Seminars
i-Target Seminars
Location for results colloquium, journal club, educational colloquium and research seminars
Medizinische Klinik und Poliklinik IV, Ziemssenstr. 1, Ärztekasino, 2nd floor, Room 226
Time
Results colloquium or educational colloquium: 17:00 to 18:00
Journal club: 18:00 to 18:30
Summer semester 2020
| No. | Date | Speaker | Topic |
| 220 | 25th of May 2020 | ||
| (per Video) | Results colloquium | Lisa Pfeuffer (AG Ruland) | The role of Wasp-interacting protein in pre B-ALL |
| Journal club | Jonathan Trautwein (AG Mougiakakos/Mackensen) | Kaparlov et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death, Nature Chemical Biology 2020 | |
| 219 | 18th of May 2020 | ||
| (per Video) | Educational colloquium | Dr. Anne Trefzer, AG Subklewe | Antigen-exhausted CD4+ T cells deviate towards multiple states of anergy |
| Journal club | Florian Märkl, AG Kobold | Schober et al. Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection, Nature Immunology 2020 | |
| 218 | 11th of May 2020 | ||
| (per Video) | Results colloquium | Theo Lorenzini, AG Kobold | Migration-optimized CAR T cell therapy for individual solid tumor patients
|
| Journal club | Laura Sellmer, AG Tufman |
Yu et al. Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma. Journal of Toracic Oncology 2018 |
|
| 217 | 4th of May 2020 | Guest speaker | |
|
Johannes vom Berg, PhD Institute of Laboratory Animal Science, |
Local immunotherapy of brain cancer with compartment locked biologics |
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| 216 | 27th of April 2020 | ||
| (per Video) | Results colloquium |
Judit Rial Saborido AG Mougiakakos |
Metabolic alterations in T cells in the context of CLL |
| Journal club |
Martin Kirmaier AG Theurich |
Roth et al. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies, Cell 2020 | |
| 215 | 20th of April 2020 | ||
| (per Video) | Results colloquium |
Vera Maria Bauer AG Mocikat |
Targeting regulatory T cells in an endogenous lymphoma mouse model |
| Journal club |
Janina Dörr AG Kobold |
Millar et al. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy, Nature Biotechnology 2020 |
Winter semester 2019/2020
| No. | Date | Speaker | Topic |
| 211-214 | Pause due to the COVID pandemic | ||
| 210 | 9th of March 2020 | ||
| Journal club |
Larsen Vornholz AG Ruland |
Luksch et al. STING-associated lung disease in mice relies on T cells but not type I interferon, J Allergy Clin Immunol 2019 | |
| 209 | 2nd of March 2020 | ||
| Educational colloquium |
Prof. Lauber AG Lauber |
Radiotherapy in small animal models: Chances and challenges | |
| Journal club |
Melanie Schwerdtfeger AG Kobold |
Singh et al. Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction, Cancer Discovery 2020 | |
| 208 | 24th of February 2020 | ||
| Results colloquium |
Julian Benkel AG Subklewe |
Intrinsic Resistance mechanisms to T-cell recruiting antibody constructs for therapy of AML. | |
| Journal club |
Daniel Lüthy AG Berger |
Li et al. Persistent polyfunctional chimeric antigen receptor T cells that target glypican 3 eliminate orthotopic hepatocellular carcinomas in mice, Gastroenterology 2020 | |
| 207 | 17th of February 2020 | ||
| Educational colloquium |
Dr. Bastian Höchst AG Knolle |
Regulatory myeloid cells paralyze T cell immunity through cell-cell transfer of methylglyoxal | |
| Journal club |
Konstantin Schnell AG Anz |
Hatzioannou et al. An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion, Immunity 2019 | |
| 206 | 10th of February 2020 | ||
| Results colloquium |
Saskia Schmitt AG Hopfner |
Multifunctional antibody derivative to target and activate dendritic cells in vivo | |
| Journal club |
Antonio Santos AG Rothenfußer |
Chng et al. Large-Scale HLA tetramer tracking of T cells during dengue infection reveals broad acute activation and differentiation into two memory cell fates, Immunity 2019 | |
| 205 | 3rd of February 2020 | ||
| Results colloquium |
Lisa Brandmeier AG Ruland |
The Role of Diet and Exercise in CLL | |
| Journal club |
Dario Dhoqina AG Kobold |
Reinhard et al. An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors, Science 2020 | |
| 204 | 27th of January 2020 | ||
| Educational colloquium |
Dr. Carolin Perleberg AG Anz |
Next generation sequencing – Applications and Hurdles | |
| Journal club |
Lisa Rohrbacher AG Subklewe |
Crowther MD et al. Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1, Nature Immunology 2020 | |
| 203 | 20th of January 2020 | ||
| Results colloquium |
Daniel Berger AG Klein |
Dual targeting antibodies against AML steam cells. | |
| Journal club |
Theo Lorenzini AG Kobold |
Lynn et al. c-Jun overexpression in CAR T cells induces exhaustion resistance, Nature 2019 | |
| 202 | 13th of January 2020 | ||
| Results colloquium |
Duc Huynh AG Kobold |
NK Memory Formation. | |
| Journal club |
Lisa Pfeuffer AG Ruland |
Guièze et al. Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies, Cancer Cell 2019 | |
| 201 | 16th of December 2019 | ||
| Results colloquium |
Magdalena Zaucha AG Rotherfußer |
Analysis of expression quantitative trait loci after yellow fever vaccination. | |
| Journal club |
Matthias Seifert AG Kobold |
Scott et al. TOX is a critical regulator of tumour-specific T cell differentiation, Nature 2019 |
|
| 200 | 9th of December 2019 | ||
| Educational colloquium |
Dr. Lars König AG König-Schnurr |
Databases, Resources and Online Tools for your PhD. | |
| 199 | 25th of November 2019 | ||
| Results colloquium |
AG Ruland |
CBM signaling in innate immunity | |
|
AG Feuchtinger |
Thaker et al. GTPase-activating protein RasalI associates with ZAP-70 of TCR and negatively regulates T cell tumor immunity, Nature Communications, 2019 | ||
| 198 | 18th of November 2019 |
AG Böttcher (TUM) |
Beyond pretty pictures – applying microscopic imaging techniques to resolve immune cell dynamics in tissues |
|
AG Mocikat (Helmholtz Zentrum) |
Akkaya et al. Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells, Nature immunology 2019 | ||
| 197 | 11th of November 2019 | ||
| Results Colloquium | Implications of CD98 in Chronic lymphocytic leukemia | ||
| Journal Club | Yang et al. Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity, Nature medicine, 2019 | ||
| 196 | 4th of November 2019 | ||
| Results Colloquium | The influence of Interleukin-37 on cancer. | ||
| Journal Club |
Lee et al. Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters, Nature Communications 2019 |
||
| 195 | 28th of October 2019 | ||
| Educational Colloquium | Metabolism as a Determinant of Function | ||
| Journal Club | Mastelic-Gavillet et al. Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells,Journal for ImmunoTherapy of Cancer 2019 | ||
