Research Areas

Atherosclerosis

Atherosclerosis is a chronic inflammatory disease of the medium and large sized arteries of the body characterised by a gradual infiltration of the arterial wall by lipids and different types of immune cells. In humans atherosclerosis is related to coronary artery disease (CAD) which can lead to life threatening conditions such as myocardial infarction due to thrombotic phenomena triggered by atherosclerotic plaque rupture. [mehr...]

Cardiovascular Immunology

Our research focuses on the role of immune cells in development, cardiovascular remodeling and thrombosis. This includes the study of macrophage biology and their potential functions in relation to their origin and developmental paths. [mehr...]

Immunothrombosis

Immunothrombosis designates an innate immune response induced by the formation of thrombi inside blood vessels. It is initiated by immune cells and by specific thrombosis related molecules generating an intravascular scaffold that facilitates the recognition, containment and destruction of pathogens to protect host integrity. [mehr...]

Ontogeny of Megakaryocytes in Health and Disease

We are investigating the lineage-commitment of hematopoietic progenitor cells into megakaryo-erythroid precursors and finally mature megakaryocytes during mammalian development. Our aim is to track megakaryopoiesis in its different niches, revealing novel interactions with surrounding cells. [mehr...]

Mechanism of Thrombosis

Our work investigates the role of platelets during the development of arterial thrombosis. We focus on the molecular mechanisms that regulate platelet-matrix interactions. [mehr...]

Morphodynamics of Blood Platelets

Platelet plug formation is a major step in physiological hemostasis, but also in pathological thrombosis after atherosclerotic plaque rupture, triggering myocardial infarction or stroke. Approximately 750 billion platelets circulate in human blood, constantly scanning the vasculature for damage of the endothelial surface. [mehr...]

Mechanisms of sterile inflammation in cardiovascular diseases

Sterile inflammation is the pathophysiologic basis of cardiovascular diseases like atherosclerosis, thrombosis and myocardial infarction. We focus on identifying new cellular and molecular factors causing these diseases by connecting the fields of thrombosis and inflammation. [mehr...]