Publikationen

The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy. Kitzberger C, Spellerberg R, Morath V, Schwenk N, Schmohl KA, Schug C, Urnauer S, Tutter M, Eiber M, Schilling F, Weber WA, Ziegler S, Bartenstein P, Wagner E, Nelson PJ, Spitzweg C. EJNMMI Res. 2022 May 3;12(1):25. doi: 10.1186/s13550-022-00888-w. Free PMC article. Review.
PMID: 35503582

[Medullary thyroid carcinoma: current clinical progress]. Kroiss M, Koehler VF, Spitzweg C. Dtsch Med Wochenschr. 2021 Nov;146(23):e114. doi: 10.1055/a-1708-7360. Epub 2021 Dec 7. German. No abstract available.
PMID: 34875710

Selective sodium iodide symporter (NIS) genetherapy of glioblastoma mediatedby EGFR-targeted lipopolyplexes. Spellerberg R, Benli-Hoppe T, Kitzberger C, Berger S, Schmohl KA, Schwenk N, Yen HY, Zach C, Schilling F, Weber WA, Kälin RE, Glass R, Nelson PJ, Wagner E, Spitzweg C. Mol Ther Oncolytics. 2021 Oct 30;23:432-446. doi: 10.1016/j.omto.2021.10.011. eCollection 2021 Dec 17. Free PMC article.
PMID: 34853814

[Medullary thyroid carcinoma: current clinical progress]. Kroiss M, Koehler VF, Spitzweg C. Dtsch Med Wochenschr. 2021 Nov;146(23):1527-1532. doi: 10.1055/a-1495-2991. Epub 2021 Nov 26. German.
PMID: 34826838

Course of Disease and Clinical Management of Patients with Poorly Differentiated Thyroid Carcinoma. Grawe F, Cahya A, Fabritius MP, Beyer L, Wenter V, Ruebenthaler J, Geyer T, Burgard C, Bartenstein P, Ilhan H, Spitzweg C, Todica A. Cancers (Basel). 2021 Oct 22;13(21):5309. doi: 10.3390/cancers13215309. Free PMC article.
PMID: 34771473

Medullary thyroid cancer with ectopic Cushing's syndrome: A multicentre case series. Koehler VF, Fuss CT, Berr CM, Frank-Raue K, Raue F, Hoster E, Hepprich M, Christ E, Pusl T, Reincke M, Spitzweg C, Kroiss M; German Study Group for Rare Malignant Tumours of the Thyroid and Parathyroid Glands. Clin Endocrinol (Oxf). 2022 Jun;96(6):847-856. doi: 10.1111/cen.14617. Epub 2021 Nov 6.
PMID: 34743368

[Hypothyroidism]. Köhler VF, Spitzweg C. MMW Fortschr Med. 2021 Oct;163(17):44-49. doi: 10.1007/s15006-021-0264-2.Review. German. No abstract available.
PMID: 34595647

FGF-Receptors and PD-L1 in Anaplastic and Poorly Differentiated Thyroid Cancer: Evaluation of the Preclinical Rationale. Adam P, Kircher S, Sbiera I, Koehler VF, Berg E, Knösel T, Sandner B, Fenske WK, Bläker H, Smaxwil C, Zielke A, Sipos B, Allelein S, Schott M, Dierks C, Spitzweg C, Fassnacht M, Kroiss M. Front Endocrinol (Lausanne). 2021 Aug 12;12:712107. doi: 10.3389/fendo.2021.712107. eCollection 2021. Free PMC article.
PMID: 34475850

Real-World Efficacy and Safety of Multi-Tyrosine Kinase Inhibitors in Radioiodine Refractory Thyroid Cancer. Koehler VF, Berg E, Adam P, Weber GL, Pfestroff A, Luster M, Kutsch JM, Lapa C, Sandner B, Rayes N, Fuss CT, Kreissl MC, Hoster E, Allelein S, Schott M, Todica A, Fassnacht M, Kroiss M, Spitzweg C. Thyroid. 2021 Oct;31(10):1531-1541. doi: 10.1089/thy.2021.0091.
PMID: 34405734

