Startseite » Seminars


i-Target Seminars


Location for results colloquium, journal club, educational colloquium and research seminars

Medizinische Klinik und Poliklinik IV, Ziemssenstr. 1, Ärztekasino, 2nd floor, Room 226


Results colloquium or educational colloquium: 17:00 to 18:00

Journal club: 18:00 to 18:30 


Summer semester 2019


No. Date Speaker Topic
179 15th of April 2019
Results colloquium Sehmus Tohumeken

AG Mackensen

AML exosomes promote TLR2-mediated induction of glycolytic MDSC.
Research Seminar Simone Formisano

AG König/Schnurr

Staedtke et al. Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome, Nature 2018.
178 8th of April 2019
Results colloquium Veronika Ecker

AG Ruland

Negative feedback inhibition as novel therapeutic approach in chronic lymphocytic leukemia
Research Seminar Kim Pawelka

AG Knolle

Smith et al. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors, JCI 2017.
177 1st of April 2019
Results colloquium Prof. Dr. Dimitrios Mougiakakos

AGMougiakakos Erlangen

Stroma cells: an immune metabolic hub.
Journal Club Sascha Göttert

AG Poeck/Haas

Gopalakrishnan et al. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018.

Winter semester 2018/2019

(15th October 2018 till 9th February 2019)

No. Date Speaker Topic
176 25th of March 2019
Journal Club Larsen Vornholz

AG Ruland

Cox et al. Choline acetyltransferase-expressing T cells are required to control chronic viral infection, Science 2019.
175 18th of March 2019
Guest Speaker Professor Charles Dinarello Role of NLRP3 regulation of IL-1beta in cancer.
174 11th of March 2019
Guest Speaker

Vincenzo Desiderio, Ph.D.

Inhibition of pentose phosphate pathway suppresses tumor growth and metastasis by inducing endoplasmic reticulum stress and autophagy.
173 4th of March 2019
Results colloquium Dr. Daria Briukhovetska

AG Kobold

The roles of C5a receptor 1 and chemokine receptor 5 in Toxoplasma gondii infection.
Journal Club Konstantinos Panagiotidis

AG Mougiakakos

Jones et al. Inhibition of amino acid metabolism selectively targets human leukemia stem cells, Cancer Cell 2018.
172 25th of February 2019
Results colloquium Javier Suarez Gosalvez

AG Kobold

The impact of interleukin-22 on metastasis formation.
Journal Club Natascha Röhrle

AG Anz

Spranger et al. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy, Cancer Cell 2017.
171 18th of February 2019
Results colloquium Daniel Bergér

AG Klein

Multi-specific Antibodies to target Cancer stem cells in AML via CD200.
Journal Club Dana Stenger

AG Feuchtinger

Yamamoto et al. T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy, JCI 2019.
170 11th of March 2019
Guest Speaker Dr. Vincenzo Desiderio Inhibition of pentose phosphate pathway suppresses tumor growth and metastasis by inducing endoplasmic reticulum stress and autophagy.
169 18th of February 2019
i-Target seminar awards 2018 the presentation of the i-Target seminar awards 2018 for the best talk, the best discussing person and the best journal club quiz performance.
168 11th of February 2019
Results colloquium Dr. Laia Pascual Ponce

AG Hopfner

CD47-SIRPalpha: the myeloid-specific immune checkpoint.
Journal Club Clara Karches

AG Kobold

Feucht et al. Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency, Nature Medicine 2018.
167 4th February 2019
Results colloquium Alina Lohner

AG Subklewe

Expansion & Characterization of AML-specific T Cells to test novel in vivo DC targeting AB Constructs.
Journal Club Anne Marie Senz

AG Schnurr

André et al. Anti-NKG2A mAb is a checkpoint Inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells, Cell 2018.
166 21th January 2019
Educational colloquium Dr. Meino Rohlfs

AG Klein

Next generation sequencing.
Journal Club Magdalena Zaucha

AG Rothenfußer

Boettcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell 2018.
165 14th January 2019
Results colloquium Kim Pawelka

AG Knolle

iMATE-forming monocytes - a population with unique functional properties.
Journal Club Duc Huynh

AG Kobold

Wight et al. Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses, PNAS 2018.
164 7th January 2019
Results colloquium Svenja Rausch

AG Kobold

Effect of PD-1-CD28 fusion receptor transduced T cells in adoptive T cell therapy.
Journal Club Alina Lohner

AG Subklewe

Sahin et al: Personalized vaccines for cancer immunotherapy, Sciences 2018.
163 17th December 2018
Research Seminar Prof.Dr. Sebastian Theurich

Professorship for Cancer & Immuno-Metabolism, Attending Physician, Dpt. of Medicine III, University Hospital Munich

NK cells in Metaflammation
162 10th December 2018
Journal Club Daniel Bergér

AG Klein

Shivange et al. A single-agent dual-specificity targeting of FOLR1 and DR5 as an effective strategy for ovarian cancer, Cancer Cell 2018
161 3rd December 2018
Educational colloquium Dr. Nicholas Tokarew

