, 2016
 

 

Winter semester 2016/2017

(17th October 2016 till 11th February 2017)

No. Date Speaker Topic
102 27th March 2017
Educational colloquium Dr. Maike Buchner B cell development malignant transformation and signaling thresholds
Journal club Lukas Mallaun Eyquem J et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature, 2017
 
101 20th March 2017
Results colloquium cancelled due to ITOC Conference
Journal club
 
100 13th March 2017
Results colloquium Monika Herrmann Releasing the T cell brake - novel strategy of local PD-1/PD-L1 checkpoint blockade to fight immune evasion in AML
Journal club Maurine Rothe Bronte V et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 2016
 
99 6th March 2017
21th Research Seminar

Dr. Jan Böttcher

The Francis Crick Institute, London

Evasion of the antitumor immunity by prostaglandin E2 production
 
98 20th February 2017
20th Research Seminar

Dr. Arndt Schottelius

MorphoSys, Munich

Anti-CD38 monoclonal antibodies as an evolving new backbone therapy in multiple myeloma
 
97 13th February 2017
Educational colloquium Paul Schwarzlmüller Basics in Statistics
Journal club Lara Hartjes Damgaard R B et al. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell, 2016
 
96 10th of February at 10:30

Yi Xeng, China

Medical research in China (15 min)

 
95 6th February 2017
Result colloquium Phillip Metzger PD-1 expression of non-T cells
Journal club Bruno Cadilha Buck M D et al. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell, 2016
 
94 30th January 2017
Educational colloquium Anna Kaufmann Autophagy and its role in cancer
Journal club Xiaomei Chen Arbore G et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 2016
 
93 26th January 2017
19th Research Seminar

Prof. Charles Dinarello,

University of Colorado, Denver

From fever to autoinflammation - the roadmap of interleukin-1 beta
 
92 23th January 2017
18th Research Seminar

Dr. Nisit Khandelwal

iOmx Therapeutics AG, Munich

Research seminar: Mapping the tumor's immune-evasion strategies beyond the existing paradigm

 
91 16th January 2017
Themenkolloqium Kim Pawelka Plasticity of myeloid cells in the iMate context
Journal Club Steffi Lesch Faitschuk E et al. Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells. Blood, 128: 1711-1722
 
90 09th January 2017
Themenkolloqium Saskia Schmitt Characterization of multispecific antibody derivates to target and activate dendritic cells in vivo
Journal Club Laura Frey Moroishi T et al. The hippo pathway kinases LATS1/2 suppress cancer immunity. Cell, 167:1525-1539.
 
89 19th December 2016
17th Research Seminar

Dr. A. Schottelius

Morphosys AG

Clinical update on MOR208, an antibody targeting CD19 in Non-Hodgkin Lymphomas

 
88 28th November 2016
Themenkolloqium AG Rothenfußer TBA
Journal Club
 
87 14th November 2016
Themenkolloqium Clara Karches Activating fusion receptors as a novel approach for targeting autoreactive B cell receptors on chronic lymphatic leukaemia cells
Journal Club Julia Stein A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression
 
86 11th November 2016
16th Research Seminar

Dr. Jasper von Boorn

University Hospital Bonn

Biomedical Center

Institute for Clinial Chemistry and Clin. Pharmacology

Pigment cell-specific NK cell memory revealed

 
85 07th November 2016
15th Research Seminar

Dr. Carolin Daniel

Helmholtz Zentrum München

Deutsches Forschungszentrum für Gesundheit und Umwelt

Institut für Diabetesforschung

Immune tolerance in autoimmune type 1 diabetes

 
84 24th October 2016
Themenkolloqium AG Subklewe
Journal Club Hanna Nowotny

Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies

 
83 17th October 2016
14th Research Seminar

Prof. Georgios Stathopoulos

On the role of mutant KRAS in malignant pleural disease

 
82 10th October 2016
Themenkolloqium Julia Kobuch Metastasis: Colonial policy in the body and models for its investigation
Journal Club Philipp Metzger Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
 
