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Role of α-1-antitrypsin in large artery stroke

An exome-wide association study led by ISD investigators found M1(A213V) in SERPINA1 to be associated with stroke, with the variant changing its functional dynamics towards neutrophil elastase in the presence of lipid-containing plasma [mehr...]


Neural substrate of cognitive reserve in Alzheimer’s

More years of education is associated with reduced risk of Alzheimer’s dementia. ISD researchers found that higher connectivity of a hub region in the frontal cortex may subserve protective effects of education... [mehr...]


Homoarginine Improves Function in Heart Failure

Low homoarginine (HA) is an emerging biomarker for cardiovascular diseases. In collaboration, Dorothee Atzler from the Vascular Biology team at the ISD showed that HA is more than a bystander biomarker, since HA-supplementation helps to support cardiac function in chronic heart failure in mice [mehr...]


Tracing the neuroimmune response in AD

The emergence of neuroinflammation in the pathological cascade of Alzheimer’s disease is still unknown. The teams of C. Haass (DZNE) and M. Ewers (ISD) demonstrated dynamic changes in the novel biomarker of microglia activity, called TREM2, to be closely coupled to neurodegeneration occurring seve... [mehr...]


Dominik Paquet joins ISD as Professor of Neurobiology

December 1st, 2016 coming from The Rockefeller University (New York, USA), Dominik Paquet has joined the ISD. He was appointed Professor for Neurobiology and is a member of the Munich Cluster for Sy... [mehr...]

Interfering with the Chronic Immune Response

Traumatic brain injury (TBI) frequently causes chronic complications including epilepsy and dementia. A new study by Ali Ertürk and colleagues shows that TBI causes a long-lasting brain immune respo... [mehr...]



Prof. Dr. med. Martin Dichgans

CSD im Überblick...

Centrum für Schlaganfall- und Demenzforschung