AG Kobold

The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and its Relationship with the Sonic Hedgehog Pathway.
Journal Club Saskia Schmitt

AG Hopfner

Akahori et al. Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination, Blood 2018.
160 26th November 2018
Journal Club Eva Ortner

AG Feuchtinger

Han et al. Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Nature communications 2018.
159 19th November 2018
Results colloquium Corinna Meyer-Gehlen

AG Rothenfußer

Characterization of new potential MAVS interaction partners.
Journal Club Maryam Schübele

AG Kobold

Zhang et al. Blockade of the checkpoint receptor TIGIT prevent NK cell exhaustion and elicits potent anti-tumor immunity, Nature Immunology 2018.
158 12th November 2018
Results colloquium Dr. Heiko Bruns

AG Mackensen

Tumour associated macrophages and therapeutic antibodies.
Journal Club Tanja Stief

AG Feuchtinger

Osborn et al. CRISPR-based cellular engineering for targeted gene overexpression, Int. J. Mol. Sci. 2018.
157 5th November 2018
Results colloquium Paula Rothämel and Jonas Wilhelm

AG Feuchtinger

Blast-T cell interaction in pediatric leukaemia.
Journal Club Bruno Cadilha

AG Kobold

Deng et al. LILRB4 signaling in leukaemia cells mediates T cell suppression and tumour infiltration, Nature letters 2018.
156 29th October 2018
Results colloquium Mohamed-Reda Benmebarek

AG Kobold

Mesothelin-targeted bispecific antibodies drive synthetic agonistic receptor-transduced T cells to mediate specific and conditional therapy of human pancreatic cancer models.
Journal Club Judit Rial

AG Mougiakakos

Pilipow et al. Antioxidant metabolism regulates CD8+ T cell memory stem cell formation and antitumor immunity, JCI insight 2018.
155 22nd October 2018
Educational colloquium Prof. Dr. Percy Knolle

Local immune regulation in the liver: new insights into an organ with dual function in controlling immunity and metabolism.
Journal Club Jasmin Mahdawi

AG Feuchtinger

Lai et al. Toll-like receptor 2 costimulation potentiates antitumor efficacy of CAR T Cells, Leukemia 2018.
154 15th October 2018
Journal Club Johannes Lutz

AG Kobold

Adachi et al. Il-7 and CC19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor, Nature biotechnology 2018.


Summer semester 2018

(9th April 2018 till 14th July 2018)

153 8th October 2018
Results colloquium Lara Hartjes

AG Ruland

Identification of novel MALT1 substrate.
Journal Club Raphael Rubens

AG Kobold

Rafiq et al. Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo, Nature Biotechnology, 2018.
156 1st October 2018

Prof. Dr. Hans-Georg Rammensee

Head of the Department of Immunology, Institute for Cell Biology, University of Tübingen

On the development of personalized cancer vaccines
153 24th September 2018
Results colloquium Sehmus Tohumeken

AG Mackensen

AML exosomes promote induction of glycolytic MDSCs.
Journal Club Konstantinos Panagiotidis

AG Mougiakakos

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
153 10th September 2018
Educational colloquium Prof. Dr. Marion Subklewe

Women in science.
Results colloquium Bruno Cadilha

AG Kobold

C-C Chemokine receptor 8 and TGF-β-Receptor 2 genetic engineering combination make for successful Chimeric antigen receptor T cell therapy in solid tumors.
152 23th July 2018
Research colloquium Philipp Metzger

AG Schnurr

The role of IRF4 in MDSC in an orthotopic pancreatic cancer mode.
151 18th July 2018

PD Dr. Louisa von Baumgarten

Neurologische Klinik und Poliklinik, Klinikum Großhadern, München

In vivo imaging of brain tumors to monitor novel therapeutic strategies
150 9th July 2018
Educational colloquium Dr. Maike Buchner

AG Ruland

The impact of nutrition on cancer and immune cell signaling.
Journal club Philipp Metzger

AG Schnurr

Li et al. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy, Immunity 2018.
149 2nd July 2018
Journal club Sehmus Tohumeken

AG Mackensen

Wang et al. Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis, AACR Journal 2018
148 2nd July 2018

Professor Shaun McColl

Professor of Immunology, Head of Chemokine Biology, Faculty of Sciences, The University of Adelaide, Australia

Chemokines and their receptors in metastatic cancer.
147 25th June 2018
Results colloquium Dana Stenger

AG Feuchtinger

Generation of CD19 CAR T cells with a CRISPR/Cas9 mediated T cell receptor knock out.
Journal club Javier Suarez Gosalvez

AG Kobold

Brown et al. Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice, Science 2018.
146 18th June 2018
Educational colloquium Dr. Jin Zhang

AG Kobold

Understanding T cell receptor initial triggering.
Journal club Paula Rothämel

AG Feuchtinger

Morsut et al. Engineering customized cell sensing and response behaviors using synthetic notch receptors, Cell 2016.
145 11th June 2018
Educational colloquium Professor Lauber

