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Univ.Prof. Dr. med. Hans-Walter Pfister

Leitender Oberarzt und Personaloberarzt


Department of Neurology
Ludwig-Maximilians-University Munich, Klinikum Großhadern
Marchioninistr. 15, 81377 Munich, Germany

Tel. ++ 49 89 4400-72561 (Mrs. D. Förth - Secretary)
Fax ++ 49 89 4400-75561

Further Information:
Arbeitsgruppe Neuroinfectiology



Main Clinical Topics


1. General neurology

2. Infectious diseases of the central nervous system (CNS) (e.g., neuroborreliosis, bacterial meningitis, brain and spinal abscess, CNS-tuberculosis, HIV infection), Encephalitis (infectious/autoimmune encephalitis).

3. Neurological intensive care medicine.

4. Brain trauma



Main Research Topics


1. Pathogenesis and therapy of CNS infectious diseases (e.g., bacterial meningitis and neuroborreliosis).

2. Investigation of potential biomarkers in CNS infections and CNS lymphoma (e.g., significance of the chemokine CXCL13).

3. Intensive care neurology (e.g., clinical studies assessing complications, course and treatment of CNS diseases).



Selected Literature


• Buchholz G, Koedel U, Pfister HW, Kastenbauer S, Klein M. Dramatic reduction of mortality in pneumococcal meningitis. Crit Care 2016;20:312.

• Pfister H, Bühler R, Eiffert H et al. Ambulant erworbene bakterielle Meningoenzephalitis. AWMF Leitlinie 030-089, 2016.

• Koedel U, Pfister HW. Lyme neuroborreliosis. Curr Opin Infect Dis 2016.

• van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB). ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect. 2016 May;22 Suppl 3:S37-62.

• Koedel U, Fingerle V, Pfister HW. Lyme neuroborreliosis-epidemiology, diagnosis and management. Nat Rev Neurol 2015;11:446-56.

• Laurent SA, Hoffmann FS, Kuhn PH et al. γ-Secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun. 2015 Jun 11; 6:7333.

• Wache C, Klein M, Ostergaard C, et al. Myeloid-Related Protein 14 Promotes Inflammation and Injury in Meningitis. J Infect Dis 2015; 212: 247-57.

• Brouwer MC, Meijers JC, Baas F, et al. Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis. Acta Neuropathol 2013;127:553-64.

• Höhne C, Wenzel M, Angele B, et al. High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis. Brain 2013;136:1746-59.

• Woehrl B, Brouwer MC, Murr C, et al. Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J Clin Invest 2011;121:3943-53.

• Schmidt C, Plate A, Angele B, et al. A prospective study on the role of CXCL13 in Lyme neuroborreliosis. Neurology 2011;76:1051-8.

• Woehrl B, Klein M, Rupprecht TA, et al. CXCL16 contributes to neutrophil recruitment to the CSF in pneumococcal meningitis. J Infect Dis 2010;202:1389-96.

• Koedel U, Frankenberg T, Kirschnek S, et al. Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. PLoS Pathog 2009;5:e1000461.

• Klein M, Angele B, Pfister HW, Wagner H, Koedel U, Kirschning CJ. Detection of pneumococcal infection of the central nervous system depends upon TLR2 and TLR4. J Infect Dis 2008;198:1028-36.

• Koedel U, Merbt UM, Schmidt C, et al. Acute Brain Injury Triggers MyD88-Dependent, TLR2/4-Independent Inflammatory Responses. Am J Pathol 2007;171:200-13.




1) Cell culture systems (e.g. cerebral endothelial cells, human granulocytes, macrophages).

2) Models of experimental meningitis.

3) Measurement of cerebral blood flow using laser-doppler flowmetry, monitoring of intracranial pressure and blood-brain barrier permeability.

4) RT-PCR, immunohistochemistry, ELISA, Western-Blot, chemiluminescence, zymography, histology, cytotoxicity assays.




Deutsche Forschungsgemeinschaft


Forschungs-/Lehrfonds der Universität München


Team Members


Prof. Dr. med. Uwe Ködel

PD Dr. med. Matthias Klein

Barbara Angele (MTA)

Dr. med. Grete Buchholz

Frau Susanne Dyckhoff

Dr. med. Tobias Högen

Dr. med. Ilias Masouris

Dr. med. Stefanie Völk

Dr. med. Michael Wenzel

Dr. med. Bianca Wöhrl



Johanna Fritsche

Philipp OIdemeierl

Marco Zierhut



Cooperation with


Prof. A. Fontana (Zurich, CH)

Prof. W.M. Scheld (Charlottesville, USA)

Prof. S. Hammerschmidt (University of Greifswald;

Prof. C. Kirschning (University of Duisburg-Essen)

Dr. S. Ricci (Universitaria Senese)

Dr. V. Fingerle (National Reference Center for Borrelia, Bavarian Health and Food Safety Authority)

Prof. A. Straube, PD Dr. L.von Baumgarten (Neurooncology Study Group of the Department of Neurology, LMU Munich)

Prof. A. Giese (Center for Neuropathology, LMU Munich)

Dr. M. Wick, Institute of Laboratory Medicine, LMU Munich

European Study Group for Infectious Diseases of the Brain (an official ESCMID study group)




Neurologische Klinik und Poliklinik & Deutsches Schwindel- und Gleichgewichtszentrum DSGZ
Ludwig-Maximilians-Universität München, Klinikum Großhadern, Marchioninistraße 15
D-81377 München

Univ.Prof. Dr. med. Marianne Dieterich, FANA, FEAN

Tel. (089) 4400-0