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Publikationen

Selected Publications

1. Pfefferkorn T, Holtmannspotter M, Patzig M, Bruckmann H, Ottomeyer C, Opherk C, Dichgans M, Fesl G: Preceding intravenous thrombolysis facilitates endovascular mechanical recanalization in large intracranial artery occlusion. International journal of stroke : official journal of the International Stroke Society 2012, 7(1):14-18.

2. Hockel K, Scholler K, Trabold R, Nussberger J, Plesnila N: Vasopressin v1a receptors mediate posthemorrhagic systemic hypertension thereby determining rebleeding rate and outcome after experimental subarachnoid hemorrhage. Stroke; a journal of cerebral circulation 2012, 43(1):227-232.

3. Gunda B, Herve D, Godin O, Bruno M, Reyes S, Alili N, Opherk C, Jouvent E, During M, Bousser MG et al: Effects of Gender on the Phenotype of CADASIL. Stroke; a journal of cerebral circulation 2012, 43(1):137-141.

4. Thal SE, Zhu C, Thal SC, Blomgren K, Plesnila N: Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice. Neuroscience letters 2011, 499(1):1-3.

5. Terpolilli NA, Kim SW, Thal SC, Kataoka H, Zeisig V, Nitzsche B, Klaesner B, Zhu C, Schwarzmaier S, Meissner L et al: Inhalation of Nitric Oxide Prevents Ischemic Brain Damage in Experimental Stroke by Selective Dilatation of Collateral Arterioles. Circulation research 2011.

6. Scholler K, Feiler S, Anetsberger S, Kim SW, Plesnila N: Contribution of bradykinin receptors to the development of secondary brain damage after experimental subarachnoid hemorrhage. Neurosurgery 2011, 68(4):1118-1123.

7. Pfefferkorn T, Saam T, Rominger A, Habs M, Gerdes LA, Schmidt C, Cyran C, Straube A, Linn J, Nikolaou K et al: Vessel wall inflammation in spontaneous cervical artery dissection: a prospective, observational positron emission tomography, computed tomography, and magnetic resonance imaging study. Stroke; a journal of cerebral circulation 2011, 42(6):1563-1568.

8. Linn J, Fesl G, Ottomeyer C, Straube A, Dichgans M, Bruckmann H, Pfefferkorn T: Intra-arterial application of nimodipine in reversible cerebral vasoconstriction syndrome: a diagnostic tool in select cases? Cephalalgia : an international journal of headache 2011, 31(10):1074-1081.

9. Jouvent E, Reyes S, Mangin JF, Roca P, Perrot M, Thyreau B, Herve D, Dichgans M, Chabriat H: Apathy is related to cortex morphology in CADASIL. A sulcal-based morphometry study. Neurology 2011, 76(17):1472-1477.

10. Habs M, Pfefferkorn T, Cyran CC, Grimm J, Rominger A, Hacker M, Opherk C, Reiser MF, Nikolaou K, Saam T: Age determination of vessel wall hematoma in spontaneous cervical artery dissection: A multi-sequence 3T Cardiovascular Magnetic Resonance Study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2011, 13(1):76.

11. Friedrich B, Muller F, Feiler S, Scholler K, Plesnila N: Experimental subarachnoid hemorrhage causes early and long-lasting microarterial constriction and microthrombosis: an in-vivo microscopy study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011.

12. Freilinger T, Dimitriadis K, Nikolaou K, Reiser MF, Dichgans M, Saam T: Stroke while squeezing a pimple: traumatic rupture of a vulnerable carotid artery plaque. Neurology 2011, 76(3):305-306.

13. Fesl G, Wiesmann M, Patzig M, Holtmannspoetter M, Pfefferkorn T, Dichgans M, Brueckmann H: Endovascular mechanical recanalisation of acute carotid-T occlusions: a single-center retrospective analysis. Cardiovascular and interventional radiology 2011, 34(2):280-286.