AG Lauber

Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and precinical experiences.
Journal club Svenja Rausch

AG Kobold

Cho et al. Universal chimeric antigen receptors for multiplexed and logical control of T cell responses, Cell 2018 .
144 28th May 2018
Educational colloquium Justyna Ogonek

AG Kobold

CMV-specific T cells in immunotherapy for stem cell transplantation - associated complications.
Journal club Lara Hartjes

AG Ruland

Wong, B. Visual strategies for biological data, part I, Nat. Methods.
143 14th May 2018
Results colloquium Laura Frey

AG Klein

Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45).
Journal club Clarissa Zappe

AG Rothenfußer

Yu et al. Activation of the MDA5-IPS1 viral sensing pathway induces cancer cell death and type I interferon-dependent antitumor immunity, Cancer Res, 2016.
142 7th May 2018
Results colloquium Siret Tahk

AG Hopfner

Targeting the AML leukemic stem cell population using anti-CD123 antibodies that simultaneously disrupt the CD47–SIRPα interaction.
Journal club Simone Formisano

AG Schnurr

Xiaolin Yu, et al. Targeting EGFR/HER2/HER3 with a three-in-one aptamer-siRNA chimera confers superior activity against HER2+ breast cancer, Molecular Therapy, Nucleic Acids, 2017.
141 23th April 2018
Educational colloquium Daniel Böhmer

AG Schnurr

Molecular mechanisms of nucleic acid-mediated cytotoxicity.
Journal club Simon Dedic

AG Hopfner

Cheng et al. Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma, CellDeath and Disease, 2018.
140 16th April 2018
29th Research Seminar Dr. Georg Fertig

Head of Dept. Screening & Functional Assays, Large Molecule Research Roche, Penzberg

Transformative antibody therapeutics at Roche
139 9th April 2018
Results colloquium Bastian Meyer

AG Anz

Identification of functional receptors for CCL22 via APEX2 proximity labeling.


Winter semester 2017/2018

(16th Oktober 2017 till 10th February 2018)

No. Date Speaker Topic
138 26th March 2018
Results colloquium Saskia Schmitt

AG Hopfner

Multispecific antibody derivatives to target and activate dendritic cells in vivo.
Journal club Angelina Krächan

AG Kobold

Barrow et al. Natural killer cells control tumor growth by sensing a growth factor, Cell, 2018.
137 19th March 2018
Results colloquium Anna Maier

AG Subklewe

Influence of immunosuppressive cellular and humoral factors on T-cell function in Acute Myeloid Leukemia.
Journal club Kim Pawelka

AG Knolle

Wang et al. A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair, Cell, 2016.
136 12th March 2018
Results colloquium Raphael Kfuri Rubens

AG Schnurr

Indolamine 2,3-dioxygenase in T cells.
Journal club Svenja Rausch

AG Kobold

Böttcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell, 2018.
135 5th March 2018
Educational colloquium Dr. Martin Böttcher

AG Mougiakakos

2-HG-A a novel oncometabolite with immune modulation properties.
Journal club Veronika Ecker

AG Ruland

Kikushige et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia, Cancer Cell, 2011.
134 26th February 2018
Results colloquium Tanja Stief

AG Feuchtinger

CRISPR/Cas-mediated T cell editing for the treatment of refractory viral infections.
Journal club Magdalena Scheck

AG Rothenfußer

Clift et al. A method for the acute and rapid degradation of endogenous proteins, Cell, 2018.
133 19th February 2018
Results colloquium Julius Keyl

AG Kobold

Fusion receptor- transduced T cells combined with bispecific antibodies to improve the therapy of malignant melanomas.
Journal club Jonas Wilhelm

AG Feuchtinger

Duell et al. Frequency of regulatory T cells determines the outcome of theT-cell-engaging antibody blinatumomab in patients with B-precursor ALL, Leukemia, 2017.
132 12th February 2018
Educational colloquium Dr. Selina Keppler

AG Ruland

Dectin-1: a C- type lectin receptor on dendritic cells in antifungal immunity.
Journal club Clara Karches

AG Kobold

Lan et al. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β, Science Translational Medicine, 2018.
131 5th February 2018
28th Research seminar Ph.D., Ph.D. Santiago González Intravital characterization of the inflammatory response that follows vaccination in the draining lymph node
130 29th January 2018
Results colloquium Stefanie Lesch

AG Kobold

Whole transcriptome analysis of adoptively transferred tumor infiltrating T-cells.
Journal club Antonia Apfelbeck

AG Feuchtinger

Xiaojun et al. A chimeric switch-receptor targeting PD1 augments the efficacy of second generation CAR T-Cells in advanced solid tumors, Cancer Res, 2017.
129 22nd January 2018
Educational colloquium Dr. Claudia Roskopf

AG Hopfner

Insights into cell-mediated cytotoxicity and phagocytosis: how tumor cells are killed.
Journal club Raphael Kfuri Rubens

