Publikationen der Arbeitsgruppen


Joos S, Nettelbeck DN, Reil-Held A, Engelmann K, Moosmann A, Eggert A, Hiddemann W, Krause M, Peters C, Schuler M, Schulze-Osthoff K, Serve H, Wick W, Puchta J and Baumann M.

German Cancer Consortium (DKKT) - a national consortium for translational cancer research.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Mol Oncol. 2018 Dec 18


Herrmann M, Krupka C, Deiser K, Brauchle B, Marcinek A, Ogrinc Wagner A, Rataj F, Mocikat R, Metzeler KH, Spiekermann K, Kobold S, Fenn NC, Hopfner KP and Subklewe M.

Bifunctional PD-1xaCD3xaCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood. 2018 Dec 6


Greif PA, Hartmann L, Vosberg S, Stief SM, Mattes R, Hellmann I, Metzeler KH, Herold T, Bamopoulos SA, Kerbs P, Jurinovic V, Schumacher D, Pastore F, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Graf A, Krebs, S, Blum H, Neumann M, Baldus CD, Bohlander SK, Wolf S, Görlich D, Berdel WE, Wörmann BJ, Hiddemann W and Spiekermann K.

Evolution of cytogenetically normal acute myeloid leukemia during therapy and relapse: an exome sequencing study of 50 patients.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Clin Cancer Res. 2018 Apr 1


Schranz K, Hubmann, M, Harin E, Vosberg S, Herold T, Metzeler KH, Rothenberg-Thurley M, Janke H, Bräundl K, Ksienzyk B, Batcha AMN, Schaaf S, Schneider S, Bohlander SK, Görlich D, Berdel WE, Wörmann BJ, Braess J, Krebs S, Hiddemann W, Mansmann U, Spiekermann K, and Greif PA.

Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Oncotarget. 2018 Jul 10


Vosberg S, Hartmann L, Metzeler KH, Konstandin NP, Schneider S, Varadharajan A, Hauser A, Krebs S, Blum H, Bohlander SK, Hiddemann W, Tischer J, Spiekermann K, and Greif PA.

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Haematologica. 2018 Jun 28


Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, and Kuster B.

The target landscape of clinical kinase drugs.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Science. 2017 Dec 1


Reiter K, Polzer H, Krukpa C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M, Greif PA.

Tyrosine kinase inhibitor increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia. 2017 Aug 14.


Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bamopoulos SA, Bräundl K, Zellmeier K, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA.

ZBTB7a mutations in acute myeloid leukemia with t(8;21) translocation.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Nat Commun. 2016 Jun 2;7:11733.


Herold T, Metzeler KH, Vosberg S, Hartmann L, Jurinovi V, Opatz S, Konstandin NP, Schneider S, Zellmeier E, Ksienzyk B, Graf A, Krebs S, Blum H, Sauerland CM, Büchner T, Berdel WE, Wörmann BJ, Mansmann U, Hiddemann W, Bohlander SK, Spiekermann K, Greif PA

Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Genes Chromosomes Cancer 2016 Sep 16. doi: 10.1002/gcc.22418


Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2016 Aug 4. doi: 10.1182/blood-2016-01-693879


Sandhöfer N, Bauer J, Reiter K, Dufour A, Rothenberg M, Konstandin NP, Zellmeier E, Tizazu B, Greif PA, Metzeler KH, Hiddemann W, Polzer H, Spiekermann K

The new and recurrent FLT3 juxtamembrane deletion mutations shows a dominant negative effect on the wild-type FLT3 receptor.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Scientific Reports 2016 Jun 27. doi: 10.1038/srep28032


Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bampopulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin N, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Hiddemann W, Spiekermann K, Greif PA

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Nature Communications 2016 Jun 2. doi: 10.1038/ncomms11733