The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment. Spitzweg C, Nelson PJ, Wagner E, Bartenstein P, Weber WA, Schwaiger M, Morris JC. Endocr Relat Cancer. 2021 Sep 3;28(10):T193-T213. doi: 10.1530/ERC-21-0177. Review.
PMID: 34259647

An unusual case of struma ovarii. Koehler VF, Keller P, Waldmann E, Schwenk N, Kitzberger C, Schmohl KA, Knösel T, Stief CG, Spitzweg C. Endocrinol Diabetes Metab Case Rep. 2021 Mar 5;2021:20-0142. doi: 10.1530/EDM-20-0142. Online ahead of print. Free PMC article.
PMID: 33682680

The diagnostic challenge of coexistent sarcoidosis and thyroid cancer - a retrospective study. Wenter V, Albert NL, Ahmaddy F, Unterrainer M, Hornung J, Ilhan H, Bartenstein P, Spitzweg C, Kneidinger N, Todica A. BMC Cancer. 2021 Feb 7;21(1):139. doi: 10.1186/s12885-020-07745-w. Free PMC article.
PMID: 33550991

18F-FDG-PET/CT in Patients with Advanced, Radioiodine Refractory Thyroid Cancer Treated with Lenvatinib. Ahmaddy F, Burgard C, Beyer L, Koehler VF, Bartenstein P, Fabritius MP, Geyer T, Wenter V, Ilhan H, Spitzweg C, Todica A. Cancers (Basel). 2021 Jan 16;13(2):317. doi: 10.3390/cancers13020317. Free PMC article.
PMID: 33467085

Radiation to the Primary Tumor in Metastatic Anaplastic Thyroid Cancer. Augustin T, Oliinyk D, Rauch J, Koehler VF, Spitzweg C, Belka C, KÄsmann L. In Vivo. 2021 Jan-Feb;35(1):461-465. doi: 10.21873/invivo.12279. Free PMC article.
PMID: 33402497

Effects of the Minimal Extrathyroidal Extension on Early Response Rates after (Adjuvant) Initial Radioactive Iodine Therapy in PTC Patients. Ahmaddy F, Wenter V, Ilhan H, Wacker D, Unterrainer M, Knösel T, Bartenstein P, Spitzweg C, Lehner S, Todica A. Cancers (Basel). 2020 Nov 13;12(11):3357. doi: 10.3390/cancers12113357. Free PMC article.
PMID: 33202736

Integrin αvβ3-dependent thyroid hormone effects on tumour proliferation and vascularisation. Schmohl KA, Han Y, Tutter M, Schwenk N, Sarker RSJ, Steiger K, Ziegler SI, Bartenstein P, Nelson PJ, Spitzweg C. Endocr Relat Cancer. 2020 Dec;27(12):685-697. doi: 10.1530/ERC-20-0353.
PMID: 33112795

Regional Hyperthermia Enhances Mesenchymal Stem Cell Recruitment to Tumor Stroma: Implications for Mesenchymal Stem Cell-Based Tumor Therapy. Tutter M, Schug C, Schmohl KA, Urnauer S, Kitzberger C, Schwenk N, Petrini M, Zach C, Ziegler S, Bartenstein P, Weber WA, Multhoff G, Wagner E, Lindner LH, Nelson PJ, Spitzweg C. Mol Ther. 2021 Feb 3;29(2):788-803. doi: 10.1016/j.ymthe.2020.10.009. Epub 2020 Oct 15. Free PMC article.
PMID: 33068779

Clinical Outcome and Toxicity in the Treatment of Anaplastic Thyroid Cancer in Elderly Patients. Augustin T, Oliinyk D, Köhler VF, Rauch J, Belka C, Spitzweg C, Käsmann L. J Clin Med. 2020 Oct 9;9(10):3231. doi: 10.3390/jcm9103231. Free PMC article.
PMID: 33050286

Hypofractionated Radiotherapy for Anaplastic Thyroid Cancer: Systematic Review and Pooled Analysis. Oliinyk D, Augustin T, Koehler VF, Rauch J, Belka C, Spitzweg C, Käsmann L. Cancers (Basel). 2020 Sep 3;12(9):2506. doi: 10.3390/cancers12092506. Free PMC article.
PMID: 32899355