81 19th September 2016
Themenkolloqium Felicitas Rataj About CARs and TRUCKs - Do we have the drivers' license?
Journal Club Anna Tiefenthaller

Caloric restriction mimetics enhance anticancer immunosurveillance

 


Summer semester 2016

(11. April 2016 bis 16. Juli 2016)

 

80 25. Juli 2016
13th Research Seminar

Prof. Samuel Huber

Peter Hans Hofschneider Professor

Molecular Gastroenterology and Immunology

University Medical Center Hamburg-Eppendorf

Control of Th17 cells in the intestine

 
79 18. Juli 2016
12th Research Seminar

Dr. Annette Künkele

Department of Pediatric Oncology/Hematology/SCT

Charité-Universitätsmedizin Berlin

What we learned from bench to beside with the neuroblastoma targeting CD171 -specific CAR

 
78 11. Juli 2016
Themenkolloqium Severin Rodler The IL-22/IL22-R-axis in renal cell carcinoma (RCC)
Journal Club Celina Aithal Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
 
77 04. Juli 2016
Themenkolloqium Viktoria Bothe Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX
Journal Club Stefan Stoiber In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
 
76 27. Juni 2016
Themenkolloqium Viktoria Bothe Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX
Journal Club Stefan Stoiber In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
 
75 20. Juni 2016
11th Research Seminar

Dr. Arndt Schottelius

Morphosys AG

Clinical update on MOR202, a HuCAL antibody targeting CD38 in multiple myeloma

 
74 13. Juni 2016
Themenkolloqium Laura Posselt Targeting RIG-I with 5’ppp-modified RNA for immunotherapy of hepatocellular carcinoma (HCC)
Journal Club AG Rothenfusser
 
73 06. Juni 2016
Themenkolloqium Monika Herrmann Design of a new multispecific antibody derivative targeting the PD-1/PD-L1 immune checkpoint
Journal Club Adrian Gottschlich The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity
 
72 30. Mai 2016
Themenkolloqium Fabian Kraus
Journal Club Tim Wartewig Disparate Individual Fates Compose Robust CD8+ T Cell Immunity
 
71 02. Mai 2016
Themenkolloqium AG Klein
Journal Club Saskia Schmitt Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas
 
70 25. April 2016
10th Research Seminar

Dr. Ignazio Caruana

Cellular and Gene Therapy of Pediatric Tumour IRCCS Bambino Gesù Hospital Rome, Italy

Optimization of Chimeric Antigen Receptor T cell therapy in solid tumourss

 
69 18. April 2016
Themenkolloquium Daniel Böhmer Non-canonical pathways of RLH-induced cell death
Journal Club Clara Karches Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
 
68 11. April 2016
Themenkolloquium Angelina Krächan Impact of TLR7-Agonists on NK cell cytotoxicity, phenotype and migration
Journal Club Laura Frey IL-17-producing cd T cells and neutrophils conspire to promote breast cancer metastasis
 
67 04. April 2016
Themenkolloquium Simon Rothenfußer
Journal Club AG Hopfner
 


Winter semester 2014/2015

(6. Oktober 2014 bis 6. Februar 2015)

 

66 28. März 2016
Themenkolloquium
Journal Club
 
65 21. März 2016
Themenkolloquium
Journal Club
 
64 16. März 2016
9th Research Seminar

Prof. Charles Dinarello

Department of Medicine Division of Infectious Diseases University of Colorado Denver Aurora, CO, USA

The interleukin-1 family in 2016: solving secrets, helping patients

 
63 14. März 2016
 
Themenkolloquium Lisa Weigand Characterization and Targeting of MDSCs in AML
Journal Club Romy Loschinski Autophagy enforces funktional integrity ofregulatory T cells by coupling environmental cues and metabolic homeostasis
 
