Immunothrombosis

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Immunothrombosis designates an innate immune response induced by the formation of thrombi inside blood vessels. It is initiated by immune cells and by specific thrombosis related molecules generating an intravascular scaffold that facilitates the recognition, containment and destruction of pathogens to protect host integrity. We are investigating this biological process and its association with arterial and venous thrombosis in humans in order to develop novel treatment options.

 

PI  Prof. Dr. Steffen Massberg  steffen.massberg@med.uni-muenchen.de

 

   

Key Publications:

 

Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium†.

Riegger J, Byrne RA, Joner M, Chandraratne S, Gershlick AH, Ten Berg JM, Adriaenssens T, Guagliumi G, Godschalk TC, Neumann FJ, Trenk D, Feldman LJ, Steg PG, Desmet W, Alfonso F, Goodall AH, Wojdyla R, Dudek D, Philippi V, Opinaldo S, Titova A, Malik N, Cotton J, Jhagroe DA, Heestermans AA, Sinnaeve P, Vermeersch P, Valina C, Schulz C, Kastrati A, Massberg S; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort PRESTIGE Investigators.

Eur Heart J. 2015 Aug 30. pii: ehv419. [Epub ahead of print] Review.

 

Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.

Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu WH, Schulz AS, Oostendorp RA, Massberg S, Fässler R.

J Exp Med. 2015 Aug 24;212(9):1415-32. doi: 10.1084/jem.20150269. Epub 2015 Aug 17.


Thrombosis as an intravascular effector of innate immunity.

Engelmann B, Massberg S.

Nat Rev Immunol. 2013 Jan;13(1):34-45. doi: 10.1038/nri3345. Epub 2012 Dec 7. Review.

 

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs.

Stark K, Eckart A, Haidari S, Tirniceriu A, Lorenz M, von Brühl ML, Gärtner F, Khandoga AG, Legate KR, Pless R, Hepper I, Lauber K, Walzog B, Massberg S.

Nat Immunol. 2013 Jan;14(1):41-51. doi: 10.1038/ni.2477. Epub 2012 Nov 25.

 

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.

von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S.

J Exp Med. 2012 Apr 9;209(4):819-35. doi: 10.1084/jem.20112322. Epub 2012 Mar 26.

 

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.

Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B.

Nat Med. 2010 Aug;16(8):887-96. doi: 10.1038/nm.2184. Epub 2010 Aug 1.