Real-World Efficacy and Safety of Cabozantinib and Vandetanib in Advanced Medullary Thyroid Cancer. Koehler VF, Adam P, Frank-Raue K, Raue F, Berg E, Hoster E, Allelein S, Schott M, Kroiss M, Spitzweg C. Thyroid. 2021 Mar;31(3):459-469. doi: 10.1089/thy.2020.0206. Epub 2020 Sep 23.
PMID: 32781914

Clinical impact of follicular oncocytic (Hürthle cell) carcinoma in comparison with corresponding classical follicular thyroid carcinoma. Wenter V, Albert NL, Unterrainer M, Ahmaddy F, Ilhan H, Jellinek A, Knösel T, Bartenstein P, Spitzweg C, Lehner S, Todica A. Eur J Nucl Med Mol Imaging. 2021 Feb;48(2):449-460. doi: 10.1007/s00259-020-04952-2. Epub 2020 Jul 18. Free PMC article.
PMID: 32683470

Clinical Presentation, Treatment, and Outcome of Parathyroid Carcinoma: Results of the NEKAR Retrospective International Multicenter Study. Lenschow C, Schrägle S, Kircher S, Lorenz K, Machens A, Dralle H, Riss P, Scheuba C, Pfestroff A, Spitzweg C, Zielke A, Nießen A, Dotzenrath C, Riemann B, Quinkler M, Vorländer C, Zahn A, Raue F, Chiapponi C, Iwen KA, Steinmüller T, Kroiss M, Schlegel N; NEKAR study group. Ann Surg. 2022 Feb 1;275(2):e479-e487. doi: 10.1097/SLA.0000000000004144.
PMID: 32649472

Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells. Tutter M, Schug C, Schmohl KA, Urnauer S, Schwenk N, Petrini M, Lokerse WJM, Zach C, Ziegler S, Bartenstein P, Weber WA, Wagner E, Lindner LH, Nelson PJ, Spitzweg C. Theranostics. 2020 Mar 15;10(10):4490-4506. doi: 10.7150/thno.41489. eCollection 2020. Free PMC article.
PMID: 32292510

Bone Metastases in Medullary Thyroid Carcinoma: High Morbidity and Poor Prognosis Associated With Osteolytic Morphology. Vogel T, Wendler J, Frank-Raue K, Kreissl MC, Spitzweg C, Fassnacht M, Raue F, Kroiss M. J Clin Endocrinol Metab. 2020 Jun 1;105(6):dgaa077. doi: 10.1210/clinem/dgaa077.
PMID: 32072159

Integrin αvβ3-Mediated Effects of Thyroid Hormones on Mesenchymal Stem Cells in Tumor Angiogenesis. Schmohl KA, Mueller AM, Dohmann M, Spellerberg R, Urnauer S, Schwenk N, Ziegler SI, Bartenstein P, Nelson PJ, Spitzweg C. Thyroid. 2019 Dec;29(12):1843-1857. doi: 10.1089/thy.2019.0413. Epub 2019 Dec 9.
PMID: 31816265

[The Thyroid and Pregnancy]. Koehler VF, Auernhammer CJ, Spitzweg C. Dtsch Med Wochenschr. 2019 Dec;144(24):1681-1685. doi: 10.1055/a-0660-6126. Epub 2019 Dec 2. German.
PMID: 31791071

The added diagnostic value of complementary gadoxetic acid-enhanced MRI to 18F-DOPA-PET/CT for liver staging in medullary thyroid carcinoma. Puhr-Westerheide D, Cyran CC, Sargsyan-Bergmann J, Todica A, Gildehaus FJ, Kunz WG, Stahl R, Spitzweg C, Ricke J, Kazmierczak PM. Cancer Imaging. 2019 Nov 14;19(1):73. doi: 10.1186/s40644-019-0263-z. Free PMC article.
PMID: 31727170