| 194 | 21th of October 2019 | ||
| Results Colloquium | Adapting immune cells to the nutrient deprivation in the tumor microenvironment by solute carrier (SLC) overexpression. | ||
| Journal Club | Mariathasan et al. TGFbeta attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells, Nature 2018 | ||
| 193 | 14th of October 2019 | ||
| Results Colloquium | Indoleamine 2,3-dioxygenase 1 in T cells. | ||
| Journal Club | Guièze et al. Mitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies, Cancer Cell 2019 | ||
| 192 | 7th of October 2019 | ||
| Educational Colloquium | Synergy of CCR8-guidance and TGF-β-resistance enables CAR T cells to reject pancreatic tumors. | ||
| Journal Club | Langan et al. De novo design of bioactive protein switches, Nature 2019 |
Summer semester 2019
| No. | Date | Speaker | Topic |
| 191 | 30th of September 2019 | ||
| Results Colloquium |
Florian Maerkl AG Kobold-Endres |
T cell engineering for improving T cell therapy in chronic lymphocytic leukemia. | |
| Journal Club |
Anja Wessely AG Berking |
Koopmans et al. Bispecific Antibody Approach for Improved Melanoma-Selective PD-L1 Immune Checkpoint Blockade, Journal of Investigative Dermatology 2019 | |
| 190 | 23rd of September 2019 | ||
| Results Colloquium |
Eva Ortner AG Feuchtinger |
Induction of T-cell attack against ALL through a TIM-3/CD28 fusion receptor. | |
| Journal Club |
Lisa Lehmann AG Rothenfußer |
Kao et al. Combination of modified NS1 and NS3 as a novel vaccine strategy against dengue virus infection, Immunologists 2019 | |
| 189 | 9th of September 2019 | ||
| Results Colloquium |
Duc Huynh AG Kobold |
TBA | |
| Journal Club |
Vasil Toskov AG Feuchtinger |
S. Gautam et al. The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity, Nature Immun 2019 |
|
| 188 | 22nd of July 2019 | ||
| Guest Speaker |
Prof. Dr. Angela Krackhardt IIIrd Medical Department, Hematology and Oncology, Klinikum rechts der Isar, TU Munich |
Development of personalised treatment and novel monitoring approaches for T-cell based immunotherapies in cancer | |
| 187 | 15th of July 2019 | ||
| Educational Colloquium |
Dr. Justyna Ogonek AG Kobold |
Chemokine receptor-overexpressing CAR T cells for enhanced adoptive therapy of solid cancer | |
| Journal Club |
Martin Kirmaier AG Theurich |
Hamieh et al. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape, Nature 2019 | |
| 186 | 8th of July 2019 | ||
| Results Colloquium |
Anja Wessely AG Berking |
The transcription factor SOX10 and its functional role in uveal melanoma | |
| Journal Club |
Daniel Berger AG Klein |
F. Basheer et al. Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML, JEM 2019 | |
| 185 | 1st of July 2019 | ||
| Guest Speaker |
Prof. Dr. Jörg Renkawitz Biomedical Center Munich (BMC) |
Principles of leukocyte navigation in 3D microenvironments. | |
| 184 | 24th of June 2019 | ||
| Results colloquium | Philipp Metzger
AG König-Schnurr |
TBA. | |
| Journal Club | Mohamed-Reda Benmebarek
AG Kobold-Endres |
Claus et al. Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy, Sci. Transl. Med 2019. | |
| 183 | 17th of June 2019 | ||
| Results colloquium | Lisa Rohrbacher
AG Subklewe |
Effects of Idelalisib on immune cells. | |
| Journal Club | Siret Tahk
AG Hopfner |
Su et al. Immune checkpoint inhibition overcomes ADCP-induced immunosuppression by macrophages, Cell 2018. | |
| 182 | 3rd of June 2019 | ||
| Results colloquium | Sascha Göttert
AG Haas/Poeck |
The role of type I interferon-inducing metabolites in Prophylaxis of Graft-versus-Host disease. | |
| Journal Club | Carlotta Rambuscheck
AG König-Schnurr |
XM. Evrard et al. Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector function, Cell Press 2018. | |
| 181 | 27th of Mai 2019 | ||
| Results colloquium | Dr. Maike Buchner
AG Ruland |
Pathologically enforced RANK signaling in B Cells triggers autoimmune lymphoproliferation and chronic lymphoytic leukemia development. | |
| Journal Club | Konstantinos Panagiotidis
AG Mougiakaos |
Xu et al. Translation control of the immune checkpoint in cancer and its therapeutic trageting, Nature medicine 2019. | |
| 180 | 20th of Mai 2019 | ||
| Results colloquium | Steffen Dickopf, Roche
AG Kobold-Endres |
Next generation T cell bispecific antibodies. | |
| Statistical lecture | Larsen Vornholz
AG Ruland |
Statistic lecture 101. | |
| 179 | 6th of April 2019 | ||
| Results colloquium | Jasmin Mahdawi
AG Feuchtinger |
Generation and Characterization of CD19 CAR T cells with CTLA-4/CD28 fusion receptor. | |
| Journal Club | Janina Dörr
AG Kobold |
Rosato et al. Virus-specific memory T cells populate tumors and can be repurposes for tumor immunotherapy, Nature communications 2019. | |
| 178 | 29th of April 2019 | ||
| Results colloquium | Prof. Dr. Marion Subklewe
AG Subklewe |
The Evolution of Immunotherapy in AML. | |
| Journal Club | Lisa Rohrbacher
AG Subklewe |
Poggio et al. Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory, Cell 2019. | |
| 177 | 15th of April 2019 | ||
| Results colloquium | Sehmus Tohumeken
AG Mackensen |
AML exosomes promote TLR2-mediated induction of glycolytic MDSC. | |
| Research Seminar | Simone Formisano
AG König/Schnurr |
Staedtke et al. Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome, Nature 2018. | |
| 176 | 8th of April 2019 | ||
| Results colloquium | Veronika Ecker
AG Ruland |
Negative feedback inhibition as novel therapeutic approach in chronic lymphocytic leukemia | |
| Research Seminar | Kim Pawelka
AG Knolle |
Smith et al. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors, JCI 2017. | |
| 175 | 1st of April 2019 | ||
| Results colloquium | Prof. Dr. Dimitrios Mougiakakos
AG Mougiakakos Erlangen |
Stroma cells: an immune metabolic hub. | |
| Journal Club | Sascha Göttert
AG Poeck/Haas |
Gopalakrishnan et al. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients, Science 2018. | |
Winter semester 2018/2019
| No. | Date | Speaker | Topic |
| 174 | 25th of March 2019 | ||
| Journal Club | Larsen Vornholz
AG Ruland |
Cox et al. Choline acetyltransferase-expressing T cells are required to control chronic viral infection, Science 2019. | |
| 173 | 18th of March 2019 | ||
| Guest Speaker |
Professor Charles Dinarello University of Colorado, Denver |
Role of NLRP3 regulation of IL-1beta in cancer. | |
| 172 | 11th of March 2019 | ||
| Guest Speaker |
Vincenzo Desiderio, Ph.D. |
Inhibition of pentose phosphate pathway suppresses tumor growth and metastasis by inducing endoplasmic reticulum stress and autophagy. | |
| 171 | 4th of March 2019 | ||
| Results colloquium | Dr. Daria Briukhovetska
AG Kobold |
The roles of C5a receptor 1 and chemokine receptor 5 in Toxoplasma gondii infection. | |