Vosberg S, Herold T, Hartmann L, Neumann M, Opatz S, Metzeler KH, Schneider S, Graf A, Krebs S, Blum H, Baldus CD, Hiddemann W, Spiekermann K, Bohlander SK, Mansmann U, Greif PA

Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukmia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Genes Chromosomes Cancer 2016 May 2. doi: 10.1002/gcc.22359


Dutta S, Krause A, Vosberg S, Herold T, Ksienzyk B, Quintanilla-Martinez L, Tizazu B, Chopra M, Graf A, Krebs S, Blum H, Greif PA, Vetter A, Metzler K, Rothenberg-Thurley M, Schneider MR, Dahloff M, Spiekermann K, Zimber-Strobl U, Wolf E, Bohlander SK

The target cell of transformation is dinstinct from the leukemia stem cell in murine CALM/AF10 leukemia models.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2015 Dec 21. doi: 10.1038/leu.2015.349.


Vick B, Rothenberg M, Sandhöfer N, Carlet M, Finkenzeller C, Krupka C, Grunert M, Trumpp A, Corbacioglu S, Ebinger M, André MC, Hiddemann W, Schneider S, Subklewe M, Metzeler KH, Spiekermann K, Jeremias I

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

PlosOne 2015 Mar 20. doi: 10.1371/journal.pone.0120925


Sandhöfer N, Metzeler KH, Rothenberg M, Herold T, Tiedt S, Groiß V, Carlet M, Walter G, Hinrichsen T, Wachter O, Grunert M, Schneider S, Subklewe M, Dufour A, Fröhling S, Klein HG, Hiddemann W, Jeremias I, Spiekermann K

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Leukemia 2014 Oct 17. doi: 10.1038/leu.2014.305


Herold T, Metzeler KH, Vosberg S, Hartmann L, Röllig C, Stölzel F, Schneider S, Hubmann M, Zellmeier E, Ksienzyk B, Jurinovic V, Pasalic Z, Kakadia PM, Dufour A, Graf A, Krebs S, Blum H, Sauerland MC, Büchner T, Berdel WE, Woermann BJ, Bornhäuser M, Ehninger G, Mansmann U, Hiddemann W, Bohlander DK, Spiekermann K, Greif PA (2014)

Isolated trisomy 13 defines a genetically homogenous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2014 Aug 21. doi: 10.1182/blood-2013-12-540716


Neumann M, Seehawer M, Schlee C, Vosberg S, Heesch S, von der Heide EK, Graf A, Krebs S, Blum H, Gökbuget N, Schwartz S, Hoelzer D, Greif PA, Baldus CD (2014)

FAT1 expression and mutations in adult acute lymphoblastic leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood Cancer Journal 2014 Jun 27. doi: 10.1038/bcj.2014.44


Opatz S, Polzer H, Herold T, Konstandin NP, Ksienzyk B, Zellmeier E, Vosberg S, Graf A, Krebs S, Blum H, Hopfner KP, Kakadia PM, Schneider S, Dufour A, Braess J, Sauerland MC, Berdel WE, Büchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA (2013)

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2013 Sep 5. doi: 10.1182/blood-2013-01-476473


Neumann M, Greif PA, Baldus CD (2013)

Mutational landscape of adult ETP-ALL.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Oncotarget 2013 Jul. 4(7):954-955


Neumann M, Heesch S, Schlee C, Schwartz S, Gökbuget N, Hoelzer D, Konstandin NP, Ksienzyk B, Vosberg S, Graf A, Krebs S, Blum H, Raff T, Brüggemann M, Hofmann WK, Hecht J, Bohlander SK, Greif PA, Baldus CD (2013)

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.

Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich (LMU), Germany; German Cancer Consortium (DKTK), Germany; German Cancer Research Center (DKFZ), Germany

Blood 2013 Jun 6. doi: 10.1182/blood-2012-11-465138


  Verantwortlich für den Inhalt: Prof. Dr. K. Spiekermann, Stand: 1. Januar 2018