PAH activity landscapes web application

The PAH activity landscape web resource is a database on PAH genotypes and genotype-specific PAH enzymatic function. We map the regional distribution of most common PAH genotypes in Europe and the Middle East and provide information on PAH enzyme function associated with specific genotypes. This database is intended to further the understanding of PAH function in the individual patient's situation, taking different metabolic or therapeutic states into account. Moreover, the information provided may support clinicians in designing personalized treatment strategies for patients suffering from PAH deficiency.