Thyroid Hormone Effects on Mesenchymal Stem Cell Biology in the Tumour Microenvironment. Schmohl KA, Müller AM, Nelson PJ, Spitzweg C. Exp Clin Endocrinol Diabetes. 2020 Jun;128(6-07):462-468. doi: 10.1055/a-1022-9874. Epub 2019 Oct 24. Review.
PMID: 31648351

Long-term outcome of rare oncocytic papillary (Hürthle cell) thyroid carcinoma following (adjuvant) initial radioiodine therapy. Wenter V, Jellinek A, Unterrainer M, Ahmaddy F, Lehner S, Albert NL, Bartenstein P, Knösel T, Spitzweg C, Ilhan H, Todica A. Eur J Nucl Med Mol Imaging. 2019 Nov;46(12):2526-2535. doi: 10.1007/s00259-019-04456-8. Epub 2019 Aug 13.
PMID: 31410542

Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell-Mediated Sodium Iodide Symporter (NIS) Gene 131I Therapy. Schug C, Kitzberger C, Sievert W, Spellerberg R, Tutter M, Schmohl KA, Eberlein B, Biedermann T, Steiger K, Zach C, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C. Clin Cancer Res. 2019 Oct 1;25(19):5997-6008. doi: 10.1158/1078-0432.CCR-18-4092. Epub 2019 Jun 13.
PMID: 31196853

Tetrac as an anti-angiogenic agent in cancer. Schmohl KA, Nelson PJ, Spitzweg C. Endocr Relat Cancer. 2019 Jun 1;26(6):R287-R304. doi: 10.1530/ERC-19-0058. Review.
PMID: 31063970

[Thyroid nodules: What now?]. Ladurner R, Hallfeldt K, Angele M, Werner J, Reincke M, Spitzweg C, Lottspeich C. MMW Fortschr Med. 2019 Apr;161(7):38-43. doi: 10.1007/s15006-019-0406-y. Review. German. No abstract available.
PMID: 30989520

Dual-targeted NIS polyplexes-a theranostic strategy toward tumors with heterogeneous receptor expression. Urnauer S, Schmohl KA, Tutter M, Schug C, Schwenk N, Morys S, Ziegler S, Bartenstein P, Clevert DA, Wagner E, Spitzweg C. Gene Ther. 2019 Apr;26(3-4):93-108. doi: 10.1038/s41434-019-0059-6. Epub 2019 Jan 25.
PMID: 30683895

[Erratum to: Hypothyroidism-when and how to treat?]. Koehler VF, Reincke M, Spitzweg C. Internist (Berl). 2019 Jan;60(1):108. doi: 10.1007/s00108-018-0520-4. German. No abstract available.
PMID: 30361741

A Novel Approach for Image-Guided 131I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery. Schug C, Gupta A, Urnauer S, Steiger K, Cheung PF, Neander C, Savvatakis K, Schmohl KA, Trajkovic-Arsic M, Schwenk N, Schwaiger M, Nelson PJ, Siveke JT, Spitzweg C. Mol Cancer Res. 2019 Jan;17(1):310-320. doi: 10.1158/1541-7786.MCR-18-0185. Epub 2018 Sep 17.
PMID: 30224540

TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer. Schug C, Urnauer S, Jaeckel C, Schmohl KA, Tutter M, Steiger K, Schwenk N, Schwaiger M, Wagner E, Nelson PJ, Spitzweg C. Endocr Relat Cancer. 2019 Jan 1;26(1):89-101. doi: 10.1530/ERC-18-0173.
PMID: 30121623

[Update of the S2k guidelines : Surgical treatment of benign thyroid diseases]. Musholt TJ, Bockisch A, Clerici T, Dotzenrath C, Dralle H, Goretzki PE, Hermann M, Holzer K, Karges W, Krude H, Kussmann J, Lorenz K, Luster M, Niederle B, Nies C, Riss P, Schabram J, Schabram P, Schmid KW, Simon D, Spitzweg C, Steinmüller T, Trupka A, Vorländer C, Weber T, Bartsch DK; Leitliniengruppe der CAEK. Chirurg. 2018 Sep;89(9):699-709. doi: 10.1007/s00104-018-0653-y. Review. German.
PMID: 29876616

