 |
Neurologische Klinik und Deutsches Schwindel- und Gleichgewichtszentrum Klinikum der Ludwig-Maximilians-Universität München, Campus Grosshadern Marchioninistr. 15, 81377 München
Tel. ++ 49 89 4400-73678 Fax ++ 49 89 4400-76673 michael.strupp(at)med.uni-muenchen.de
Further Information: Arbeitsgruppe Schwindel
Arbeitsgruppe Gangstörungen
Publikationen, CV
|
|
1. Schwindel und Gleichgewichtsstörungen: Diagnose und Therapie
2. Kleinhirnerkrankungen: Therapie
3. Augenbewegungsstörungen und Nystagmus: Diagnose und Therapie
4. Gangstörungen
5. Klinische Studien zu Schwindel, Kleinhirnerkrankungen und Nystagmus
6. Angeborene neurologische Stoffwechselerkrankungen
7. Allgemeine Neurologie
|
|
Michael Strupp, MD, FANA, FEAN
Professor of Neurology
Dept. of Neurology and German Center for Vertigo and Balance Disorders Ludwig-Maximilians-University Hospital Munich,Campus Großhadern Marchioninistr. 15, 81377 Munich, Germany
Tel. ++ 49 89 4400-73678 Fax ++ 49 89 4400-76673 michael.strupp(at)med.uni-muenchen.de
Further Information: Arbeitsgruppe Schwindel
Publikationen, CV
|
|
1. Vertigo, dizziness and balance disorders: diagnosis and treatment
2. Cerebellar disorders: Treatment
3. Eye movement disorders, including nystagmus: diagnosis and treatment
4. Gait disorders
5.Clinical trials on vestibular, ocular motor and cerebellar disorders, in particular to improve their treatment
6. Inherited neuro-metabolic disorders
7. General Neurology
|
|
Vestibular, ocular motor and cerebellar disorders
- Peripheral vestibular disorders
- Vestibular neuritis: etiology, viral pathogenesis, and therapy; distribution of Herpes simplex virus in cranial nerve ganglia and different nuclei in the brainstem
- Cerebellar disorders: treatment and diagnosis
- Central compensation of unilateral peripheral vestibular lesions: role of vestibular exercises, drug therapy (aminopyridines, betahistine, acetyl-DL-leucine), and somatosensory substitution in humans and animal models
- Genetics with genome-wide association study, pathophysiology, and etiology of vestibular disorders, such as autoimmunological mechanisms of bilateral vestibulopathy and Cogan’s syndrome.
- Pharmacotherapy of vestibular disorders with clinical trials in Menière’s disease with betahistine, vestibular paroxysmia with carbamazepine, and BPPV with vitamin D
- Central vestibular disorders and nystagmus
- oPharmacotherapy of nystagmus, such as downbeat and upbeat nystagmus with aminopyridines and chlorzoxazone
- oPharmacotherapy of cerebellar disorders, such as episodic ataxia type 2 and cerebellar ataxias with aminopyridines and acetyl-DL-leucine
- Evaluation of the mechanism of nicotine-induced nystagmus and nausea
- oDifferential effects of walking and running in vestibular lesions
- Central ocular motor disorders
- Development of tools to diagnose inherited metabolic disorders such as Niemann-Pick type C and Gaucher disease type 3
- Animal models and studies
- Central compensation of acute unilateral vestibular lesions on a behavioural level and with imaging techniques (cooperation with A. Zwergal)
- Animal studies on inherited metabolic disorders (cooperation with F. Platt, Oxford)
- Measurements of inner ear blood flow to study the pharmacological mechanisms of betahistine and its metabolites (cooperation with M. Canis)
|
|
zur Publikationsliste aus Pubmed
- Books
- Brandt T, Dieterich M, Strupp M. Vertigo – Leitsymptom Schwindel. 2nd edition, Springer Medizin, Darmstadt (2013)
- Strupp M (editor) A clinical approach to vertigo, dizziness and balance disorders. KWX communications, New Delhi (2013
- Strupp M, Kremmyda O, Brandt T. Ocular motor disorders and vertigo in clinical practice. Springer, London (2017)
