PRONIA "Personalized Prognostic Tools for Early Psychosis Management" was a research project funded by the European Union to significantly improve the early detection of psychotic illness. The project aimed to produce an easily accessible prognostic service for early illness detection. This forecasting system used clinical information, cognitive data, neuroimaging, and DNA, RNA, and metabolomics.

PRONIA was comprised by a professional, motivated, and international team who developed computer models that assessed the risk of psychosis development, illness outcomes, and a range of other critical diagnostic and prognostic endpoints. Results from the project will help doctors and psychologists to better assess and treat the course of the disease. For more information on this project see


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PNKT "Personalized neuro-cognitive training in depression and psychosis (high risk)" was a project in which researchers worked on the development of personalized neuro-cognitive therapies based on an individualized stratification of the risk for psychosis and a reduced functional level.

In addition to the typical symptoms of affective and non-affective psychosis, affected patients regularly suffer from cognitive impairments. Deficits in cognitive abilities in patients with psychosis are closely related to their quality of life and therefore represent a special focus in the rehabilitation of those affected. To date, it has been shown that computer-assisted neuro-cognitive training can be successfully used to reduce these cognitive deficits and at the same time improve the psychosocial function level of patients. However, previous studies show that only subpopulation of these patients offers a satisfactory response to cognitive training. One aim of the study was, therefore, to predict the positive response to this measure in order to offer cognitive training to those patients who will most likely benefit from it.

In the PNKT study, patients participated in a detailed clinical, neuro-cognitive, and imaging survey, followed by several weeks of computer-assisted cognitive training. Participation in the study ended with a follow-up examination. On the basis of multivariate pattern analyses, it is hoped that it will be possible to determine which data patterns are best for predicting whether and under what conditions a patient will benefit from cognitive training.


CIP - Cannabis-induced psychosis - was a DFG-funded study aiming to identify individuals with cannabis-induced psychosis at an early stage and, in the context of a longitudinal imaging study, to find out in which affected individuals the psychotic symptoms remit spontaneously after abstinence and which patients were likely to develop a permanent form of psychosis.

Studies have shown that up to 50% of all patients with cannabis-induced psychosis develop a form of psychosis in the long term. Thus, patients with cannabis-induced psychosis represent the population with the highest known risk of permanent forms of psychosis. However, the neurobiological fundamentals of the connection between psychosis and cannabis use have hardly been understood so far. Nevertheless, this is urgently needed in order to identify the individuals with an increased risk of psychosis already at an early stage and to prevent the development of the disease and to positively influence the course of the disease.

In the CIP study, patients with cannabis-induced psychosis were tested for baseline and follow-up after 9 months by clinical and neuropsychological tests, as well as by using structural, functional and molecular imaging. The data was then evaluated by multivariate pattern analysis to identify brain patterns associated with clinical and neuropsychological variables.


TYPIA was a DFG-funded bicentric study conducted at the University of Bonn and the LMU Hospital in Munich. The aim of the study was to find out why not all people with highly pronounced schizotypic personality traits developed psychosis and the factors that protect against the development of psychosis. The project was based on observations of that suggest a continuum of psychosis symptoms between the individuals with no symptoms and populations of patients with psychosis.

Within the framework of TYPIA, test persons with high positive or negative schizotypic characteristics, control subjects with low schizotypic characteristics, and patients suffering from psychosis for the first time in the last three years were examined. The age range for all groups was between 18 and 40 years. The participation included examinations of personality, cognition, DNA, a clinical interview, as well as images of brain structure and function using magnetic resonance imaging (MRI).