Forschungsgruppe Molekulare Neurodegeneration
Research Group Molecular Neurodegeneration
Dr. med. Thomas Koeglsperger
Upper row from left to right: Rohit Kumar, Yi Tan, Felix Machleid, Pan Gao. Lower row from left to right:
Moritz Kolling, Anna Kurz, Qilin Tang, Diana Mahlstedt, Thomas Koeglsperger.
Contact:
Dr. med. Thomas Koeglsperger
Department of Neurology &
Graduate School of Systemic Neurosciences (GSN)
Ludwig Maximilian University Munich
E-Mail to: thomas.koeglsperger@med.uni-muenchen.de
Research Summary:
Neurodegenerative diseases, such as Parkinson’s disease (PD) are a major burden in an aging society.
We aim to understand the pathophysiological mechanisms that underlie the demise of neurons in PD and related diseases. In order to investigate the effect of disease-associated pathogenic proteins, such as Alpha-Synuclein (SNCA) and others, we us a combination of patch-clamp electrophysiology, biochemistry and an array of optical and optogenetic approaches such as pH- and calcium-sensitive dye imaging.
In addition, we aim to contribute to the discovery of early disease biomarkers for PD. Currently, we examine the function and abundance of distinct micro RNAs (miRNAs) in enteric biopsies from PD patients.
Clinically, we are interested in advancing Deep Brain Stimulation (DBS) therapy for movement disorders, where we investigate novel, patient-centered programming strategies.
We are located at and we are part of the Department of Translational Brain Research (Prof. J. Herms) at the German Center for Neurodegenerative Diseases (DZNE).
5 Key Publications:
- Kumar R, Tang Q, Müller SA, Gao P, Mahlstedt D, Zampagni S, Tan Y, Klingl A, Bötzel K, Lichtenthaler SF, Höglinger GU, Koeglsperger T (2020) Fibroblast Growth Factor 2‐Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons. Advanced Science 115:1902372–15. doi: 10.1002/advs.201902372
- Tan Y, Sgobio C, Arzberger T, Machleid F, Tang Q, Findeis E, Tost J, Chakroun T, Gao P, Höllerhage M, Bötzel K, Herms J, Höglinger G, Koeglsperger T (2019) Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson’s disease. Acta Neuropathologica 1–27. doi: 10.1007/s00401-019-02099-5
- Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL (2014) Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nature Neuroscience 17:131–143. doi: 10.1038/nn.3599
- Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL (2013) Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia 61:985–1002. doi: 10.1002/glia.22490
- Koeglsperger T, Palleis C, Hell F, Mehrkens JH, Bötzel K (2019) Deep Brain Stimulation Programming for Movement Disorders: Current Concepts and Evidence-Based Strategies. Frontiers in Neurology 10:410. doi: 10.3389/fneur.2019.00410
Research Support:
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