- Strupp M, Cohen B, Büttner U (Editors) Basic and Clinical Aspects of Vertigo and Dizziness. Ann NY Acad Sci (2009)
- Guidelines of the German Neurological Society (Editor: Diener HC, Weimar C), 5th edition, Thieme, Stuttgart 2012:
- Augenbewegungsstörungen inklusive Nystagmus. Straumann D, Straube A, Strupp M. In charge: D. Straumann (pp 648-655)
- Schwindel – Diagnose. Brandt T, von Brevern M, Dieterich M, Eckhardt-Henn A, Straumann D, Strupp M, Westhofen M, Wiest, G. In charge: M. Strupp (pp 622-635)
- Schwindel – Therapie. Brandt T, von Brevern M, Dieterich M, Eckhardt-Henn A, Straumann D, Strupp M, Westhofen M, Wiest, G. In charge: M. Strupp (pp 636-655)
|
|
1) 2- and 3-D video-oculography, scleral-coil technique, measurements of the gain of the VOR by video head impulse test
2) Motion analysis using a 3-D ultrasound system
3) Testing of otolith function with cervical and ocular vestibular evoked myogenic potentials (VEMP)
4) Posturography
5) “Neuro-orthoptic” examination techniques, e.g., scanning-laser ophthalmoscopy and subjective visual vertical
6) Animal models on acute and recurrent vestibular disorders, inherited metabolic disorders, ataxias
7) In vitro techniques:
- Patch-clamp recordings from isolated vestibular hair cells, neurons and brainstem slices
- PCR, single-cell PCR, in-situ hybridization in peripheral and central nervous structures
- Immunological techniques
- Blood-flow measurements in the inner ear (pharmacological studies with betahistine and its metabolites)
|
|
BMBF:
- Prophylactic treatment of vestibular migraine with metoprolol (PROVEMIG)
- Betahistine in acute vestibular neuritis: effects on central compensation (BETAVEST)
- Episodic ataxia type 2: Fampridine versus acetazolamide versus placebo (EAT2TREAT)
- Vitamin D in BPPV: secondary prophylaxis (VitD@BPPV)
- Carbamazepine in vestibular paroxysmia (VesPa)
- Fampridine in cerebellar gait ataxia (FACEG)
- Acetyl-DL-Leucine in cerebellar ataxia (ALCAT)
Sensorion: Symptomatic treatment of acute unilateral vestibulopathy with Sens-111
Novartis: Effects of oxcarbazepine in vestibular paroxysmia
Actelion: Diagnosis of Niemann-Pick type C by examination of the ocular motor system
|
|
Vestibular and oculomotor system: S. Bardins, Dipl. Ing.; O. Bayer, MD; I Berger, MD; T. Bremova, MD, PhD; K. Feil, MD; C. Frenzel, C. Fischer, MD; M. Glaser,N. Goldschagg, MD; S. Himmelein, PhD; C. Karch; O. Kremmyda, MD; PhD, N. Lehrer, I. Naumann, J. Teufel, MD
In vitro experiments: S. Himmelein, PhD; K. Hüfner, MD
|
|
Local:
- C. Adrion, PhD
- C. Adamczyk, MD
- T. Brandt, MD
- M. Dieterich, MD
- S. Glasauer, PhD
- E. Grill, PhD
- A. Horn-Bechtler, PhD
- P- MacNeilage, PhD
- U. Mannsmann, MD, PhD
- A. Rieger, PhD
- E. Schneider, PhD
- S. Schneider, MD, PhD
- R. Schniepp, MD
- F. Schöberl, MD
- H. Straka, PhD
- J.C. Tonn, MD
- A. Zwergal, MD
National:
- M. Bertlich, MD, Göttingen
- M. von Brevern, MD, Berlin
- M. Canis, MD, Göttingen
- J. Classen, MD, Essen
- F. Ihler, MD, Göttingen
- R. Kalla, Bern
- T. Klockgether, Bonn
- T. Lempert, MD, Berlin
- D. Obrist, Bern
- H. Rambold, MD, Altötting
- L. Schölz, Tübingen
- D. Timmann-Braun, Essen
- 12 clinical study centers in Germany
International:
- Y. Agraval, Baltimore, U.S.A.
- A. Bisdorff, Esch-sur-Alzette, Luxemburg
- S. Boesch, Innsbruck, Austria
- A. Bronstein, London, U.K.
- L. Hofmeyr, Johannesburg, South Africa
- J. Jen, Los Angeles, U.S.A.
- R. Kalla, Bern, CH
- C. Kennard, Oxford, U.K
- H. Kingma, NL
- J.S. Kim, Seoul, South Korea
- J. Leigh, Cleveland, U.S.A.
- F. Platt, Oxford, UK
- J. Staab, Rochester, MN, U.S.A.
- R. Spiegel, Basel
- D. Straumann, Zurich, CH
- B.P. van de Warrenburg, Nijmegen, NL
- C.W. Yip, Singapore
- D. Zee, Baltimore, U.S.A.
|