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Arbeitsgruppe Prof. Dr. med. Nicole Reisch

The focus of Prof. Reisch’s research is on congenital gonadal and adrenal disorders. In particular, Prof. Reisch is a leading international expert in congenital adrenal hyperplasia (CAH). CAH is one of the most common diseases in the group of rare diseases with an incidence of 1:10,000 to 1:15,000. Since the introduction of glucocorticoid replacement therapy sixty years ago, CAH has been regarded as a prototype for a treatable genetic disease and, later, for genetic screening in human populations. It is a disease that is relevant for endocrinologists, geneticists, gynaecologists, urologists, (paediatric) surgeons as well as psychologists. For many years CAH was considered a paediatric disease. Only quite recently has the focus shifted also to adult patients and clinicians have begun to realise the substantial morbidity and increased mortality in patients with CAH.

Main research topics

• Molecular mechanisms of CAH
Protein misfolding and protein-protein interactions as molecular pathophysiological background in congenital adrenal hyperplasia (CAH) potentially offering novel therapeutic options with pharmacological chaperons
• Natural history and outcome of CAH
From research of health care provision to evidence based medicine: Natural history, outcome and comorbidities in CAH as examples for effects and side effects of glucocorticoids and sex steroids
• Novel medical treatment of CAH
Novel medical treatment in CAH: international Phase III study Chronocort®, study of efficacy, safety and tolerability of Chronocort® compared with standard glucocorticoid replacement therapy in the treatment of congenital adrenal hyperplasia, the first orphan drug for CAH
• Novel diagnostic procedures of CAH
Safety of prenatal dexamethasone in CAH and non-invasive prenatal diagnostics in CAH for treatment-related reasons


Univ.-Prof. Dr. Nicole Reisch
Medizinische Klinik und Poliklinik IV
Ziemssenstraße 1
80336 München
Raum F 1.83a
Phone: +49 (0) 89-4400-52110

Lebenslauf, Publikationsliste

Wissenschaftliche Mitarbeiter:
Dr. Matthias Auer, Assistenzarzt
Dr. Christian Lottspeich, Assistenzarzt
Nicolas Meese, PhD Student
Qi Shi, PhD Studentin

Kerstin Schaefer, BTA
Jessica Birlack, Studienassistenz

Medizinische Doktoranden
Duygu Büyükerzurumlu
Sophie Wimmer
Andrea Sappl