| Journal Club | Konstantinos Panagiotidis
AG Mougiakakos |
Jones et al. Inhibition of amino acid metabolism selectively targets human leukemia stem cells, Cancer Cell 2018. | |
| 170 | 25th of February 2019 | ||
| Results colloquium | Javier Suarez Gosalvez
AG Kobold |
The impact of interleukin-22 on metastasis formation. | |
| Journal Club | Natascha Röhrle
AG Anz |
Spranger et al. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy, Cancer Cell 2017. | |
| 169 | 18th of February 2019 | ||
| i-Target seminar awards 2018 | the presentation of the i-Target seminar awards 2018 for the best talk, the best discussing person and the best journal club quiz performance. | ||
| Results colloquium |
Daniel Bergér AG Klein |
Multi-specific Antibodies to target Cancer stem cells in AML via CD200. | |
| Journal Club |
Dana Stenger AG Feuchtinger |
Yamamoto et al. T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy, JCI 2019. | |
| 168 | 11th of February 2019 | ||
| Results colloquium | Dr. Laia Pascual Ponce
AG Hopfner |
CD47-SIRPalpha: the myeloid-specific immune checkpoint. | |
| Journal Club | Clara Karches
AG Kobold |
Feucht et al. Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency, Nature Medicine 2018. | |
| 167 | 4th February 2019 | ||
| Results colloquium | Alina Lohner
AG Subklewe |
Expansion & Characterization of AML-specific T Cells to test novel in vivo DC targeting AB Constructs. | |
| Journal Club | Anne Marie Senz
AG Schnurr |
André et al. Anti-NKG2A mAb is a checkpoint Inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells, Cell 2018. | |
| 166 | 21th January 2019 | ||
| Educational colloquium | Dr. Meino Rohlfs
AG Klein |
Next generation sequencing. | |
| Journal Club | Magdalena Zaucha
AG Rothenfußer |
Boettcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell 2018. | |
| 165 | 14th January 2019 | ||
| Results colloquium | Kim Pawelka
AG Knolle |
iMATE-forming monocytes - a population with unique functional properties. | |
| Journal Club | Duc Huynh
AG Kobold |
Wight et al. Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses, PNAS 2018. | |
| 164 | 7th January 2019 | ||
| Results colloquium | Svenja Rausch
AG Kobold |
Effect of PD-1-CD28 fusion receptor transduced T cells in adoptive T cell therapy. | |
| Journal Club | Alina Lohner
AG Subklewe |
Sahin et al: Personalized vaccines for cancer immunotherapy, Sciences 2018. | |
| 163 | 17th December 2018 | ||
| Research Seminar | Prof.Dr. Sebastian Theurich
Professorship for Cancer & Immuno-Metabolism, Attending Physician, Dpt. of Medicine III, University Hospital Munich |
NK cells in Metaflammation | |
| 162 | 10th December 2018 | ||
| Journal Club | Daniel Bergér
AG Klein |
Shivange et al. A single-agent dual-specificity targeting of FOLR1 and DR5 as an effective strategy for ovarian cancer, Cancer Cell 2018 | |
| 161 | 3rd December 2018 | ||
| Educational colloquium | Dr. Nicholas Tokarew
AG Kobold |
The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and its Relationship with the Sonic Hedgehog Pathway. | |
| Journal Club | Saskia Schmitt
AG Hopfner |
Akahori et al. Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination, Blood 2018. | |
| 160 | 26th November 2018 | ||
| Journal Club | Eva Ortner
AG Feuchtinger |
Han et al. Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression, Nature communications 2018. | |
| 159 | 19th November 2018 | ||
| Results colloquium | Corinna Meyer-Gehlen
AG Rothenfußer |
Characterization of new potential MAVS interaction partners. | |
| Journal Club | Maryam Schübele
AG Kobold |
Zhang et al. Blockade of the checkpoint receptor TIGIT prevent NK cell exhaustion and elicits potent anti-tumor immunity, Nature Immunology 2018. | |
| 158 | 12th November 2018 | ||
| Results colloquium | Dr. Heiko Bruns
AG Mackensen |
Tumour associated macrophages and therapeutic antibodies. | |
| Journal Club | Tanja Stief
AG Feuchtinger |
Osborn et al. CRISPR-based cellular engineering for targeted gene overexpression, Int. J. Mol. Sci. 2018. | |
| 157 | 5th November 2018 | ||
| Results colloquium | Paula Rothämel and Jonas Wilhelm
AG Feuchtinger |
Blast-T cell interaction in pediatric leukaemia. | |
| Journal Club | Bruno Cadilha
AG Kobold |
Deng et al. LILRB4 signaling in leukaemia cells mediates T cell suppression and tumour infiltration, Nature letters 2018. | |
| 156 | 29th October 2018 | ||
| Results colloquium | Mohamed-Reda Benmebarek
AG Kobold |
Mesothelin-targeted bispecific antibodies drive synthetic agonistic receptor-transduced T cells to mediate specific and conditional therapy of human pancreatic cancer models. | |
| Journal Club | Judit Rial
AG Mougiakakos |
Pilipow et al. Antioxidant metabolism regulates CD8+ T cell memory stem cell formation and antitumor immunity, JCI insight 2018. | |
| 155 | 22nd October 2018 | ||
| Educational colloquium | Prof. Dr. Percy Knolle | Local immune regulation in the liver: new insights into an organ with dual function in controlling immunity and metabolism. | |
| Journal Club | Jasmin Mahdawi
AG Feuchtinger |
Lai et al. Toll-like receptor 2 costimulation potentiates antitumor efficacy of CAR T Cells, Leukemia 2018. | |
| 154 | 15th October 2018 | ||
| Journal Club | Johannes Lutz
AG Kobold |
Adachi et al. Il-7 and CC19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor, Nature biotechnology 2018. | |
Summer semester 2018
(9th April 2018 till 14th July 2018)
| 153 | 8th October 2018 | ||
| Results colloquium | Lara Hartjes
AG Ruland |
Identification of novel MALT1 substrate. | |
| Journal Club | Raphael Rubens
AG Kobold |
Rafiq et al. Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo, Nature Biotechnology, 2018. | |
| 156 | 1st October 2018 |
Prof. Dr. Hans-Georg Rammensee Head of the Department of Immunology, Institute for Cell Biology, University of Tübingen |
On the development of personalized cancer vaccines |
| 153 | 24th September 2018 | ||
| Results colloquium | Sehmus Tohumeken
AG Mackensen |
AML exosomes promote induction of glycolytic MDSCs. | |
| Journal Club | Konstantinos Panagiotidis
AG Mougiakakos |
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate. | |
| 153 | 10th September 2018 | ||
| Educational colloquium | Prof. Dr. Marion Subklewe | Women in science. | |
| Results colloquium | Bruno Cadilha
AG Kobold |
C-C Chemokine receptor 8 and TGF-β-Receptor 2 genetic engineering combination make for successful Chimeric antigen receptor T cell therapy in solid tumors. | |
| 152 | 23th July 2018 | ||
| Research colloquium | Philipp Metzger
AG Schnurr |
The role of IRF4 in MDSC in an orthotopic pancreatic cancer mode. | |
| 151 | 18th July 2018 |
PD Dr. Louisa von Baumgarten Neurologische Klinik und Poliklinik, Klinikum Großhadern, München |