62 07. März 2016
Themenkolloquium
Journal Club
 
61 29. Februar 2016
Themenkolloquium Christoph Klein Primary Immunodeficiency Disorders
Journal Club Florian Asang Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
 
60 22. Februar 2016
Themenkolloquium Lars König Cell Culture: Basics, Tips and Quality Control
Journal Club Michael Ruzicka Agonist antibody that induces human malignant cells to kill one another
 
59 15. Februar 2016
Themenkolloquium Jürgen Ruland ITAM Receptors in Innate Immunity and Oncogenesis
Journal Club Claudia Roskopf Talimogene Laherparepvec improves durable response rate in patients with advanced melanoma
 
58 8. Februar 2016
Themenkolloquium
Journal Club
 
57 1. Februar 2016
Themenkolloquium
Journal Club Rachel Mak'Anyengo
 
56 25. Januar 2016
Themenkolloquium Jennifer Heinrich Engineering of PD1-CD28 fusion receptor for improved functionality
Journal Club Severin Rodler Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids
   
55 18. Januar 2016
Themenkolloquium Nadine Moritz Development of a novel antibody format to target AML
Journal Club Veronica Ecker Signalling thresholds and negative B-cells selection in acute lymphoblastic leukaemia
 
55 11. Januar 2016
Themenkolloquium Prof. Stefan Endres Immunotherapie of cancer - update 2016
PD Dr. Sebastian kobold i-Target program 2016
 
53 21. Dezember 2015
Themenkolloquium Bruno Cadilha Redirecting T cells and enabling their TGF-beta resistance
Journal Club
 
52 14. Dezember 2015
Themenkolloquium Clara Karches Combination of bispecific antibody with activating fusion Receptor for cancer therapy
Journal Club Lara Hartjes The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquination by LUBAC to dampen lymphocyte NF-kB signaling
 
51 07. Dezember 2015
Themenkolloquium Michael Ruzicka Immunotherapy of AML with bifunctional siRNA
Journal Club Angelina Krächan
 
50 30. November 2015
Themenkolloquium Maurine Rothe
Journal Club Daniel Böhmer A genome-wide CRISPR screen identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation
 
49 26. November 2015
Themenkolloquium Julia Ahlfeld
Journal Club Laura Frey

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

 
48 18. November 2015
8th Research Seminar

PhD Nadia Cherradi

INSERM U1036 - Biologie du Cancer et de l'Infection

iRTSV/CEA Grenoble

Post-transcriptional regulation in cancer: Focus on RNA-binding proteins and microRNAs

 
47 16. November 2015
Themenkolloquium Philipp Metzger
Journal Club Clara Karches Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
 
46 09. November 2015
Themenkolloquium Bruno Cadilha
Journal Club Maurine Rothe Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells
 
45 02. November 2015
Themenkolloquium
Journal Club
 
44 26. Oktober 2015
Themkolloquium Claudia Roskopf Selective, T cell-dependent lysis of CD19+ leukemia cells mediated by single chain triplebodies with dual-targeting
Journal Club Tim Wartewig
 
43 19. Oktober 2015
Themenkolloquium
Journal Club Florian Asang
 
42 12. Oktober 2015
7th Research Seminar

Professor Matthias Feige

Cellular Protein Biochemistry Lab

TU München

Molecular Quality Control in the Immune System
 
41 05. Oktober 2015
Themenkolloquium AG Ruland
Journal Club Stefanie Lesch (Kobold/Endres) FcgammaRs modulate the anti-tumor activity if antibodies targeting the
Pd-1/PD-L1 axis
 
40 28. September 2015
Themenkolloquium Prof. Karl-Peter Hopfner
Journal Club Monika Herrmann (AG Hopfner) CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
 
39 21. September 2015
Themenkolloquium Tim Wartewig
Journal Club Bruno Cadhila (AG Kobold/Endres) NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
 
