Medizinische Klinik und Poliklinik III » Forschung » Arbeitsgruppe Liposomen

Arbeitsgruppe Liposomen

Leitung

Prof. Dr. L. H. Lindner
E-Mail Lars.Lindner@med.uni-muenchen.de

Forschungsprojekte / Forschungsschwerpunkte

Entwicklung und in vivo Testung neuartiger thermosensitiver Liposomen für die zielgerichtete Tumortherapie in Kombination mit lokaler Hyperthermie.

Ausgewählte Publikationen

Kneidl B, Peller M, Winter G, Lindner LH, Hossann M. Thermosensitive liposomal drug delivery systems: state of the art review. Int J Nanomedicine. 2014;9:4387-98.

Limmer S, Hahn J, Schmidt R, Wachholz K, Zengerle A, Lechner K, Eibl H, Issels RD, Hossann M, Lindner LH. Gemcitabine treatment of rat soft tissue sarcoma with phosphatidyldiglycerol-based thermosensitive liposomes. Pharm Res. 2014;31(9):2276-86.

Schiener M, Hossann M, Viola JR, Ortega-Gomez A, Weber C, Lauber K, Lindner LH, Soehnlein O. Nanomedicine-based strategies for treatment of atherosclerosis. Trends Mol Med. 2014;20(5):271-81.

Hossann M, Wang T, Syunyaeva Z, Wiggenhorn M, Zengerle A, Issels RD, Reiser M, Lindner LH, Peller M. Non-ionic Gd-based MRI contrast agents are optimal for encapsulation into phosphatidyldiglycerol-based thermosensitive liposomes. J Control Release. 2013;166(1):22-29.

Manzoor AA, Lindner LH, Landon CD, Park JY, Simnick AJ, Dreher MR, Das S, Hanna G, Park W, Chilkoti A, Koning GA, ten Hagen TL, Needham D, Dewhirst MW. Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. Cancer Res. 2012;72(21):5566-75.

Hossann M, Syunyaeva Z, Schmidt R, Zengerle A, Eibl H, Issels RD, Lindner LH. Proteins and cholesterol lipid vesicles are mediators of drug release from thermosensitive liposomes. J Control Release. 2012;162(2):400-6.

Hossann M, Wang T, Wiggenhorn M, Schmidt R, Zengerle A, Winter G, Eibl H, Peller M, Reiser M, Issels RD, Lindner LH. Size of thermosensitive liposomes influences content release. J Control Release. 2010;147(3):436-43.

Peller M, Schwerdt A, Hossann M, Reinl HM, Wang T, Sourbron S, Ogris M, Lindner LH. MR characterization of mild hyperthermia-induced gadodiamide release from thermosensitive liposomes in solid tumors. Invest Radiol. 2008;43(12):877-92.

Lindner LH, Hossann M, Vogeser M, Teichert N, Wachholz K, Eibl H, Hiddemann W, Issels RD. Dual role of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes: active ingredient and mediator of drug release. J Control Release. 2008;125(2):112-20.

Hossann M, Wiggenhorn M, Schwerdt A, Wachholz K, Teichert N, Eibl H, Issels RD, Lindner LH. In vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes. Biochim Biophys Acta. 2007;1768(10):2491-9.

Lindner LH, Eichhorn ME, Eibl H, Teichert N, Schmitt-Sody M, Issels RD, Dellian M. Novel temperature-sensitive liposomes with prolonged circulation time. Clin Cancer Res. 2004;10(6):2168-78

 

Mitarbeiter

  • A. Knauerhase (MTA)

  • B. Kneidl

  • Dr. S. Limmer (Tierärztin)

  • L. Pointner (CTA)

  • L. Willerding 

Kontakt

Prof. Dr. L. H. Lindner

Klinikum der Universität München
Medizinische Klinik III

Marchioninistraße 15
D-81377 München

Telefon (089) 4400 - 74768
Fax (089) 4400 - 78876
E-Mail Lars.Lindner@med.uni-muenchen.de

  Verantwortlich für den Inhalt: Prof. Dr. L. Lindner; Stand: Mai 2015