In vivo imaging of brain tumors to monitor novel therapeutic strategies |
| 150 | 9th July 2018 | ||
| Educational colloquium | Dr. Maike Buchner
AG Ruland |
The impact of nutrition on cancer and immune cell signaling. | |
| Journal club | Philipp Metzger
AG Schnurr |
Li et al. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy, Immunity 2018. | |
| 149 | 2nd July 2018 | ||
| Journal club | Sehmus Tohumeken
AG Mackensen |
Wang et al. Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis, AACR Journal 2018 | |
| 148 | 2nd July 2018 |
Professor Shaun McColl Professor of Immunology, Head of Chemokine Biology, Faculty of Sciences, The University of Adelaide, Australia |
Chemokines and their receptors in metastatic cancer. |
| 147 | 25th June 2018 | ||
| Results colloquium | Dana Stenger
AG Feuchtinger |
Generation of CD19 CAR T cells with a CRISPR/Cas9 mediated T cell receptor knock out. | |
| Journal club | Javier Suarez Gosalvez
AG Kobold |
Brown et al. Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice, Science 2018. | |
| 146 | 18th June 2018 | ||
| Educational colloquium | Dr. Jin Zhang
AG Kobold |
Understanding T cell receptor initial triggering. | |
| Journal club | Paula Rothämel
AG Feuchtinger |
Morsut et al. Engineering customized cell sensing and response behaviors using synthetic notch receptors, Cell 2016. | |
| 145 | 11th June 2018 | ||
| Educational colloquium | Professor Lauber
AG Lauber |
Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and precinical experiences. | |
| Journal club | Svenja Rausch
AG Kobold |
Cho et al. Universal chimeric antigen receptors for multiplexed and logical control of T cell responses, Cell 2018 . | |
| 144 | 28th May 2018 | ||
| Educational colloquium | Justyna Ogonek
AG Kobold |
CMV-specific T cells in immunotherapy for stem cell transplantation - associated complications. | |
| Journal club | Lara Hartjes
AG Ruland |
Wong, B. Visual strategies for biological data, part I, Nat. Methods. | |
| 143 | 14th May 2018 | ||
| Results colloquium | Laura Frey
AG Klein |
Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45). | |
| Journal club | Clarissa Zappe
AG Rothenfußer |
Yu et al. Activation of the MDA5-IPS1 viral sensing pathway induces cancer cell death and type I interferon-dependent antitumor immunity, Cancer Res, 2016. | |
| 142 | 7th May 2018 | ||
| Results colloquium | Siret Tahk
AG Hopfner |
Targeting the AML leukemic stem cell population using anti-CD123 antibodies that simultaneously disrupt the CD47–SIRPα interaction. | |
| Journal club | Simone Formisano
AG Schnurr |
Xiaolin Yu, et al. Targeting EGFR/HER2/HER3 with a three-in-one aptamer-siRNA chimera confers superior activity against HER2+ breast cancer, Molecular Therapy, Nucleic Acids, 2017. | |
| 141 | 23th April 2018 | ||
| Educational colloquium | Daniel Böhmer
AG Schnurr |
Molecular mechanisms of nucleic acid-mediated cytotoxicity. | |
| Journal club | Simon Dedic
AG Hopfner |
Cheng et al. Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma, CellDeath and Disease, 2018. | |
| 140 | 16th April 2018 | ||
| 29th Research Seminar | Dr. Georg Fertig
Head of Dept. Screening & Functional Assays, Large Molecule Research Roche, Penzberg |
Transformative antibody therapeutics at Roche | |
| 139 | 9th April 2018 | ||
| Results colloquium | Bastian Meyer
AG Anz |
Identification of functional receptors for CCL22 via APEX2 proximity labeling. | |
Winter semester 2017/2018
(16th Oktober 2017 till 10th February 2018)
| No. | Date | Speaker | Topic |
| 138 | 26th March 2018 | ||
| Results colloquium | Saskia Schmitt
AG Hopfner |
Multispecific antibody derivatives to target and activate dendritic cells in vivo. | |
| Journal club | Angelina Krächan
AG Kobold |
Barrow et al. Natural killer cells control tumor growth by sensing a growth factor, Cell, 2018. | |
| 137 | 19th March 2018 | ||
| Results colloquium | Anna Maier
AG Subklewe |
Influence of immunosuppressive cellular and humoral factors on T-cell function in Acute Myeloid Leukemia. | |
| Journal club | Kim Pawelka
AG Knolle |
Wang et al. A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair, Cell, 2016. | |
| 136 | 12th March 2018 | ||
| Results colloquium | Raphael Kfuri Rubens
AG Schnurr |
Indolamine 2,3-dioxygenase in T cells. | |
| Journal club | Svenja Rausch
AG Kobold |
Böttcher et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control, Cell, 2018. | |
| 135 | 5th March 2018 | ||
| Educational colloquium | Dr. Martin Böttcher
AG Mougiakakos |
2-HG-A a novel oncometabolite with immune modulation properties. | |
| Journal club | Veronika Ecker
AG Ruland |
Kikushige et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia, Cancer Cell, 2011. | |
| 134 | 26th February 2018 | ||
| Results colloquium | Tanja Stief
AG Feuchtinger |
CRISPR/Cas-mediated T cell editing for the treatment of refractory viral infections. | |
| Journal club | Magdalena Scheck
AG Rothenfußer |
Clift et al. A method for the acute and rapid degradation of endogenous proteins, Cell, 2018. | |
| 133 | 19th February 2018 | ||
| Results colloquium | Julius Keyl
AG Kobold |
Fusion receptor- transduced T cells combined with bispecific antibodies to improve the therapy of malignant melanomas. | |
| Journal club | Jonas Wilhelm
AG Feuchtinger |
Duell et al. Frequency of regulatory T cells determines the outcome of theT-cell-engaging antibody blinatumomab in patients with B-precursor ALL, Leukemia, 2017. | |
| 132 | 12th February 2018 | ||
| Educational colloquium | Dr. Selina Keppler
AG Ruland |
Dectin-1: a C- type lectin receptor on dendritic cells in antifungal immunity. | |
| Journal club | Clara Karches
AG Kobold |
Lan et al. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β, Science Translational Medicine, 2018. | |
| 131 | 5th February 2018 | ||
| 28th Research seminar | Ph.D., Ph.D. Santiago González | Intravital characterization of the inflammatory response that follows vaccination in the draining lymph node | |
| 130 | 29th January 2018 | ||
| Results colloquium | Stefanie Lesch
AG Kobold |
Whole transcriptome analysis of adoptively transferred tumor infiltrating T-cells. | |
| Journal club | Antonia Apfelbeck
AG Feuchtinger |
Xiaojun et al. A chimeric switch-receptor targeting PD1 augments the efficacy of second generation CAR T-Cells in advanced solid tumors, Cancer Res, 2017. | |
| 129 | 22nd January 2018 | ||
| Educational colloquium | Dr. Claudia Roskopf
AG Hopfner |
Insights into cell-mediated cytotoxicity and phagocytosis: how tumor cells are killed. | |
| Journal club | Raphael Kfuri Rubens
AG Schnurr |
Routy et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science 2017. | |
| 128 | 15th January 2018 | ||