AG Schnurr

Routy et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science 2017.
128 15th January 2018
Results colloquium Kim Pawelka

AG Knolle

Unique functional properties of iMATE forming myeloid cells.
Journal club Steffeni Mountford

AG Bufler

Hong et al. Correction of a pathogenic gene mutation in human embryos. Nature 2017
127 8th January 2018
Results colloquium Clara Karches

AG Kobold

Synthetic agonistic receptors as an approach for immunotherapy.
Journal club Maurine Rothe

AG Subclewe

Shapiro et al. Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia. Haematologica, 2017.
126 18th December 2017
Results colloquium Mohamed-Reda Benmebarek

AG Kobold

Combination of bispecific antibodies with genetically modified T-cells for cancer immunotherapy.
Journal club Mohamed-Reda Benmebarek

AG Kobold

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nature medicine, 2017
125 11th December 2017
Educational colloquium Dr. Jin Zhang

AG Kobold

Phospholipid Scramblase 1 regulates T-cell antitumor immunity by activating PI3K signaling.
Journal club Steffeni Moundford

AG Bufler

NLRP1 promotes tumor growth by enhancing inflammasone activation and suppresisng apoptosis in metastatic melanoma. Oncogene, 2017
124 4th December 2017
Results colloquium Laura Frey

AG Klein

Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45).
Journal club Steffen Dickopf

AG Kobold

Patel et al. Identification of essential genes for cancer immuntherapy. Nature, 2017
123 27th November 2017
27th Research seminar Dr. Arndt Schottelius

Kymab, Cambridge UK

KY1044, a novel anti-ICOS antibody, elicits long term in vivo anti-tumour efficacy as monotherapy and in combination with immune checkpoint inhibitors.
122 20th November 2017
Results colloquium Steffen Dickopf

AG Kobold

A robust tool for optimizing CRISPR/Cas9-mediated gene editing - the whole story.
Journal club Dana Stenger

AG Feuchtinger

Hu B. et al. Augmentation of antitumor immunity by human and mouse CAR T Cells secreting IL-18. Cell Reports, 2017
121 13th November 2017
Results colloquium Javier S. Golsavez

AG Kobold

Impact of interleukin-22 on metastasis formation
Journal club Anna Maier

AG Subklewe

Mangaonkar A. et al. A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression. Scientific Reports, 2017
120 6th November 2017
26th Research seminar Dr. Alexander Buchner

Urologische Klinik und Poliklinik, Klinikum der Universität München

Basics of statistics - important for doctoral thesis and publication
119 16th October 2017
25th Research seminar Dr. Sebastian P. Haen

Med. Universitätsklinik, Tübingen

T cell reactivity against self-antigens - Autoimmunity after allogeneic hematopoietic cell transplantation 
118 9th October 2017
Results colloquium Prof. Duska Dragun

AG Subklewe

Journal club

117 2nd October 2017
Results colloquium Lara Hartjes

AG Ruland

Identification of novel MALT1 substrates
Journal club



Summer semester 2017

(24th April 2017 till 29th July 2017)

No. Date Speaker Topic
116 25th September 2017
24th Research seminar Prof. Dr. Jürgen Bernhagen


Immune-mediated mechanisms in cardiovascular disease and cancer: focus on MIF proteins
115 18th September 2017
Educational colloquium

AG Mougiakakos

Immune metabolic interplay in cancer
Journal club Semjon Willier

AG Feuchtinger

Mezzadra R. et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 2017
114 24th July 2017
Educational colloquium Dr. Benedikt Jacobs

AG Mackensen

NK cells - from biology to clinical trials.
Journal club Sehmus Tohumeken

AG Mackensen

Liu Y. et al. Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell, 2016
113 17th July 2017
23th Research seminar Dr. Matthias Klinger

AMGEN Research, Munich

Innovative drug development at AMGEN
112 10th July 2017
Result colloquium Romy Loschinski

AG Mougiakakos

IL-21 as an immunometabolic T-cell modulator.
Journal club Javier Suarez Gosalvez

AG Kobold

Whole-body imaging of lymphovascular niches identifies pre- metastatic roles of midkine. Nature Letters, 2017
111 3rd July 2017
Educational colloquium Dr. Lars König

AG Kobold

How-to guide to creating CRISPR-KOs
Journal club Clara Karches

AG Kobold

Rulla M et al. Overcoming the immunosuppressive tumor microenviroment of Hodgking lymphoma using chimeric antigen receptor T cells. American Association for Cancer, 2017
110 26th June 2017
Results colloquium Bruno Cadilha

AG Kobold

Redirecting T cells through CCR8-CCL1 axis and shielding from TGF-β for effective adoptive T cell therapy
Journal club Tanja Stief

AG Feuchtinger

Rupp LJ et al. CRISPR/Cas9-mediated PD-1disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Nature, 2017
109 19th June 2017
22th Research seminar Dr. Rajkumar Savai