14. Fesl G, Patzig M, Holtmannspoetter M, Mayer TE, Pfefferkorn T, Opherk C, Brueckmann H, Wiesmann M: Endovascular Mechanical Recanalisation After Intravenous Thrombolysis in Acute Anterior Circulation Stroke: The Impact of a New Temporary Stent. Cardiovascular and interventional radiology 2011.

15. Epelbaum S, Benisty S, Reyes S, O'Sullivan M, Jouvent E, During M, Herve D, Opherk C, Hernandez K, Kurtz A et al: Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL. Neurobiology of aging 2011, 32(12):2172-2182.

16. Engel T, Plesnila N, Prehn JH, Henshall DC: In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011, 31(5):1196-1210.

17. Duering M, Zieren N, Herve D, Jouvent E, Reyes S, Peters N, Pachai C, Opherk C, Chabriat H, Dichgans M: Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL. Brain : a journal of neurology 2011, 134(Pt 8):2366-2375.

18. Duering M, Karpinska A, Rosner S, Hopfner F, Zechmeister M, Peters N, Kremmer E, Haffner C, Giese A, Dichgans M et al: Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis. Human molecular genetics 2011, 20(16):3256-3265.

19. Peters N, Dichgans M. : Vaskuläre Demenz. 2010 81(10):1245-1253.

20. Jahn K DM: Herz-Hirn-Interaktion in der Intensivmedizin. Dtsch Med Wochenschr 2010 135(47):2347-2352.

21. Thal SC, Thal SE, Plesnila N: Characterization of a 3-vessel occlusion model for the induction of complete global cerebral ischemia in mice. Journal of neuroscience methods 2010, 192(2):219-227.

22. Saam T, Habs M, Pollatos O, Cyran C, Pfefferkorn T, Dichgans M, Dietrich O, Glaser C, Reiser MF, Nikolaou K: High-resolution black-blood contrast-enhanced T1 weighted images for the diagnosis and follow-up of intracranial arteritis. The British journal of radiology 2010, 83(993):e182-184.

23. Pfefferkorn T, Schuller U, Cyran C, Hufner K, Fesl G, Seelos K, Dichgans M, Pfister HW, Nikolaou K, Kretzschmar H et al: Giant cell arteritis of the Basal cerebral arteries: correlation of MRI, dsa, and histopathology. Neurology 2010, 74(20):1651-1653.

24. Pfefferkorn T, Holtmannspotter M, Schmidt C, Bender A, Pfister HW, Straube A, Mayer TE, Bruckmann H, Dichgans M, Fesl G: Drip, ship, and retrieve: cooperative recanalization therapy in acute basilar artery occlusion. Stroke; a journal of cerebral circulation 2010, 41(4):722-726.

25. Linn J, Michl S, Katja B, Pfefferkorn T, Wiesmann M, Hartz S, Dichgans M, Bruckmann H: Cortical vein thrombosis: the diagnostic value of different imaging modalities. Neuroradiology 2010, 52(10):899-911.

26. Linn J, Halpin A, Demaerel P, Ruhland J, Giese AD, Dichgans M, van Buchem MA, Bruckmann H, Greenberg SM: Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology 2010, 74(17):1346-1350.

27. Laufs U, Hoppe UC, Rosenkranz S, Kirchhof P, Bohm M, Diener HC, Endres M, Grond M, Hacke W, Meinertz T et al: [Cardiac workup after cerebral ischemia. Consensus paper of the Working Group on Heart and Brain of the German Cardiac Society and German Stroke Society]. Der Nervenarzt 2010, 81(4):444-462.

28. Lanktree MB, Dichgans M, Hegele RA: Advances in genomic analysis of stroke: what have we learned and where are we headed? Stroke; a journal of cerebral circulation 2010, 41(4):825-832.

29. Kernt M, Gschwendtner A, Neubauer AS, Dichgans M, Haritoglou C: Effects of intravitreal bevacizumab treatment on proliferative retinopathy in a patient with cerebroretinal vasculopathy. Journal of neurology 2010, 257(7):1213-1214.