[Hypothyroidism-when and how to treat?]. Koehler VF, Reincke M, Spitzweg C. Internist (Berl). 2018 Jul;59(7):644-653. doi: 10.1007/s00108-018-0438-x. Review. German.
PMID: 29872890

External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery. Schug C, Sievert W, Urnauer S, Müller AM, Schmohl KA, Wechselberger A, Schwenk N, Lauber K, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C. Hum Gene Ther. 2018 Nov;29(11):1287-1300. doi: 10.1089/hum.2018.025. Epub 2018 May 3.
PMID: 29724129

[Differentiated thyroid cancer - is less (therapy) more?]. Todica A, Ladurner R, Spitzweg C. Dtsch Med Wochenschr. 2018 Apr;143(7):453-458. doi: 10.1055/s-0044-102192. Epub 2018 Apr 3. German.
PMID: 29614533

EGFR-targeted nonviral NIS gene transfer for bioimaging and therapy of disseminated colon cancer metastases.
Urnauer S, Müller AM, Schug C, Schmohl KA, Tutter M, Schwenk N, Rödl W, Morys S, Ingrisch M, Bertram J, Bartenstein P, Clevert DA, Wagner E, Spitzweg C. Oncotarget. 2017 Sep 16;8(54):92195-92208. doi: 10.18632/oncotarget.21028. eCollection 2017 Nov 3.
PMID: 29190908

Reintroducing the Sodium-Iodide Symporter to Anaplastic Thyroid Carcinoma.
Schmohl KA, Dolp P, Schug C, Knoop K, Klutz K, Schwenk N, Bartenstein P, Nelson PJ, Ogris M, Wagner E, Spitzweg C.
Thyroid. 2017 Dec;27(12):1534-1543. doi: 10.1089/thy.2017.0290. Epub 2017 Nov 10.
PMID: 29032724

[Thyroid emergencies : Thyroid storm and myxedema coma].
Spitzweg C, Reincke M, Gärtner R. Internist (Berl). 2017 Oct;58(10):1011-1019. doi: 10.1007/s00108-017-0306-0. Review. German.
PMID: 28939923

EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent.
Morys S, Urnauer S, Spitzweg C, Wagner E. Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700203. Epub 2017 Sep 6.
PMID: 28877405

Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes. Urnauer S, Klutz K, Grünwald GK, Morys S, Schwenk N, Zach C, Gildehaus FJ, Rödl W, Ogris M, Wagner E, Spitzweg C. J Gene Med. 2017 May;19(5). doi: 10.1002/jgm.2957.
PMID: 28423213

Increased trace amine-associated receptor 1 (TAAR1) expression is associated with a positive survival rate in patients with breast cancer. Vattai A, Akyol E, Kuhn C, Hofmann S, Heidegger H, von Koch F, Hermelink K, Wuerstlein R, Harbeck N, Mayr D, Spitzweg C, Toth B, Mahner S, Jeschke U, Ditsch N. J Cancer Res Clin Oncol. 2017 Sep;143(9):1637-1647. doi: 10.1007/s00432-017-2420-8. Epub 2017 Apr 13.
PMID: 28409272

Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene.
Schmohl KA, Gupta A, Grünwald GK, Trajkovic-Arsic M, Klutz K, Braren R, Schwaiger M, Nelson PJ, Ogris M, Wagner E, Siveke JT, Spitzweg C. Oncotarget. 2017 May 16;8(20):33393-33404. doi: 10.18632/oncotarget.16499.
PMID: 28380420

Clinical presentation, treatment and outcome of anaplastic thyroid carcinoma: results of a multicenter study in Germany.
Wendler J, Kroiss M, Gast K, Kreissl MC, Allelein S, Lichtenauer U, Blaser R, Spitzweg C, Fassnacht M, Schott M, Führer D, Tiedje V. Eur J Endocrinol. 2016 Dec;175(6):521-529.
PMID: 27926471

