Startseite » Forschung » ExperiMed » Jaw bone

Jaw Bone and Osteonecrosis of the Jaw


Bisphosphonate related osteonecrosis of the jaw is a new entity of tissue necrosis first described in 2003. It is most frequently diagnosed in patients suffering from bone metastasis and receiving bisphosphonates in the course of their supportive oncologic treatment intravenously. Patients receiving an oral bisphosphonate therapy due to osteoporosis are also affected by this form of osteonecrosis, but the incidence is a magnitude lower. The clinical hallmark of the disease is exposed bone in the oral in the mandible or the maxilla with no healing tendency. If diagnosed or treated with delay severe complications such as pathological fracture of the jaw can occur. The pathogenesis of the disease is still poorly understood.   TissueNecrosis

Current Projects

  1. Evaluation of the novel technique of fluorescence guided bone resection (clinical project)
    (biochemical, biophysical and morphological characterisation)
  2. Collection of epidemiologic data (clinical project)
  3. Establishment of a large animal model for bisphosphonate related osteonecrosis (cooperation with the Technical University of Munich and University of Rostock).
  4. Cell culture experiments with focus on the influence of the pH value and the bisphosphonate derivate on the onset of the ostoenecrosis

Group Leader

Dr. med. Dr. med. dent. Sven Otto is a board certified specialist for Oral- and Maxillofacial Surgery. He received his dental degree (DDS - 2002) and medical degree (MD - 2006) from the University of Leipzig / Germany. Since 2006 he is a resident at the Department of Oral and Maxillofacial Surgery of the Ludwig-Maximilians-University of Munich / Germany (Head Prof. Dr. Dr. Michael Ehrenfeld). His major fields of interest are Bisphosphonate-related Osteonecrosis of the Jaws, especially the pathophysiology underlying the disease and bone regeneration especially scaffold based tissue engineering of bone. He has published numerous articles in leading scientific journals and has lectured nationally and internationally on these subjects. Since 2011, he is appointed group leader “Jaw bone and osteonecrosis of the jaw” in the laboratory for Experimental Surgery and Regenerative Medicine (ExperiMed) of the Ludwig-Maximilians-University of Munich / Germany.