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Nationale und internationale Kooperationen

Institute of Molecular Immunology, Hematologikum, Helmholtz Zentrum München, National Research Center for Environmental Health (Prof. Dr. E. Nößner)

Institute of Virology, Technische Universität München/Helmholtz Zentrum München, German Center for Infection Research (Prof. Dr. U. Protzer)

  • Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U. Interferon-? and Tumor Necrosis Factor-a Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis. Gastroenterology. 2016 Jan;150(1):194-205.
  • Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014 Mar 14; 343(6176):1221-8.

II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München (Prof. Dr. O. Ebert)

  • Marozin S, Altomonte J, Muñoz-Álvarez KA, Rizzani A, De Toni EN, Thasler WE, Schmid RM, Ebert O. STAT3 inhibition reduces toxicity of oncolytic VSV and provides a potentially synergistic combination therapy for hepatocellular carcinoma. Cancer Gene Ther. 2015 May1.
  • Marozin S, De Toni EN, Rizzani A, Altomonte J, Junger A, Schneider G, Thasler WE, Kato N, Schmid RM, Ebert O. Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma. PLoS One 2010 Jun 7; 5(6):e10988.

Department of Internal Medicine I, University Hospital Regensburg, University of Regensburg (Prof. Dr. C. Hellerbrandt)

  • Mahli A, Thasler WE, Patsenker E, Müller S, Stickel F, Müller M, Seitz HK, Cederbaum AI, Hellerbrand C. Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro. Oncotarget. 2015 Dec 8;6(39):41464-78.
  • Bauer R, Valletta D, Bauer K, Thasler WE, Hartmann A, Müller M, Reichert T, Hellerbrand C. Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity. International Journal of Clinical and Experimental Pathology 2014 Aug 15; 7(9):6125-32.
  • Engelmann JC, Amann T, Ott-Rötzer B, Nützel M, Reinders Y, Reinders J, Thasler WE, Kristl T, Teufel A, Huber CG, Oefner PJ, Spang R, Hellerbrand C. Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NF?B Signaling in Hepatocellular Carcinoma. PLoS Comput Biol. 2015 May 28;11(5). 
  • Mahli A, Thasler WE, Müller M, Seitz HK, Cederbaum AI, Hellerbrand C.  Identification of cytochrome CYP2E1 as critical mediator of alcohol effects on steatotic hepatocytes. Journal of Hepatology, accepted 07/2014.
  • Arndt S, Wacker E, Dorn C, Koch A, Saugspier M, Thasler WE, Hartmann A, Bosserhoff AK, Hellerbrand C. Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease. Gut. 2014 Jul 10.
  • Czech B, Dettmer K, Valletta D, Saugspier M, Koch A, Stevens AP, Thasler WE, Müller M, Oefner PJ, Bosserhoff AK, Hellerbrand C. Expression and function of methylthioadenosine phosphorylase in chronic liver disease. PLoS One. 2013 Dec 6;8(12):e80703.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich (Prof. Dr. GA Kullak-Ublick)

  • Schaffner CA, Mwinyi J, Gai Z, Thasler WE, Eloranta JJ, Kullak-Ublick GA. The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes. Liver Int. 2014 Apr 5.

BG Trauma Center, Siegfried Weller Institute, Eberhard Karls University Tübingen (Prof. Dr. AK Nüssler)

  • Seeliger C, Culmes M, Schyschka L, Yan X, Damm G, Wang Z, Kleeff J, Thasler WE, Hengstler J, Stöckle U, Ehnert S, Nüssler AK. Decrease of global Methylation improves significantly hepatic Differentiation of Ad-MSCs: Possible future Application for Urea Detoxification. Cell Transplant 2012 Apr 10.
  • Ehnert S, Knobeloch D, Blankenstein A, Müller A, Böcker U, Gillen S, Friess H, Thasler WE, Dooley S, Nussler AK. Neohepatocytes from alcoholics and controls express hepatocyte markers and display reduced fibrogenic TGF-ß/Smad3 signaling: advantage for cell transplantation? Alcohol Clin Exp Res 2010 Apr; 34(4):708-18.

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund (Prof. Dr. J Hengstler)

  • Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG. Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol. 2014 Dec; 88(12):2261-87.
  • Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Prof. Dr. O. Burk)
  • Bitter A, Nüssler AK, Thasler WE, Klein K, Zanger UM, Schwab M, Burk O. Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression. Cell Physiol Biochem. 2015; 35(2):803-15.
  • Hoffart E, Ghebreghiorghis L, Nussler AK, Thasler WE, Weiss TS, Schwab M, Burk O. Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor, Br J Pharmacol 2012 Mar;165(5):1595-608.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart/Universität Tübingen, Medizinische Fakultät, Molecular and Cell Biology (Prof. Dr. UM Zanger)

  • Keller R, Klein M, Thomas M, Dräger A, Metzger U, Templin MF, Joos TO, Thasler WE, Zell A, Zanger UM. Coordinating Role of RXRa in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling. PLoS Comput Biol. 2016 Jan 4;12(1)
  • Kandel BA, Ekins S, Leuner K, Thasler WE, Harteneck C, Zanger UM. No activation of human pregnane X receptor by hyperforin-related phloroglucinols. J Pharmacol Exp Ther. 2014 Mar; 348(3):393-400.
  • Bucher J, Riedmaier S, Schnabel A, Marcus K, Vacun G, Weiss TS, Thasler WE, Nüssler AK, Zanger UM, Reuss M. A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes. BMC Syst Biol 2011 May 6; 5:66.
  • Schröder A, Wollnik J, Wrzodek C, Dräger A, Bonin M, Burk O, Thomas M, Thasler WE, Zanger UM, Zell A. Inferring statin-induced gene regulatory relationships in primary human hepatocytes. Bioinformatics 2011 Sep 15; 27(18):2473-7.
  • Feidt DM, Klein K, Hofmann U, Riedmaier S, Knobeloch D, Thasler WE, Weiss TS, Schwab M, Zanger UM. Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes. Drug Metab Dispos 2010 Sep; 38(9):1589-97.
 
 

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Seit dem 6.12.2007 ist die Gewebebank i. A. HTCR der Chirurgischen Klinik und Poliklinik Großhadern nach DIN ISO 9001:2008 zertifiziert.