Seminars
Location for results colloquium, journal club, educational colloquium and research seminars
Seminar room A0.11 (Lindwurmstraße 2a, MKG-Chirurgie (Ground floor, right side))
Time
Results colloquium or educational colloquium: Monday, 17:00 to 18:00
Journal club: Monday, 18:00 to 18:30
Summer semester 2022
| No. | Date | Speaker | Topic |
| 297 | May 23th, 2022 | ||
| Guest Speaker | Prof. Dr. Maya Saleh, University of Bordeaux | Exploiting innate immunity for cancer immunotherapy | |
| 296 | May 16th, 2022 | ||
| Results colloquium | Alexandra Leutbecher, AG Subklewe | Characterization of Ovarian Cancer and Evaluation of a TCB targeting Wilm’s Tumor 1 to Treat Ovarian Cancer | |
| cancelled | Journal club | Anne Marie Senz, AG König-Schnurr | Jin et al. CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in sold cancers, Nature Biomedical Engineering 2022 |
| 295 | May 9nd, 2022 | ||
| cancelled | Results colloquium | Miriam Back, AG Feuchtinger | Characterisation of high ranked transcription factors in transcriptomes from T cells of patients with acute lymphatic leukemia |
| Results colloquium | Veronika Igl, AG Kobold | CD180 CAR T cells and their possibilities in haematological malignancies | |
| 294 | May 2nd, 2022 | ||
| Educational colloquium | Dr. med. Daniel Böhmer, AG König-Schnurr | Endogenous dsRNAs and their recognition by the innate immune system | |
| Journal club | Jingle Tu, AG Theurich | Poznanski et al. Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment, Cell Metabolism 2021 | |
| 293 | April 4th, 2022 | ||
| Guest Speaker | Dr. Daniela Thommen, NKI Amsterdam | Dissecting and modulating reactive anti-tumor immunity in human cancers | |
| Journal club | Thaddäus Strzalkowski, AG Kobold | Agarwalla et al. Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells, Nature Biotechnology 2022 | |
| 293 | April 25th, 2022 | ||
| Results colloquium | Abhinav Joshi, AG Ruland | PD-1 represses mTOR activity in pre-malignant cells | |
| Journal club | Alejandra Hernandez Caceres, AG Hopfner | Belmontes et al. Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors, Science Translational Medicine 2021 | |
| 291 | April 4th, 2022 | ||
| Guest Speaker | Lauriane Cabon, PhD, F. Hoffmann-La Roche AG, Basel | Reimagining preclinical safety assessment of cancer immunotherapeutics | |
| Journal club | Elena Nikolova, AG Rothenfußer | Glaros et al. Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response, Immunity 2021 |
Winter semester 2021/2022
| No. | Date | Speaker | Topic |
| 290 | March 28th, 2022 | ||
| Results colloquium | Anne Marie Senz, AG König/Schnurr | Combining RIG-I-targeted therapy with CAR T cells to treat pancreatic cancer | |
| Journal club | Frederike Warlitz, AG Feuchtinger | Melenhorst et al. Decade-long leukaemia remissions with persistence of CD4+ CAR T cells, Nature 2021 | |
| 289 | March 21th, 2022 | ||
| Results colloquium | Judit Rial Saborido, AG Mougiakakos/Machensen | Metabolic adaptation of T cells in Chronic lymphocytic leukemia | |
| Journal club | Sebastian Spajic, AG Kobold | Gahessmi et al. Rapid manufacturing of non-activated potent CAR T cells, Nature Biomedical Engineering 2022 | |
| 288 | March 14th, 2022 | ||
| Guest Speaker | Frau Prof. Helfrich, LMU Hospital Munich | Plasticity & Resistance in Melanoma – The chicken or egg hypothesis | |
| Journal club | Sabine Oganesian, AG Theurich | Liu et al. Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma, Nature Communication 2022 | |
| 287 | March 7th, 2022 | ||
| Results colloquium | Jan Gaertig, AG Anz | Block the riposte: Influence of CCL22 on GM-CSF-based cancer immunotherapy | |
| Journal club | David Andreu Sanz, AG Kobold | Prinzing et al. Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity, Science Translation Medicine 2021 | |
| 286 | February 28th, 2022 | ||
| Results colloquium | Anna-Kristina Kluever, AG Kobold | Th9 CD4+ T cells as effector cells for CAR T cell therapy | |
| Journal club | Monika Sponheimer, AG Subklewe | Mansilla-Soto et al., HLA-independent T cell receptors for targeting tumors with low antigen density, Nature medicine 2022 | |
| 285 | February 21th, 2022 | ||
| Educational colloquium | Dr. Martin Böttcher, AG Mougiakakos/Mackensen | CSI in the Lab: Metabolicc profiling of cells | |
| Journal club | Theresa Seifert, AG Rothenfusser | Jarosch et al. Multiplexed imaging and automated signal quantification in formalin-fixed paraffin-embedded tissues by ChipCytometry, Cell Reports Methods 2021 | |
| 284 | February 14th, 2022 | ||
| Results colloquium | Lisa Rohrbacher, AG Subklewe | CARs and Bi(TE)cycles on the way to cure AML | |
| Journal club | Antonia Beimert, AG Anz | Davar et al. Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients, Science 2021 | |
| 283 | February 7th, 2022 | ||
| Results colloquium | Alejandra Hernandez Caceres, AG Hopfner | First steps in the development and characterization of a T cell regulating monoclonal antibody | |
| Journal club | Amar Hadzic, AG Theurich | Sun et al. Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion, Nature 2021 | |
| 282 | January 31th, 2022 | ||
| i-Target Quiz | Emanuele Carlini, AG Kobold | Heitzeneder et al. GPC2-CAR T cells turned for low antigen density mediate potent activity against neuroblastoma without toxicity, Cancer Cell 2022 | |
| 281 | January 24th, 2022 | ||
| Educational colloquium | Dr. med. Sophia Stock, AG Kobold | The Process of CAR-T Cell Therapy | |
| Journal Club | Titus Butzlaff, AG Feuchtinger | Gardner et al. Engineering CAR-T cells to activate small-molecule drugs in situ, Nature Chemical Biology 2021 | |
| 280 | January 17th, 2022 | ||
| Results colloquium | Amar Hadzic, AG Theurich | Metabolic engineering of murine T cells via ectopic expression of the large neutral amino acid transporter 1 (LAT1, CD98) | |
| Journal Club | Daniel Bergér, AG Klein | Luo et al. Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration, Cell death and Disease 2020 | |
| 279 | January 10th, 2022 | ||
| Results colloquium | Stephanos Michaelides, AG Kobold | Generating a human chemokine receptor library as a screening platform for T cell infiltration in Adpotive Cellular Therapy | |
| Journal Club | Larsen Vornholz, AG Ruland | Wu et al. Interferon-independent activities of Mammalian STING mediate antiviral response and tumor immune evasion, Immunity 2020 | |
| 278 | Dezember 13th, 2021 | ||
| Educational colloquium | Dr. Maike Buchner, AG Ruland | B cell development, antibody production, and malignant transformation | |
| Journal club | Lisa Rohrbacher, AG Subklewe | Good et al. An NK-like CAR T cell transition in CAR T cell dysfunction, Cell 2021 | |
| 277 | Dezember 6th, 2021 | ||
| Results colloquium | Janina Dörr, AG Kobold | Prostaglandin E2-resistant CAR T cells | |
| Journal club | Veronika Igl, AG Kobold | Haftmann et al. Protection against autoimmunity is driven by thymic epithelial cell–mediated regulation of Treg development, Science Immunology 2021 | |
| 276 | November 29th, 2021 | ||
| Results colloquium | Magdalena Zaucha, Ag Rothenfußer | Host and genetic factors influencing the immune response to Yellow Fever vaccination | |
| Journal club | Anja Wittner, AG Hopfner | Moghimi et al. Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma, Nature Communications 2021 | |
| 275 | November 22nd, 2021 | ||
| Results colloquium | Jonathan Trautwein, AG Mougiakakos/Mackensen | Ferroptosis-an iron dependent form of regulated cell death in immune cells | |
| Journal club | Ramya Nair, AG Baldauf | Xu et al. An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma, Nature Communications 2021 | |
| Canceld, postponed to 2022 | November 15th, 2021 | ||
| Guest speaker | Prof. Dr. med. Frederick Klauschen, Direktor Pathalogisches Institut, LMU | ||
| 274 | November 8th, 2021 | ||
| Results colloquium | Anne Marie Senz, AG König/Schnurr | Combining RIG-I-targeted therapy with CAR T cells to treat pancreatic cancer | |
| Journal club | Sabine Oganesian, AG Theurich | Phillips et al. Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma | |
| 273 | October 25th, 2021 | ||
| Results colloquium | Alexandra Leutbecher, AG Subklewe | Characterization of ovarian cancer and evaluation of a bifunctional antibody in ovarian cancer | |
| Journal club | Anne Marie Senz, AG König/Schnurr | Johnson et al. The immunostimulatory RNARN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function, Cell 2021 | |
| 272 | October 11th, 2021 | ||
| Results colloquium | Larsen Vorholz, AG Ruland | Role of CBM signaling in autoinflammatory disease | |
| Journal club | Judit Rial Saborido, AG Mougiakakos/Mackensen | Luu et al. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer, Nature Communications 2021 | |
| 271 | October 4th, 2021 | ||
| Results colloquium | Antonio Santos del Peral, AG Rothenfußer | Impact of pre-existing immunity on the response to Yellow Fever Virus | |
| Journal club | Jan Gärtig, AG Anz | Abdel-Hakeem et al. Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation, Nature Immunology 2021 |
Summer semester 2021
| No. | Date | Speaker | Topic |
| 270 | September 27th, 2021 | ||
| Guest speaker |
Dr. James Yarmolinsky, |
Using human genetics to evaluate the causal role of circulating inflammatory markers in risk of adult cancer | |
| 269 | September 20th, 2021 | ||
| Results colloquium | Laura Velezmoro, AG Lauber | Inhibition of DNA damage response in sarcoma: Radiosensitization and more | |
| Journal club | Anna-Kristina Klüver, AG Kobold |
Weber et al. Transient “rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling, Science 2021 | |
| 268 | September 13th, 2021 | ||