Max Planck Institute, Bad Nauheim

The lung tumor microenvironment: targeting the soil to kill the tumor seed
108 29th May 2017
Results colloquium Sehmus Tohumeken

AG Mackensen

Characterization and targeting of myeloid-derived suppressor cells in acute myeloid leukemia
Journal club Heike Anders

AG Lauber

Rodriguez-Ruiz M E et al. Abscopal effects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming, Cancer Research 2016
107 22th May 2017
Results colloquium Dr. Selina Keppler

AG Ruland

Imaging B cells: linking receptors, the actin cytoskeleton and aberrant immune responses
106 15th May 2017
Progress report Veronika Ecker

AG Ruland

Drug delivery improvement for leukemia and lymphoma
105 8th Mai 2017
Educational colloquium Dr. Marcin Lyszkiewicz

AG Klein

T cell development by the numbers
Journal club Stefan Stoiber

AG Kobold

Long A H et al. 4-1BB costimulation ameliorates T cell exhaustion induces by tonic signaling of chimeric antigen receptors. Nature Medicine, 2015
104 24th April 2017
Results colloquium Steffeni Mountford

AG Bufler

Modulation of liver inflammation and fibrosis by the IL-1 homologue IL-37
103 3rd April 2017
Results colloquium Maurine Rothe

AG Subklewe

Blockade of LAG-3 enhances dentritic cell-induced T-cell responses more than blockade of PD-1
Journal club Mareike Lepenies

AG Feuchtinger

McGranahan N et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science, 2016


Winter semester 2016/2017

(17th October 2016 till 11th February 2017)

No. Date Speaker Topic
102 27th March 2017
Educational colloquium Dr. Maike Buchner B cell development malignant transformation and signaling thresholds
Journal club Lukas Mallaun Eyquem J et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature, 2017
101 20th March 2017
Results colloquium cancelled due to ITOC Conference
Journal club
100 13th March 2017
Results colloquium Monika Herrmann Releasing the T cell brake - novel strategy of local PD-1/PD-L1 checkpoint blockade to fight immune evasion in AML
Journal club Maurine Rothe Bronte V et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 2016
99 6th March 2017
21th Research Seminar

Dr. Jan Böttcher

The Francis Crick Institute, London

Evasion of the antitumor immunity by prostaglandin E2 production
98 20th February 2017
20th Research Seminar

Dr. Arndt Schottelius

MorphoSys, Munich

Anti-CD38 monoclonal antibodies as an evolving new backbone therapy in multiple myeloma
97 13th February 2017
Educational colloquium Paul Schwarzlmüller Basics in Statistics
Journal club Lara Hartjes Damgaard R B et al. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell, 2016
96 10th of February at 10:30

Yi Xeng, China

Medical research in China (15 min)

95 6th February 2017
Result colloquium Phillip Metzger PD-1 expression of non-T cells
Journal club Bruno Cadilha Buck M D et al. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell, 2016
94 30th January 2017
Educational colloquium Anna Kaufmann Autophagy and its role in cancer
Journal club Xiaomei Chen Arbore G et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 2016
93 26th January 2017
19th Research Seminar

Prof. Charles Dinarello,

University of Colorado, Denver

From fever to autoinflammation - the roadmap of interleukin-1 beta
92 23th January 2017
18th Research Seminar

Dr. Nisit Khandelwal

iOmx Therapeutics AG, Munich

Research seminar: Mapping the tumor's immune-evasion strategies beyond the existing paradigm

91 16th January 2017
Themenkolloqium Kim Pawelka Plasticity of myeloid cells in the iMate context
Journal Club Steffi Lesch Faitschuk E et al. Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells. Blood, 128: 1711-1722
90 09th January 2017
Themenkolloqium Saskia Schmitt Characterization of multispecific antibody derivates to target and activate dendritic cells in vivo
Journal Club Laura Frey Moroishi T et al. The hippo pathway kinases LATS1/2 suppress cancer immunity. Cell, 167:1525-1539.
89 19th December 2016
17th Research Seminar

Dr. A. Schottelius

Morphosys AG

Clinical update on MOR208, an antibody targeting CD19 in Non-Hodgkin Lymphomas

88 28th November 2016
Themenkolloqium AG Rothenfußer TBA
Journal Club
87 14th November 2016
Themenkolloqium Clara Karches Activating fusion receptors as a novel approach for targeting autoreactive B cell receptors on chronic lymphatic leukaemia cells
Journal Club Julia Stein A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression
86 11th November 2016
16th Research Seminar

Dr. Jasper von Boorn

University Hospital Bonn

Biomedical Center

Institute for Clinial Chemistry and Clin. Pharmacology

Pigment cell-specific NK cell memory revealed

85 07th November 2016
15th Research Seminar

Dr. Carolin Daniel

Helmholtz Zentrum München

Deutsches Forschungszentrum für Gesundheit und Umwelt

Institut für Diabetesforschung

Immune tolerance in autoimmune type 1 diabetes

84 24th October 2016
Themenkolloqium AG Subklewe
Journal Club Hanna Nowotny

Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies

83 17th October 2016
14th Research Seminar

Prof. Georgios Stathopoulos

On the role of mutant KRAS in malignant pleural disease

82 10th October 2016
Themenkolloqium Julia Kobuch Metastasis: Colonial policy in the body and models for its investigation
Journal Club Philipp Metzger Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
81 19th September 2016
Themenkolloqium Felicitas Rataj About CARs and TRUCKs - Do we have the drivers' license?
Journal Club Anna Tiefenthaller

