Dept. of Neurology
Ludwig-Maximilians-University Munich, Klinikum Großhadern
Marchioninistr. 15, 81377 Munich, Germany

Tel. ++ 49 89 7095 3678
Fax ++ 49 89 7095 6673
michael.strupp(at)med.uni-muenchen.de

Further Information: Arbeitsgruppe Schwindel

Publikationen

Klinische Schwerpunkte

1. Schwindel und Gleichgewichtsstörungen

2. Augenbewegungsstörungen

3. Gangstörungen

4. Liquorunterdrucksyndrom und Liquorpunktion

5. Normaldruckhydrozephalus

6. Hirnvenenthrombose

Main Research Topics

1. Vestibular system

• Peripheral vestibular disorders
  • Central compensation of unilateral peripheral vestibular lesions: role of vestibular exercises, drug therapy and somatosensory substitution.
  • Vestibular neuritis: Aetiology, viral pathogenesis and therapy. Distribution of Herpes simplex virus in cranial nerve ganglia and different nuclei in the brainstem; drug therapy of vestibular neuritis.
  • Autoimmunological mechanisms of bilateral vestibulopathy and Cogan’s syndrome.
  • Evaluation of the differential effects of walking and running on gait deviation, perception and vestibular ocular reflex.
  • Treatment of downbeat and upbeat nystagmus, episodic ataxia and familial hemiplegic migraine with aminopyridines
  • Genetics and pathogenesis of bilateral vestibulopathy
• Evaluation of the mechanism of nicotine-induced nystagmus and nausea
• Differential effects of walking and running in vestibular lesions
• Patch clamp recordings on isolated mammalian vestibular hair cells and neurons from vestibular compensation.

2. Imaging techniques
(MRI, diffusion- and perfusion-weighted MRI, functional MRI)

• Evaluation of the mechanisms of transient global amnesia.
• Follow-up studies in sinus venous thrombosis.
• Regional blood flow and volume in normal pressure hydrocephalus.
• Imagination of stance and locomotion.

3. Postlumbar puncture headaches (PLPH)

• Effects of different techniques on the frequency of PLPH

4. Multiple Sclerosis

• Effects of mitoxantrone in primary and secondary chronic progressive MS

Selected Literature

- Arbusow V, Schulz P, Strupp M, v. Reinhardstoettner A, Dieterich M, Brandt T (1999) Distribution of HSV-1 in human geniculate and vestibular ganglia: implications for vestibular neuritis. Ann Neurol 46: 416-419

- Arbusow V, Strupp M, Wasicky R, Horn AKE, Schulz P, Brandt T (2000) Central and peripheral distribution of HSV-1. Neurology 55: 508-582

- Brandt T, Strupp M, Benson J (1999) You are better off running than walking with acute vestibulopathy. The Lancet 354: 746

- Brandt T, Strupp M, Benson J (1999) You are better off running than walking with acute vestibulopathy. The Lancet 354: 746

- Jahn K, Naessl A, Schneider E, Strupp M, Brandt T, Dieterich M (2003) Inverse U-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulation. Brain 126: 1579-89

- Jahn K, Strupp M, Brandt T (2002) Both actual and imagined locomotion suppress spontaneous vestibular nystagmus. NeuroReport 13: 2125-2128

- Jahn K, Strupp M, Krafczyk S, Schüler O, Glasauer S, Brandt T (2003) Suppression of eye movements improves balance. Brain 125: 2005-2011.

- Jahn K, Strupp M, Schneider E, Brandt T (2001) Visually induced gait deviations during different locomotion speeds. Exp Brain Res 141: 370-374

- Pereira CB, Strupp M, Eggert Th, Straube A, Brandt T (2000) Three-D analysis of nicotine-induced nystagmus. Neurology 55: 1563-1565

- Strupp M, Arbusow V, Dieterich M, Sautier W, Brandt T (1998) Perceptual and oculomotor effects of neck muscle vibration in vestibular neuritis: ipsilateral somatosensory substitution of vestibular function. Brain 121: 677-686

- Strupp M, Arbusow V, Maag, KP, Gall C, Brandt T (1998) Vestibular exercises improve central vestibulo-spinal compensation after vestibular neuritis. Neurology 51: 838-844

- Strupp M, Covi M, Seelos K, Dichgans M, Brandt T (2002) Cerebral venous thrombosis: Correlation between recanalization and clinical outcome - A long-term follow-up of 40 patients. J Neurol 249: 1123-1124

- Strupp M, Brandt T (1997) Should one reinsert the stylet during lumbar puncture? N Engl J Med 336: 1190

- Strupp M, Brüning R, Wu RH, Deimling M, Reiser M, Brandt T (1998) Diffusion-weighted MRI in transient global amnesia: elevated signal intensity in the left mesial temporal lobe in 7 of 10 patients. Ann Neurol 43: 164-170

- Strupp M, Glasauer S, Schneider E, Eggert T, Glaser M, Jahn K, Brandt T (2003) Anterior canal failure: ocular torsion without perceptual tilt due to preserved otolith function. J Neurol Neurosurg Psychiatry 74: 1336-1338.

