DKTK Publikationen der Arbeitsgruppen

Stief SM, Hanneforth AL, Weser S, Mattes R, Charlet M, Liu WH, Bartoschek MD, Dominguesz Moreno H, Oettle M, Kempf J, Vick B, Ksienzyk B, Tizazu B, Rothenberg-Thurley M, Quentmeier H, Hiddemann W, Vosberg S, Greif PA, Metzeler KM, Schotta G, Bultmann S, Jeremias I, Leonhardt H and Spiekermann K.

Loss of KDM6A confers drug resistance in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2019 Jun 14


Lynch JR, Salik B, Connerty P, Vick B, Leung H, Pijning A, Jeremias I, Spiekermann K, Trahair T, Liu T, Haber M, Norrsi MD, Hogg P, Wang J and Wang JY.

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2019 Jun


Senft D and Jeremias I.

Tumor Cell Dormancy-Triggered by the Niche.

German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Developmental Cell 2019 May 6


Sandner AS, Weggel R, Mehraein Y, Schneider S, Hiddemann W and Spiekermann K.

Frequency of hematologic and solid malignancies in the family history of 50 patients with acute myeloid leukemias - a single center analysis.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

PLoS One 2019 Apr 18


Heckl BC, Carlet M, Vick B, Roolf C, Alsdaeg A, Grunert M, Liu WH, Liebl A, Hiddemann W, Marschalek K, Schewe DM, Spiekermann K, Junghanss C and Jeremias I.

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia and Lymphoma 2019 Mar


Bormann F, Stintzing S, Tierling S, Morkel M, Markeloca MR, Walter J, Weichert W, Roßner F, Kuhn N, Perner J, Dietz J, Ispasanie S, Dietel M, Schäfer R, Heinemann V and Sers C.

Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

International Journal of Cancer 2019 Feb 1


Haubner S, Perna F, Köhnke T, Schmidt C, Berman S, Augsberger C, Schnorfeil FM, Krupka C, Lichtenegger FS, Liu X, Kerbs P, Schneider S, Metzeler KHSpiekermann S, Hiddemann W, Greif PA, Herold T, Sadelain M and Subklewe M.

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2019 Jan


Holch JW, Ricard I, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Vehling-Kaiser U, Heintges T, Kahl C, Kullmann F, Scheithauer W, Moheler M, Jelas I, Modest DP, Westphalen CB, von Einem JC, Michl M and Heinemann V.

Relevance of baseline carcinoembryonic antigen for first-line treatment against metastatic colorectal cancer with FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial).

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

European Journal of Cancer 2019 Jan


Chen-Wichmann L, Shvartsmann M, Preiss C, Hockings C, Windisch R, Redondo-Monte E, Leubolt GSpiekermann K, Lausen J, Brendel C, Grez M, Greif PA and Wichmann C.

Compatibilitiy of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Oncogene 2019 Jan


Joos S, Nettelbeck DN, Reil-Held A, Engelmann K, Moosmann A, Eggert A, Hiddemann W, Krause M, Peters C, Schuler M, Schulze-Osthoff K, Serve H, Wick W, Puchta J and Baumann M.

German Cancer Consortium (DKTK) - a national consortium for translational cancer research.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Molecular Oncology 2018 Dec 18


Herrmann M, Krupka C, Deiser K, Brauchle B, Marcinek A, Ogrinc Wagner A, Rataj F, Mocikat R, Metzeler KH, Spiekermann K, Kobold S, Fenn NC, Hopfner KP and Subklewe M.

Bifunctional PD-1xaCD3xaCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2018 Dec 6


Froelich MF, Heinemann V, Sommer WH, Holch JW, Schoeppe F, Hesse N, Baumann AB, Kunz, WG, Reiser MF, Ricke J, D'Anastasi M, Stintzing S, Modest DP, Kazmierczak PM and Hoffmann FO.

CT attenuation of liver metastasis before targeted therapy is a prognostic factor of overall survival in colorectal cancer patients. Results from randomised, open-label FIRE3/AIO KRK0306 trial.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

European Radiology 2018 Dec 


Prassek VV, Rothenberg-Thurley M, Sauerland MC, Herold T, Janke H, Ksienzyk B, Konstandin NP, Goerlich D, Krug U, Faldum A, Berdel WE, Wörmann B, Braess J, Schneider S, Subklewe M, Bohlander SK, Hiddeman W, Spiekermann K and Metzeler KH.

Genetics of acute myeloid leukemias in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years and older.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Haematologica 2018 Nov


Neumann J, Heinemann V, Engel J, Kirchner T and Stintzing S.

The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Virchows Archiv 2018 Aug 


Rothenberg-Thurley M, Amler S, Sauerland MC, Berdel WE, Wörmann BJ, Bohlander SK, Braess J, Hiddemann W, Lehmann S, Marescahl S, Spiekermann K, Metzeler KH, Herold T and Boulesteix AL.

Mediation analyssi reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia. 