| Results colloquium | Martin Kirmaier, AG Theurich | Adapting immune cells to the nutrient deprivation in the tumor microenvironment by Solute Carrier (Slc) Overexpression | |
| Journal club | Lisa Brandmeir, AG Ruland | Kohlhaas er al. Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1, Blood 2021 | |
| 267 | September 6th, 2021 | ||
| Educational colloquium | Dr. Florian Gothe | Multisystemic autoimmunity as a consequence of variants in the beta-chain of the IL-2 receptor impairing Treg survival and NK/CD8-T cell maturation | |
| Journal club | Paul Trinkner, AG Theurich | Cortellini et al. Another side of the association between body mass index (BMI) and clinical outcomes of cancer patients receiving programmed cell death protein-1 (PD-1)/ Programmed cell death-ligand 1 (PD-L1) checkpoint inhibitors, European Journal of Cancer 2021 | |
| Summer break | until September 6th 2021 | ||
| 266 | July 19th, 2021 | ||
| Results colloquium | Ann-Sophie Schücke, AG Kobold |
Investigation of thermosensitive fluorchromes | |
| Journal club | Daryna Kechur, AG Kobold | Griffin et al. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity, Nature 2021 | |
| 265 | July 12th, 2021 | ||
| Results colloquium | Duc Huynh, AG Kobold | NK Memory Formation | |
| Introduction round | |||
| 264 | July 5th, 2021 | ||
| Educational colloquium | Dr. rer. nat. Lars König | Targeting innate immune receptors for immunotherapy of tumors | |
| Journal club | Florian Märkl, AG Kobold | Forsberg et al. HER2 CAR-T cells eradicate uveal melanoma and T-cell therapy–resistant human melanoma in IL2 transgenic NOD/SCID IL2 receptor knockout mice, Cancer Research 2019 | |
| 263 | June 28th, 2021 | ||
| Results colloquium | Lisa Rohrbacher, AG Subklewe | On the road to cure AML: Bi(TE)cycles versus CARs | |
| Journal club | Stefanos Michaelides, AG Kobold |
Guo et al. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity, Nature Immunology 2021 | |
| 262 | June 21th, 2021 | ||
| Results colloquium |
Isabel Brand/Leonard Gilberg, Infectiology/AG Kobold |
Broad T cell targeting of structural proteins after SARS-CoV-2 infection | |
| Journal club | Duc Huynh, AG Kobold | Rousso-Noori et al. P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas, Nature Communications 2021 | |
| 261 | June 14th, 2021 | ||
| Educational colloquium | PD Dr. Hanna-Mari Baldauf | SAMHD1 as a biomarker for cytarabine drug resistance in AML cells | |
| Journal club | Larsen Vornholz, AG Ruland | Lu et al. DNA Sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity, Cancer Cell 2020 | |
| 260 | June 7th, 2021 | ||
| Results colloquium | Öykü Umut, AG Kobold | Improvement of adoptive T cell therapy of solid tumors with combined expression of chemokine receptors CCR4 and CXCR6 in CD8+ T cells | |
| Journal club | Monika Sponheimer, AG Subklewe |
Sauer et al. CD70 specific CAR T-cells have potent activity against acute myeloid leukemia without HSC toxicity, Blood 2021. | |
| 259 | May 31th, 2021 | ||
| Results colloquium | Daniel Bergér, AG Klein | Dual targeting of AML cancer stem cells | |
| Journal club | Leonrad Gilberg, Infectiology/AG Kobold | Ogbe at al. T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses, Nature Commun. 2021 | |
| 258 | May 17th, 2021 | ||
| Educational colloquium | Dr. Hadi Karimzadeh, AG Rothenfußer |
Viral escape mutations and persistent infections: a matter of concern for Covid-19 pandemic? | |
| Journal club |
Jonathan Trautwein, |
Beatty et al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1, Nature Com. 2021 | |
| 257 | May 10th, 2021 | ||
| Results colloquium | Abhinav Joshi, AG Ruland | Targeting mTOR signalling in Pd-1 null T cell NHL | |
| Journal Club | Theodora Ispyridou, AG Feuchtinger |
Awwad et al. Selective elimination of immunosuppressive T cells in patients with multiple myeloma, Leukemia 2021 | |
| 256 | May 3rd, 2021 | ||
| Results colloquium | Hannah Obeck, AG Kobold | Inducible Apoptosis as a safetymechanism in adoptive T cell therapy | |
| Journal Club | Laura Sellmer, AG Tufman | Lu et al. Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer, Nature Medicine 2020 | |
| 255 | April 26th, 2021 | ||
| Educational colloquium | Dr. Sonja Lacher, AG Subklewe |
Checkpoint Expression and Function in GvHD | |
| Journal Club | Laura Velezmoro, AG Lauber | Zheng et al. Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells, Cell Death and Disease 2020 |
|
| 254 | April 19th, 2021 | ||
| Results colloquium | Monika Sponheimer, AG Subklewe |
Evaluation of CD70 as an immunotherapeutic target for the treatment of acute myeloid leukemia | |
| Journal club | Ann-Sophie Schücke, AG Theurich |
Boulch et al. A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity, Science Immunology 2021 | |
| 253 | April 12th, 2021 | ||
| Educational colloquium | Dr. Björn Hiller, AG Hopfner | Prevent collateral damage – know the off-target effects | |
| Journal club | Alexandra Leutbecher, AG Subklewe |
Deuse et al. The SIRPα–CD47 immune checkpoint in NK cells, JEM 2021 |
Winter semester 2020/2021
| No. | Date | Speaker | Topic |
| 252 | March 29th, 2021 | ||
| Results colloquium | Judit Rial, AG Mougiakakos | CLL cells impair T cells via lipotoxicity | |
| Journal club | Luisa Delius, AG König-Schnurr | Xiao et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation, Cancer Cell 2021 | |
| 251 | March 22nd, 2021 | ||
| Results Colloquium | Vera Bauer, AG Mocikat | Targeting regulatory T cells in an endogenous lymphoma mouse model | |
| Journal Club | Janina Dörr, AG Kobold | Yingzhong et al. Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity, Nature Cancer 2021 | |
| 250 | March 15th, 2021 | ||
| Results colloquium | Ruth Grünmeier, AG Kobold | Dual T cell-based CSF1R targeting approach for the treatment of Hodgkin Lymphoma | |
| Journal club |
Moritz Schrenk, AG Rothenfußer |
Wu et al. SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO, Cell Press 2021 | |
| 249 | March 8th, 2021 | ||
| Educational Colloquium | Prof. Dr. Sebastian Theurich | The impact of energy metabolism on cancer and immune cells | |
| Journal Club | Isabel Brand, Infectiology/AG Kobold | Sekine et al. Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID 19, Cell Press 2020 | |
| 248 | March 1st, 2021 | ||
| Guest speaker | Prof. Dr. Almut Schulze, DKFZ Heidelberg | Targeting Lipid Metabolism in Cancer | |
| 247 | February 22th, 2021 | ||
| Results colloquium | Nora Zieger, AG Subklewe | Recovering from Burnout: Resting Mitigates CD19xCD3 BiTE®-Mediated T-Cell Exhaustion | |
| Journal club | Sophie Günther, AG Theurich | Cortellini et al. Weighing the role of skeletal muscle mass and muscle density in cancer patients receiving PD-1/ PD-L1 checkpoint inhibitors: a multicenter real-life study, Nature 2020 | |
| 246 | February 15th, 2021 | ||
| Results colloquium | Anja Wittner, AG Hopfner | Development and functional in vitro characterization of OX40L-fusion antibodies | |
| Journal club | Melanie Schwerdtfeger, AG Kobold | Srivastava et al. Immunogenic chemotherapy enhances recruitment of CAR-T cells to lung tumors and improves antitumor efficacy when combined with checkpoint blockade, Cancer Cell 2020 | |
| 245 | February 8th, 2021 | ||
| Results colloquium | Sabine Oganesian, AG Theurich | Characterization of the immunometabolic microenvironment in cutaneous T-cell lymphoma focusing on tumor infiltrating B cells | |
| Journal club | Juliane Grün, AG Anz | Xu et al. Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4+ Treg cells in ovarian cancer cells microenvironment, Cell Death and Disease 2021 | |
| 244 | February 1st, 2021 | ||
| Results colloquium | Laura Sellmer, AG Tufman | Theruvath et al. Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors, Nature Medicine 2020 | |
| Journal club | Julian Kolorz, AG Kappler | Morphological and molecular characteristics in NSCLC tumors and matched tumor bearing and non-tumor bearing lymph nodes | |
| 243 | January 24th, 2021 | ||
| Educational colloquium | Dr. Katrin Manske, AG Kobold | T cell immunity against viral infection of the liver | |
| Journal club | Lena Jablonowski, AG Feuchtinger | Liu et al. IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor, Nature Immunology 2021 | |
| 242 | January 18th, 2021 | ||
| Results colloquium | Lisa Pfeuffer, AG Ruland | The role of Wasp-Interacting protein in B-cell acute lymphoblastic leukemia | |
| Journal club | Daniel Bergér, AG Klein | Forte et al. Bone marrow mesenchymal stem cells support acute myeloid leukemia bioenergetics and enhance antioxidant defense and escape from chemotherapy, Cell Metabolism 2020 | |
| 241 | January 11th, 2021 | ||
| Results colloquium | Florian Märkl, AG Kobold | Bispecific antibody-driven synthetic agonistic receptor-transduced T cell mediate specific and conditional therapy in melanoma cancer models | |
| Journal club | Malte Ohlemeyer, AG Subklewe | HS Han et al. TOX-expressing terminally exhausted tumor-infiltrating CD8+ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer, Cancer Letters 2021 | |
| 240 | December 14th, 2020 | ||
| Results colloquium | Magdalena Zaucha, AG Rothenfußer | Genetic factors influencing the immune response to Yellow Fever vaccination. | |
| i-Target Quiz | |||
| 239 | December 7th, 2020 | ||
| Educational colloquium | Dr. Christof Winter, AG Ruland | Liquid profiling of head and neck cancer patients in blood and saliva | |
| Journal club | Ruth Grünmeier, AG Kobold | Amor et al. Senolytic CAR T cells reverse senescence-associated pathologies, Nature 2020 | |
| 238 | November 30th, 2020 | ||
| Results colloquium | Janina Dörr, AG Kobold | Influence of interleukin-37 on cancer | |