Caloric restriction mimetics enhance anticancer immunosurveillance


Summer semester 2016

(11. April 2016 bis 16. Juli 2016)


80 25. Juli 2016
13th Research Seminar

Prof. Samuel Huber

Peter Hans Hofschneider Professor

Molecular Gastroenterology and Immunology

University Medical Center Hamburg-Eppendorf

Control of Th17 cells in the intestine

79 18. Juli 2016
12th Research Seminar

Dr. Annette Künkele

Department of Pediatric Oncology/Hematology/SCT

Charité-Universitätsmedizin Berlin

What we learned from bench to beside with the neuroblastoma targeting CD171 -specific CAR

78 11. Juli 2016
Themenkolloqium Severin Rodler The IL-22/IL22-R-axis in renal cell carcinoma (RCC)
Journal Club Celina Aithal Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
77 04. Juli 2016
Themenkolloqium Viktoria Bothe Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX
Journal Club Stefan Stoiber In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
76 27. Juni 2016
Themenkolloqium Viktoria Bothe Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX
Journal Club Stefan Stoiber In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
75 20. Juni 2016
11th Research Seminar

Dr. Arndt Schottelius

Morphosys AG

Clinical update on MOR202, a HuCAL antibody targeting CD38 in multiple myeloma

74 13. Juni 2016
Themenkolloqium Laura Posselt Targeting RIG-I with 5’ppp-modified RNA for immunotherapy of hepatocellular carcinoma (HCC)
Journal Club AG Rothenfusser
73 06. Juni 2016
Themenkolloqium Monika Herrmann Design of a new multispecific antibody derivative targeting the PD-1/PD-L1 immune checkpoint
Journal Club Adrian Gottschlich The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity
72 30. Mai 2016
Themenkolloqium Fabian Kraus
Journal Club Tim Wartewig Disparate Individual Fates Compose Robust CD8+ T Cell Immunity
71 02. Mai 2016
Themenkolloqium AG Klein
Journal Club Saskia Schmitt Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas
70 25. April 2016
10th Research Seminar

Dr. Ignazio Caruana

Cellular and Gene Therapy of Pediatric Tumour IRCCS Bambino Gesù Hospital Rome, Italy

Optimization of Chimeric Antigen Receptor T cell therapy in solid tumourss

69 18. April 2016
Themenkolloquium Daniel Böhmer Non-canonical pathways of RLH-induced cell death
Journal Club Clara Karches Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
68 11. April 2016
Themenkolloquium Angelina Krächan Impact of TLR7-Agonists on NK cell cytotoxicity, phenotype and migration
Journal Club Laura Frey IL-17-producing cd T cells and neutrophils conspire to promote breast cancer metastasis
67 04. April 2016
Themenkolloquium Simon Rothenfußer
Journal Club AG Hopfner

Wintersemester 2014/2015

(6. Oktober 2014 bis 6. Februar 2015)


66 28. März 2016
Journal Club
65 21. März 2016
Journal Club
64 16. März 2016
9th Research Seminar

Prof. Charles Dinarello

Department of Medicine Division of Infectious Diseases University of Colorado Denver Aurora, CO, USA

The interleukin-1 family in 2016: solving secrets, helping patients

63 14. März 2016
Themenkolloquium Lisa Weigand Characterization and Targeting of MDSCs in AML
Journal Club Romy Loschinski Autophagy enforces funktional integrity ofregulatory T cells by coupling environmental cues and metabolic homeostasis
62 07. März 2016
Journal Club
61 29. Februar 2016
Themenkolloquium Christoph Klein Primary Immunodeficiency Disorders
Journal Club Florian Asang Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
60 22. Februar 2016
Themenkolloquium Lars König Cell Culture: Basics, Tips and Quality Control
Journal Club Michael Ruzicka Agonist antibody that induces human malignant cells to kill one another
59 15. Februar 2016
Themenkolloquium Jürgen Ruland ITAM Receptors in Innate Immunity and Oncogenesis
Journal Club Claudia Roskopf Talimogene Laherparepvec improves durable response rate in patients with advanced melanoma
58 8. Februar 2016
Journal Club
57 1. Februar 2016
Journal Club Rachel Mak'Anyengo
56 25. Januar 2016
Themenkolloquium Jennifer Heinrich Engineering of PD1-CD28 fusion receptor for improved functionality
Journal Club Severin Rodler Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids
55 18. Januar 2016
Themenkolloquium Nadine Moritz Development of a novel antibody format to target AML
Journal Club Veronica Ecker Signalling thresholds and negative B-cells selection in acute lymphoblastic leukaemia
55 11. Januar 2016
Themenkolloquium Prof. Stefan Endres Immunotherapie of cancer - update 2016
PD Dr. Sebastian kobold i-Target program 2016
53 21. Dezember 2015
Themenkolloquium Bruno Cadilha Redirecting T cells and enabling their TGF-beta resistance
Journal Club
52 14. Dezember 2015
Themenkolloquium Clara Karches Combination of bispecific antibody with activating fusion Receptor for cancer therapy
Journal Club Lara Hartjes The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquination by LUBAC to dampen lymphocyte NF-kB signaling
51 07. Dezember 2015
Themenkolloquium Michael Ruzicka Immunotherapy of AML with bifunctional siRNA
Journal Club Angelina Krächan
50 30. November 2015
Themenkolloquium Maurine Rothe
Journal Club Daniel Böhmer A genome-wide CRISPR screen identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation
49 26. November 2015
Themenkolloquium Julia Ahlfeld
Journal Club Laura Frey

