Publications (selected)

2020

• Buitinga M, Cohrs CM, Eter WA, Claessens-Joosten L, Frielink C, Bos D, Sandker G, Brom M, Speier S, Gotthardt M. Noninvasive Monitoring of Glycemia-Induced Regulation of GLP-1R Expression in Murine and Human Islets of Langerhans.  Diabetes. 2020 Nov;69(11):2246-2252. doi: 10.2337/db20-0616. Epub 2020 Aug 25. PMID: 32843570
  
  
• Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S. Dysfunction of Persisting β-Cells is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Rep. Apr 7;31(1):107469. doi: 10.1016/j.celrep.2020.03.033.
  
  
• Cohrs CM, Chen C, Speier S. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging. Methods Mol Biol. 2020;2128:149-157. doi: 10.1007/978-1-0716-0385-7_11.
  
  
• Panzer JK, Hiller H, Cohrs CM, Almaca J, Enos SJ, Beery M, Cechin S, Drotar DM, Weitz JR, Santini J, Huber MK, Qadir MMF, Pastori RL, Domínguez-Bendala J, Phelps EA, Atkinson MA, Pugliese A, Caicedo A, Kusmartseva I, Speier S. Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis. JCI Insight Apr 23;5(8):e134525. doi: 10.1172/jci.insight.134525
  
  
• Panzer JK, Cohrs CM, Speier S. Using Pancreas Tissue Slices for the Study of Islet Physiology. Methods Mol Biol. 2020;2128:301-312. doi: 10.1007/978-1-0716-0385-7_20.

2017

• Chen, C., Cohrs, C.M., Stertmann, J., Bozsak, R., Speier, S. Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis. Mol Metab. 6(9), 943-957.
  
  
• Cohrs, C.M., Chen, C., Jahn, S.R., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., et al. Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation. Endocrinology 158(5), 1373-1385.

• Kemter, E., Cohrs, C.M., Schäfer, M., Schuster, M., Steinmeyer, K., Wolf-van Buerck, L., Wuensch, A., Kurome, M., Kessler, B., Zakharchenko, V., et al. INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters. Diabetologia 60(6), 1152-1156.
  
  

2016

• Chen, C., Chmelova, H., Cohrs, C.M., Chouinard, J.A., Jahn, S.R., Stertmann, J., Uphues, I., Speier, S., Kahn, S., Hull, R., et al. Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Diabetes 65, 840–846.

2015

• Chmelova, H., Cohrs, C.M., Chouinard, J.A., Petzold, C., Kuhn, M., Chen, C., Roeder, I., Kretschmer, K., and Speier, S. Distinct roles of β-cell mass and function during type 1 diabetes onset and remission. Diabetes 64, 2148–2160.
  
  
• Helmbrecht, M.S., Soellner, H., Truckenbrodt, A.M.L., Sundermeier, J., Cohrs, C., Hans, W., de Angelis, M.H., Feuchtinger, A., Aichler, M., Fouad, K., et al. Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling. Dev. Biol. 399, 2–14.

2014

• Marciniak, A., Cohrs, C.M., Tsata, V., Chouinard, J.A., Selck, C., Stertmann, J., Reichelt, S., Rose, T., Ehehalt, F., Weitz, J., et al. Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology. Nat. Protoc. 9, 2809–2822.

2013

• Thiele, F., Cohrs, C.M., Przemeck, G.K.H., Wurst, W., Fuchs, H., and De Angelis, M.H. In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system. J. Bone Miner. Metab. 31, 293–303.

2012

• Thiele, F., Cohrs, C.M., Flor, A., Lisse, T.S., Przemeck, G.K.H., Horsch, M., Schrewe, A., Gailus-Durner, V., Ivandic, B., Katus, H.A., et al. Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Hum. Mol. Genet. 21, 3535–3545.
  
  
• Ale, A., Ermolayev, V., Herzog, E., Cohrs, C., de Angelis, M.H., and Ntziachristos, V. FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography. Nat. Methods 9, 615–620.
  
  
• Fuchs, H., Gailus-Durner, V., Neschen, S., Adler, T., Afonso, L.C., Aguilar-Pimentel, J.A., Becker, L., Bohla, A., Calzada-Wack, J., Cohrs, C., et al. Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm. Genome 23, 611–622.

2011

• Gailus-Durner, V., Naton, B., Adler, T., Afonso, L., Aguilar-Pimentel, J.A., Becker, L., Calzada-Wack, J., Cohrs, C., da Silva-Buttkus, P., Hans, W., et al. The German Mouse Clinic - Running an Open Access Platform. Mouse as a Model Org. From Anim. to Cells 11–44.