30. Jacqmin M, Herve D, Viswanathan A, Guichard JP, During M, Dichgans M, Chabriat H: Confluent thalamic hyperintensities in CADASIL. Cerebrovasc Dis 2010, 30(3):308-313.

31. Hegele RA, Dichgans M: Advances in stroke 2009: update on the genetics of stroke and cerebrovascular disease 2009. Stroke; a journal of cerebral circulation 2010, 41(2):e63-66.

32. Freilinger T, Schmidt C, Duering M, Linn J, Straube A, Peters N: Reversible cerebral vasoconstriction syndrome associated with hormone therapy for intrauterine insemination. Cephalalgia : an international journal of headache 2010, 30(9):1127-1132.

33. Freilinger T, Saam T, Duering M, Dichgans M, Peters N: Internal Carotid Artery Dissection and Ischemic Cerebral Infarction in the Setting of Essential Thrombocythemia. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2010.

34. Feiler S, Friedrich B, Scholler K, Thal SC, Plesnila N: Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring. Journal of neuroscience methods 2010, 190(2):164-170.

35. Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K et al: The Causative Classification of Stroke system: an international reliability and optimization study. Neurology 2010, 75(14):1277-1284.

36. Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, Nyholt DR, Dimas AS, Freilinger T, Muller-Myhsok B et al: Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nature genetics 2010, 42(10):869-873.

37. The International Stroke Genetics Consortium and the Welcome Trust Case Control Consortium 2. Failure to Validate Associations between Variants on 12p13 and Ischemic Stroke. New Engl J Med 2010, 362(16):1547-1550.

38. Opherk C, Peters N, Dichgans M: [Vasculitis and hereditary small vessel diseases]. Der Internist 2009, 50(11):1200-1209.

39. Opherk C, Duering M, Peters N, Karpinska A, Rosner S, Schneider E, Bader B, Giese A, Dichgans M: CADASIL mutations enhance spontaneous multimerization of NOTCH3. Human molecular genetics 2009, 18(15):2761-2767.

40. Ringel F, Plesnila N: Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells. Neuroscience letters 2008, 442(3):219-223.

41. Pfefferkorn T, Bitterling H, Hufner K, Opherk C, Schewe S, Pfister HW, Straube A, Dichgans M: Malignant hemispheric infarction in Takayasu arteritis. Journal of neurology 2008, 255(9):1425-1426.

42. Peters N, Freilinger T, Opherk C, Pfefferkorn T, Dichgans M: Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL. Journal of neurology 2008, 255(8):1203-1208.

43. Thal SC, Plesnila N: Non-invasive intraoperative monitoring of blood pressure and arterial pCO2 during surgical anesthesia in mice. Journal of neuroscience methods 2007, 159(2):261-267.

44. Scholler K, Trinkl A, Klopotowski M, Thal SC, Plesnila N, Trabold R, Hamann GF, Schmid-Elsaesser R, Zausinger S: Characterization of microvascular basal lamina damage and blood-brain barrier dysfunction following subarachnoid hemorrhage in rats. Brain research 2007, 1142:237-246.

45. Peters N, Freilinger T, Opherk C, Pfefferkorn T, Dichgans M: Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASIL. Journal of the neurological sciences 2007, 260(1-2):100-105.

46. Ringel F, Bieringer F, Baethmann A, Plesnila N: Effect of oxidative stress on glial cell volume. Journal of neurotrauma 2006, 23(11):1693-1704.

47. Peters N, Holtmannspotter M, Opherk C, Gschwendtner A, Herzog J, Samann P, Dichgans M: Brain volume changes in CADASIL: a serial MRI study in pure subcortical ischemic vascular disease. Neurology 2006, 66(10):1517-1522.

48. Opherk C, Peters N, Holtmannspotter M, Gschwendtner A, Muller-Myhsok B, Dichgans M: Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers. Stroke; a journal of cerebral circulation 2006, 37(11):2684-2689.