Leveraging the immune system to treat advanced thyroid cancers.
French JD, Bible K, Spitzweg C, Haugen BR, Ryder M. Lancet Diabetes Endocrinol. 2017 Jun;5(6):469-481. doi: 10.1016/S2213-8587(16)30277-7. Epub 2016 Oct 20. Review.
PMID: 27773653

Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery. Müller AM, Schmohl KA, Knoop K, Schug C, Urnauer S, Hagenhoff A, Clevert DA, Ingrisch M, Niess H, Carlsen J, Zach C, Wagner E, Bartenstein P, Nelson PJ, Spitzweg C. Oncotarget. 2016 Aug 23;7(34):54795-54810. doi: 10.18632/oncotarget.10758.
PMID: 27458162

Fine Needle Aspiration in the Investigation of Thyroid Nodules. Feldkamp J, Führer D, Luster M, Musholt TJ, Spitzweg C, Schott M. Dtsch Arztebl Int. 2016 May 20;113(20):353-9. doi: 10.3238/arztebl.2016.0353. Review.
PMID: 27294815

Harnessing mesenchymal stem cell homing as an anticancer therapy. Hagenhoff A, Bruns CJ, Zhao Y, von Lüttichau I, Niess H, Spitzweg C, Nelson PJ. Expert Opin Biol Ther. 2016 Sep;16(9):1079-92. doi: 10.1080/14712598.2016.1196179. Epub 2016 Jun 13. Review.
PMID: 27270211

New drugs for medullary thyroid cancer: new promises? Spitzweg C, Morris JC, Bible KC.
Endocr Relat Cancer. 2016 Jun;23(6):R287-97. doi: 10.1530/ERC-16-0104. Epub 2016 May 16. Review.
PMID: 27185870

Sequence-defined cMET/HGFR-targeted Polymers as Gene Delivery Vehicles for the Theranostic Sodium Iodide Symporter (NIS) Gene. Urnauer S, Morys S, Krhac Levacic A, Müller AM, Schug C, Schmohl KA, Schwenk N, Zach C, Carlsen J, Bartenstein P, Wagner E, Spitzweg C. Mol Ther. 2016 Aug;24(8):1395-404. doi: 10.1038/mt.2016.95. Epub 2016 May 9.
PMID: 27157666

Establishment of an Effective Radioiodide Thyroid Ablation Protocol in Mice. Schmohl KA, Müller AM, Schwenk N, Knoop K, Rijntjes E, Köhrle J, Heuer H, Bartenstein P, Göke B, Nelson PJ, Spitzweg C. Eur Thyroid J. 2015 Sep;4(Suppl 1):74-80. doi: 10.1159/000381019. Epub 2015 May 23.
PMID: 26601076

Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3. Schmohl KA, Müller AM, Wechselberger A, Rühland S, Salb N, Schwenk N, Heuer H, Carlsen J, Göke B, Nelson PJ, Spitzweg C. Endocr Relat Cancer. 2015 Dec;22(6):941-52. doi: 10.1530/ERC-15-0245. Epub 2015 Aug 25.
PMID: 26307023

(124)I-PET Assessment of Human Sodium Iodide Symporter Reporter Gene Activity for Highly Sensitive In Vivo Monitoring of Teratoma Formation in Mice. Lehner S, Lang C, Kaissis G, Todica A, Zacherl MJ, Boening G, Spitzweg C, Herbach N, Franz WM, Krause BJ, Steinhoff G, Bartenstein P, Hacker M, David R. Mol Imaging Biol. 2015 Dec;17(6):874-83. doi: 10.1007/s11307-015-0857-1.
PMID: 25896817

Quantification of in vitro mesenchymal stem cell invasion into tumor spheroids using selective plane illumination microscopy.
Rühland S, Wechselberger A, Spitzweg C, Huss R, Nelson PJ, Harz H. J Biomed Opt. 2015 Apr;20(4):040501. doi: 10.1117/1.JBO.20.4.040501.
PMID: 25839427