| Journal club | Anja Wittner, AG Hopfner | Semionatto et al. Extracellular vesicles produced by immunomodulatory cells harboring OX40 ligand and 4‐1BB ligand enhance antitumor immunity, Scientific Reports 2020 | |
| 237 | November 23th, 2020 | ||
| Guest speaker |
Dr. Carsten Marr Institute of Computational Biology, Helmholtz Zentrum München |
Artificial intelligence in computational hematopathology | |
| 236 | November 9th, 2020 | ||
| Results colloquium | Jonathan Trautwein, AG Mougiakakos/Mackensen | Ferroptosis-an iron dependent form of regulated cell death in immune cells. | |
| Journal club | Veronika Ecker, AG Ruland | Chan et al. Signalling input from divergent pathways subverts B cell transformation, Nature 2020 | |
| 235 | November 2nd, 2020 | ||
| Results colloquium | Anne Marie Senz, AG König/Schnurr | IDO1-deleted CAR T cells show improved therapeutic efficacy in murine pancreatic cancer models | |
| Journal club | Hannah Obeck ,AG Kobold | Liu et al. TGF-β suppresses type 2 immunity to cancer, Nature 2020 | |
| 234 | October 26th, 2020 | ||
| Educational colloquium | Dr. Heiko Bruns, AG Mougiakakos/Mackensen | Effector mechanisms of therapeutic antibodies | |
| Journal club | Sabine Oganesian, AG Theurich | Kumagai et al. The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies, Nature immunology 2020 | |
| 233 | October 19th, 2020 | ||
| Results colloquium | Larsen Vornholz, AG Ruland | CBM signaling in innate immunity | |
| Journal club | Daryna Kechur, AG König/Schnurr | Li et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection, Nature Communications 2020 | |
| 232 | October 12th, 2020 | ||
| Results colloquium |
Malte Ohlmeyer, AG Subklewe |
Understanding the modulation of T cell function by costimulatory and coinhibitory molecules during continous application of CD19/CD3 T cell recruiting antibody constructs for treatment of B cell malignancies | |
| Journal club |
Sebastian Goresch, AG Rothenfußer |
Folegatti et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial, Lancet 2020 | |
| 231 | October 5th, 2020 | ||
| Results colloquium |
Antonio Santos, AG Rothenfußer |
Generation of protective anti-viral immunity by the effective immunopriming of yellow fever vaccine virus | |
| Journal club |
Jakob Jobst, AG Kobold |
La Sala et al. Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains. Nat. Commun. 2020 |
Summer semester 2020
| No. | Date | Speaker | Topic |
| 230 | 29th of September | ||
| Results colloquium | Wyona Claire Mate AG Feuchtinger | The influence of the CD200 – CD200 receptor axis on the functionality of CAR T cells against acute lymphoblastic leukemia | |
| Journal club | Judit Rial Saborido AG Mougiakakos/Mackensen | Manzo et al. Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells, JEM 2020 | |
| 229 | 21th of September | ||
| Results colloquium | Martin Kirmaier AG Theurich | Adapting immune cells to the nutrient deprivation in the tumor microenvironment by solute carrier (Slc) overexpression. | |
| Journal club | Öykü Umut AG Kobold | Nelson et al. Identification of human CD4+ T cell populations with distinct antitumor activity, Science Advances 2020 | |
| 228 | 14th of September | ||
| Educational colloquium | Dr. rer. nat. Lars König | Databases, Resources and Online Tools for your PhD | |
| Journal club | Anne Marie Senz AG König-Schnurr | Li et al. cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy, Sci. Transl. Med. 2020 | |
| 227 | 7th of September | ||
| Results colloquium | Melanie Schwerdtfeger AG Kobold | Engineering synthetic agonistic receptor-transduced T-cells with chemokine receptors for improved homing in solid tumor models | |
| Journal club | Monika Sponheimer | Riether et al. Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents, Nature medicine 2020 | |
| Summer break | 27th of July until 7th of September | ||
| 226 | 20th of July | ||
| (per Video) | Results colloquium | Nora Zieger AG Subklewe | Recovering from Burnout: Resting Mitigates BiTE®-Mediated T-Cell Exhaustion |
| Journal club | Duc Huynh AG Kobold | Klichinsky et al. Human chimeric antigen receptor macrophages for cancer immunotherapy, Nature Biotechnology 2020 | |
| 225 | 13th of July | ||
| (per Video) | Educational colloquium | Prof. Dr. Sebastian Kobold | How to write an abstract and prepare a poster |
| Journal club | Lisa Brandmeier AG Ruland | Abdelrasoul et al. Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in philadelphia chromosome-positive acute lymphoblastic leukemia, Nat Communication 2020 | |
| 224 | 6th of July 2020 | Guest speaker | |
| per Video | Dr. Oliver Kepp, INSERM Paris | Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis | |
| 223 | 29th of June 2020 | ||
| per Video | Results colloquium | Dario Dhoqina AG Kobold | Using an anti-CSF1R-CAR T cell therapy against solid tumors |
| Journal club | Magdalena Zaucha AG Rothenfußer | Tonnerre et al. Evolution of the innate and adaptive immune response in women with acute Zika virus infection, Nat. Mircobiol 2020 | |
| 222 | 22th of June 2020 | ||
| per Video | Educational colloquium | Dr. Selina Keppler AG Ruland | Inflammation and (Auto-)Immunity in the gut |
| Journal club | Jan Wulf AG Subklewe | Teijeira et al. CXCR1 and CXCR2 Chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity, Immunity 2020 | |
| 221 | 15th of June 2020 | Guest speaker | |
| (per Video) |
Dr. med. Sarah Kim-Hellmuth Dr. von Haunerschen Children’s Hospital, University Hospital LMU |
Understanding the diversity of genetic effects on gene expression in health and disease |
|
| 220 | 25th of May 2020 | ||
| (per Video) | Results colloquium | Lisa Pfeuffer AG Ruland | The role of Wasp-interacting protein in pre B-ALL |
| Journal club | Jonathan Trautwein AG Mougiakakos/Mackensen | Kaparlov et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death, Nature Chemical Biology 2020 | |
| 219 | 18th of May 2020 | ||
| (per Video) | Educational colloquium | Dr. Anne Trefzer, AG Subklewe | Antigen-exhausted CD4+ T cells deviate towards multiple states of anergy |
| Journal club | Florian Märkl, AG Kobold | Schober et al. Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection, Nature Immunology 2020 | |
| 218 | 11th of May 2020 | ||
| (per Video) | Results colloquium | Theo Lorenzini, AG Kobold | Migration-optimized CAR T cell therapy for individual solid tumor patients
|
| Journal club | Laura Sellmer, AG Tufman |
Yu et al. Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma. Journal of Toracic Oncology 2018 |
|
| 217 | 4th of May 2020 | Guest speaker | |
|
Johannes vom Berg, PhD Institute of Laboratory Animal Science, |
Local immunotherapy of brain cancer with compartment locked biologics |
||
| 216 | 27th of April 2020 | ||
| (per Video) | Results colloquium |
Judit Rial Saborido AG Mougiakakos |
Metabolic alterations in T cells in the context of CLL |
| Journal club |
Martin Kirmaier AG Theurich |
Roth et al. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies, Cell 2020 | |
| 215 | 20th of April 2020 | ||
| (per Video) | Results colloquium |
Vera Maria Bauer AG Mocikat |
Targeting regulatory T cells in an endogenous lymphoma mouse model |
| Journal club |
Janina Dörr AG Kobold |
Millar et al. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy, Nature Biotechnology 2020 |
Winter semester 2019/2020
| No. | Date | Speaker | Topic |
| 211-214 | Pause due to the COVID pandemic | ||
| 210 | 9th of March 2020 | ||
| Journal club |
Larsen Vornholz AG Ruland |
Luksch et al. STING-associated lung disease in mice relies on T cells but not type I interferon, J Allergy Clin Immunol 2019 | |
| 209 | 2nd of March 2020 | ||
| Educational colloquium |
Prof. Lauber AG Lauber |
Radiotherapy in small animal models: Chances and challenges | |
| Journal club |
Melanie Schwerdtfeger AG Kobold |
Singh et al. Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction, Cancer Discovery 2020 | |
| 208 | 24th of February 2020 | ||
| Results colloquium |
Julian Benkel AG Subklewe |
Intrinsic Resistance mechanisms to T-cell recruiting antibody constructs for therapy of AML. | |
| Journal club |
Daniel Lüthy AG Berger |
Li et al. Persistent polyfunctional chimeric antigen receptor T cells that target glypican 3 eliminate orthotopic hepatocellular carcinomas in mice, Gastroenterology 2020 | |
| 207 | 17th of February 2020 | ||
| Educational colloquium |
Dr. Bastian Höchst AG Knolle |
Regulatory myeloid cells paralyze T cell immunity through cell-cell transfer of methylglyoxal | |
| Journal club |
Konstantin Schnell AG Anz |
Hatzioannou et al. An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion, Immunity 2019 | |
| 206 | 10th of February 2020 | ||
| Results colloquium |
Saskia Schmitt AG Hopfner |
Multifunctional antibody derivative to target and activate dendritic cells in vivo | |
| Journal club |
Antonio Santos AG Rothenfußer |
Chng et al. Large-Scale HLA tetramer tracking of T cells during dengue infection reveals broad acute activation and differentiation into two memory cell fates, Immunity 2019 | |
| 205 | 3rd of February 2020 | ||
| Results colloquium |
Lisa Brandmeier AG Ruland |
The Role of Diet and Exercise in CLL | |
| Journal club |
Dario Dhoqina AG Kobold |
Reinhard et al. An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors, Science 2020 | |
| 204 | 27th of January 2020 | ||
| Educational colloquium |
Dr. Carolin Perleberg AG Anz |
Next generation sequencing – Applications and Hurdles | |
| Journal club |
Lisa Rohrbacher AG Subklewe |
Crowther MD et al. Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1, Nature Immunology 2020 | |
| 203 | 20th of January 2020 | ||
| Results colloquium |
Daniel Berger AG Klein |
Dual targeting antibodies against AML steam cells. | |
| Journal club |
Theo Lorenzini AG Kobold |
