The TROPICAL-ACS (TESTING RESPONSIVENESS TO PLATELET INHIBITION ON CHRONIC ANTIPLATELET TREATMENT FOR ACUTE CORONARY SYNDROMES) Trial ( identifier NCT01959451) was initiated by our group in 2013. This study is an investigator-initiated, prospective, randomized, parallel-group, open-label, multicentre trial (IIT) designed to evaluate the benefits of personalized antiplatelet therapy in patients with acute coronary syndromes treated with percutaneous coronary intervention. The study will enrol 2600 patients from > 30 investigational centres across Europe and aims at investigating a safe way of de-escalating the antiplatelet treatment in ACS patients undergoing PCI.



Study Principal Investigator             PD Dr. med. Dirk Sibbing




Co-Principal Investigator                  Prof. Dr. med. Julinda Mehilli




Coordinating Investigator                 Dr. med. Lisa Gross

(Campus Großhadern)                



Coordinating Investigator                 Dr. med. Martin Orban

(Campus Innenstadt)                  




Coordinating Study Nurse:                 Monika Baylacher



Study Team:                                       Kristin Schneider

                                                           Study Nurse


                                                           Anne Krieg

                                                           Doctoral Fellow, Medical Student


                                                           Sabine Deuschl

                                                           Doctoral Fellow, Medical Student




Study Flow Chart






Study sites


1. Germany:  

  • Klinikum Augsburg, Department of Cardiology
  • Heart Center Bad Krozingen
  • Asklepios Stadtklinik Bad Tölz, Internal Medicine
  • St. Josef Hospital, Katholisches Klinikum Bochum, Department of Cardiology
  • Universitätsklinikum Frankfurt, Department of Cardiology
  • Kliniken Ostallgäu-Kaufbeuren, Klinik Füssen
  • Heart Center at the University Medical Center Goettingen
  • Universitätsmedizin Greifswald, Klinik u. Poliklinik für Innere Medizin B
  • Universitäres Herzzentrum Hamburg, UKE
  • Herzzentrum der Universität zu Köln
  • University Hospital Mainz, Department of Cardiology
  • Klinikum Memmingen, Innere Medizin I
  • Klinikum Neuperlach, Department of Cardiology
  • Munich University Hospital, Department of Cardiology
  • Klinikum Bogenhausen, Department of Cardiology
  • Klinikum Oldenburg, Department of Cardiology
  • Universitätsmedizin Rostock, Zentrum für Innere Medizin
  • University Hospital of Tuebingen, Department of Cardiology
  • Kliniken Nordoberpfalz AG, Klinikum Weiden, Medizinische Klinik II
  • Klinikum Siegburg, Department of Cardiology


2. Austria: (Local PI: Prof. Kurt Huber) 

  • Medizin-Universität Graz, Univ. Klinik für Innere Medizin
  • Wilhelminenspital Wien, 3. Medizinische Abteilung 


3. Hungary: (Local PI: Dr. Daniel Aradi) 

  • Heart and Vascular Center, Semmelweis University Budapest
  • Heart Center Balatonfüred
  • Budapest Military Hospital
  • Heart Institute, University of Pecs
  • University of Szeged, Department of Cardiology


4. Poland: (Local PI: Dr. Lukasz Koltowski & Dr. Zenon Huczek)

  • University of Warschau
  • Institute of Cardiology Warschau
  • Institute of Cardiology Katowice
  • Institute of Cardiology Poznan





Principal Investigator:             

PD Dr. med. Dirk Sibbing

Postadresse / mail address:

Medizinische Klinik I

Campus Großhadern

Marchioninistraße 15

81377 München, Germany


Coordinating Investigator:                

Dr. med. Lisa Gross