Publikationsliste

Publikationen der AG pädiatrische Infektiologie:

 

1.        Broszat M, Nacke H, Blasi R, Siebe C, Huebner J, Daniel R, Grohmann E. 2014. Wastewater irrigation increases abundance of potentially harmful Gammaproteobacteria in soils from Mezquital Valley, Mexico. Appl Environ Microbiol. (in press)

2.        Borde JP, Batin N, Rieg S, Feik R, Reimling C, Kern WV, de With K, Hübner J, Ruhnke M, Kaier K. 2014. Adherence to an antibiotic stewardship bundle targeting Staphylococcus aureus blood stream infections at a 200-bed community hospital. Infection. (in press)

3.        Hufnagel M, Sixel K, Hammer F, Kropec A, Sava IG, Theilacker C, Berner R, Huebner J. 2014. Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations. Infection. (in press)

4.        Dwyer M, Shan Q, D'Ortona S, Maurer R, Mitchell R, Olesen H, Thiel S, Huebner J, Gadjeva M. 2014. Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor. J Innate Immun. (in press)

5.        Helwig P, Morlock J, Oberst M, Hauschild O, Hübner J, Borde J, Südkamp NP, Konstantinidis L. 2014. Periprosthetic joint infection-effect on quality of life. Int Orthop 38:1077–1081.

6.        Goessweiner-Mohr N, Fercher C, Arends K, Birner-Gruenberger R, Laverde-Gomez D, Huebner J, Grohmann E, Keller W. 2014. The type IV secretion protein TraK from the Enterococcusconjugative plasmid pIP501 exhibits a novel fold. Acta Crystallogr D Biol Crystallogr 70:1124–1135.

7.        Diederich A-K, Wobser D, Spiess M, Sava IG, Huebner J, Sakιnç T. 2014. Role of Glycolipids in the Pathogenesis of Enterococcus faecalis Urinary Tract Infection. PLoS ONE 9:e96295.

9.        Haller C, Berthold M, Wobser D, Kropec A, Lauriola M, Schlensak C, Huebner J. 2014. Cell-Wall Glycolipid Mutations and Their Effects on Virulence of E. faecalis in a Rat Model of Infective Endocarditis. PLoS ONE 9:e91863.

12.     Goessweiner-Mohr N, Grumet L, Arends K, Pavkov-Keller T, Gruber CC, Gruber K, Birner-Gruenberger R, Kropec-Huebner A, Huebner J, Grohmann E, Keller W. 2013. The 2.5 A Structure of the Enterococcus Conjugation Protein TraM resembles VirB8 Type IV Secretion Proteins. J Biol Chem 288:2018–2028.

13.     Castillo-Rojas G, Mazari-Hiriart M, Ponce-de-León S, Amieva-Fernández RI, Agis-Juárez RA, Huebner J, López-Vidal Y. 2013. Comparison of Enterococcus faecium and Enterococcus faecalis Strains Isolated from Water and Clinical Samples: Antimicrobial Susceptibility and Genetic Relationships. PLoS ONE 8:e59491.

15.     Geiss-Liebisch S, Rooijakkers SHM, Beczala A, Sanchez-Carballo P, Kruszynska K, Repp C, Sakinc T, Vinogradov E, Holst O, Huebner J, Theilacker C. 2012. Secondary cell wall polymers of Enterococcus faecalis are critical for resistance to complement activation via mannose-binding lectin. J Biol Chem 287:37769–37777.

16.     Skurnik D, Kropec A, Roux D, Theilacker C, Huebner J, Pier GB. 2012. Natural antibodies in normal human serum inhibit Staphylococcus aureus capsular polysaccharide vaccine efficacy. Clinical Infectious Diseases 55:1188–1197.

20.     Hübner J. 2012. Impfungen im 21. Jahrhundert: Zeitgemäß oder überholt?. MMW Fortschr Med 154:43–46.

22.     Theilacker C, Kropec A, Hammer F, Sava I, Wobser D, Sakinc T, Codée JDC, Hogendorf WFJ, Van der Marel GA, Huebner J. 2012. Protection against Staphylococcus aureus by antibody to the polyglycerolphosphate backbone of heterologous lipoteichoic acid. J INFECT DIS 205:1076–1085.