| Results colloquium | Kim Pawelka
AG Knolle |
Unique functional properties of iMATE forming myeloid cells. | |
| Journal club | Steffeni Mountford
AG Bufler |
Hong et al. Correction of a pathogenic gene mutation in human embryos. Nature 2017 | |
| 127 | 8th January 2018 | ||
| Results colloquium | Clara Karches
AG Kobold |
Synthetic agonistic receptors as an approach for immunotherapy. | |
| Journal club | Maurine Rothe
AG Subclewe |
Shapiro et al. Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia. Haematologica, 2017. | |
| 126 | 18th December 2017 | ||
| Results colloquium | Mohamed-Reda Benmebarek
AG Kobold |
Combination of bispecific antibodies with genetically modified T-cells for cancer immunotherapy. | |
| Journal club | Mohamed-Reda Benmebarek
AG Kobold |
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Nature medicine, 2017 | |
| 125 | 11th December 2017 | ||
| Educational colloquium | Dr. Jin Zhang
AG Kobold |
Phospholipid Scramblase 1 regulates T-cell antitumor immunity by activating PI3K signaling. | |
| Journal club | Steffeni Moundford
AG Bufler |
NLRP1 promotes tumor growth by enhancing inflammasone activation and suppresisng apoptosis in metastatic melanoma. Oncogene, 2017 | |
| 124 | 4th December 2017 | ||
| Results colloquium | Laura Frey
AG Klein |
Molecular mechanisms of severe congenital neutropenia (SCN) associated with deficiencies in vacuolar protein sorting 45 homolog (VPS45). | |
| Journal club | Steffen Dickopf
AG Kobold |
Patel et al. Identification of essential genes for cancer immuntherapy. Nature, 2017 | |
| 123 | 27th November 2017 | ||
| 27th Research seminar | Dr. Arndt Schottelius
Kymab, Cambridge UK |
KY1044, a novel anti-ICOS antibody, elicits long term in vivo anti-tumour efficacy as monotherapy and in combination with immune checkpoint inhibitors. | |
| 122 | 20th November 2017 | ||
| Results colloquium | Steffen Dickopf
AG Kobold |
A robust tool for optimizing CRISPR/Cas9-mediated gene editing - the whole story. | |
| Journal club | Dana Stenger
AG Feuchtinger |
Hu B. et al. Augmentation of antitumor immunity by human and mouse CAR T Cells secreting IL-18. Cell Reports, 2017 | |
| 121 | 13th November 2017 | ||
| Results colloquium | Javier S. Golsavez
AG Kobold |
Impact of interleukin-22 on metastasis formation | |
| Journal club | Anna Maier
AG Subklewe |
Mangaonkar A. et al. A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression. Scientific Reports, 2017 | |
| 120 | 6th November 2017 | ||
| 26th Research seminar | Dr. Alexander Buchner
Urologische Klinik und Poliklinik, Klinikum der Universität München |
Basics of statistics - important for doctoral thesis and publication | |
| 119 | 16th October 2017 | ||
| 25th Research seminar | Dr. Sebastian P. Haen
Med. Universitätsklinik, Tübingen |
T cell reactivity against self-antigens - Autoimmunity after allogeneic hematopoietic cell transplantation | |
| 118 | 9th October 2017 | ||
| Results colloquium | Prof. Duska Dragun
AG Subklewe |
TBA | |
| Journal club | cancelled | ||
| 117 | 2nd October 2017 | ||
| Results colloquium | Lara Hartjes
AG Ruland |
Identification of novel MALT1 substrates | |
| Journal club | |||
Summer semester 2017
(24th April 2017 till 29th July 2017)
| No. | Date | Speaker | Topic |
| 116 | 25th September 2017 | ||
| 24th Research seminar | Prof. Dr. Jürgen Bernhagen
Munich |
Immune-mediated mechanisms in cardiovascular disease and cancer: focus on MIF proteins | |
| 115 | 18th September 2017 | ||
| Educational colloquium |
AG Mougiakakos |
Immune metabolic interplay in cancer | |
| Journal club | Semjon Willier
AG Feuchtinger |
Mezzadra R. et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 2017 | |
| 114 | 24th July 2017 | ||
| Educational colloquium | Dr. Benedikt Jacobs
AG Mackensen |
NK cells - from biology to clinical trials. | |
| Journal club | Sehmus Tohumeken
AG Mackensen |
Liu Y. et al. Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell, 2016 | |
| 113 | 17th July 2017 | ||
| 23th Research seminar | Dr. Matthias Klinger
AMGEN Research, Munich |
Innovative drug development at AMGEN | |
| 112 | 10th July 2017 | ||
| Result colloquium | Romy Loschinski
AG Mougiakakos |
IL-21 as an immunometabolic T-cell modulator. | |
| Journal club | Javier Suarez Gosalvez
AG Kobold |
Whole-body imaging of lymphovascular niches identifies pre- metastatic roles of midkine. Nature Letters, 2017 | |
| 111 | 3rd July 2017 | ||
| Educational colloquium | Dr. Lars König
AG Kobold |
How-to guide to creating CRISPR-KOs | |
| Journal club | Clara Karches
AG Kobold |
Rulla M et al. Overcoming the immunosuppressive tumor microenviroment of Hodgking lymphoma using chimeric antigen receptor T cells. American Association for Cancer, 2017 | |
| 110 | 26th June 2017 | ||
| Results colloquium | Bruno Cadilha
AG Kobold |
Redirecting T cells through CCR8-CCL1 axis and shielding from TGF-β for effective adoptive T cell therapy | |
| Journal club | Tanja Stief
AG Feuchtinger |
Rupp LJ et al. CRISPR/Cas9-mediated PD-1disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Nature, 2017 | |
| 109 | 19th June 2017 | ||
| 22th Research seminar | Dr. Rajkumar Savai
Max Planck Institute, Bad Nauheim |
The lung tumor microenvironment: targeting the soil to kill the tumor seed | |
| 108 | 29th May 2017 | ||
| Results colloquium | Sehmus Tohumeken
AG Mackensen |
Characterization and targeting of myeloid-derived suppressor cells in acute myeloid leukemia | |
| Journal club | Heike Anders
AG Lauber |
Rodriguez-Ruiz M E et al. Abscopal effects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming, Cancer Research 2016 | |
| 107 | 22th May 2017 | ||
| Results colloquium | Dr. Selina Keppler
AG Ruland |
Imaging B cells: linking receptors, the actin cytoskeleton and aberrant immune responses | |
| 106 | 15th May 2017 | ||
| Progress report | Veronika Ecker
AG Ruland |
Drug delivery improvement for leukemia and lymphoma | |
| 105 | 8th Mai 2017 | ||
| Educational colloquium | Dr. Marcin Lyszkiewicz
AG Klein |
T cell development by the numbers | |
| Journal club | Stefan Stoiber
AG Kobold |
Long A H et al. 4-1BB costimulation ameliorates T cell exhaustion induces by tonic signaling of chimeric antigen receptors. Nature Medicine, 2015 | |
| 104 | 24th April 2017 | ||
| Results colloquium | Steffeni Mountford
AG Bufler |
Modulation of liver inflammation and fibrosis by the IL-1 homologue IL-37 | |
| 103 | 3rd April 2017 | ||
| Results colloquium | Maurine Rothe
AG Subklewe |
Blockade of LAG-3 enhances dentritic cell-induced T-cell responses more than blockade of PD-1 | |
| Journal club | Mareike Lepenies
AG Feuchtinger |
McGranahan N et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science, 2016 | |