Lynn et al. c-Jun overexpression in CAR T cells induces exhaustion resistance, Nature 2019 | |
| 202 | 13th of January 2020 | ||
| Results colloquium |
Duc Huynh AG Kobold |
NK Memory Formation. | |
| Journal club |
Lisa Pfeuffer AG Ruland |
Guièze et al. Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies, Cancer Cell 2019 | |
| 201 | 16th of December 2019 | ||
| Results colloquium |
Magdalena Zaucha AG Rotherfußer |
Analysis of expression quantitative trait loci after yellow fever vaccination. | |
| Journal club |
Matthias Seifert AG Kobold |
Scott et al. TOX is a critical regulator of tumour-specific T cell differentiation, Nature 2019 |
|
| 200 | 9th of December 2019 | ||
| Educational colloquium |
Dr. Lars König AG König-Schnurr |
Databases, Resources and Online Tools for your PhD. | |
| 199 | 25th of November 2019 | ||
| Results colloquium |
AG Ruland |
CBM signaling in innate immunity | |
|
AG Feuchtinger |
Thaker et al. GTPase-activating protein RasalI associates with ZAP-70 of TCR and negatively regulates T cell tumor immunity, Nature Communications, 2019 | ||
| 198 | 18th of November 2019 |
AG Böttcher (TUM) |
Beyond pretty pictures – applying microscopic imaging techniques to resolve immune cell dynamics in tissues |
|
AG Mocikat (Helmholtz Zentrum) |
Akkaya et al. Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells, Nature immunology 2019 | ||
| 197 | 11th of November 2019 | ||
| Results Colloquium | Implications of CD98 in Chronic lymphocytic leukemia | ||
| Journal Club | Yang et al. Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity, Nature medicine, 2019 | ||
| 196 | 4th of November 2019 | ||
| Results Colloquium | The influence of Interleukin-37 on cancer. | ||
| Journal Club |
Lee et al. Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters, Nature Communications 2019 |
||
| 195 | 28th of October 2019 | ||
| Educational Colloquium | Metabolism as a Determinant of Function | ||
| Journal Club | Mastelic-Gavillet et al. Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells,Journal for ImmunoTherapy of Cancer 2019 | ||
| 194 | 21th of October 2019 | ||
| Results Colloquium | Adapting immune cells to the nutrient deprivation in the tumor microenvironment by solute carrier (SLC) overexpression. | ||
| Journal Club | Mariathasan et al. TGFbeta attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells, Nature 2018 | ||
| 193 | 14th of October 2019 | ||
| Results Colloquium | Indoleamine 2,3-dioxygenase 1 in T cells. | ||
| Journal Club | Guièze et al. Mitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies, Cancer Cell 2019 | ||
| 192 | 7th of October 2019 | ||
| Educational Colloquium | Synergy of CCR8-guidance and TGF-β-resistance enables CAR T cells to reject pancreatic tumors. | ||
| Journal Club | Langan et al. De novo design of bioactive protein switches, Nature 2019 |
Summer semester 2019
| No. | Date | Speaker | Topic |
| 191 | 30th of September 2019 | ||
| Results Colloquium |
Florian Maerkl AG Kobold-Endres |
T cell engineering for improving T cell therapy in chronic lymphocytic leukemia. | |
| Journal Club |
Anja Wessely AG Berking |
Koopmans et al. Bispecific Antibody Approach for Improved Melanoma-Selective PD-L1 Immune Checkpoint Blockade, Journal of Investigative Dermatology 2019 | |
| 190 | 23rd of September 2019 | ||
| Results Colloquium |
Eva Ortner AG Feuchtinger |
Induction of T-cell attack against ALL through a TIM-3/CD28 fusion receptor. | |
| Journal Club |
Lisa Lehmann AG Rothenfußer |
Kao et al. Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection, Immunologists 2019 | |
| 189 | 9th of September 2019 | ||
| Results Colloquium |
Duc Huynh AG Kobold |
TBA | |
| Journal Club |
Vasil Toskov AG Feuchtinger |
S. Gautam et al. The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity, Nature Immun 2019 |
|
| 188 | 22nd of July 2019 | ||
| Guest Speaker |
Prof. Dr. Angela Krackhardt IIIrd Medical Department, Hematology and Oncology, Klinikum rechts der Isar, TU Munich |
Development of personalised treatment and novel monitoring approaches for T-cell based immunotherapies in cancer | |
| 187 | 15th of July 2019 | ||
| Educational Colloquium |
Dr. Justyna Ogonek AG Kobold |
Chemokine receptor-overexpressing CAR T cells for enhanced adoptive therapy of solid cancer | |
| Journal Club |
Martin Kirmaier AG Theurich |
Hamieh et al. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape, Nature 2019 | |
| 186 | 8th of July 2019 | ||
| Results Colloquium |
Anja Wessely AG Berking |
The transcription factor SOX10 and its functional role in uveal melanoma | |
| Journal Club |
Daniel Berger AG Klein |
F. Basheer et al. Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML, JEM 2019 | |
| 185 | 1st of July 2019 | ||
| Guest Speaker |
Prof. Dr. Jörg Renkawitz Biomedical Center Munich (BMC) |
Principles of leukocyte navigation in 3D microenvironments. | |
| 184 | 24th of June 2019 | ||
| Results colloquium | Philipp Metzger
AG König-Schnurr |
TBA. | |
| Journal Club | Mohamed-Reda Benmebarek
AG Kobold-Endres |
Claus et al. Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy, Sci. Transl. Med 2019. | |
| 183 | 17th of June 2019 | ||
| Results colloquium | Lisa Rohrbacher
AG Subklewe |
Effects of Idelalisib on immune cells. | |
| Journal Club | Siret Tahk
AG Hopfner |
Su et al. Immune checkpoint inhibition overcomes ADCP-induced immunosuppression by macrophages, Cell 2018. | |
| 182 | 3rd of June 2019 | ||
| Results colloquium | Sascha Göttert
AG Haas/Poeck |
The role of type I interferon-inducing metabolites in Prophylaxis of Graft-versus-Host disease. | |
| Journal Club | Carlotta Rambuscheck
AG König-Schnurr |
XM. Evrard et al. Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector function, Cell Press 2018. | |
| 181 | 27th of Mai 2019 | ||
| Results colloquium | Dr. Maike Buchner
AG Ruland |
Pathologically enforced RANK signaling in B Cells triggers autoimmune lymphoproliferation and chronic lymphoytic leukemia development. | |
| Journal Club | Konstantinos Panagiotidis
AG Mougiakaos |
Xu et al. Translation control of the immune checkpoint in cancer and its therapeutic trageting, Nature medicine 2019. | |
| 180 | 20th of Mai 2019 | ||
| Results colloquium | Steffen Dickopf, Roche
AG Kobold-Endres |
Next generation T cell bispecific antibodies. | |
| Statistical lecture | Larsen Vornholz
AG Ruland |
Statistic lecture 101. | |
| 179 | 6th of April 2019 | ||
| Results colloquium | Jasmin Mahdawi
AG Feuchtinger |
Generation and Characterization of CD19 CAR T cells with CTLA-4/CD28 fusion receptor. | |
| Journal Club | Janina Dörr
AG Kobold |
Rosato et al. Virus-specific memory T cells populate tumors and can be repurposes for tumor immunotherapy, Nature communications 2019. | |
| 178 | 29th of April 2019 | ||
| Results colloquium | Prof. Dr. Marion Subklewe
AG Subklewe |
The Evolution of Immunotherapy in AML. | |
| Journal Club | Lisa Rohrbacher
AG Subklewe |
Poggio et al. Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory, Cell 2019. | |
| 177 | 15th of April 2019 | ||
| Results colloquium | Sehmus Tohumeken
AG Mackensen |
AML exosomes promote TLR2-mediated induction of glycolytic MDSC. | |
| Research Seminar | Simone Formisano
AG König/Schnurr |
Staedtke et al. Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome, Nature 2018. | |
| 176 | 8th of April 2019 | ||
| Results colloquium | Veronika Ecker
AG Ruland |
Negative feedback inhibition as novel therapeutic approach in chronic lymphocytic leukemia | |
| Research Seminar | Kim Pawelka
AG Knolle |
Smith et al. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors, JCI 2017. | |
| 175 | 1st of April 2019 | ||
| Results colloquium | Prof. Dr. Dimitrios Mougiakakos
AG Mougiakakos Erlangen |
Stroma cells: an immune metabolic hub. | |
| Journal Club | Sascha Göttert
AG Poeck/Haas |
Gopalakrishnan et al. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018. | |
Winter semester 2018/2019
| No. | Date | Speaker | Topic |
| 174 | 25th of March 2019 | ||
| Journal Club | Larsen Vornholz
AG Ruland |
Cox et al. Choline acetyltransferase-expressing T cells are required to control chronic viral infection, Science 2019. | |
| 173 | 18th of March 2019 | ||
| Guest Speaker |
Professor Charles Dinarello University of Colorado, Denver |
Role of NLRP3 regulation of IL-1beta in cancer. | |
| 172 | 11th of March 2019 | ||
| Guest Speaker |
Vincenzo Desiderio, Ph.D. |
Inhibition of pentose phosphate pathway suppresses tumor growth and metastasis by inducing endoplasmic reticulum stress and autophagy. | |
| 171 | 4th of March 2019 | ||
| Results colloquium | Dr. Daria Briukhovetska
AG Kobold |
The roles of C5a receptor 1 and chemokine receptor 5 in Toxoplasma gondii infection. | |
| Journal Club | Konstantinos Panagiotidis
AG Mougiakakos |
Jones et al. Inhibition of amino acid metabolism selectively targets human leukemia stem cells, Cancer Cell 2018. | |
| 170 | 25th of February 2019 | ||
| Results colloquium | Javier Suarez Gosalvez
AG Kobold |
The impact of interleukin-22 on metastasis formation. | |
| Journal Club | Natascha Röhrle
AG Anz |
Spranger et al. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy, Cancer Cell 2017. | |
| 169 | 18th of February 2019 | ||
| i-Target seminar awards 2018 | the presentation of the i-Target seminar awards 2018 for the best talk, the best discussing person and the best journal club quiz performance. | ||
| Results colloquium |
Daniel Bergér AG Klein |
Multi-specific Antibodies to target Cancer stem cells in AML via CD200. | |
| Journal Club |
Dana Stenger AG Feuchtinger |
Yamamoto et al. T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy, JCI 2019. | |
| 168 | 11th of February 2019 | ||