23.     Theilacker C, Holst O, Lindner B, Huebner J, Kaczynski Z. 2012. The structure of the wall teichoic acid isolated from Enterococcus faecalis strain 12030. Carbohydr Res 354:106–109.

25.     Arends K, Schiwon K, Sakinc T, Hübner J, Grohmann E. 2012. Green fluorescent protein-labeled monitoring tool to quantify conjugative plasmid transfer between Gram-positive and Gram-negative bacteria. Appl Environ Microbiol 78:895–899.

26.     Bao Y, Sakinc T, Laverde D, Wobser D, Benachour A, Theilacker C, Hartke A, Huebner J. 2012. Role of mprF1 and mprF2 in the Pathogenicity of Enterococcus faecalis. PLoS ONE 7:e38458.

27.     Dalkmann P, Broszat M, Siebe C, Willaschek E, Sakinc T, Huebner J, Amelung W, Grohmann E, Siemens J. 2012. Accumulation of pharmaceuticals, Enterococcus, and resistance genes in soils irrigated with wastewater for zero to 100 years in central Mexico. PLoS ONE 7:e45397.

28.     Borde JP, Meier S, Fingerle V, Klier C, Hübner J, Kern WV. 2012. CXCL13 may improve diagnosis in early neuroborreliosis with atypical laboratory findings. BMC Infect Dis 12:344.

29.     Rigottier-Gois L, Alberti A, Houel A, Taly J-F, Palcy P, Manson J, Pinto D, Matos RC, Carrilero L, Montero N, Tariq M, Karsens H, Repp C, Kropec A, Budin-Verneuil A, Benachour A, Sauvageot N, Bizzini A, Gilmore MS, Bessières P, Kok J, Huebner J, Lopes F, Gonzalez-Zorn B, Hartke A, Serror P. 2011. Large-Scale Screening of a Targeted Enterococcus faecalis Mutant Library Identifies Envelope Fitness Factors. PLoS ONE 6:e29023.

30.     Bychowska A, Theilacker C, Czerwicka M, Marszewska K, Huebner J, Holst O, Stepnowski P, Kaczynski Z. 2011. Chemical structure of wall teichoic acid isolated from Enterococcus faecium strain U0317. Carbohydr Res 346:2816–2819.

31.     Balabanova Y, Gilsdorf A, Buda S, Burger R, Eckmanns T, Gärtner B, Groß U, Haas W, Hamouda O, Hübner J, Jänisch T, Kist M, Kramer MH, Ledig T, Mielke M, Pulz M, Stark KA, Suttorp N, Ulbrich U, Wichmann O, Krause G. 2011. Communicable Diseases Prioritized for Surveillance and Epidemiological Research: Results of a Standardized Prioritization Procedure in Germany, 2011. PLoS ONE 6:e25691.

33.     Hogendorf WFJ, Meeuwenoord N, Overkleeft HS, Filippov DV, Laverde D, Kropec A, Huebner J, Van der Marel GA, Codée JDC. 2011. Automated solid phase synthesis of teichoic acids. Chem. Commun. (Camb.) 47:8961–8963.

34.     Gomez JAL, Hendrickx APA, Willems RJ, Top J, Sava I, Huebner J, Witte W, Werner G. 2011. Intra- and Interspecies Genomic Transfer of the Enterococcus faecalis Pathogenicity Island. PLoS ONE 6:e16720.

36.     Theilacker C, Sava I, Sanchez-Carballo P, Bao Y, Kropec A, Grohmann E, Holst O, Huebner J. 2011. Deletion of the glycosyltransferase bgsB of Enterococcus faecalis leads to a complete loss of glycolipids from the cell membrane and to impaired biofilm formation. BMC Microbiol 11:67.

37.     Theilacker C, Kaczynski Z, Kropec A, Sava I, Ye L, Bychowska A, Holst O, Huebner J. 2011. Serodiversity of Opsonic Antibodies against Enterococcus faecalis -Glycans of the Cell Wall Revisited. PLoS ONE 6:e17839.