38 14. September 2015
6th Research Seminar Prof. Dr. Tobias Feuchtinger Therapy with T cells? The challenge of adoptive T-cell transfer
 


Summer semester 2015

(13. April 2015 bis 18. Juli 2015)

 

Nr. Datum Referent Thema
37 27. Juli 2015
Themenkolloquium PD Dr. Dimitrios Mougiakakos Educational Colloqium: Oxidative stress in cancer
Journal Club Rachel Mak'Anyengo (AG Schnurr) Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine
 
36 20. Juli 2015
Themenkolloquium Prof. Christoph Klein Rare Diseases and Myeloid Leukemia
Journal Club Jennifer Heinrich (AG Kobold/Endres) Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
 
35 13. Juli 2015
5th Research Seminar

Dr. Hans-Rainer Jaenichen

Patents for Biotech Inventions

Patents for Biotech Inventions
 
34 06. Juli 2015
Ergebniskolloquium Eva Hornig Regulation of the transcription factor Brn3a in melanoma
Journal Club Bruno Cadilha (AG Kobold/Endres) Imaging liver biology in vivo using conventional confocal microscopy
 
33 29. Juni 2015
Ergebniskolloquium Stefanie Lesch (AG Kobold/Endres) Whole transcriptome analysis of adoptively transferred tumor infiltrating T cells
Journal Club AG Anz
 
32 22. Juni 2015
Ergebniskolloquium Daniel Böhmer (AG Schnurr) Non-canonical pathways of 5‘-Triphosphate–RNA induced cell death
Journal Club AG Besch/Berking
 
31 15. Juni 2015
Ergebnisqkolloqium Lara Hartjes (AG Ruland) Identification of novel MALT1 substrates
Journal Club Johannes Tossounidis (AG Rothenfusser) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
 
30 08. Juni 2015
4th Research Seminar

Dr. Johannes vom Berg

Transgenic and Reproductive Techniques Group, Institute of Laboratory Animal Science, University of Zurich

Local immunotherapy of glioblastoma using proinflammatory cytokines
 
 
29 18. Mai 2015
Ergebniskollquium Romy Loschinski (AG Mackensen/Mougiakakos)
Journal Club Lisa Weigand (AG Mackensen/Mougiakakos)
 
28 11. Mai 2015
Ergebniskolloquium Heike Anders (AG Lauber)
Journal Club AG Schulze-Koops
 
27 04. Mai 2015
Ergebniskolloquium Laura Frey (AG Klein)
Journal Club AG Kobold/Endres
 
26 27. April 2015
Ergebniskolloquium Heike Anders (AG Laube) HSP90 inhibition as a means or radiosensitizing resistant, aggressive soft tissue sarcoma
Journal Club Viktoria Bothe (AG Rothenfusser) ATP-Dependent Effector-like Functions of RIG-I-like Receptors
 
25 20. April 2015
Ergebniskolloquium Entfällt
Journal Club AG Besch/Berking
 
24 13. April 2015
Ergebniskolloquium Stefanie Lesch (AG Kobold/Endres)
Journal Club AG Schnurr
 
23 23. März 2015
Themenkolloquium AG Schnurr
Journal Club AG Kobold/Endres
 
22 16. März 2015
Ergebniskolloqium Lisa Weigand (AG Mackensen/Mougiakakos) Characterization and targeting of myeloid-derived suppressor cells (MDSCs) in acute myeloid leukemia (AML)
Journal Club Romy Loschinsky (AG Mackensen/Mougiakakos) Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions
 
21 09. März 2015
3rd Research Seminar

Dr. Ekkehard Leberer

Sanofi

Nucleic acid therapeutics: Opportunities and challenges for drug development
 
20 02. März 2015
Themenkolloquium Kirsten Lauber (AG Lauber) Tumor growth promoting apoptosis: With a little help from my dying friends?
Journal Club Eva Heuer (AG Rothenfusser) Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation
 