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

48 18. November 2015
8th Research Seminar

PhD Nadia Cherradi

INSERM U1036 - Biologie du Cancer et de l'Infection

iRTSV/CEA Grenoble

Post-transcriptional regulation in cancer: Focus on RNA-binding proteins and microRNAs

47 16. November 2015
Themenkolloquium Philipp Metzger
Journal Club Clara Karches Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
46 09. November 2015
Themenkolloquium Bruno Cadilha
Journal Club Maurine Rothe Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells
45 02. November 2015
Journal Club
44 26. Oktober 2015
Themkolloquium Claudia Roskopf Selective, T cell-dependent lysis of CD19+ leukemia cells mediated by single chain triplebodies with dual-targeting
Journal Club Tim Wartewig
43 19. Oktober 2015
Journal Club Florian Asang
42 12. Oktober 2015
7th Research Seminar

Professor Matthias Feige

Cellular Protein Biochemistry Lab

TU München

Molecular Quality Control in the Immune System
41 05. Oktober 2015
Themenkolloquium AG Ruland
Journal Club Stefanie Lesch (Kobold/Endres) FcgammaRs modulate the anti-tumor activity if antibodies targeting the
Pd-1/PD-L1 axis
40 28. September 2015
Themenkolloquium Prof. Karl-Peter Hopfner
Journal Club Monika Herrmann (AG Hopfner) CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia
39 21. September 2015
Themenkolloquium Tim Wartewig
Journal Club Bruno Cadhila (AG Kobold/Endres) NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
38 14. September 2015
6th Research Seminar Prof. Dr. Tobias Feuchtinger Therapy with T cells? The challenge of adoptive T-cell transfer

Sommersemester 2015

(13. April 2015 bis 18. Juli 2015)


Nr. Datum Referent Thema
37 27. Juli 2015
Themenkolloquium PD Dr. Dimitrios Mougiakakos Educational Colloqium: Oxidative stress in cancer
Journal Club Rachel Mak'Anyengo (AG Schnurr) Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine
36 20. Juli 2015
Themenkolloquium Prof. Christoph Klein Rare Diseases and Myeloid Leukemia
Journal Club Jennifer Heinrich (AG Kobold/Endres) Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
35 13. Juli 2015
5th Research Seminar

Dr. Hans-Rainer Jaenichen

Patents for Biotech Inventions

Patents for Biotech Inventions
34 06. Juli 2015
Ergebniskolloquium Eva Hornig Regulation of the transcription factor Brn3a in melanoma
Journal Club Bruno Cadilha (AG Kobold/Endres)
Imaging liver biology in vivo using conventional confocal microscopy
33 29. Juni 2015
Ergebniskolloquium Stefanie Lesch (AG Kobold/Endres) Whole transcriptome analysis of adoptively transferred tumor infiltrating T cells
Journal Club AG Anz
32 22. Juni 2015
Ergebniskolloquium Daniel Böhmer (AG Schnurr) Non-canonical pathways of 5‘-Triphosphate–RNA induced cell death
Journal Club AG Besch/Berking
31 15. Juni 2015
Ergebnisqkolloqium Lara Hartjes (AG Ruland) Identification of novel MALT1 substrates
Journal Club Johannes Tossounidis (AG Rothenfusser) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
30 08. Juni 2015
4th Research Seminar

Dr. Johannes vom Berg

Transgenic and Reproductive Techniques Group, Institute of Laboratory Animal Science, University of Zurich