38.     Al-Ahmad A, Maier J, Follo M, Spitzmüller B, Wittmer A, Hellwig E, Hübner J, Jonas D. 2010. Food-borne enterococci integrate into oral biofilm: an in vivo study. J Endod 36:1812–1819.

40.     Grundmann S, Huebner J, Stuplich J, Koch A, Wu K, Geibel-Zehender A, Bode C, Brunner M. 2010. Prosthetic valve endocarditis due to Actinomyces neuii successfully treated with antibiotic therapy. J Clin Microbiol 48:1008–1011.

41.     Hanin A, Sava I, Bao Y, Huebner J, Hartke A, Auffray Y, Sauvageot N. 2010. Screening of in vivo activated genes in Enterococcus faecalis during insect and mouse infections and growth in urine. PLoS ONE 5:e11879.

42.     Rieg S, Peyerl-Hoffmann G, de With K, Theilacker C, Wagner D, Hübner J, Dettenkofer M, Kaasch A, Seifert H, Schneider C, Kern WV. 2009. Mortality of S. aureus bacteremia and infectious diseases specialist consultation--a study of 521 patients in Germany. J Infect 59:232–239.

43.     Creti R, Fabretti F, Koch S, Huebner J, Garsin DA, Baldassarri L, Montanaro L, Arciola CR. 2009. Surface protein EF3314 contributes to virulence properties of Enterococcus faecalis. Int J Artif Organs 32:611–620.

44.     Sava IG, Zhang F, Toma I, Theilacker C, Li B, Baumert TF, Holst O, Linhardt RJ, Huebner J. 2009. Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells. J Biol Chem 284:18194–18201.

45.     Al-Ahmad A, Müller N, Wiedmann-Al-Ahmad M, Sava I, Hübner J, Follo M, Schirrmeister J, Hellwig E. 2009. Endodontic and salivary isolates of Enterococcus faecalis integrate into biofilm from human salivary bacteria cultivated in vitro. J Endod 35:986–991.

46.     Theilacker C, Sanchez-Carballo P, Toma I, Fabretti F, Sava I, Kropec A, Holst O, Huebner J. 2009. Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis. Mol Microbiol 71:1055–1069.

48.     Huebner J. 2008. Probiotika – evidenzbasierte Medizin oder alternativ-medizinischer Hokuspokus?

49.     Henneke P, Dramsi S, Mancuso G, Chraibi K, Pellegrini E, Theilacker C, Hübner J, Santos-Sierra S, Teti G, Golenbock DT, Poyart C, Trieu-Cuot P. 2008. Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis. J Immunol 180:6149–6158.

50.     Arciola CR, Baldassarri L, Campoccia D, Creti R, Pirini V, Huebner J, Montanaro L. 2008. Strong biofilm production, antibiotic multi-resistance and high gelE expression in epidemic clones of Enterococcus faecalis from orthopaedic implant infections. Biomaterials 29:580–586.

51.     Arciola CR, Campoccia D, Baldassarri L, Pirini V, Huebner J, Montanaro L. 2007. The role of Enterococcus faecalis in orthopaedic peri-implant infections demonstrated by automated ribotyping and cluster analysis. Biomaterials 28:3987–3995.

52.     Theilacker C, Kaczynski Z, Kropec A, Fabretti F, Sange T, Holst O, Huebner J. 2006. Opsonic antibodies to Enterococcus faecalis strain 12030 are directed against lipoteichoic acid. Infect Immun 74:5703–5712.

53.     Fabretti F, Theilacker C, Baldassarri L, Kaczynski Z, Kropec A, Holst O, Huebner J. 2006. Alanine esters of enterococcal lipoteichoic acid play a role in biofilm formation and resistance to antimicrobial peptides. Infect Immun 74:4164–4171.

54.     Hsu CT, Ganong AL, Reinap B, Mourelatos Z, Huebner J, Wang JY. 2006. Immunochemical characterization of polysaccharide antigens from six clinical strains of Enterococci. BMC Microbiol 6:62.