Winter semester 2016/2017
(17th October 2016 till 11th February 2017)
| No. | Date | Speaker | Topic |
| 102 | 27th March 2017 | ||
| Educational colloquium | Dr. Maike Buchner | B cell development malignant transformation and signaling thresholds | |
| Journal club | Lukas Mallaun | Eyquem J et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature, 2017 | |
| 101 | 20th March 2017 | ||
| Results colloquium | cancelled due to ITOC Conference | ||
| Journal club | |||
| 100 | 13th March 2017 | ||
| Results colloquium | Monika Herrmann | Releasing the T cell brake - novel strategy of local PD-1/PD-L1 checkpoint blockade to fight immune evasion in AML | |
| Journal club | Maurine Rothe | Bronte V et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nature Communications, 2016 | |
| 99 | 6th March 2017 | ||
| 21th Research Seminar |
Dr. Jan Böttcher The Francis Crick Institute, London |
Evasion of the antitumor immunity by prostaglandin E2 production | |
| 98 | 20th February 2017 | ||
| 20th Research Seminar |
Dr. Arndt Schottelius MorphoSys, Munich |
Anti-CD38 monoclonal antibodies as an evolving new backbone therapy in multiple myeloma | |
| 97 | 13th February 2017 | ||
| Educational colloquium | Paul Schwarzlmüller | Basics in Statistics | |
| Journal club | Lara Hartjes | Damgaard R B et al. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell, 2016 | |
| 96 | 10th of February at 10:30 |
Yi Xeng, China |
Medical research in China (15 min) |
| 95 | 6th February 2017 | ||
| Result colloquium | Phillip Metzger | PD-1 expression of non-T cells | |
| Journal club | Bruno Cadilha | Buck M D et al. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell, 2016 | |
| 94 | 30th January 2017 | ||
| Educational colloquium | Anna Kaufmann | Autophagy and its role in cancer | |
| Journal club | Xiaomei Chen | Arbore G et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 2016 | |
| 93 | 26th January 2017 | ||
| 19th Research Seminar |
Prof. Charles Dinarello, University of Colorado, Denver |
From fever to autoinflammation - the roadmap of interleukin-1 beta | |
| 92 | 23th January 2017 | ||
| 18th Research Seminar |
Dr. Nisit Khandelwal iOmx Therapeutics AG, Munich |
Research seminar: Mapping the tumor's immune-evasion strategies beyond the existing paradigm |
|
| 91 | 16th January 2017 | ||
| Themenkolloqium | Kim Pawelka | Plasticity of myeloid cells in the iMate context | |
| Journal Club | Steffi Lesch | Faitschuk E et al. Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells. Blood, 128: 1711-1722 | |
| 90 | 09th January 2017 | ||
| Themenkolloqium | Saskia Schmitt | Characterization of multispecific antibody derivates to target and activate dendritic cells in vivo | |
| Journal Club | Laura Frey | Moroishi T et al. The hippo pathway kinases LATS1/2 suppress cancer immunity. Cell, 167:1525-1539. | |
| 89 | 19th December 2016 | ||
| 17th Research Seminar |
Dr. A. Schottelius Morphosys AG |
Clinical update on MOR208, an antibody targeting CD19 in Non-Hodgkin Lymphomas |
|
| 88 | 28th November 2016 | ||
| Themenkolloqium | AG Rothenfußer | TBA | |
| Journal Club | |||
| 87 | 14th November 2016 | ||
| Themenkolloqium | Clara Karches | Activating fusion receptors as a novel approach for targeting autoreactive B cell receptors on chronic lymphatic leukaemia cells | |
| Journal Club | Julia Stein | A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression | |
| 86 | 11th November 2016 | ||
| 16th Research Seminar |
Dr. Jasper von Boorn University Hospital Bonn Biomedical Center Institute for Clinial Chemistry and Clin. Pharmacology |
Pigment cell-specific NK cell memory revealed |
|
| 85 | 07th November 2016 | ||
| 15th Research Seminar |
Dr. Carolin Daniel Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt Institut für Diabetesforschung |
Immune tolerance in autoimmune type 1 diabetes |
|
| 84 | 24th October 2016 | ||
| Themenkolloqium | AG Subklewe | ||
| Journal Club | Hanna Nowotny |
Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies |
|
| 83 | 17th October 2016 | ||
| 14th Research Seminar |
Prof. Georgios Stathopoulos |
On the role of mutant KRAS in malignant pleural disease |
|
| 82 | 10th October 2016 | ||
| Themenkolloqium | Julia Kobuch | Metastasis: Colonial policy in the body and models for its investigation | |
| Journal Club | Philipp Metzger | Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy | |
| 81 | 19th September 2016 | ||
| Themenkolloqium | Felicitas Rataj | About CARs and TRUCKs - Do we have the drivers' license? | |
| Journal Club | Anna Tiefenthaller |
Caloric restriction mimetics enhance anticancer immunosurveillance |
|
Summer semester 2016
(11. April 2016 bis 16. Juli 2016)
| 80 | 25. Juli 2016 | ||
| 13th Research Seminar |
Prof. Samuel Huber Peter Hans Hofschneider Professor Molecular Gastroenterology and Immunology University Medical Center Hamburg-Eppendorf |
Control of Th17 cells in the intestine |
|
| 79 | 18. Juli 2016 | ||
| 12th Research Seminar |
Dr. Annette Künkele Department of Pediatric Oncology/Hematology/SCT Charité-Universitätsmedizin Berlin |
What we learned from bench to beside with the neuroblastoma targeting CD171 -specific CAR |
|
| 78 | 11. Juli 2016 | ||
| Themenkolloqium | Severin Rodler | The IL-22/IL22-R-axis in renal cell carcinoma (RCC) | |
| Journal Club | Celina Aithal | Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells | |
| 77 | 04. Juli 2016 | ||
| Themenkolloqium | Viktoria Bothe | Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX | |
| Journal Club | Stefan Stoiber | In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity | |
| 76 | 27. Juni 2016 | ||
| Themenkolloqium | Viktoria Bothe | Analysis of MAVS-associated proteome in anti-viral signaling via spatially restricted enzymatic tagging with APEX | |
| Journal Club | Stefan Stoiber | In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity | |
| 75 | 20. Juni 2016 | ||
| 11th Research Seminar |
Dr. Arndt Schottelius Morphosys AG |
Clinical update on MOR202, a HuCAL antibody targeting CD38 in multiple myeloma |
|
| 74 | 13. Juni 2016 | ||
| Themenkolloqium | Laura Posselt | Targeting RIG-I with 5’ppp-modified RNA for immunotherapy of hepatocellular carcinoma (HCC) | |
| Journal Club | AG Rothenfusser | ||
| 73 | 06. Juni 2016 | ||
| Themenkolloqium | Monika Herrmann | Design of a new multispecific antibody derivative targeting the PD-1/PD-L1 immune checkpoint | |
| Journal Club | Adrian Gottschlich | The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity | |
| 72 | 30. Mai 2016 | ||
| Themenkolloqium | Fabian Kraus | ||
| Journal Club | Tim Wartewig | Disparate Individual Fates Compose Robust CD8+ T Cell Immunity | |
| 71 | 02. Mai 2016 | ||