Local immunotherapy of glioblastoma using proinflammatory cytokines
29 18. Mai 2015
Ergebniskollquium Romy Loschinski (AG Mackensen/Mougiakakos)
Journal Club Lisa Weigand (AG Mackensen/Mougiakakos)
28 11. Mai 2015
Ergebniskolloquium Heike Anders (AG Lauber)
Journal Club AG Schulze-Koops
27 04. Mai 2015
Ergebniskolloquium Laura Frey (AG Klein)
Journal Club AG Kobold/Endres
26 27. April 2015
Ergebniskolloquium Heike Anders (AG Laube) HSP90 inhibition as a means or radiosensitizing resistant, aggressive soft tissue sarcoma
Journal Club Viktoria Bothe (AG Rothenfusser) ATP-Dependent Effector-like Functions of RIG-I-like Receptors
25 20. April 2015
Ergebniskolloquium Entfällt
Journal Club AG Besch/Berking
24 13. April 2015
Ergebniskolloquium Stefanie Lesch (AG Kobold/Endres)
Journal Club AG Schnurr
23 23. März 2015
Themenkolloquium AG Schnurr
Journal Club AG Kobold/Endres
22 16. März 2015
Ergebniskolloqium Lisa Weigand (AG Mackensen/Mougiakakos) Characterization and targeting of myeloid-derived suppressor cells (MDSCs) in acute myeloid leukemia (AML)
Journal Club Romy Loschinsky (AG Mackensen/Mougiakakos) Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions
21 09. März 2015
3rd Research Seminar

Dr. Ekkehard Leberer


Nucleic acid therapeutics: Opportunities and challenges for drug development
20 02. März 2015
Themenkolloquium Kirsten Lauber (AG Lauber) Tumor growth promoting apoptosis: With a little help from my dying friends?
Journal Club Eva Heuer (AG Rothenfusser) Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation
19 23. Feburar 2015
Themenkolloquium AG Kobold/Endres
Journal Club AG Kobold/Endres
18 09. Februar 2015
Themenkolloquium Sebastian Kobold (AG Ruland) TLR7 agonists in cancer therapy
Journal Club Stefanie Lesch (AG Besch/Berking) Combination therapy with anti-CTLA4 and anti-PD-1 leads to distinct immunologic changes in vivo
17 02. Februar 2015
  Themenkolloquium Marion Subklewe (AG Subklewe) Therapeutic vaccines in cancer
Journal Club Severin Rodler (AG Anders) High-dimensional analysis of the murine myeloid cell system

Wintersemester 2014/2015

(6. Oktober 2014 bis 6. Februar 2015)


Nr. Datum Referent Thema
16 26. Januar 2015
Ergebniskolloquium AG Kobold/Endres
Journal Club Christine Heuer (AG Rothenfusser)
15 19. Januar 2015
Ergebniskolloquium Nadine Moritz (AG Hopfner) Development of multi-specific antibody derivatives (msADs) to target acute myeloid leukemia
Journal Club Peter May (AG Kobold/Endres) B7-H1 expressing antigen presenting cells mediate polarization of pro-tumorigenic Th22 subsets
14 12. Januar 2015
Ergebniskolloquium Moritz Schmidbauer (AG Kobold/Endres)
Journal Club Saskia Graf (AG Besch/Berking)
13 15. Dezember 2014
Ergebniskolloquium Fabian Kraus (AG Kobold)
Journal Club AG Schulze-Koops
12 08. Dezember  
  Ergebniskolloquium Viktoria Bothe (AG Rothenfusser) Characterization of RIG-I ligands during infection with Vesicular Stomatitis Virus
  Journal Club Nadine Moritz (AG Hopfner) A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity
11 01. Dezember 2014
Ergebniskolloquium Laura Posselt (AG Schnurr)
Journal Club AG Anz
10 24. November 2014
Ergebniskolloquium Fanny Matheis (AG Besch)
Journal Club Marco Wachowius (AG Conzelmann) Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine
9 17. November 2014
Ergebniskolloquium -

Journal Club Severin Jacobi (AG Kobold) The RAG Recombinase Dictates Functional Heterogenity and Cellular Fitness in Natural Killer Cells





8 10. November 2014
Ergebniskolloquium AG Anz

Journal Club Simone Romoli (AG Anders) Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death





7 03. November 2014
2nd Research Seminar i-Target Prof. Dr. Dr. Michael von Bergwelt

Klinikum der Universität zu Köln, Centrum für Integrierte Onkologie
Targeting antigen presentation cells to induce an immunosupportive tumor microenvironment
6 27. Oktober 2014
Ergebniskolloquium Eva Hornig (AG Besch)
Journal Club AG Rothenfusser
5 20. Oktober 2014

1st Research Seminar i-Target

PD Dr. Antje Menssen

Deutsches Konsortium für translationale Krebsforschung, DKFZ Heidelberg
Pathologisches Institut der Ludwig-Maximilians-Universität München

Targeting MYC-dependent metabolism and secreted factors for cancer therapy

4 13. Oktober 2014
Ergebniskolloquium Monika Herrmann (AG Hopfner)

Journal Club Daniel Böhmer (AG Schnurr)





3 6. Oktober 2014
Ergebniskolloquium Maximilian Gradel (AG Rothenfußer)

Journal Club Saskia Graf (AG Besch)





2 29. September 2014
Themenkolloquium Prof. Conzelmann

Journal Club Alex Hennrich (AG Conzelmann)





 1 25 bis 26. September 2014