55.     Creti R, Koch S, Fabretti F, Baldassarri L, Huebner J. 2006. Enterococcal colonization of the gastro-intestinal tract: role of biofilm and environmental oligosaccharides. BMC Microbiol 6:60.

56.     Hufnagel M, Kropec A, Theilacker C, Huebner J. 2005. Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in healthy human sera. Clin Diagn Lab Immunol 12:930–934.

57.     Baldassarri L, Bertuccini L, Creti R, Filippini P, Ammendolia MG, Koch S, Huebner J, Orefici G. 2005. Glycosaminoglycans mediate invasion and survival of Enterococcus faecalis into macrophages. J INFECT DIS 191:1253–1262.

58.     Theilacker C, Krueger WA, Kropec A, Huebner J. 2004. Rationale for the development of immunotherapy regimens against enterococcal infections. Vaccine 22 Suppl 1:S31–8.

59.     Koch S, Hufnagel M, Huebner J. 2004. Treatment and prevention of enterococcal infections--alternative and experimental approaches. Expert opinion on biological therapy 4:1519–1531.

61.     Hufnagel M, Hancock LE, Koch S, Theilacker C, Gilmore MS, Huebner J. 2004. Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis. J Clin Microbiol 42:2548–2557.

63.     Koch S, Hufnagel M, Theilacker C, Huebner J. 2004. Enterococcal infections: host response, therapeutic, and prophylactic possibilities. Vaccine 22:822–830.

64.     Hufnagel M, Koch S, Creti R, Baldassarri L, Huebner J. 2004. A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to production of biofilm and prolonged bacteremia in mice. J INFECT DIS 189:420–430.

65.     Krueger WA, Krueger-Rameck S, Koch S, Carey V, Pier GB, Huebner J. 2004. Assessment of the role of antibiotics and enterococcal virulence factors in a mouse model of extraintestinal translocation. Crit Care Med 32:467–471.

66.     Hufnagel M, Koch S, Kropec A, Huebner J. 2003. Opsonophagocytic assay as a potentially useful tool for assessing safety of enterococcal preparations. International Journal of Food Microbiology 88:263–267.

67.     Allerberger F, Ayliffe G, Bassetti M, Braveny I, Bucher A, Damani N, Daschner F, Dettenkofer M, Ezpeleta C, Gastmeier P, Geffers C, Giamarellou H, Goldman D, Grzesiowski P, Gubina M, Haanen PEM, Haydouchka I, Hübner J, (null), Van Knippenberg-Gordebeke G, Kranenburg AMH, Krcmery V, Kropec A, Krüger W, Lemmen S, Mayhall CG, Meester M, Mehtar S, Munzinger J, Muzlovic I, Ojajarvi J, Rüden H, Scott G, Shah P, Tambic-Andraszevic A, Unertl K, Voss A, Weist K. 2002. Routine surface disinfection in health care facilities: should we do it? Am J Infect Control 30:318–319.

 

 

Abteilungsleiter:
Prof. Dr. med. Johannes Hübner
Abteilung für pädiatrische Infektiologie
Dr. von Haunersches Kinderspital
Lindwurmstr. 4
80337 München
+49-89-4400-57970
johannes.huebner@med.uni-muenchen.de

 

Ärztliche Mitarbeiter:
Dr. Ulrich von Both
ulrich.von.both@med.uni-muenchen.de

Dr. Anita Rack-Hoch
anita.rack@med.uni-muenchen.de

 

Schwestern:
Steffi Schlieben
Gabi Strotmann
Alexandra Wichert
Nikole Hoffmann 
 
Sekretariat:
Frau Gruber
089-4400-57849
Frau Valerie Spiess
089-4400-57705

 

bakteriologisches Labor:
Frau Laniado
Frau Hanings
Frau Zeilhofer
Frau Eydin
089-4400-53154
varia.lab@med.uni-muenchen.de

 

Forschungslabor (Doktoranden):
Friederike Rossmann
Ann-Kristin Diederich