Mesenchymal stem cell-mediated, tumor stroma-targeted radioiodine therapy of metastatic colon cancer using the sodium iodide symporter as theranostic gene. Knoop K, Schwenk N, Schmohl K, Müller A, Zach C, Cyran C, Carlsen J, Böning G, Bartenstein P, Göke B, Wagner E, Nelson PJ, Spitzweg C. J Nucl Med. 2015 Apr;56(4):600-6. doi: 10.2967/jnumed.114.146662. Epub 2015 Mar 5.
PMID: 25745085

[Advanced radioiodine-refractory differentiated thyroid cancer]. Spitzweg C, Auernhammer CJ, Geisler J, Böck S, Heinemann V, Bartenstein P, Göke B. Dtsch Med Wochenschr. 2015 Feb;140(3):168-71. doi: 10.1055/s-0041-100196. Epub 2015 Feb 6. Review. German. No abstract available.
PMID: 25658401

[Thyroid dysfunction in pregnancy]. Führer D, Mann K, Feldkamp J, Krude H, Spitzweg C, Kratzsch J, Schott M. Dtsch Med Wochenschr. 2014 Oct;139(42):2148-52. doi: 10.1055/s-0034-1387300. Epub 2014 Oct 7. Review. German.
PMID: 25289925

Best supportive care from the conservative/non-surgical perspective and its costs in the treatment of patients with advanced medullary thyroid cancer: results of a Delphi panel. Kreissl MC, Jacob C, Führer D, Karges W, Luster M, Lux MP, Mann K, Mittendorf T, Schott M, Spitzweg C, Schmoll HJ. Oncol Res Treat. 2014;37(6):316-22. doi: 10.1159/000362613. Epub 2014 May 12.
PMID: 24903762

Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets. Spitzweg C, Bible KC, Hofbauer LC, Morris JC. Lancet Diabetes Endocrinol. 2014 Oct;2(10):830-42. doi: 10.1016/S2213-8587(14)70051-8. Epub 2014 Jun 2. Review.
PMID: 24898835

Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke R, Shong YK, Sherman SI, Smit JW, Chung J, Kappeler C, Peña C, Molnár I, Schlumberger MJ; DECISION investigators.
Lancet. 2014 Jul 26;384(9940):319-28. doi: 10.1016/S0140-6736(14)60421-9. Epub 2014 Apr 24.
PMID: 24768112

EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene. Grünwald GK, Vetter A, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Wagner E, Göke B, Holm PS, Ogris M, Spitzweg C. Mol Ther Nucleic Acids. 2013 Nov 5;2:e131. doi: 10.1038/mtna.2013.58.
PMID: 24193032

Systemic image-guided liver cancer radiovirotherapy using dendrimer-coated adenovirus encoding the sodium iodide symporter as theranostic gene. Grünwald GK, Vetter A, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Wagner E, Göke B, Holm PS, Ogris M, Spitzweg C. J Nucl Med. 2013 Aug;54(8):1450-7. doi: 10.2967/jnumed.112.115493. Epub 2013 Jul 10.
PMID: 23843567

Stromal targeting of sodium iodide symporter using mesenchymal stem cells allows enhanced imaging and therapy of hepatocellular carcinoma. Knoop K, Schwenk N, Dolp P, Willhauck MJ, Zischek C, Zach C, Hacker M, Göke B, Wagner E, Nelson PJ, Spitzweg C. Hum Gene Ther. 2013 Mar;24(3):306-16. doi: 10.1089/hum.2012.104.
PMID: 23402366

Adenoviral vectors coated with PAMAM dendrimer conjugates allow CAR independent virus uptake and targeting to the EGF receptor. Vetter A, Virdi KS, Espenlaub S, Rödl W, Wagner E, Holm PS, Scheu C, Kreppel F, Spitzweg C, Ogris M. Mol Pharm. 2013 Feb 4;10(2):606-18. doi: 10.1021/mp300366f. Epub 2013 Jan 18.
PMID: 23281933

Sodium iodide symporter (NIS)-mediated radiovirotherapy of hepatocellular cancer using a conditionally replicating adenovirus.
Grünwald GK, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Göke B, Holm PS, Spitzweg C. Gene Ther. 2013 Jun;20(6):625-33. doi: 10.1038/gt.2012.79. Epub 2012 Oct 4.

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PMID: 22545753