| Results colloquium | Dr. Laia Pascual Ponce
AG Hopfner |
CD47-SIRPalpha: the myeloid-specific immune checkpoint. | |
| Journal Club | Clara Karches
AG Kobold |
Feucht et al. Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency, Nature Medicine 2018. | |
| 167 | 4th February 2019 | ||
| Results colloquium | Alina Lohner
AG Subklewe |
Expansion & Characterization of AML-specific T Cells to test novel in vivo DC targeting AB Constructs. | |
| Journal Club | Anne Marie Senz
AG Schnurr |
André et al. Anti-NKG2A mAb is a checkpoint Inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells, Cell 2018. | |
| 166 | 21th January 2019 | ||
| Educational colloquium | Dr. Meino Rohlfs
AG Klein |
Next generation sequencing. | |
| Journal Club | Magdalena Zaucha
AG Rothenfußer |
Boettcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell 2018. | |
| 165 | 14th January 2019 | ||
| Results colloquium | Kim Pawelka
AG Knolle |
iMATE-forming monocytes - a population with unique functional properties. | |
| Journal Club | Duc Huynh
AG Kobold |
Wight et al. Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses, PNAS 2018. | |
| 164 | 7th January 2019 | ||
| Results colloquium | Svenja Rausch
AG Kobold |
Effect of PD-1-CD28 fusion receptor transduced T cells in adoptive T cell therapy. | |
| Journal Club | Alina Lohner
AG Subklewe |
Sahin et al: Personalized vaccines for cancer immunotherapy, Sciences 2018. | |
| 163 | 17th December 2018 | ||
| Research Seminar | Prof.Dr. Sebastian Theurich
Professorship for Cancer & Immuno-Metabolism, Attending Physician, Dpt. of Medicine III, University Hospital Munich |
NK cells in Metaflammation | |
| 162 | 10th December 2018 | ||
| Journal Club | Daniel Bergér
AG Klein |
Shivange et al. A single-agent dual-specificity targeting of FOLR1 and DR5 as an effective strategy for ovarian cancer, Cancer Cell 2018 | |
| 161 | 3rd December 2018 | ||
| Educational colloquium | Dr. Nicholas Tokarew
AG Kobold |
The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and its Relationship with the Sonic Hedgehog Pathway. | |
| Journal Club | Saskia Schmitt
AG Hopfner |
Akahori et al. Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination, Blood 2018. | |
| 160 | 26th November 2018 | ||
| Journal Club | Eva Ortner
AG Feuchtinger |
Han et al. Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Nature communications 2018. | |
| 159 | 19th November 2018 | ||
| Results colloquium | Corinna Meyer-Gehlen
AG Rothenfußer |
Characterization of new potential MAVS interaction partners. | |
| Journal Club | Maryam Schübele
AG Kobold |
Zhang et al. Blockade of the checkpoint receptor TIGIT prevent NK cell exhaustion and elicits potent anti-tumor immunity, Nature Immunology 2018. | |
| 158 | 12th November 2018 | ||
| Results colloquium | Dr. Heiko Bruns
AG Mackensen |
Tumour associated macrophages and therapeutic antibodies. | |
| Journal Club | Tanja Stief
AG Feuchtinger |
Osborn et al. CRISPR-based cellular engineering for targeted gene overexpression, Int. J. Mol. Sci. 2018. | |
| 157 | 5th November 2018 | ||
| Results colloquium | Paula Rothämel and Jonas Wilhelm
AG Feuchtinger |
Blast-T cell interaction in pediatric leukaemia. | |
| Journal Club | Bruno Cadilha
AG Kobold |
Deng et al. LILRB4 signaling in leukaemia cells mediates T cell suppression and tumour infiltration, Nature letters 2018. | |
| 156 | 29th October 2018 | ||
| Results colloquium | Mohamed-Reda Benmebarek
AG Kobold |
Mesothelin-targeted bispecific antibodies drive synthetic agonistic receptor-transduced T cells to mediate specific and conditional therapy of human pancreatic cancer models. | |
| Journal Club | Judit Rial
AG Mougiakakos |
Pilipow et al. Antioxidant metabolism regulates CD8+ T cell memory stem cell formation and antitumor immunity, JCI insight 2018. | |
| 155 | 22nd October 2018 | ||
| Educational colloquium | Prof. Dr. Percy Knolle | Local immune regulation in the liver: new insights into an organ with dual function in controlling immunity and metabolism. | |
| Journal Club | Jasmin Mahdawi
AG Feuchtinger |
Lai et al. Toll-like receptor 2 costimulation potentiates antitumor efficacy of CAR T Cells, Leukemia 2018. | |
| 154 | 15th October 2018 | ||
| Journal Club | Johannes Lutz
AG Kobold |
Adachi et al. Il-7 and CC19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor, Nature biotechnology 2018. | |
Summer semester 2018
(9th April 2018 till 14th July 2018)
| 153 | 8th October 2018 | ||
| Results colloquium | Lara Hartjes
AG Ruland |
Identification of novel MALT1 substrate. | |
| Journal Club | Raphael Rubens
AG Kobold |
Rafiq et al. Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo, Nature Biotechnology, 2018. | |
| 156 | 1st October 2018 |
Prof. Dr. Hans-Georg Rammensee Head of the Department of Immunology, Institute for Cell Biology, University of Tübingen |
On the development of personalized cancer vaccines |
| 153 | 24th September 2018 | ||
| Results colloquium | Sehmus Tohumeken
AG Mackensen |
AML exosomes promote induction of glycolytic MDSCs. | |
| Journal Club | Konstantinos Panagiotidis
AG Mougiakakos |
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. | |
| 153 | 10th September 2018 | ||
| Educational colloquium | Prof. Dr. Marion Subklewe | Women in science. | |
| Results colloquium | Bruno Cadilha
AG Kobold |
C-C Chemokine receptor 8 and TGF-β-Receptor 2 genetic engineering combination make for successful Chimeric antigen receptor T cell therapy in solid tumors. | |
| 152 | 23th July 2018 | ||
| Research colloquium | Philipp Metzger
AG Schnurr |
The role of IRF4 in MDSC in an orthotopic pancreatic cancer mode. | |
| 151 | 18th July 2018 |
PD Dr. Louisa von Baumgarten Neurologische Klinik und Poliklinik, Klinikum Großhadern, München |
In vivo imaging of brain tumors to monitor novel therapeutic strategies |
| 150 | 9th July 2018 | ||
| Educational colloquium | Dr. Maike Buchner
AG Ruland |
The impact of nutrition on cancer and immune cell signaling. | |
| Journal club | Philipp Metzger
AG Schnurr |
Li et al. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy, Immunity 2018. | |
| 149 | 2nd July 2018 | ||
| Journal club | Sehmus Tohumeken
AG Mackensen |
Wang et al. Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis, AACR Journal 2018 | |
| 148 | 2nd July 2018 |
Professor Shaun McColl Professor of Immunology, Head of Chemokine Biology, Faculty of Sciences, The University of Adelaide, Australia |
Chemokines and their receptors in metastatic cancer. |
| 147 | 25th June 2018 | ||
| Results colloquium | Dana Stenger
AG Feuchtinger |
Generation of CD19 CAR T cells with a CRISPR/Cas9 mediated T cell receptor knock out. | |
| Journal club | Javier Suarez Gosalvez
AG Kobold |
Brown et al. Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice, Science 2018. | |
| 146 | 18th June 2018 | ||
| Educational colloquium | Dr. Jin Zhang
AG Kobold |
Understanding T cell receptor initial triggering. | |
| Journal club | Paula Rothämel
AG Feuchtinger |
Morsut et al. Engineering customized cell sensing and response behaviors using synthetic notch receptors, Cell 2016. | |
| 145 | 11th June 2018 | ||
| Educational colloquium | Professor Lauber
AG Lauber |
Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and precinical experiences. | |
| Journal club | Svenja Rausch
AG Kobold |
Cho et al. Universal chimeric antigen receptors for multiplexed and logical control of T cell responses, Cell 2018 . | |
| 144 | 28th May 2018 | ||
| Educational colloquium | Justyna Ogonek
AG Kobold |
CMV-specific T cells in immunotherapy for stem cell transplantation - associated complications. | |
| Journal club | Lara Hartjes
AG Ruland |
Wong, B. Visual strategies for biological data, part I, Nat. Methods. | |
| 143 | 14th May 2018 | ||
| Results colloquium | Laura Frey
AG Klein |
Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45). | |
| Journal club | Clarissa Zappe
AG Rothenfußer |
Yu et al. Activation of the MDA5-IPS1 viral sensing pathway induces cancer cell death and type I interferon-dependent antitumor immunity, Cancer Res, 2016. | |
| 142 | 7th May 2018 | ||
| Results colloquium | Siret Tahk
AG Hopfner |
Targeting the AML leukemic stem cell population using anti-CD123 antibodies that simultaneously disrupt the CD47–SIRPα interaction. | |
| Journal club | Simone Formisano
AG Schnurr |
Xiaolin Yu, et al. Targeting EGFR/HER2/HER3 with a three-in-one aptamer-siRNA chimera confers superior activity against HER2+ breast cancer, Molecular Therapy, Nucleic Acids, 2017. | |
| 141 | 23th April 2018 | ||
| Educational colloquium | Daniel Böhmer
AG Schnurr |
Molecular mechanisms of nucleic acid-mediated cytotoxicity. | |
| Journal club | Simon Dedic
AG Hopfner |
Cheng et al. Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma, CellDeath and Disease, 2018. | |
| 140 | 16th April 2018 | ||
| 29th Research Seminar | Dr. Georg Fertig
Head of Dept. Screening & Functional Assays, Large Molecule Research Roche, Penzberg |
Transformative antibody therapeutics at Roche | |
| 139 | 9th April 2018 | ||
| Results colloquium | Bastian Meyer
AG Anz |
Identification of functional receptors for CCL22 via APEX2 proximity labeling. | |
Winter semester 2017/2018
(16th Oktober 2017 till 10th February 2018)
| No. | Date | Speaker | Topic |
| 138 | 26th March 2018 | ||
| Results colloquium | Saskia Schmitt
AG Hopfner |
Multispecific antibody derivatives to target and activate dendritic cells in vivo. | |
| Journal club | Angelina Krächan
AG Kobold |
Barrow et al. Natural killer cells control tumor growth by sensing a growth factor, Cell, 2018. | |
| 137 | 19th March 2018 | ||
| Results colloquium | Anna Maier
AG Subklewe |