19 23. Feburar 2015
Themenkolloquium AG Kobold/Endres
Journal Club AG Kobold/Endres
 
18 09. Februar 2015
Themenkolloquium Sebastian Kobold (AG Ruland) TLR7 agonists in cancer therapy
Journal Club Stefanie Lesch (AG Besch/Berking) Combination therapy with anti-CTLA4 and anti-PD-1 leads to distinct immunologic changes in vivo
 
17 02. Februar 2015
  Themenkolloquium Marion Subklewe (AG Subklewe) Therapeutic vaccines in cancer
Journal Club Severin Rodler (AG Anders) High-dimensional analysis of the murine myeloid cell system


Winter semester 2014/2015

(6. Oktober 2014 bis 6. Februar 2015)

 

Nr. Datum Referent Thema
16 26. Januar 2015
Ergebniskolloquium AG Kobold/Endres
Journal Club Christine Heuer (AG Rothenfusser)
 
15 19. Januar 2015
Ergebniskolloquium Nadine Moritz (AG Hopfner) Development of multi-specific antibody derivatives (msADs) to target acute myeloid leukemia
Journal Club Peter May (AG Kobold/Endres) B7-H1 expressing antigen presenting cells mediate polarization of pro-tumorigenic Th22 subsets
 
14 12. Januar 2015
Ergebniskolloquium Moritz Schmidbauer (AG Kobold/Endres)
Journal Club Saskia Graf (AG Besch/Berking)
 
13 15. Dezember 2014
Ergebniskolloquium Fabian Kraus (AG Kobold)
Journal Club AG Schulze-Koops
 
12 08. Dezember  
  Ergebniskolloquium Viktoria Bothe (AG Rothenfusser) Characterization of RIG-I ligands during infection with Vesicular Stomatitis Virus
  Journal Club Nadine Moritz (AG Hopfner) A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity
       
11 01. Dezember 2014
Ergebniskolloquium Laura Posselt (AG Schnurr)
Journal Club AG Anz
 
10 24. November 2014
Ergebniskolloquium Fanny Matheis (AG Besch)
Journal Club Marco Wachowius (AG Conzelmann) Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine
 
9 17. November 2014
Ergebniskolloquium -

Journal Club Severin Jacobi (AG Kobold) The RAG Recombinase Dictates Functional Heterogenity and Cellular Fitness in Natural Killer Cells

 

 

 

 

8 10. November 2014
Ergebniskolloquium AG Anz

Journal Club Simone Romoli (AG Anders) Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

 

 

 

 

7 03. November 2014
2nd Research Seminar i-Target Prof. Dr. Dr. Michael von Bergwelt

Klinikum der Universität zu Köln, Centrum für Integrierte Onkologie
Targeting antigen presentation cells to induce an immunosupportive tumor microenvironment
 
6 27. Oktober 2014
Ergebniskolloquium Eva Hornig (AG Besch)
Journal Club AG Rothenfusser
 
5 20. Oktober 2014

1st Research Seminar i-Target

PD Dr. Antje Menssen

Deutsches Konsortium für translationale Krebsforschung, DKFZ Heidelberg
Pathologisches Institut der Ludwig-Maximilians-Universität München

Targeting MYC-dependent metabolism and secreted factors for cancer therapy

   
4 13. Oktober 2014
Ergebniskolloquium Monika Herrmann (AG Hopfner)

Journal Club Daniel Böhmer (AG Schnurr)

 

 

 

 

3 6. Oktober 2014
Ergebniskolloquium Maximilian Gradel (AG Rothenfußer)

Journal Club Saskia Graf (AG Besch)

 

 

 

 

2 29. September 2014
Themenkolloquium Prof. Conzelmann

Journal Club Alex Hennrich (AG Conzelmann)

 

 

 

 

 1 25 bis 26. September 2014

ImmunoFest

 

 

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Surface-exposed and soluble calreticulin: conflicting  biomarkers for cancer prognosis