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2017

Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer

11.07.2017 - The clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer was evaluated. 1199 ... [mehr...]

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

11.07.2017 - Abiraterone acetate is used in combination with prednisone in metastatic castration-resistant prostate cancer. In the STAMPEDE trial the effect of additional Abiraterone in men starting long-term ... [mehr...]

Radiochemotherapie beim Blasenkarzinom

25.04.2017 - In einer Metaanalyse von Caffo et al. (2015) wurden aus 8 Studien insgesamt 190 Patienten mit Blasenkarzinom (überwiegend im frühen Stadium T1/T2) ausgewertet, bei denen keine Zystektomie, sondern e... [mehr...]

PET-CT surveillance versus Neck Dissection in advanced head and neck cancer

24.03.2017 - Management of N2/N3 in patients with squamous cell carcinoma of the head and neck after chemo-radiation varies. Can PET/CT guided surveillance spare neck dissections with the same oncologic outcome ... [mehr...]

Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer

21.02.2017 - In order to evaluate the therapeutic feasibility of organ preservation in selected rectal cancer patients with good treatment response after neoadjuvant (C)RT, a watch-and-wait approach in CR and ad... [mehr...]

Benefit of Adjuvant Radiotherapy After Breast-Conserving Therapy Among Elderly Women With T1-T2N0 Estrogen Receptor-Negative Breast Cancer

14.02.2017 - The effect of RT in elderly breast cancer patients has been widely discussed in previous trials. Nonetheless, patients with ER negative tumors are frequently underrepresented. The aim of this retros... [mehr...]

2016

Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ):

26.10.2016 - This study aimed to compare the treatment of cerebral metastasis of NSCLC unsuitable for resection or stereotactic radiotherapy. This is a non inferiority phase 3 multicenter study with 538 patients... [mehr...]

A phase III randomized controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma (CCTG CE.6, EORTC 26062-22061, TROG 08.02, NCT00482677)

01.10.2016 - The EORTC (26981-22981)/NCIC CTG (CE.3) trial showed increased OS with concomitant and adjuvant TMZ added to RT. However, a trend of decreasing benefit from the addition of TMZ with increasing age w... [mehr...]

The value of adjuvant radiotherapy on survival and recurrence in triple-negative breast cancer: A systematic review and meta-analysis of 5507 patients

13.09.2016 - The value of adjuvant radiotherapy in triple negative breast cancer (TNBC) remains unclear. For that reason a systematic review and meta-analysis was conducted in TNBC patients to assess survival an... [mehr...]

Treatment-Related Death during Concurrent Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Studies.

13.09.2016 - Treatment related death (TRD) is the worst adverse event in chemotherapy and radiotherapy for patients with cancer, the reports for TRDs were sporadically. This metaanalysis aimed to study TRDs in n... [mehr...]

Salvage radiotherapy with or without short-term hormone therapy for rising prostate-specific antigen concentration after radical prostatectomy (GETUG-AFU 16): a randomised, multicentre, open-label phase 3 trial.

04.08.2016 - Salvage radiotherapy (SRT) is the standard therapy for patients (pts) with rising PSA after radical prostatectomy. But would they profit from a combined treatment of SRT and short-term androgen depr... [mehr...]

Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma

03.08.2016 - This study was a phase 3 study, including grade 2 glioma. Randomization was between radiation therapy (RT) alone and RT plus six cycles of combination chemotherapy (RT: 54 Gy à 1.8 Gy; chemotherapy:... [mehr...]

Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study

01.08.2016 - The RetroEMBRACE study is a retrospective multicenter cohort analysis evaluating image guided brachytherapy (IGBT) in locally advanced cervical cancer. Twelve experienced centers included 731 patien... [mehr...]

Prospective randomized trial of prone accelerated intensity modulated breast radiation therapy with a daily vs. weekly boost to the tumor bed.

28.07.2016 - Adjuvant Radiotherapy is essential after breast conserving surgery. Cooper et Al. report about a prospective trial comparing a daily versus weekly boost during an accelerated radiotherapy of the bre... [mehr...]

Comparison of every 3 week cisplatin or weekly cetuximab with concurrent radiotherapy for locally advanced head and neck cancer.

23.07.2016 - This is a retrospective analysis on 279 patients with head and neck cancer treated either with radiochemotherapy (Cisplatin 75-100mg/m²) q3 for 2-3 cycles (241 pts) or radioimmuntherapy (Cetuximab w... [mehr...]

Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10-year update and subset analysis

12.07.2016 - This study reports the long-term outcome of 119 pts with nonmetastatic stage III/IV resectable head and neck squamous cell carcinoma. Pts were either randomized to receive primary surgery with adjuv... [mehr...]