Influence of immunosuppressive cellular and humoral factors on T-cell function in Acute Myeloid Leukemia. | |
| Journal club | Kim Pawelka
AG Knolle |
Wang et al. A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair, Cell, 2016. | |
| 136 | 12th March 2018 | ||
| Results colloquium | Raphael Kfuri Rubens
AG Schnurr |
Indolamine 2,3-dioxygenase in T cells. | |
| Journal club | Svenja Rausch
AG Kobold |
Böttcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell, 2018. | |
| 135 | 5th March 2018 | ||
| Educational colloquium | Dr. Martin Böttcher
AG Mougiakakos |
2-HG-A a novel oncometabolite with immune modulation properties. | |
| Journal club | Veronika Ecker
AG Ruland |
Kikushige et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia, Cancer Cell, 2011. | |
| 134 | 26th February 2018 | ||
| Results colloquium | Tanja Stief
AG Feuchtinger |
CRISPR/Cas-mediated T cell editing for the treatment of refractory viral infections. | |
| Journal club | Magdalena Scheck
AG Rothenfußer |
Clift et al. A method for the acute and rapid degradation of endogenous proteins, Cell, 2018. | |
| 133 | 19th February 2018 | ||
| Results colloquium | Julius Keyl
AG Kobold |
Fusion receptor- transduced T cells combined with bispecific antibodies to improve the therapy of malignant melanomas. | |
| Journal club | Jonas Wilhelm
AG Feuchtinger |
Duell et al. Frequency of regulatory T cells determines the outcome of theT-cell-engaging antibody blinatumomab in patients with B-precursor ALL, Leukemia, 2017. | |
| 132 | 12th February 2018 | ||
| Educational colloquium | Dr. Selina Keppler
AG Ruland |
Dectin-1: a C- type lectin receptor on dendritic cells in antifungal immunity. | |
| Journal club | Clara Karches
AG Kobold |
Lan et al. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β, Science Translational Medicine, 2018. | |
| 131 | 5th February 2018 | ||
| 28th Research seminar | Ph.D., Ph.D. Santiago González | Intravital characterization of the inflammatory response that follows vaccination in the draining lymph node | |
| 130 | 29th January 2018 | ||
| Results colloquium | Stefanie Lesch
AG Kobold |
Whole transcriptome analysis of adoptively transferred tumor infiltrating T-cells. | |
| Journal club | Antonia Apfelbeck
AG Feuchtinger |
Xiaojun et al. A chimeric switch-receptor targeting PD1 augments the efficacy of second generation CAR T-Cells in advanced solid tumors, Cancer Res, 2017. | |
| 129 | 22nd January 2018 | ||
| Educational colloquium | Dr. Claudia Roskopf
AG Hopfner |
Insights into cell-mediated cytotoxicity and phagocytosis: how tumor cells are killed. | |
| Journal club | Raphael Kfuri Rubens
AG Schnurr |
Routy et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science 2017. | |
| 128 | 15th January 2018 | ||
| Results colloquium | Kim Pawelka
AG Knolle |
Unique functional properties of iMATE forming myeloid cells. | |
| Journal club | Steffeni Mountford
AG Bufler |
Hong et al. Correction of a pathogenic gene mutation in human embryos. Nature 2017 | |
| 127 | 8th January 2018 | ||
| Results colloquium | Clara Karches
AG Kobold |
Synthetic agonistic receptors as an approach for immunotherapy. | |
| Journal club | Maurine Rothe
AG Subclewe |
Shapiro et al. Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia. Haematologica, 2017. | |
| 126 | 18th December 2017 | ||
| Results colloquium | Mohamed-Reda Benmebarek
AG Kobold |
Combination of bispecific antibodies with genetically modified T-cells for cancer immunotherapy. | |
| Journal club | Mohamed-Reda Benmebarek
AG Kobold |
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nature medicine, 2017 | |
| 125 | 11th December 2017 | ||
| Educational colloquium | Dr. Jin Zhang
AG Kobold |
Phospholipid Scramblase 1 regulates T-cell antitumor immunity by activating PI3K signaling. | |
| Journal club | Steffeni Moundford
AG Bufler |
NLRP1 promotes tumor growth by enhancing inflammasone activation and suppresisng apoptosis in metastatic melanoma. Oncogene, 2017 | |
| 124 | 4th December 2017 | ||
| Results colloquium | Laura Frey
AG Klein |
Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45). | |
| Journal club | Steffen Dickopf
AG Kobold |
Patel et al. Identification of essential genes for cancer immuntherapy. Nature, 2017 | |
| 123 | 27th November 2017 | ||
| 27th Research seminar | Dr. Arndt Schottelius
Kymab, Cambridge UK |
KY1044, a novel anti-ICOS antibody, elicits long term in vivo anti-tumour efficacy as monotherapy and in combination with immune checkpoint inhibitors. | |
| 122 | 20th November 2017 | ||
| Results colloquium | Steffen Dickopf
AG Kobold |
A robust tool for optimizing CRISPR/Cas9-mediated gene editing - the whole story. | |
| Journal club | Dana Stenger
AG Feuchtinger |
Hu B. et al. Augmentation of antitumor immunity by human and mouse CAR T Cells secreting IL-18. Cell Reports, 2017 | |
| 121 | 13th November 2017 | ||
| Results colloquium | Javier S. Golsavez
AG Kobold |
Impact of interleukin-22 on metastasis formation | |
| Journal club | Anna Maier
AG Subklewe |
Mangaonkar A. et al. A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression. Scientific Reports, 2017 | |
| 120 | 6th November 2017 | ||
| 26th Research seminar | Dr. Alexander Buchner
Urologische Klinik und Poliklinik, Klinikum der Universität München |
Basics of statistics - important for doctoral thesis and publication | |
| 119 | 16th October 2017 | ||
| 25th Research seminar | Dr. Sebastian P. Haen
Med. Universitätsklinik, Tübingen |
T cell reactivity against self-antigens - Autoimmunity after allogeneic hematopoietic cell transplantation | |
| 118 | 9th October 2017 | ||
| Results colloquium | Prof. Duska Dragun
AG Subklewe |
TBA | |
| Journal club | cancelled | ||
| 117 | 2nd October 2017 | ||
| Results colloquium | Lara Hartjes
AG Ruland |
Identification of novel MALT1 substrates | |
| Journal club | |||
Summer semester 2017
(24th April 2017 till 29th July 2017)
| No. | Date | Speaker | Topic |
| 116 | 25th September 2017 | ||
| 24th Research seminar | Prof. Dr. Jürgen Bernhagen
Munich |
Immune-mediated mechanisms in cardiovascular disease and cancer: focus on MIF proteins | |
| 115 | 18th September 2017 | ||
| Educational colloquium |
AG Mougiakakos |
Immune metabolic interplay in cancer | |
| Journal club | Semjon Willier
AG Feuchtinger |
Mezzadra R. et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 2017 | |
| 114 | 24th July 2017 | ||
| Educational colloquium | Dr. Benedikt Jacobs
AG Mackensen |
NK cells - from biology to clinical trials. | |
| Journal club | Sehmus Tohumeken
AG Mackensen |
Liu Y. et al. Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell, 2016 | |
| 113 | 17th July 2017 | ||
| 23th Research seminar | Dr. Matthias Klinger
AMGEN Research, Munich |
Innovative drug development at AMGEN | |
| 112 | 10th July 2017 | ||
| Result colloquium | Romy Loschinski
AG Mougiakakos |
IL-21 as an immunometabolic T-cell modulator. | |
| Journal club | Javier Suarez Gosalvez
AG Kobold |
Whole-body imaging of lymphovascular niches identifies pre- metastatic roles of midkine. Nature Letters, 2017 | |
| 111 | 3rd July 2017 | ||
| Educational colloquium | Dr. Lars König
AG Kobold |
How-to guide to creating CRISPR-KOs | |
| Journal club | Clara Karches
AG Kobold |
Rulla M et al. Overcoming the immunosuppressive tumor microenviroment of Hodgking lymphoma using chimeric antigen receptor T cells. American Association for Cancer, 2017 | |
| 110 | 26th June 2017 | ||
| Results colloquium | Bruno Cadilha
AG Kobold |
Redirecting T cells through CCR8-CCL1 axis and shielding from TGF-β for effective adoptive T cell therapy | |
| Journal club | Tanja Stief
AG Feuchtinger |
Rupp LJ et al. CRISPR/Cas9-mediated PD-1disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Nature, 2017 | |
| 109 | 19th June 2017 | ||
| 22th Research seminar | Dr. Rajkumar Savai
Max Planck Institute, Bad Nauheim |
The lung tumor microenvironment: targeting the soil to kill the tumor seed | |
| 108 | 29th May 2017 | ||
| Results colloquium | Sehmus Tohumeken
AG Mackensen |
Characterization and targeting of myeloid-derived suppressor cells in acute myeloid leukemia | |
| Journal club | Heike Anders
AG Lauber |
Rodriguez-Ruiz M E et al. Abscopal effects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming, Cancer Research 2016 | |
| 107 | 22th May 2017 | ||
| Results colloquium | Dr. Selina Keppler
AG Ruland |
Imaging B cells: linking receptors, the actin cytoskeleton and aberrant immune responses | |
| 106 | 15th May 2017 | ||
| Progress report | Veronika Ecker
AG Ruland |
Drug delivery improvement for leukemia and lymphoma | |
| 105 | 8th Mai 2017 | ||
| Educational colloquium | Dr. Marcin Lyszkiewicz
AG Klein |
T cell development by the numbers | |
| Journal club | Stefan Stoiber
AG Kobold |
Long A H et al. 4-1BB costimulation ameliorates T cell exhaustion induces by tonic signaling of chimeric antigen receptors. Nature Medicine, 2015 | |
| 104 | 24th April 2017 | ||
| Results colloquium | Steffeni Mountford
AG Bufler |
Modulation of liver inflammation and fibrosis by the IL-1 homologue IL-37 | |
| 103 | 3rd April 2017 | ||
| Results colloquium | Maurine Rothe
AG Subklewe |
Blockade of LAG-3 enhances dentritic cell-induced T-cell responses more than blockade of PD-1 | |
| Journal club | Mareike Lepenies
AG Feuchtinger |
McGranahan N et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science, 2016 | |
Winter semester 2016/2017
(17th October 2016 till 11th February 2017)
| No. | Date | Speaker | Topic |
| 102 | 27th March 2017 | ||
| Educational colloquium | Dr. Maike Buchner | B cell development malignant transformation and signaling thresholds | |
| Journal club | Lukas Mallaun | Eyquem J et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature, 2017 | |