| Themenkolloqium | AG Klein | ||
| Journal Club | Saskia Schmitt | Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas | |
| 70 | 25. April 2016 | ||
| 10th Research Seminar |
Dr. Ignazio Caruana Cellular and Gene Therapy of Pediatric Tumour IRCCS Bambino Gesù Hospital Rome, Italy |
Optimization of Chimeric Antigen Receptor T cell therapy in solid tumourss |
|
| 69 | 18. April 2016 | ||
| Themenkolloquium | Daniel Böhmer | Non-canonical pathways of RLH-induced cell death | |
| Journal Club | Clara Karches | Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor | |
| 68 | 11. April 2016 | ||
| Themenkolloquium | Angelina Krächan | Impact of TLR7-Agonists on NK cell cytotoxicity, phenotype and migration | |
| Journal Club | Laura Frey | IL-17-producing cd T cells and neutrophils conspire to promote breast cancer metastasis | |
| 67 | 04. April 2016 | ||
| Themenkolloquium | Simon Rothenfußer | ||
| Journal Club | AG Hopfner | ||
Wintersemester 2014/2015
(6. Oktober 2014 bis 6. Februar 2015)
| 66 | 28. März 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 65 | 21. März 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 64 | 16. März 2016 | ||
| 9th Research Seminar |
Prof. Charles Dinarello Department of Medicine Division of Infectious Diseases University of Colorado Denver Aurora, CO, USA |
The interleukin-1 family in 2016: solving secrets, helping patients |
|
| 63 | 14. März 2016 | ||
| Themenkolloquium | Lisa Weigand | Characterization and Targeting of MDSCs in AML | |
| Journal Club | Romy Loschinski | Autophagy enforces funktional integrity ofregulatory T cells by coupling environmental cues and metabolic homeostasis | |
| 62 | 07. März 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 61 | 29. Februar 2016 | ||
| Themenkolloquium | Christoph Klein | Primary Immunodeficiency Disorders | |
| Journal Club | Florian Asang | Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes | |
| 60 | 22. Februar 2016 | ||
| Themenkolloquium | Lars König | Cell Culture: Basics, Tips and Quality Control | |
| Journal Club | Michael Ruzicka | Agonist antibody that induces human malignant cells to kill one another | |
| 59 | 15. Februar 2016 | ||
| Themenkolloquium | Jürgen Ruland | ITAM Receptors in Innate Immunity and Oncogenesis | |
| Journal Club | Claudia Roskopf | Talimogene Laherparepvec improves durable response rate in patients with advanced melanoma | |
| 58 | 8. Februar 2016 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 57 | 1. Februar 2016 | ||
| Themenkolloquium | |||
| Journal Club | Rachel Mak'Anyengo | ||
| 56 | 25. Januar 2016 | ||
| Themenkolloquium | Jennifer Heinrich | Engineering of PD1-CD28 fusion receptor for improved functionality | |
| Journal Club | Severin Rodler | Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids | |
| 55 | 18. Januar 2016 | ||
| Themenkolloquium | Nadine Moritz | Development of a novel antibody format to target AML | |
| Journal Club | Veronica Ecker | Signalling thresholds and negative B-cells selection in acute lymphoblastic leukaemia | |
| 55 | 11. Januar 2016 | ||
| Themenkolloquium | Prof. Stefan Endres | Immunotherapie of cancer - update 2016 | |
| PD Dr. Sebastian kobold | i-Target program 2016 | ||
| 53 | 21. Dezember 2015 | ||
| Themenkolloquium | Bruno Cadilha | Redirecting T cells and enabling their TGF-beta resistance | |
| Journal Club | |||
| 52 | 14. Dezember 2015 | ||
| Themenkolloquium | Clara Karches | Combination of bispecific antibody with activating fusion Receptor for cancer therapy | |
| Journal Club | Lara Hartjes | The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquination by LUBAC to dampen lymphocyte NF-kB signaling | |
| 51 | 07. Dezember 2015 | ||
| Themenkolloquium | Michael Ruzicka | Immunotherapy of AML with bifunctional siRNA | |
| Journal Club | Angelina Krächan | ||
| 50 | 30. November 2015 | ||
| Themenkolloquium | Maurine Rothe | ||
| Journal Club | Daniel Böhmer | A genome-wide CRISPR screen identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation | |
| 49 | 26. November 2015 | ||
| Themenkolloquium | Julia Ahlfeld | ||
| Journal Club | Laura Frey |
Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells |
|
| 48 | 18. November 2015 | ||
| 8th Research Seminar |
PhD Nadia Cherradi INSERM U1036 - Biologie du Cancer et de l'Infection iRTSV/CEA Grenoble |
Post-transcriptional regulation in cancer: Focus on RNA-binding proteins and microRNAs |
|
| 47 | 16. November 2015 | ||
| Themenkolloquium | Philipp Metzger | ||
| Journal Club | Clara Karches | Remote control of therapeutic T cells through a small molecule-gated chimeric receptor | |
| 46 | 09. November 2015 | ||
| Themenkolloquium | Bruno Cadilha | ||
| Journal Club | Maurine Rothe | Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells | |
| 45 | 02. November 2015 | ||
| Themenkolloquium | |||
| Journal Club | |||
| 44 | 26. Oktober 2015 | ||
| Themkolloquium | Claudia Roskopf | Selective, T cell-dependent lysis of CD19+ leukemia cells mediated by single chain triplebodies with dual-targeting | |
| Journal Club | Tim Wartewig | ||
| 43 | 19. Oktober 2015 | ||
| Themenkolloquium | |||
| Journal Club | Florian Asang | ||
| 42 | 12. Oktober 2015 | ||
| 7th Research Seminar |
Professor Matthias Feige Cellular Protein Biochemistry Lab TU München |
Molecular Quality Control in the Immune System | |
| 41 | 05. Oktober 2015 | ||
| Themenkolloquium | AG Ruland | ||
| Journal Club | Stefanie Lesch (Kobold/Endres) | FcgammaRs modulate the anti-tumor activity if antibodies targeting the Pd-1/PD-L1 axis |
|
| 40 | 28. September 2015 | ||
| Themenkolloquium | Prof. Karl-Peter Hopfner | ||
| Journal Club | Monika Herrmann (AG Hopfner) | CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia | |
| 39 | 21. September 2015 | ||
| Themenkolloquium | Tim Wartewig | ||
| Journal Club | Bruno Cadhila (AG Kobold/Endres) | NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma | |
| 38 | 14. September 2015 | ||
| 6th Research Seminar | Prof. Dr. Tobias Feuchtinger | Therapy with T cells? The challenge of adoptive T-cell transfer | |
Sommersemester 2015
(13. April 2015 bis 18. Juli 2015)
| Nr. | Datum | Referent | Thema |
| 37 | 27. Juli 2015 | ||
| Themenkolloquium | PD Dr. Dimitrios Mougiakakos | Educational Colloqium: Oxidative stress in cancer | |
| Journal Club | Rachel Mak'Anyengo (AG Schnurr) | Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine | |
| 36 | 20. Juli 2015 | ||
| Themenkolloquium | Prof. Christoph Klein | Rare Diseases and Myeloid Leukemia | |
| Journal Club | Jennifer Heinrich (AG Kobold/Endres) | Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes | |
| 35 | 13. Juli 2015 | ||
| 5th Research Seminar |