49. Opherk C, Gruber C, Steude U, Dichgans M, Botzel K: Successful bilateral pallidal stimulation for Meige syndrome and spasmodic torticollis. Neurology 2006, 66(4):E14.

50. Le Corre S, Klafki HW, Plesnila N, Hubinger G, Obermeier A, Sahagun H, Monse B, Seneci P, Lewis J, Eriksen J et al: An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(25):9673-9678.

51. Klasner B, Lumenta DB, Pruneau D, Zausinger S, Plesnila N: Therapeutic window of bradykinin B2 receptor inhibition after focal cerebral ischemia in rats. Neurochemistry international 2006, 49(5):442-447.

52. Culmsee C, Plesnila N: Targeting Bid to prevent programmed cell death in neurons. Biochemical Society transactions 2006, 34(Pt 6):1334-1340.

53. Becattini B, Culmsee C, Leone M, Zhai D, Zhang X, Crowell KJ, Rega MF, Landshamer S, Reed JC, Plesnila N et al: Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(33):12602-12606.

54. Vakili A, Kataoka H, Plesnila N: Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005, 25(8):1012-1019.

55. Peters N, Opherk C, Danek A, Ballard C, Herzog J, Dichgans M: The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementia. The American journal of psychiatry 2005, 162(11):2078-2085.

56. Peters N, Opherk C, Bergmann T, Castro M, Herzog J, Dichgans M: Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies. Archives of neurology 2005, 62(7):1091-1094.

57. Holtmannspotter M, Peters N, Opherk C, Martin D, Herzog J, Bruckmann H, Samann P, Gschwendtner A, Dichgans M: Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study. Stroke; a journal of cerebral circulation 2005, 36(12):2559-2565.

58. Groger M, Lebesgue D, Pruneau D, Relton J, Kim SW, Nussberger J, Plesnila N: Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005, 25(8):978-989.

59. Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M, Blomgren K, Plesnila N: Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience 2005, 25(44):10262-10272.

60. Tronche F, Opherk C, Moriggl R, Kellendonk C, Reimann A, Schwake L, Reichardt HM, Stangl K, Gau D, Hoeflich A et al: Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes & development 2004, 18(5):492-497.

61. Peters N, Opherk C, Zacherle S, Capell A, Gempel P, Dichgans M: CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk. Experimental cell research 2004, 299(2):454-464.

62. Opherk C, Tronche F, Kellendonk C, Kohlmuller D, Schulze A, Schmid W, Schutz G: Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol Endocrinol 2004, 18(6):1346-1353.

63. Opherk C, Peters N, Herzog J, Luedtke R, Dichgans M: Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients. Brain : a journal of neurology 2004, 127(Pt 11):2533-2539.

64. Liebetrau M, Mayer TE, Bruning R, Opherk C, Hamann GF: Intra-arterial thrombolysis of complete deep cerebral venous thrombosis. Neurology 2004, 63(12):2444-2445.

65. Haritoglou C, Rudolph G, Hoops JP, Opherk C, Kampik A, Dichgans M: Retinal vascular abnormalities in CADASIL. Neurology 2004, 62(7):1202-1205.

66. Opherk C, Hirsch LJ: Ictal heart rate differentiates epileptic from non-epileptic seizures. Neurology 2002, 58(4):636-638.

67. Opherk C, Coromilas J, Hirsch LJ: Heart rate and EKG changes in 102 seizures: analysis of influencing factors. Epilepsy research 2002, 52(2):117-127.

68. Kellendonk C, Opherk C, Anlag K, Schutz G, Tronche F: Hepatocyte-specific expression of Cre recombinase. Genesis 2000, 26(2):151-153.

69. Kellendonk C, Tronche F, Casanova E, Anlag K, Opherk C, Schutz G: Inducible site-specific recombination in the brain. Journal of molecular biology 1999, 285(1):175-182.

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