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Scientific Report 2018 Jul 26


Schranz K, Hubmann, M, Harin E, Vosberg S, Herold T, Metzeler KH, Rothenberg-Thurley M, Janke H, Bräundl K, Ksienzyk B, Batcha AMN, Schaaf S, Schneider S, Bohlander SK, Görlich D, Berdel WE, Wörmann BJ, Braess J, Krebs S, Hiddemann W, Mansmann U, Spiekermann K, and Greif PA.

Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Oncotarget 2018 Jul 10


Vosberg S, Hartmann L, Metzeler KH, Konstandin NP, Schneider S, Varadharajan A, Hauser A, Krebs S, Blum H, Bohlander SK, Hiddemann W, Tischer J, Spiekermann K, and Greif PA.

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Haematologica 2018 Jun 28


Shimabukuro-Vornhagen A, Gödel P, Subklewe M, Stemmler HJ, Schlößer HA, Schlaak M, Kochanek M, Böll B and von Bergwelt-Baildon MS.

Cytokine release syndrome.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

J Immunother Cancer 2018 Jun 15


Greif PA, Hartmann L, Vosberg S, Stief SM, Mattes R, Hellmann I, Metzeler KH, Herold T, Bamopoulos SA, Kerbs P, Jurinovic V, Schumacher D, Pastore F, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Graf A, Krebs, S, Blum H, Neumann M, Baldus CD, Bohlander SK, Wolf S, Görlich D, Berdel WE, Wörmann BJ, Hiddemann W and Spiekermann K.

Evolution of cytogenetically normal acute myeloid leukemia during therapy and relapse: an exome sequencing study of 50 patients.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Clinical Cancer Research 2018 Apr 1


Hofmann FO, Holch JW, Heinemann V, Ricard I, Reiser M,F, Baumann AB, Hesse N, D'Anastasi M, Modest DP, Stintzing S and Sommer WH.

Prognostic value of radiologically enlarged lymph nodes in patients with metastatic colorectal cancer: Subgroup finding of the randomized, open-label FIRE-3/AIO KRK0306 trial.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

European Journal of Radiology 2018 Mar


Herold T, Jurinovic V, Batcha AMN, Bamopoulos SA, Rothenberg-Thurley M, Ksienzyk B, Hartmann L, Greif PA, Phillippou-Massier J, Krebs S, Blum H, Amler S, Schneider S, Konstandin N, Sauerland MC, Görlich D, Berdel WE, Wörmann BJ, Tischer J, Subklewe M, Bohlander SK, Braess J, Hiddemann W, Metzeler KH, Mansmann U, and Spiekermann S.

A 29-gene and cytogenetic  score for the prediciton of resistance to induction treatment in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Haematologica 2018 Mar


Lichtenegger FS, Rothe M, Schnorfeil FM, Deiser K, Krupka C, Augsberger C, Schlüter M, Neitz J and Subklewe M.

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Front Immunol 2018 Feb 27


Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, and Kuster B.

The target landscape of clinical kinase drugs.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Science 2017 Dec 1


Köhnke T, Wittman VK, Bücklein VL, Lichtenegger FS, Pasalic Z, Hiddemann W, Spiekermann S and Subklewe M.

Diagnosis of CLL revisited: increased specificity by a modified five-marker scoring system including CD200.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Br J Haematol 2017 Nov


Holch JW, Metzeler KH, Jung A, Riedmann K, Jost PJ, Weichert W, Kirchner T and Heinemann V.

Universal Genomic Testing: The next step in oncological decision-making or dead end street?

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

European Journal of Cancer 2017 Sep


Reiter K, Polzer H, Krukpa C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M and Greif PA.

Tyrosine kinase inhibitor increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2017 Aug 14


Lichtenegger FS, Krupka C, Haubner S, Köhnke T and Subklewe M.

Recent developments in immunotherapy of acute myeloid leukemia. 

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

J Hematol Oncol 2017 Jul 25


von der Heide EK, Neumann M, Vosberg S, James AR, Schroeder MP, Ortiz-Tanchez J, Isaakidis K, Schlee C, Luther M, Jöhrens K, Anagnostopoulos I, Mochmann LH, Nowak D, Hofmann WK, Greif PA and Baldus CD.

Molecular alterations in bone marrow mesenchymal stromal cells derived form acute myeloid leukmia patients.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2017 May


Ebinger S, Özdemdir EZ, Ziegenhain C, Tiedt S, Castro Alves C, Grunert M, Dworzak M, Lutz C, Turvati VA, Enver T, Horny HP, Sotlar K, Parekh S, Spiekermann KHiddemann W, Schepers A, Polzer B, Kirsch S, Hoffmann M, Knapp B, Hasenauer J, Pfeifer H, Panzer-Grünmayer R, Enard W, Gires O and Jeremias I.

Characterization or rare, dormant, and therapy-resistanct cells in acute lymphoblastic leukemia. 