Dr. Hans-Rainer Jaenichen Patents for Biotech Inventions |
Patents for Biotech Inventions | |
| 34 | 06. Juli 2015 | ||
| Ergebniskolloquium | Eva Hornig | Regulation of the transcription factor Brn3a in melanoma | |
| Journal Club | Bruno Cadilha (AG Kobold/Endres) |
Imaging liver biology in vivo using conventional confocal microscopy | |
| 33 | 29. Juni 2015 | ||
| Ergebniskolloquium | Stefanie Lesch (AG Kobold/Endres) | Whole transcriptome analysis of adoptively transferred tumor infiltrating T cells | |
| Journal Club | AG Anz | ||
| 32 | 22. Juni 2015 | ||
| Ergebniskolloquium | Daniel Böhmer (AG Schnurr) | Non-canonical pathways of 5‘-Triphosphate–RNA induced cell death | |
| Journal Club | AG Besch/Berking | ||
| 31 | 15. Juni 2015 | ||
| Ergebnisqkolloqium | Lara Hartjes (AG Ruland) | Identification of novel MALT1 substrates | |
| Journal Club | Johannes Tossounidis (AG Rothenfusser) | CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes | |
| 30 | 08. Juni 2015 | ||
| 4th Research Seminar |
Dr. Johannes vom Berg Transgenic and Reproductive Techniques Group, Institute of Laboratory Animal Science, University of Zurich |
Local immunotherapy of glioblastoma using proinflammatory cytokines | |
| 29 | 18. Mai 2015 | ||
| Ergebniskollquium | Romy Loschinski (AG Mackensen/Mougiakakos) | ||
| Journal Club | Lisa Weigand (AG Mackensen/Mougiakakos) | ||
| 28 | 11. Mai 2015 | ||
| Ergebniskolloquium | Heike Anders (AG Lauber) | ||
| Journal Club | AG Schulze-Koops | ||
| 27 | 04. Mai 2015 | ||
| Ergebniskolloquium | Laura Frey (AG Klein) | ||
| Journal Club | AG Kobold/Endres | ||
| 26 | 27. April 2015 | ||
| Ergebniskolloquium | Heike Anders (AG Laube) | HSP90 inhibition as a means or radiosensitizing resistant, aggressive soft tissue sarcoma | |
| Journal Club | Viktoria Bothe (AG Rothenfusser) | ATP-Dependent Effector-like Functions of RIG-I-like Receptors | |
| 25 | 20. April 2015 | ||
| Ergebniskolloquium | Entfällt | ||
| Journal Club | AG Besch/Berking | ||
| 24 | 13. April 2015 | ||
| Ergebniskolloquium | Stefanie Lesch (AG Kobold/Endres) | ||
| Journal Club | AG Schnurr | ||
| 23 | 23. März 2015 | ||
| Themenkolloquium | AG Schnurr | ||
| Journal Club | AG Kobold/Endres | ||
| 22 | 16. März 2015 | ||
| Ergebniskolloqium | Lisa Weigand (AG Mackensen/Mougiakakos) | Characterization and targeting of myeloid-derived suppressor cells (MDSCs) in acute myeloid leukemia (AML) | |
| Journal Club | Romy Loschinsky (AG Mackensen/Mougiakakos) | Promoting Thiol Expression Increases the Durability of Antitumor T-cell Functions | |
| 21 | 09. März 2015 | ||
| 3rd Research Seminar |
Dr. Ekkehard Leberer Sanofi |
Nucleic acid therapeutics: Opportunities and challenges for drug development | |
| 20 | 02. März 2015 | ||
| Themenkolloquium | Kirsten Lauber (AG Lauber) | Tumor growth promoting apoptosis: With a little help from my dying friends? | |
| Journal Club | Eva Heuer (AG Rothenfusser) | Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation | |
| 19 | 23. Feburar 2015 | ||
| Themenkolloquium | AG Kobold/Endres | ||
| Journal Club | AG Kobold/Endres | ||
| 18 | 09. Februar 2015 | ||
| Themenkolloquium | Sebastian Kobold (AG Ruland) | TLR7 agonists in cancer therapy | |
| Journal Club | Stefanie Lesch (AG Besch/Berking) | Combination therapy with anti-CTLA4 and anti-PD-1 leads to distinct immunologic changes in vivo | |
| 17 | 02. Februar 2015 | ||
| Themenkolloquium | Marion Subklewe (AG Subklewe) | Therapeutic vaccines in cancer | |
| Journal Club | Severin Rodler (AG Anders) | High-dimensional analysis of the murine myeloid cell system |
Wintersemester 2014/2015
(6. Oktober 2014 bis 6. Februar 2015)
| Nr. | Datum | Referent | Thema |
| 16 | 26. Januar 2015 | ||
| Ergebniskolloquium | AG Kobold/Endres | ||
| Journal Club | Christine Heuer (AG Rothenfusser) | ||
| 15 | 19. Januar 2015 | ||
| Ergebniskolloquium | Nadine Moritz (AG Hopfner) | Development of multi-specific antibody derivatives (msADs) to target acute myeloid leukemia | |
| Journal Club | Peter May (AG Kobold/Endres) | B7-H1 expressing antigen presenting cells mediate polarization of pro-tumorigenic Th22 subsets | |
| 14 | 12. Januar 2015 | ||
| Ergebniskolloquium | Moritz Schmidbauer (AG Kobold/Endres) | ||
| Journal Club | Saskia Graf (AG Besch/Berking) | ||
| 13 | 15. Dezember 2014 | ||
| Ergebniskolloquium | Fabian Kraus (AG Kobold) | ||
| Journal Club | AG Schulze-Koops | ||
| 12 | 08. Dezember | ||
| Ergebniskolloquium | Viktoria Bothe (AG Rothenfusser) | Characterization of RIG-I ligands during infection with Vesicular Stomatitis Virus | |
| Journal Club | Nadine Moritz (AG Hopfner) | A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity | |
| 11 | 01. Dezember 2014 | ||
| Ergebniskolloquium | Laura Posselt (AG Schnurr) | ||
| Journal Club | AG Anz | ||
| 10 | 24. November 2014 | ||
| Ergebniskolloquium | Fanny Matheis (AG Besch) | ||
| Journal Club | Marco Wachowius (AG Conzelmann) | Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine | |
| 9 | 17. November 2014 | ||
| Ergebniskolloquium | - | ||
| Journal Club | Severin Jacobi (AG Kobold) | The RAG Recombinase Dictates Functional Heterogenity and Cellular Fitness in Natural Killer Cells | |
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| 8 | 10. November 2014 | ||
| Ergebniskolloquium | AG Anz | ||
| Journal Club | Simone Romoli (AG Anders) | Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death | |
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| 7 | 03. November 2014 | ||
| 2nd Research Seminar i-Target | Prof. Dr. Dr. Michael von Bergwelt Klinikum der Universität zu Köln, Centrum für Integrierte Onkologie |
Targeting antigen presentation cells to induce an immunosupportive tumor microenvironment | |
| 6 | 27. Oktober 2014 | ||
| Ergebniskolloquium | Eva Hornig (AG Besch) | ||
| Journal Club | AG Rothenfusser | ||
| 5 | 20. Oktober 2014 | ||
| 1st Research Seminar i-Target |
PD Dr. Antje Menssen |
Targeting MYC-dependent metabolism and secreted factors for cancer therapy |
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| 4 | 13. Oktober 2014 | ||
| Ergebniskolloquium | Monika Herrmann (AG Hopfner) | ||
| Journal Club | Daniel Böhmer (AG Schnurr) | ||
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| 3 | 6. Oktober 2014 | ||
| Ergebniskolloquium | Maximilian Gradel (AG Rothenfußer) | ||
| Journal Club | Saskia Graf (AG Besch) | ||
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| 2 | 29. September 2014 | ||
| Themenkolloquium | Prof. Conzelmann | ||
| Journal Club | Alex Hennrich (AG Conzelmann) | ||
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| 1 | 25 bis 26. September 2014 |
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