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PROJECTS
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Project group A: Antigenrecognition and induction of autoimmunereactions
- A1: Antigen recognition and presentation in target organs of neuroimmunological diseases
- A2: Characterization of the psoriatic autoantigens using recombinant T-cell receptor transfectants
- A4: Pathogenic relevance of native and posttranslationally altered epitopes of PR3 in Wegener's granulomatosis
- A5: Characterization of immune responses in horses with sponteaneous recurrent uveitis (ERU)
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Project group B: Mechanism of immune regulation and tolerance
- B5: On the role of cross-presenting Dendritic Cells in T cell tolerance induction
- B6: MOG specific T- and B cell autoimmunity
- B8: Regulation of T cell responses by autoantigen: The mechanism of antigen-independent proliferation of CD8+ T cells
- B9: A phenotypic and molecular roadmap of regulatory T cell development
- B10: Control of T cell tolerance and regulation through NFAT complex formation
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Project group C: Effector mechanisms and interactions with the target organ
- C2: Analysis of regulatory pathways and target genes linked to progressive renal autoimmunopathies
- C3: Interactions between the immune system and the nervous system, the target tissue of multiple sclerosis
- C6: Live analysis of encephalitogenic T cells within autoimmune central nervous system lesions
- C7: Regulation of mononuclear phagocytic migration, differentiation and effector function in autoimmune CNS disease
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Project group D: Therapeutic strategies
- D3: Antigen-specific Pathomechanisms and Regulation of Experimental Autoimmune Uveitis (EAU) in Lewis rats
- D5: Mechanism of integrin activation - a process fundamental for the priming and transmigration of autoreactive T-cells in MS
- D8: Autoimmune and environmental connections: Plasticity of helper T cell differentiation and immune modulation by helminth parasites
- D9: Interleukin-4-mediated immundysregulation in the pathogenesis of rheumatoid arthritis
- D10: Modulations of regulatory T cells by endogenous TLR ligands and DC subpopulations in SLE
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