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Cancer Cell 2016 Dec 12


Herold T, Metzeler KH, Vosberg S, Hartmann L, Jurinovi V, Opatz S, Konstandin NP, Schneider S, Zellmeier E, Ksienzyk B, Graf A, Krebs S, Blum H, Sauerland CM, Büchner T, Berdel WE, Wörmann BJ, Mansmann U, Hiddemann W, Bohlander SK, Spiekermann K and Greif PA

Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Genes Chromosomes Cancer 2016 Sep 16


Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess Jand Spiekermann K; AMLCG Study Group

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2016 Aug 4


Sandhöfer N, Bauer J, Reiter K, Dufour A, Rothenberg M, Konstandin NP, Zellmeier E, Tizazu B, Greif PA, Metzeler KH, Hiddemann W, Polzer H and Spiekermann K

The new and recurrent FLT3 juxtamembrane deletion mutations shows a dominant negative effect on the wild-type FLT3 receptor.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Scientific Reports 2016 Jun 27


Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bampopulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin N, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Hiddemann W, Spiekermann K and Greif PA

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Nature Communications 2016 Jun 2


Vosberg S, Herold T, Hartmann L, Neumann M, Opatz S, Metzeler KH, Schneider S, Graf A, Krebs S, Blum H, Baldus CD, Hiddemann W, Spiekermann K, Bohlander SK, Mansmann U and Greif PA

Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukmia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Genes Chromosomes Cancer 2016 May 2


Krupka C, Kufer P, Kischel R, Zugmaier G, Lichtenegger FS, Köhnke T, Vick B, Jeremias I, Metzleler KH, Altman T, Schneider S, Fiegl M, Spiekermann S, Bauerle PA, Hiddemann W, Riethmüller G and Subklewe M

Blockade ot the PD-1/PD-L1 axis augemts lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced imune escape mechanism.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2016 Feb


Dutta S, Krause A, Vosberg S, Herold T, Ksienzyk B, Quintanilla-Martinez L, Tizazu B, Chopra M, Graf A, Krebs S, Blum H, Greif PA, Vetter A, Metzler K, Rothenberg-Thurley M, Schneider MR, Dahloff M, Spiekermann K, Zimber-Strobl U, Wolf E and Bohlander SK

The target cell of transformation is dinstinct from the leukemia stem cell in murine CALM/AF10 leukemia models.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2015 Dec 21


Vick B, Rothenberg M, Sandhöfer N, Carlet M, Finkenzeller C, Krupka C, Grunert M, Trumpp A, Corbacioglu S, Ebinger M, André MC, Hiddemann W, Schneider S, Subklewe M, Metzeler KH, Spiekermann K and Jeremias I

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

PlosOne 2015 Mar 20


Köhnke T, Sauter D, Ringel K, Hoster E, Laubender RP, Hubmann M, Bohlander SK, Kakadia PM, Schneider S, Dufour A, Sauerland MC, Berdel WE, Bühcner T, Wörmann B, Braess J, Hiddemann W, Spiekermann K and Subklewe M.

Early assessment of minimal redisual disease in AML by flow cytometry during aplasia identifiers patients at increased risk of relapse.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2015 Feb


Sandhöfer N, Metzeler KH, Rothenberg M, Herold T, Tiedt S, Groiß V, Carlet M, Walter G, Hinrichsen T, Wachter O, Grunert M, Schneider S, Subklewe M, Dufour A, Fröhling S, Klein HG, Hiddemann W, Jeremias I and Spiekermann K

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2014 Oct 17


Herold T, Metzeler KH, Vosberg S, Hartmann L, Röllig C, Stölzel F, Schneider S, Hubmann M, Zellmeier E, Ksienzyk B, Jurinovic V, Pasalic Z, Kakadia PM, Dufour A, Graf A, Krebs S, Blum H, Sauerland MC, Büchner T, Berdel WE, Woermann BJ, Bornhäuser M, Ehninger G, Mansmann U, Hiddemann W, Bohlander DK, Spiekermann K and Greif PA 

Isolated trisomy 13 defines a genetically homogenous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2014 Aug 21


Neumann M, Seehawer M, Schlee C, Vosberg S, Heesch S, von der Heide EK, Graf A, Krebs S, Blum H, Gökbuget N, Schwartz S, Hoelzer D, Greif PA and Baldus CD

FAT1 expression and mutations in adult acute lymphoblastic leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood Cancer Journal 2014 Jun 27


Janke H, Pastore F, Schumacher D, Herold T, Hopfner KP, Schneider S, Berdel WE, Büchner T, Woermann BJ, Subklewe M, Bohlander SK, Hiddemann W and Spiekermann S.

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myelosi leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

PLoS ONe 2014 Mar 7


Opatz S, Polzer H, Herold T, Konstandin NP, Ksienzyk B, Zellmeier E, Vosberg S, Graf A, Krebs S, Blum H, Hopfner KP, Kakadia PM, Schneider S, Dufour A, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK and Greif PA

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2013 Sep 5


Neumann M, Greif PA and Baldus CD

Mutational landscape of adult ETP-ALL.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Oncotarget 2013 Jul


Neumann M, Heesch S, Schlee C, Schwartz S, Gökbuget N, Hoelzer D, Konstandin NP, Ksienzyk B, Vosberg S, Graf A, Krebs S, Blum H, Raff T, Brüggemann M, Hofmann WK, Hecht J, Bohlander SK, Greif PA and Baldus CD

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2013 Jun 6


  Verantwortlich für den Inhalt: Prof. Dr. K. Spiekermann, Stand: 1. Juni 2019