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IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

20.07.2015 - Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF.
Nature Immunololgy. 2015 Apr;16(4):354-65. [Epub 2015 Mar 2]
Claudia Nold-Petry and Marcel Nold from the Department of Pediatrics in Victoria, Australia, report the multifaceted anti-inflammatory function of IL-1 ligand family member IL-37. The Molecular Pediatrics, in collaboration with Philip Bufler, characterized the formation of the IL-37 - SIGIRR - IL–18R complex in living cells by means of BRET. This work exemplifies how the application of different in vivo BRET techniques can unravel the dynamics of multi-protein complexes.