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Prof. Dr.med. Susanne Schneider

schneider

Dept. of Neurology
Ludwig-Maximilians-University Munich, Klinikum Großhadern
Feodor-Lynen-Straße 19, 81377 Munich, Germany

Tel. ++ 49 89 4400-74828
Fax ++ 49 89 4400-74801
susanne.schneider(at)med.uni-muenchen.de

Publications

 

Klinische Schwerpunkte

 

1. Bewegungsstörungen

  • Parkinson, Dystonie, Tremor, Chorea, Tics, Myoclonus, paroxysmale Dyskinesien
  • vererbte / genetische Formen

2. Klinische Genetik, seltene Erkrankungen

 

Main Research Topics

 

1. Clinical, diagnostic, pathophysiological and therapeutic aspects of Movement Disorders

2. Genetic Aspects of Movement Disorders

3. Neurodegenerative Diseases

4. Syndromes of Neurodegeneration with Brain Iron Accumulation (NBIA-Syndromes)

5. Elektrophysiological abnormalities of Movement Disorders (transcranial magnetic stimulation, TMS)

 

Selected Literature

 

- Paisan-Ruiz C, Bhatia KP, Li A, Hernandez D, Davis M, Wood NW, Hardy J, Houlden H, Singleton A, Schneider SA. Characterisation of PLA2G6 as a locus for dystonia-parkinsonism. Ann Neurol. 2009;65:19-23

- Djarmati A*, Schneider SA*, Lohmann K, Winkler S, Pawlack H, Hagenah J, Brüggemann N, Zittel S, Fuchs T, Raković A, Schmidt A, Jabusch HC, Wilcox R, Kostić VS, Siebner H, Altenmüller E, Münchau A, Ozelius LJ, Klein C. Mutations in the THAP1 (DYT6) and generalized dystonia with prominent spasmodic dysphonia: a genetic screening study. Lancet Neurol. 2009;8:447-52

- Schneider SA, Bhatia KP, Hardy J. Complicated recessive dystonia parkinsonism syndromes. MovDisord. 2009;24:490-9

- Weber YG, Storch A, Wuttke TV, Brockmann K, Kempfle J, Maljevic S, Margari L, Kamm C, Schneider SA, Huber SM, Pekrun A, Roebling R, Seebohm G, Koka S, Lang C, Kraft E, Blazevic D, Salvo-Vargas A, Fauler M, Mottaghy FM, Münchau A, Edwards MJ, Presicci A, Margari F, Gasser T, Lang F, Bhatia KP, Lehmann-Horn F, Lerche H. Paroxysmal exertion-induced dyskinesias are caused by mutations in GLUT1 and an associated hemolytic anemia is linked to a cation leak of this glucose transporter. J Clin Invest. 2008;118:2157-68

- Schneider SA, van de Warrenburg BP, Hughes T, Davis M, Sweeney M, Wood N, Quinn NP, Bhatia KP. Phenotypic homogeneity of the Huntington’s disease-like presentation in a SCA17 family. Neurology. 2007;67:1701-3

- Schneider SA, Talelli P, Cheeran B, Khan N, Wood NW, Rothwell J, Bhatia KP. Corticospinal and intracortical excitability in patients and asymptomatic carriers with parkin gene mutations: a TMS study. MovDisord. 2008;23:1812-9

- Schneider SA, Pleger B, Draganski B, Cordivari C, Rothwell JC, Bhatia KP, Dolan RJ. Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia - an fMRI-TMS study. MovDisord 2010;25:76-83

- Kun-Rodrigues C, Ganos C, Guerreiro R, Schneider SA, Schulte C, Lesage S, Darwent L, Holmans P, Singleton A; International Parkinson's Disease Genomics Consortium (IPDGC), Bhatia K, Bras J. A systematic screening to identify de novo mutations causing sporadic early-onset Parkinson's disease. Hum Mol Genet. 2015;24(23):6711-20

- Bras J, Guerreiro RJ, Teo JH, Darwent L, Vaughan J, Molloy S, Hardy J, Schneider SA. Atypical parkinsonism-dystonia syndrome caused by a novel DJ1 mutation. Mov Disord Clin Pract, 1/2014; 1(1)

- Dusek P, Tovar-Martinez E, Istvan Madai V, Jech R, Sobesky J, Paul F, Niendorf T, Wuerfel J, Schneider SA. Seven Tesla MRI for brain iron quantification in homozygous and heterozygous PANK2 mutation carriers. MDCP 12/2014; 1(4)

- Schneider SA, Boettner M, Alexoudi A, Zorenkova D, Deuschl G, Wedel T. Can we use peripheral tissue biopsies to diagnose Parkinson´s disease? A review of the literature. Eur J Neurol (epub ahead of print)

- Brändl B, Schneider SA, Loring JF, Hardy J, Müller FJ. Stem cell research and reprogramming: basic implications and future perspective for movement disorders. Mov Disord 2015;30:301-12

- Donaldson C, Marsden CD, Schneider SA, Bhatia KP. Marsden’s Book of Movement Disorders. Oxford University Press. ISBN13: 9780192619112ISBN10: 019261911X Hardback, 1552 pages

 

Methods

 

1) Klinische Genetik

2) Phänotyp-Genotyp-Korrelation

3) Radiologische Charakterisierung

4) Elektrophysiologie (Transkranielle Magnetstimulation /TMS)

 

Grants

 

Eugene Brehm Bequest, UCL London (2005)

JJ Astor Prize, Brain Research Trust, UK (2005-2008)

Intramurale Förderung durch die Universität zu Lübeck (2008-2010)

Graduierten-Stipendium der Novartis-Stiftung (2008)

Initiativgruppe „Neurobiomedizinische Forschung“ der Medizinischen Fakultäten der Universität zu Lübeck und der Christian-Albrechts-Universität zu Kiel (2010-2012)

Intramurale Förderung der Universität Kiel (2013)

Else Kröner-Fresenius-Stiftung (seit 2013)

Eva Luise und Horst Köhler Stiftung für seltene Erkrankungen (seit 2012)

 

Team Members

 

n.n.

 

Cooperation with

 

Queen Square Institute of Neurology, England

Abt. für Neurologie, Universität Kiel

Max-Dellbrück Centrum (MDC) Charite Berlin

Abt. für Neurologie, Universität Prag

 
 

Anschrift

Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ
Ludwig-Maximilians-Universität München, Klinikum Großhadern, Marchioninistraße 15
D-81377 München

Direktorin:
Univ.Prof. Dr. med. Marianne Dieterich, FANA, FEAN
direktion.neurologie
(at)med.uni-muenchen.de

Telefonzentrale
Tel. (089) 4400-0