Cardiovascular Immunology

Myeloid Cell 

Our research focuses on the role of immune cells in development, cardiovascular remodeling and thrombosis. This includes the study of macrophage biology and their potential functions in relation to their origin and developmental paths. We are also interested in the interaction of immune cells with platelets and the vascular wall. To address these questions we employ an integrated approach combining molecular studies, state-of-the art intravital imaging and clinical techniques.




PI  Prof. Dr. Christian Schulz



Key publications:


Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

C. Stremmel, R. Schuchert, F. Wagner, R. Thaler, T. Weinberger, R. Pick, E. Mass, H. C. Ishikawa-Ankerhold, A. Margraf, S. Hutter, R. Vagnozzi, S. Klapproth, J. Frampton, S. Yona, C. Scheiermann, J. D. Molkentin, U. Jeschke, M. Moser, M. Sperandio, S. Massberg, F. Geissmann, C. Schulz

Nature Communications 9, Article number: 75 (2018).

The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor.

Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, de Bruijn M, Rodewald HR, Geissmann F.

Immunity. 2015 Dec 15;43(6):1023-4. doi: 10.1016/j.immuni.2015.11.022. No abstract available.


Myocardial infarction: a critical role of macrophages in cardiac remodeling.

Weinberger T, Schulz C.

Front Physiol. 2015 Apr 7;6:107. doi: 10.3389/fphys.2015.00107. eCollection 2015. Review.


Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.

Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, Garner H, Trouillet C, de Bruijn MF, Geissmann F, Rodewald HR.

Nature. 2015 Feb 26;518(7540):547-51. doi: 10.1038/nature13989. Epub 2014 Dec 3.


Atherosclerosis--multiple pathways to lesional macrophages.

Schulz C, Massberg S.

Sci Transl Med. 2014 Jun 4;6(239):239ps2. doi: 10.1126/scitranslmed.3008922. Review.


A lineage of myeloid cells independent of Myb and hematopoietic stem cells.

Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K, Prinz M, Wu B, Jacobsen SE, Pollard JW, Frampton J, Liu KJ, Geissmann F.

Science. 2012 Apr 6;336(6077):86-90. doi: 10.1126/science.1219179. Epub 2012 Mar 22