| 101 | 20th March 2017 | ||
| Results colloquium | cancelled due to ITOC Conference | ||
| Journal club | |||
| 100 | 13th March 2017 | ||
| Results colloquium | Monika Herrmann | Releasing the T cell brake - novel strategy of local PD-1/PD-L1 checkpoint blockade to fight immune evasion in AML | |
| Journal club | Maurine Rothe | Bronte V et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 2016 | |
| 99 | 6th March 2017 | ||
| 21th Research Seminar |
Dr. Jan Böttcher The Francis Crick Institute, London |
Evasion of the antitumor immunity by prostaglandin E2 production | |
| 98 | 20th February 2017 | ||
| 20th Research Seminar |
Dr. Arndt Schottelius MorphoSys, Munich |
Anti-CD38 monoclonal antibodies as an evolving new backbone therapy in multiple myeloma | |
| 97 | 13th February 2017 | ||
| Educational colloquium | Paul Schwarzlmüller | Basics in Statistics | |
| Journal club | Lara Hartjes | Damgaard R B et al. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell, 2016 | |
| 96 | 10th of February at 10:30 |
Yi Xeng, China |
Medical research in China (15 min) |
| 95 | 6th February 2017 | ||
| Result colloquium | Phillip Metzger | PD-1 expression of non-T cells | |
| Journal club | Bruno Cadilha | Buck M D et al. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell, 2016 | |
| 94 | 30th January 2017 | ||
| Educational colloquium | Anna Kaufmann | Autophagy and its role in cancer | |
| Journal club | Xiaomei Chen | Arbore G et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 2016 | |
| 93 | 26th January 2017 | ||
| 19th Research Seminar |
Prof. Charles Dinarello, University of Colorado, Denver |
From fever to autoinflammation - the roadmap of interleukin-1 beta | |
| 92 | 23th January 2017 | ||
| 18th Research Seminar |
Dr. Nisit Khandelwal iOmx Therapeutics AG, Munich |
Research seminar: Mapping the tumor's immune-evasion strategies beyond the existing paradigm |
|
| 91 | 16th January 2017 | ||
| Themenkolloqium | Kim Pawelka | Plasticity of myeloid cells in the iMate context | |
| Journal Club | Steffi Lesch | Faitschuk E et al. Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells. Blood, 128: 1711-1722 | |
| 90 | 09th January 2017 | ||
| Themenkolloqium | Saskia Schmitt | Characterization of multispecific antibody derivates to target and activate dendritic cells in vivo | |
| Journal Club | Laura Frey | Moroishi T et al. The hippo pathway kinases LATS1/2 suppress cancer immunity. Cell, 167:1525-1539. | |
| 89 | 19th December 2016 | ||
| 17th Research Seminar |
Dr. A. Schottelius Morphosys AG |
Clinical update on MOR208, an antibody targeting CD19 in Non-Hodgkin Lymphomas |
|
| 88 | 28th November 2016 | ||
| Themenkolloqium | AG Rothenfußer | TBA | |
| Journal Club | |||
| 87 | 14th November 2016 | ||
| Themenkolloqium | Clara Karches | Activating fusion receptors as a novel approach for targeting autoreactive B cell receptors on chronic lymphatic leukaemia cells | |
| Journal Club | Julia Stein | A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression | |
| 86 | 11th November 2016 | ||
| 16th Research Seminar |
Dr. Jasper von Boorn University Hospital Bonn Biomedical Center Institute for Clinial Chemistry and Clin. Pharmacology |
Pigment cell-specific NK cell memory revealed |
|
| 85 | 07th November 2016 | ||
| 15th Research Seminar |
Dr. Carolin Daniel Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt Institut für Diabetesforschung |
Immune tolerance in autoimmune type 1 diabetes |
|
| 84 | 24th October 2016 | ||
| Themenkolloqium | AG Subklewe | ||
| Journal Club | Hanna Nowotny |
Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies |
|
| 83 | 17th October 2016 | ||
| 14th Research Seminar |
Prof. Georgios Stathopoulos |
On the role of mutant KRAS in malignant pleural disease |
|
| 82 | 10th October 2016 | ||
| Themenkolloqium | Julia Kobuch | Metastasis: Colonial policy in the body and models for its investigation | |
| Journal Club | Philipp Metzger | Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy | |
| 81 | 19th September 2016 | ||
| Themenkolloqium | Felicitas Rataj | About CARs and TRUCKs - Do we have the drivers' license? | |
| Journal Club | Anna Tiefenthaller |
Caloric restriction mimetics enhance anticancer immunosurveillance |
|
Summer semester 2016
(11. April 2016 bis 16. Juli 2016)
| 80 | 25. Juli 2016 | ||
| 13th Research Seminar |
Prof. Samuel Huber Peter Hans Hofschneider Professor Molecular Gastroenterology and Immunology University Medical Center Hamburg-Eppendorf |
Control of Th17 cells in the intestine |
|
| 79 | 18. Juli 2016 | ||
| 12th Research Seminar |
Dr. Annette Künkele Department of Pediatric Oncology/Hematology/SCT Charité-Universitätsmedizin Berlin |
What we learned from bench to beside with the neuroblastoma targeting CD171 -specific CAR |
|
| 78 | 11. Juli 2016 | ||
| Themenkolloqium | Severin Rodler | The IL-22/IL22-R-axis in renal cell carcinoma (RCC) | |
| Journal Club | Celina Aithal | Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells | |
| 77 | 04. Juli 2016 | ||
| Themenkolloqium | Viktoria Bothe | Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX | |
| Journal Club | Stefan Stoiber | In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity | |
| 76 | 27. Juni 2016 | ||
| Themenkolloqium | Viktoria Bothe | Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX | |
| Journal Club | Stefan Stoiber | In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity | |
| 75 | 20. Juni 2016 | ||
| 11th Research Seminar |
Dr. Arndt Schottelius Morphosys AG |
Clinical update on MOR202, a HuCAL antibody targeting CD38 in multiple myeloma |
|
| 74 | 13. Juni 2016 | ||
| Themenkolloqium | Laura Posselt | Targeting RIG-I with 5’ppp-modified RNA for immunotherapy of hepatocellular carcinoma (HCC) | |
| Journal Club | AG Rothenfusser | ||
| 73 | 06. Juni 2016 | ||
| Themenkolloqium | Monika Herrmann | Design of a new multispecific antibody derivative targeting the PD-1/PD-L1 immune checkpoint | |
| Journal Club | Adrian Gottschlich | The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity | |
| 72 | 30. Mai 2016 | ||
| Themenkolloqium | Fabian Kraus | ||
| Journal Club | Tim Wartewig | Disparate Individual Fates Compose Robust CD8+ T Cell Immunity | |
| 71 | 02. Mai 2016 | ||
| Themenkolloqium | AG Klein | ||
| Journal Club | Saskia Schmitt | Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas | |
| 70 | 25. April 2016 | ||
| 10th Research Seminar |
Dr. Ignazio Caruana Cellular and Gene Therapy of Pediatric Tumour IRCCS Bambino Gesù Hospital Rome, Italy |
Optimization of Chimeric Antigen Receptor T cell therapy in solid tumourss |
|
| 69 | 18. April 2016 | ||
| Themenkolloquium | Daniel Böhmer | Non-canonical pathways of RLH-induced cell death | |
| Journal Club | Clara Karches | Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor | |
| 68 | 11. April 2016 | ||
| Themenkolloquium | Angelina Krächan | Impact of TLR7-Agonists on NK cell cytotoxicity, phenotype and migration | |
| Journal Club | Laura Frey | IL-17-producing cd T cells and neutrophils conspire to promote breast cancer metastasis | |
| 67 | 04. April 2016 | ||
| Themenkolloquium | Simon Rothenfußer | ||
| Journal Club | AG Hopfner | ||
Winter semester 2014/2015
(6. Oktober 2014 bis 6. Februar 2015)
| 66 | 28. März 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 65 | 21. März 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 64 | 16. März 2016 | ||
| 9th Research Seminar |
Prof. Charles Dinarello Department of Medicine Division of Infectious Diseases University of Colorado Denver Aurora, CO, USA |
The interleukin-1 family in 2016: solving secrets, helping patients |
|
| 63 | 14. März 2016 | ||
| Themenkolloquium | Lisa Weigand | Characterization and Targeting of MDSCs in AML | |
| Journal Club | Romy Loschinski | Autophagy enforces funktional integrity ofregulatory T cells by coupling environmental cues and metabolic homeostasis | |
| 62 | 07. März 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 61 | 29. Februar 2016 | ||
| Themenkolloquium | Christoph Klein | Primary Immunodeficiency Disorders | |
| Journal Club | Florian Asang | Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes | |
| 60 | 22. Februar 2016 | ||
| Themenkolloquium | Lars König | Cell Culture: Basics, Tips and Quality Control | |
| Journal Club | Michael Ruzicka | Agonist antibody that induces human malignant cells to kill one another | |
| 59 | 15. Februar 2016 | ||
| Themenkolloquium | Jürgen Ruland | ITAM Receptors in Innate Immunity and Oncogenesis | |
| Journal Club | Claudia Roskopf | Talimogene Laherparepvec improves durable response rate in patients with advanced melanoma | |
| 58 | 8. Februar 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 57 | 1. Februar 2016 | ||
| Themenkolloquium | |||
| Journal Club | Rachel Mak'Anyengo | ||
| 56 | 25. Januar 2016 | ||
| Themenkolloquium | Jennifer Heinrich | Engineering of PD1-CD28 fusion receptor for improved functionality | |
| Journal Club | Severin Rodler | Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids | |
| 55 | 18. Januar 2016 | ||
| Themenkolloquium | Nadine Moritz | Development of a novel antibody format to target AML | |
| Journal Club | Veronica Ecker | Signalling thresholds and negative B-cells selection in acute lymphoblastic leukaemia | |
| 55 | 11. Januar 2016 | ||
| Themenkolloquium | Prof. Stefan Endres | Immunotherapie of cancer - update 2016 | |
| PD Dr. Sebastian kobold | i-Target program 2016 | ||
| 53 | 21. Dezember 2015 | ||
| Themenkolloquium | Bruno Cadilha | Redirecting T cells and enabling their TGF-beta resistance | |
| Journal Club | |||
| 52 | 14. Dezember 2015 | ||