The role of postoperative radiation therapy for endometrial cancer: Executive Summary of an American Society for Radiation Oncology evidence-based guideline

09.07.2016 - This article deals with stage dependent recommendations for adjuvant radiotherapy for endometrial cancer. For low risk patients with an absolute risk of recurrence of 'lt' 5% an additional radiother... [mehr...]

Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database

06.07.2016 - Retroperitoneal sarcomas often fail from locoregional recurrence resulting in reduced OS even if complete resection was achieved. Additional treatment with pre- or postoperative radiotherapy therefo... [mehr...]

Treatment Selection and Survival Outcomes in Early-Stage Diffuse Large B-Cell Lymphoma: Do We Still Need Consolidative Radiotherapy?

30.06.2016 - The addition of radiotherapy to chemotherapy in DLBCL remains controversial. During the last few years, a decline in radiotherapeutic treatment can be observed. This retrospective study analyzed 59.... [mehr...]

PET-CT Surveillance vs Neck dissection after primary chemoradiation in advanced Head and Neck cancer

23.06.2016 - Primary chemoradiation is an effective and potentially curative treatment of locally advanced squamous cell cancer of the head and neck. Studies showed that neck dissection in node positive patients... [mehr...]

Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study.

17.06.2016 - Preoperative chemoradiotherapy has been regarded as the standard treatment for patients with advanced rectal cancer. A short-course 5-day radiation regimen followed by chemotherapy prior to surgery ... [mehr...]

Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the Radiation Therapy Oncology Group 0129 trial: long-term report of efficacy and toxicity.

05.06.2016 - There are several trials comparing accelerated radiotherapy alone vs. standard fractionated chemoradiotherapy in locally advanced head and neck carcinoma. But this randomized phase III study tested ... [mehr...]

Radiation therapy for glioblastoma: Executive summary of an American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline.

17.05.2016 - A systemic literature review on the therapy of glioblastoma was performed by the American Society for Radiation Oncology (ASTRO). The literature was analysed to give recommendations on four question... [mehr...]

Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma

07.04.2016 - HCC is the third leading cause of cancer mortality worldwide. Surgical resection is the standard therapy, however most of the patients with HCC were not surgical candidates. Therefore other therapy ... [mehr...]

Reducing Uncertainties about the Effects of Chemoradiotherapy for Cervical Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data from 18 Randomized Trials

14.03.2016 - After issuance of a National Cancer Institute (NCI) clinical alert in 1999, CRT has become widely used in treating women with cervical cancer. This meta-analysis aimed to collate individual patient ... [mehr...]

Competing event risk stratification may improve the design and efficiency of clinical trials: Secondary analysis of SWOG 8794

02.03.2016 - Or what could be reasons, why only in SWOG 8794 overall survival was significantly improved by adjuvant radiotherapy? ARO 96-02, EORTC 22911 and SWOG 8794 are the three landmark trials on adjuvant r... [mehr...]

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs. Temozolomide Alone for Glioblastoma

15.01.2016 - Tumor-treating fields (TTF) are low-intensity, intermediate frequency (200 kHz) alternating electric fields that disrupt mitosis that are delivered via transducer arrays applied to the shaved scalp.... [mehr...]

2015

Neues aus der Forschung: Radiochirurgie bei Hirnmetastasen

29.01.2015 - DIe Radiochirurgie bei Hirnmetastasen ist seit langem eine etablierte Methode zur Behandlung einer begrenzten Hirnmetastasierung. In einer Analyse der eigenen Behandlungsergebnisse von 340 Patienten... [mehr...]

Neues aus der Forschung: Brustkrebs

29.01.2015 - Die Rolle der Strahlentherapie für bei Behandlung von Brustkrebserkrankungen ist seit Jahren extrem gut belegt. Allerdings liegen die großen randomisierten Studien lange zurück. Um Auszuschliessen d... [mehr...]

4D Ultraschall bei der Bestrahlung der Prostata

29.01.2015 - Die Strahlentherapie der Prostata ist einer der Operation völlig gleichrangige Behandlungsoption zu Heilung der Krebserkrankung. Vorraussetzung ist die optimale Bewegungskontrolle und Lagekontrolle ... [mehr...]

Herzschonung bei Brustbestrahlung

09.02.2016 - Aktuell erhalten insbesondere junge Patientinnen häufiger deutlich mehr intensive Chemotherapie als es noch vor Jahren üblich war. Diese Tatsache beruht auf der Beobachtung, dass verbesserte Heilung... [mehr...]