- Strupp M, Planck JH, Arbusow V, Steiger HJ, Brückmann H, Brandt T (2000) Rotational vertebral artery occlusion syndrome with vertigo due to transient “labyrinthine excitation”. Neurology 54: 1376-1379

- Strupp,-M; Schuler,-O; Krafczyk,-S; Jahn,-K; Schautzer,-F; Buttner,-U; Brandt,-T (2003) Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study. Neurology 61: 165-170

- Strupp M, Schüler O, Straube A, v. Stuckrad-Barre S, Brandt T (2001) „Atraumatic“ Sprotte needle reduces the incidence of post-lumbar puncture headaches. Neurology 57: 2310-2312

- Theil D, Arbusow V, Derfuss T, Strupp M, Pfeiffer M, Mascolo A, Brandt T (2001) Prevalence of HSV-1 LAT in human trigeminal, geniculate, and vestibular ganglia and its implication for cranial nerve syndromes. Brain Pathol 11: 408-13

- Theil D, Derfuss T, Strupp M, Gilden DH, Arbusow V, Brandt T (2002) Cranial Nerve Palsies: Herpes Simplex Virus Type 1 and Varizella-Zoster Virus Latency. Ann Neurol 51: 273-274

- Theil D, Derfuss T, Strupp M, Gilden DH, Arbusow V, Brandt T (2003) Cranial nerve palsies: herpes simplex virus type 1 and varizella-zoster virus latency. Ann Neurol 51: 273-4.

- Theil D, Paripovic I, Derfuss T, Herberger S, Strupp M, Arbusow V, Brandt T (2003) Dually infected (HSV-1/VZV) single neurons in human trigeminal ganglia. Ann Neurol 4: 678-82.

- Strupp M, Kalla R, Dichgans M, Freilinger T, Glasauer S, Brandt T (2004) Treatment of episodic ataxia type 2 with the potassium channel blocker 4-aminopyridine. Neurology 62:1623-1625.

- Strupp M, Zingler V, Arbusow V, Niklas D, Maag KP, Dieterich M, Bense S, Theil D, Jahn K, Brandt T (2004) Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med 351:354-361.

Methods

1) Two-and 3-D video-oculography, measurements of the gain of the VOR

2) Motion analysis by use of a 3-D ultrasound system

3) Otholith testing with ocular counter roll and scanning laser ophthalmoscope

4) Psychophysical techniques, e.g. determination of the subjective visual vertical

5) Neuroorthoptic examination techniques

6) In vitro techniques:

• Patch-clamp recordings from isolated vestibular hair cells, neurons and brainstem slices
• PCR, single-cell PCR
• In-situ hybridization in peripheral and central nervous structures
• Immunological techniques

Grants

Deutsche Forschungsgemeinschaft:
- "Untersuchungen zur Ätiologie des akuten einseitigen Labyrinthausfalls und des Hörsturzes: peripheres und zentrales Verteilungsmuster von HSV-1-DNA in humanen Ganglien der Nn. vestibularis, cochlearis und facialis sowie deren Hirnstammkernen" (Strupp/Arbusow)
- "Abhängigkeit vestibulärer Funktionen (Lokomotionssteuerung, vestibulo-okulärer Reflex, Raum- und Bewegungswahrnehmung) vom Gangmuster beim Menschen" (Strupp, Jahn, Färber Brandt)

Team Members

Vestibular and oculomotor system:
Victor Arbusow, MD; Katarina Hüfner, MD; Klaus Jahn, MD; Roger Kalla, MD; Eva Riedel, MD; Franz Schautzer, MD; Vera Zingler, MD; Miriam Glaser; Cornelia Karch; Nicole Rettinger

In vitro experiments:
D. Theil, MD; Simone Herberger, MD

Cooperation with

R. Brüning, MD, Department of Neuroradiology, University of Munich

N. Dieringer, PhD, Department of Physiology, University of Munich

M. Dieterich, MD, Department of Neurology, University of Mainz

T. Derfuß, MD, Max-Planck-Institute, Martinsried, Munich

M. Dutia, PhD, Department of Physiology, University of Edinburgh

R.A. Eatock, PhD, Baylor College of Medicine, Houston, TX

T. Eggert, PhD, Department of Neurology, University of Munich

R. Evans, MD, Department of Neurology, Baylor College of Medicine, TX

S. Glasauer, PhD, Center for Sensorimotor Research, University of Munich

M. Halmagyi, Department of Neurology, University of Sidney

K. Herrmann, MD, Department of Radiology, University of Munich

T. Klopstock, Department of Neurology, University of Munich

L. Jäger, Department of Radiology, University of Munich

C.B. Pereira, MD, Department of Neurology, Sao Paulo, Brasil

E. Schneider, PhD, Center for Sensorimotor Research, University of Munich

A. Straube, MD, Department of Neurology, University of Munich