| Themenkolloquium | Clara Karches | Combination of bispecific antibody with activating fusion Receptor for cancer therapy | |
| Journal Club | Lara Hartjes | The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquination by LUBAC to dampen lymphocyte NF-kB signaling | |
| 51 | 07. Dezember 2015 | ||
| Themenkolloquium | Michael Ruzicka | Immunotherapy of AML with bifunctional siRNA | |
| Journal Club | Angelina Krächan | ||
| 50 | 30. November 2015 | ||
| Themenkolloquium | Maurine Rothe | ||
| Journal Club | Daniel Böhmer | A genome-wide CRISPR screen identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation | |
| 49 | 26. November 2015 | ||
| Themenkolloquium | Julia Ahlfeld | ||
| Journal Club | Laura Frey |
Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells |
|
| 48 | 18. November 2015 | ||
| 8th Research Seminar |
PhD Nadia Cherradi INSERM U1036 - Biologie du Cancer et de l'Infection iRTSV/CEA Grenoble |
Post-transcriptional regulation in cancer: Focus on RNA-binding proteins and microRNAs |
|
| 47 | 16. November 2015 | ||
| Themenkolloquium | Philipp Metzger | ||
| Journal Club | Clara Karches | Remote control of therapeutic T cells through a small molecule-gated chimeric receptor | |
| 46 | 09. November 2015 | ||
| Themenkolloquium | Bruno Cadilha | ||
| Journal Club | Maurine Rothe | Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells | |
| 45 | 02. November 2015 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 44 | 26. Oktober 2015 | ||
| Themkolloquium | Claudia Roskopf | Selective, T cell-dependent lysis of CD19+ leukemia cells mediated by single chain triplebodies with dual-targeting | |
| Journal Club | Tim Wartewig | ||
| 43 | 19. Oktober 2015 | ||
| Themenkolloquium | |||
| Journal Club | Florian Asang | ||
| 42 | 12. Oktober 2015 | ||
| 7th Research Seminar |
Professor Matthias Feige Cellular Protein Biochemistry Lab TU München |
Molecular Quality Control in the Immune System | |
| 41 | 05. Oktober 2015 | ||
| Themenkolloquium | AG Ruland | ||
| Journal Club | Stefanie Lesch (Kobold/Endres) | FcgammaRs modulate the anti-tumor activity if antibodies targeting the Pd-1/PD-L1 axis |
|
| 40 | 28. September 2015 | ||
| Themenkolloquium | Prof. Karl-Peter Hopfner | ||
| Journal Club | Monika Herrmann (AG Hopfner) | CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia | |
| 39 | 21. September 2015 | ||
| Themenkolloquium | Tim Wartewig | ||
| Journal Club | Bruno Cadhila (AG Kobold/Endres) | NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma | |
| 38 | 14. September 2015 | ||
| 6th Research Seminar | Prof. Dr. Tobias Feuchtinger | Therapy with T cells? The challenge of adoptive T-cell transfer | |
Summer semester 2015
(13. April 2015 bis 18. Juli 2015)
| Nr. | Datum | Referent | Thema |
| 37 | 27. Juli 2015 | ||
| Themenkolloquium | PD Dr. Dimitrios Mougiakakos | Educational Colloqium: Oxidative stress in cancer | |
| Journal Club | Rachel Mak'Anyengo (AG Schnurr) | Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine | |
| 36 | 20. Juli 2015 | ||
| Themenkolloquium | Prof. Christoph Klein | Rare Diseases and Myeloid Leukemia | |
| Journal Club | Jennifer Heinrich (AG Kobold/Endres) | Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes | |
| 35 | 13. Juli 2015 | ||
| 5th Research Seminar |
Dr. Hans-Rainer Jaenichen Patents for Biotech Inventions |
Patents for Biotech Inventions | |
| 34 | 06. Juli 2015 | ||
| Ergebniskolloquium | Eva Hornig | Regulation of the transcription factor Brn3a in melanoma | |
| Journal Club | Bruno Cadilha (AG Kobold/Endres) |
Imaging liver biology in vivo using conventional confocal microscopy | |
| 33 | 29. Juni 2015 | ||
| Ergebniskolloquium | Stefanie Lesch (AG Kobold/Endres) | Whole transcriptome analysis of adoptively transferred tumor infiltrating T cells | |
| Journal Club | AG Anz | ||
| 32 | 22. Juni 2015 | ||
| Ergebniskolloquium | Daniel Böhmer (AG Schnurr) | Non-canonical pathways of 5‘-Triphosphate–RNA induced cell death | |
| Journal Club | AG Besch/Berking | ||
| 31 | 15. Juni 2015 | ||
| Ergebnisqkolloqium | Lara Hartjes (AG Ruland) | Identification of novel MALT1 substrates | |
| Journal Club | Johannes Tossounidis (AG Rothenfusser) | CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes | |
| 30 | 08. Juni 2015 | ||
| 4th Research Seminar |
Dr. Johannes vom Berg Transgenic and Reproductive Techniques Group, Institute of Laboratory Animal Science, University of Zurich |
Local immunotherapy of glioblastoma using proinflammatory cytokines | |
| 29 | 18. Mai 2015 | ||
| Ergebniskollquium | Romy Loschinski (AG Mackensen/Mougiakakos) | ||
| Journal Club | Lisa Weigand (AG Mackensen/Mougiakakos) | ||
| 28 | 11. Mai 2015 | ||
| Ergebniskolloquium | Heike Anders (AG Lauber) | ||
| Journal Club | AG Schulze-Koops | ||
| 27 | 04. Mai 2015 | ||
| Ergebniskolloquium | Laura Frey (AG Klein) | ||
| Journal Club | AG Kobold/Endres | ||
| 26 | 27. April 2015 | ||
| Ergebniskolloquium | Heike Anders (AG Laube) | HSP90 inhibition as a means or radiosensitizing resistant, aggressive soft tissue sarcoma | |
| Journal Club | Viktoria Bothe (AG Rothenfusser) | ATP-Dependent Effector-like Functions of RIG-I-like Receptors | |
| 25 | 20. April 2015 | ||
| Ergebniskolloquium | Entfällt | ||
| Journal Club | AG Besch/Berking | ||
| 24 | 13. April 2015 | ||
| Ergebniskolloquium | Stefanie Lesch (AG Kobold/Endres) | ||
| Journal Club | AG Schnurr | ||
| 23 | 23. März 2015 | ||
| Themenkolloquium | AG Schnurr | ||
| Journal Club | AG Kobold/Endres | ||
| 22 | 16. März 2015 | ||
| Ergebniskolloqium | Lisa Weigand (AG Mackensen/Mougiakakos) | Characterization and targeting of myeloid-derived suppressor cells (MDSCs) in acute myeloid leukemia (AML) | |
| Journal Club | Romy Loschinsky (AG Mackensen/Mougiakakos) | Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions | |
| 21 | 09. März 2015 | ||
| 3rd Research Seminar |
Dr. Ekkehard Leberer Sanofi |
Nucleic acid therapeutics: Opportunities and challenges for drug development | |
| 20 | 02. März 2015 | ||
| Themenkolloquium | Kirsten Lauber (AG Lauber) | Tumor growth promoting apoptosis: With a little help from my dying friends? | |
| Journal Club | Eva Heuer (AG Rothenfusser) | Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation | |
| 19 | 23. Feburar 2015 | ||
| Themenkolloquium | AG Kobold/Endres | ||
| Journal Club | AG Kobold/Endres | ||
| 18 | 09. Februar 2015 | ||
| Themenkolloquium | Sebastian Kobold (AG Ruland) | TLR7 agonists in cancer therapy | |
| Journal Club | Stefanie Lesch (AG Besch/Berking) | Combination therapy with anti-CTLA4 and anti-PD-1 leads to distinct immunologic changes in vivo | |
| 17 | 02. Februar 2015 | ||
| Themenkolloquium | Marion Subklewe (AG Subklewe) | Therapeutic vaccines in cancer | |
| Journal Club | Severin Rodler (AG Anders) | High-dimensional analysis of the murine myeloid cell system |
Winter semester 2014/2015
(6. Oktober 2014 bis 6. Februar 2015)
| Nr. | Datum | Referent | Thema |
| 16 | 26. Januar 2015 | ||
| Ergebniskolloquium | AG Kobold/Endres | ||
| Journal Club | Christine Heuer (AG Rothenfusser) | ||
| 15 | 19. Januar 2015 | ||
| Ergebniskolloquium | Nadine Moritz (AG Hopfner) | Development of multi-specific antibody derivatives (msADs) to target acute myeloid leukemia | |
| Journal Club | Peter May (AG Kobold/Endres) | B7-H1 expressing antigen presenting cells mediate polarization of pro-tumorigenic Th22 subsets | |
| 14 | 12. Januar 2015 | ||
| Ergebniskolloquium | Moritz Schmidbauer (AG Kobold/Endres) | ||
| Journal Club | Saskia Graf (AG Besch/Berking) | ||
| 13 | 15. Dezember 2014 | ||
| Ergebniskolloquium | Fabian Kraus (AG Kobold) | ||
| Journal Club | AG Schulze-Koops | ||
| 12 | 08. Dezember | ||
| Ergebniskolloquium | Viktoria Bothe (AG Rothenfusser) | Characterization of RIG-I ligands during infection with Vesicular Stomatitis Virus | |
| Journal Club | Nadine Moritz (AG Hopfner) | A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity | |
| 11 | 01. Dezember 2014 | ||
| Ergebniskolloquium | Laura Posselt (AG Schnurr) | ||
| Journal Club | AG Anz | ||
| 10 | 24. November 2014 | ||
| Ergebniskolloquium | Fanny Matheis (AG Besch) | ||
| Journal Club | Marco Wachowius (AG Conzelmann) | Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine | |
| 9 | 17. November 2014 | ||
| Ergebniskolloquium | - | ||
| Journal Club | Severin Jacobi (AG Kobold) | The RAG Recombinase Dictates Functional Heterogenity and Cellular Fitness in Natural Killer Cells | |
|
|
|
|
|
| 8 | 10. November 2014 | ||
| Ergebniskolloquium | AG Anz | ||
| Journal Club | Simone Romoli (AG Anders) | Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death | |
|
|
|
|
|
| 7 | 03. November 2014 | ||
| 2nd Research Seminar i-Target | Prof. Dr. Dr. Michael von Bergwelt Klinikum der Universität zu Köln, Centrum für Integrierte Onkologie |
Targeting antigen presentation cells to induce an immunosupportive tumor microenvironment | |
| 6 | 27. Oktober 2014 | ||
| Ergebniskolloquium | Eva Hornig (AG Besch) | ||
| Journal Club | AG Rothenfusser | ||
| 5 | 20. Oktober 2014 | ||
| 1st Research Seminar i-Target |
PD Dr. Antje Menssen |
Targeting MYC-dependent metabolism and secreted factors for cancer therapy |
|
| 4 | 13. Oktober 2014 | ||
| Ergebniskolloquium | Monika Herrmann (AG Hopfner) | ||
| Journal Club | Daniel Böhmer (AG Schnurr) | ||
|
|
|
|
|
| 3 | 6. Oktober 2014 | ||
| Ergebniskolloquium | Maximilian Gradel (AG Rothenfußer) | ||
| Journal Club | Saskia Graf (AG Besch) | ||
|
|
|
|
|
| 2 | 29. September 2014 | ||
| Themenkolloquium | Prof. Conzelmann | ||
| Journal Club | Alex Hennrich (AG Conzelmann) | ||
|
|
|
|
|
| 1 | 25 bis 26. September 2014 |
#
| Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis |
